Sports Nutrition: Innovation through Form and Function, backed by Science Paul Cunningham Lonza Director Australia & NZ

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Sports Nutrition: Innovation through Form and Function, backed by Science Paul Cunningham Lonza Director Australia & NZ Consumer Health & Nutrition 23 August 2018

This document is an overview for professionals and must not be distributed as such to consumers. Recipient must ensure that final communications to the consumer on food and food supplements products comply with the applicable health claims regulations in the regions / countries where the final products are marketed. Review and follow all product safety instructions. The statements made in these materials have not been evaluated by the U.S. Food and Drug Administration or any other regulatory authority. Lonza s products are not intended for use to diagnose, treat, cure or prevent any disease. All information in this presentation relates to a product as an ingredient and corresponds to Lonza s knowledge on the subject at the date of publication, but Lonza makes no warranty as to its accuracy or completeness and Lonza assumes no obligation to update it. All information in this presentation is intended for use by recipients experienced and knowledgeable in the field, who are capable of and responsible for independently determining the suitability and to ensure their compliance with applicable law. Proper use of this information is the sole responsibility of the recipient. This information may not be applicable, complete or suitable for the recipient s finished product or application; therefore republication of this information or related statements is prohibited. Information provided in this presentation by Lonza is not intended and should not be construed as a license to operate under or a recommendation to infringe any patent or other intellectual property right. All trademarks belong to Lonza or its affiliates or to their respective third parties and are used here only for informational purposes. Copyrighted material has been produced with permissions or under license, all other materials belong to Lonza. 2018 Lonza. 2

Sports Nutrition represents about 5.5% of CH&N globally Consumer Health USD217 billion OTC USD98.6 billion Vitamins and Dietary Supplements (VDS) USD90.8 billion Biggest sports nutrition markets: USA 62% / 7.4bio Western Europe Australasia Asia Pacific Latin America Eastern Europe MEA Weight Management and Wellbeing (WMW) USD15.9 billion Sports Nutrition USD11.9 billion Next 5 years CAGR of 7.9% Mainstreaming! Euromonitor International: Consumer Health Sports Nutrition Divers and Prospects 2017 3

Fastest Growing Segments Sports Nutrition, Probiotics, Glucosamine and Multivitamins are among fastest growing Fastest Growing Segments & Products Sports Protein Products % CAGR 2017-2022 9.0 16,000.00 14,000.00 14,867.5 Regional Share Ranked by Market Size USD Millions Probiotic Supplements 8.6 12,000.00 11,176.9 Supplement Nutrition Drinks 7.8 10,000.00 8,000.00 Sports Non-Protein Products 6.5 6,000.00 5,123.7 Pediatric VDS Vitamin D 5.9 5.8 4,000.00 2,000.00 3,774.9 3,634.4 3,596.7 3,449 2,460.2 2,369.8 1,414 Glucosamine 4.9 0.00 Vitamin B 4.7 Multivitamins 4.6 Vitamin C 4.4 North America Asia Pacific Western Europe Latin America Eastern Europe Middle East & Africa Australasia 4

What is Performance Nutrition Energy & Endurance Joint Health Strength, Power & Stamina Testosterone booster Peripheral segments not at the heart of sports nutrition, but close to it Healthy Ageing Beauty from within Focus & Nootropics Lean/Weight Management Sarcopenia (muscle loss with age) Body & skin Look & Feel Recovery, Immune Health & Sleep 5

The Expanding Consumer Base New user groups Elite-Athletes Pro-Actives Loyal Informed Dedicated Early adaptors Ambassadors Embrace innovation Looking for cutting-edge technologies and latest ingredients Buys frequently Performance, resultsdriven Millennials (21-34y) are the mainstream buyers GenY and Baby boomers (50-64y) are flocking to the category Look for products peripheral to training We are what we eat Clean, green, environmentally focused Performance, body image, health, weight, longevity 6

Know your customer build your tribe! Source: NMI SORD US Study 2013-2017 Source: NMI SORD US Study 2011-2015 Consumer demand for product quality, traceability of ingredients, and elimination of additives has set the stage for the advent of the clean label movement. 7

The Clean Label Movement: Sustainable and Eco-friendly % consumers indicating I am more likely to buy a supplement if it uses sustainable or e-friendly ingredients Light 34% Heavy 54% Light 34% Heavy 54% Digestive health Sports health 35% 41% Sports Cognitive health Joint/Bone health 33% 37% 41% Millennials 38% Gen X Boomer Matures 31% 33% 36% Millennials 38% Source: NMI SORD UK Study 2018 8

The Clean Label Movement: the Link with Vegetarian % consumers indicating vegetarian/no animal products is very/somewhat important in their decision to purchase supplements 83% 66% 71% 42% 51% 45% 54% 47% 51% 39% 34% 36% Light Heavy No additives Non-GMO Organic Digestive health Sports health Cognitive health Millennials Gen X Boomer Matures Source: NMI SORD UK Study 2018 Consumers looking for free-from supplements prefer vegetarian products. 1 out of 2 Heavy users, Millennials and Sports Nutrition Food supplement users prefer vegetarian products.

Capsugel s natural, free-from, vegetarian dosage forms meet the clean label expectations of consumers 10

New products Carnipure Finished Products Consumer Health & Nutrition 23 August 2018 11

Carnipure free flowing Licaps Capsules World s first and only liquid L-Carnitine capsule product, based on Lonza s Carnipure Carnipure 300 & 500mg Made from free L-Carnitine Vegetarian Liquid and pure Stable 24months, room conditions Can be combined with Vit D3 for EFSA claims (ie supports normal muscle function) Contains 300mg L-Carnitine (Carnipure ) 82.5mg Choline: Choline is important, in that it makes methionine available for carnitine s biosynthesis Contains ultra-high dosed 500ug Vit B12. Allows EFSA claims on fat metabolism, homocystein levels, and fatigue 12

Vegan protein plus Carnipure A purely herbal or ovo-lacto-vegetabile diet provides only low levels of L-carnitine Vegan plant proteins are trending but vegan protein do not have any natural content of L-carnitine Vegans therefore benefit from a targeted intake of carnitine Opportunity for plant based protein plus carnitine No products of animal origin are used in the production process. Carnipure is suitable for Vegetarians and Vegans L-carnitine can help to avoid muscle breakdown, the combination with vegan proteins makes perfect sense. Visit www.carnipure.com for more than 17 studies about the impact on muscle recovery in different types of users including middle aged men/women, athletes, vegetarians and for 6 studies and pilot clinical trials that support the weight management application. 13

Formulation possibilities with patented DUOCAP capsules DUOCAP capsule-in-capsule combination concepts with Carnipure L-Carnitine DUOCAP - a patented capsule-in-capsule delivery system that is ideally suited for combination or dual release products. liquid Carnitine plus probiotics Carnitine plus caffeine Latest science on probiotics goes beyond gut health and have shown to be capable to keep your waist trim (weight management) and to help athletes to reduce the number of URTIs. Carnipure shows exercise recovery and weight management benefits and is combined here with probiotics for an active and healthy lifestyle. Carnitine turns fat into fuel and we combined liquid carnitine with caffeine in the inner capsule for focus and further metabolic activation (and vitamin B- complex for example). This concept is an energizer for the businessman/woman and sports enthusiