Product Safety Assessment VenPure Borohydride Products Product Safety Assessment documents are available at: www.dow.com/productsafety/finder/. Select a Topic: Names Product Overview Manufacture of Product Product Description Product Uses Exposure Potential Health Information Environmental Information Physical Hazard Information Regulatory Information Additional Information References Names VenPure borohydride products VenPure SF granules CAS No. 16940-66-2 VenPure SF powder CAS No. 13762-51-1 VenPure sodium borohydride VenPure AF caplets VenPure solution VenPure AF granules Product Overview The Dow Chemical Company ( Dow ) manufactures and markets a family of sodium borohydride products under the trade name VenPure borohydrides. These products are available as granules, powders, caplets, and solution. Sodium borohydride solid products are white and odorless. 1 For further details, see Product Description. VenPure borohydride products are reducing agents used in pharmaceutical and industrial applications. For further details, see Product Uses. Worker exposure is possible during the manufacture or use of these chemicals. Consumer contact is unlikely. 1 For further details, see Exposure Potential. These products are corrosive. Eye or skin contact causes severe burns. Eye contact may result in permanent eye injury. Inhalation of product dust can cause severe irritation of the nose, throat, and lungs. 1 For further details, see Health Information. VenPure borohydride products are completely soluble in water. Sodium borohydride released to the environment would react with water in the air or soil resulting in the release of hydrogen gas (H 2 ). For further details, see Environmental Information. VenPureborohydride products are combustible. They are stable under recommended storage and use conditions. Contact with water, oxidizing agents, acids, alcohols and metals such as aluminum, copper, and zinc, can liberate flammable hydrogen gas. 1 For further details, see Physical Hazard Information. Trademark of The Dow Chemical Company ( Dow ) or an affiliated company of Dow Revised: July 28, 2014 The Dow Chemical Company Page 1 of 5
Manufacture of Product 2 Production location Dow manufactures VenPure borohydride products at its facilities in the USA. Process VenPure borohydride products are manufactured from the raw materials sodium metal, hydrogen (H 2 ), and boric acid. Product Description 1 Dow manufactures and markets a family of sodium borohydride products under the trade name VenPure borohydrides. VenPure sodium borohydride (NaBH 4 ) products are manufactured as powders, granules, capsules and solutions. Sodium borohydride solid products are white and odorless. 1 Product Uses 2,3,4 VenPure borohydride products are reducing agents used in pharmaceutical and industrial applications. VenPure borohydride products are used for the following applications: To reduce aldehydes, ketones, acid chlorides, and anhydrides Acid-ester reductions Dehalogenation reactions Organic synthesis processes Removal of color, odor, and oxidation precursors in organic chemical products Pharmaceuticals production Raw material for borane production a product group which includes reducing agents, drivers of stereoselectivity, and higher organoboranes Manufacture humulone derivatives (hop extracts) Manufacture lithium borohydride (LiBH 4 ) Exposure Potential 1 VenPure borohydride products are used in the production of industrial and consumer products. Based on the uses for these chemicals, individuals could be exposed to: Workplace exposure Exposure can occur in a borohydride manufacturing facility or in the various industrial or manufacturing facilities that use VenPure borohydride products. VenPure borohydrides are produced, distributed, stored, and consumed in closed systems. Those working with these chemicals in manufacturing operations could be exposed during maintenance, sampling, testing or other procedures. Each manufacturing facility should have a thorough training program for employees, appropriate work processes, and safety equipment to limit exposure. See Health Information. Consumer exposure to products containing VenPure borohydride products Dow does not sell borohydrides for direct consumer use, but they are used as a chemical reagent to manufacture consumer products such as pharmaceuticals. VenPure borohydrides are not present in the finished products. See Health Information. Environmental releases VenPure borohydrides are used in carefully-controlled closed systems. Accidental releases to the environment would result in these chemicals reacting with water or moisture in the air resulting in the release of hydrogen gas. Keep spills and cleaning runoff out of municipal sewers and open bodies of water. Contain spills immediately with inert materials (e.g. sand, earth). Transfer liquids and solid diking material to separate suitable containers for recovery or disposal. Trademark of The Dow Chemical Company ( Dow ) or an affiliated company of Dow Revised: July 28, 2014 The Dow Chemical Company Page 2 of 5
Industrial spills or releases are infrequent and are generally contained. If a large spill does occur, the focus is on containing the spill to prevent contamination of soil and surface or ground water. Evacuate personnel to safe areas. Avoid breathing dust and remain upwind. Clean-up personnel must wear respiratory protection and appropriate personal protective equipment. Because contact with water can release flammable hydrogen gas, eliminate all sources of ignition immediately. Only non-sparking tools should be used for clean up. Shovel spilled material to suitable containers equipped with a vent. In case of fire Isolate fire and deny any unnecessary entry into the area. Do not use water to extinguish fire. Contact with water can liberate flammable hydrogen gas. VenPure borohydride products are combustible and burn vigorously with intense heat. Heated material can form flammable or explosive vapors with air. Fight fire with limestone powder, dry sand, or dry sodium carbonate. Do not use carbon dioxide (CO 2 ) extinguishers. Firefighters should wear positive pressure, self-contained breathing apparatus (SCBA) with a full-face mask and protective firefighting clothing. Follow emergency procedures carefully. See Environmental, Health and Physical Hazard Information. Health Information 1,5 Eye contact Eye contact with sodium borohydride causes severe burns with possible permanent eye injury, even blindness. Skin contact Skin contact with borohydride causes skin burns. Inhalation Inhalation of product dust or mist during processing can cause severe irritation of the nose, throat, and lungs, along with coughing, shortness of breath, tightness in the chest, and wheezing. Inhalation of VenPure solution may also result in delayed lung injury and burns. Ingestion Swallowing these chemicals causes severe digestive tract burns. Environmental Information 1 VenPure borohydride products are nonvolatile (do not evaporate) and have a very low tendency to bind to soil or sediment. VenPure borohydride products are inorganic compounds and do not photodegrade and they are not expected to biodegrade. Borohydrides, the active ingredient in VenPure borohydride products, will not accumulate in the food chain (low bioconcentration potential). These products are completely soluble in water, so most environmental testing is generally not feasible because the main component reacts with water. However, once these products react with water, they form a complex mixture of numerous boro-oxygen species, some of which are considered toxic to fish and aquatic organisms on an acute basis. Trademark of The Dow Chemical Company ( Dow ) or an affiliated company of Dow Revised: July 28, 2014 The Dow Chemical Company Page 3 of 5
Physical Hazard Information 1 VenPure borohydride products are combustible and corrosive. They are stable under recommended storage and use conditions. Exposure to moisture or high temperatures will result in the release of flammable hydrogen gas. Avoid contact with water, acids, oxidizing agents, alcohols, and metals such as aluminum, copper, and zinc. Regulatory Information Regulations may exist that govern the manufacture, sale, transportation, use and/or disposal of VenPure borohydride products. These regulations may vary by city, state, country or geographic region. Information may be found by consulting the relevant Safety Data Sheet, Technical Data Sheet, or Contact Us. Additional Information Safety Data Sheet (www.dow.com/products/product_line_detail.page?product-line=1120125) or contact the Dow Customer Information Group at (www.dow.com/assistance/dowcig.htm) Contact Us (www.dow.com/assistance/thoughts.htm) Reducing Agents and Coupling Precursors: Product List for Synthesis Applications, Rohm and Haas Company (http://www.dow.com/search.aspx?q=synthesis+technologies) VenPure SF Powder Technical Data Sheet, Rohm and Haas Company http://www.dow.com/products/product-line/venpure-reducing-agents/# VenPure Solution Technical Data Sheet, Rohm and Haas VenPure AF Caplets Technical Data Sheet, Rohm and Haas VenPure SF Granules Technical Data Sheet, Rohm and Haas Chemical Safety Report for Sodium Borohydride, Rohm and Haas Europe Trading ApS, September 3, 2010 (http://apps.echa.europa.eu/registered/registered-sub.aspx) For more business information about VenPure borohydride products, visit Dow s Reducing Agents web page at www.dow.com/products/product_line_detail.page?product-line=1120125. References 1 VenPure SF Powder Material Safety Data Sheet, Rohm and Haas Company 2 Chemical Safety Report for Sodium Borohydride, Rohm and Haas Europe Trading ApS, September 3, 2010 3 Dow Reducing Agents Products for Pharmaceutical and Industrial Applications web page www.dow.com/products/product_line_detail.page?product-line=1120125. 4 Reducing Agents and Coupling Precursors: Product List for Synthesis Applications, Rohm and Haas Company, November 2009 5 VenPure Solution Material Safety Data Sheet, Rohm and Haas Company Trademark of The Dow Chemical Company ( Dow ) or an affiliated company of Dow Revised: July 28, 2014 The Dow Chemical Company Page 4 of 5
NOTICES: As part of its 2015 Sustainability Goals, Dow has committed to make publicly available safety assessments for its products globally. This product safety assessment is intended to give general information about the chemical (or categories of chemicals) addressed. It is not intended to provide an in-depth discussion of health and safety information. Additional information is available through the relevant Safety Data Sheet, which should be consulted before use of the chemical. This product safety assessment does not replace required communication documents such as the Safety Data Sheet. The information herein is supplied upon the condition that the persons receiving same will make their own determination as to its suitability for their purposes prior to use. In no event will Dow be responsible for damages of any nature whatsoever resulting from the use of or reliance upon the information herein or the product to which that information refers. Nothing contained herein is to be construed as a recommendation to use any product, process, equipment or formulation in conflict with any patent, and Dow makes no representation or warranty, express or implied, that the use thereof will not infringe any patent. NO REPRESENTATIONS OR WARRANTIES, EITHER EXPRESS OR IMPLIED, OF MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE OR OF ANY OTHER NATURE ARE MADE HEREUNDER WITH RESPECT TO INFORMATION OR THE PRODUCT TO WHICH INFORMATION REFERS. Dow makes no commitment to update or correct any information that appears on the Internet or on its World-Wide Web server. The information contained in this document is supplemental to the Internet Disclaimer, www.dow.com/homepage/term.asp Form No. 233-00835-MM-0714X Trademark of The Dow Chemical Company ( Dow ) or an affiliated company of Dow Revised: July 28, 2014 The Dow Chemical Company Page 5 of 5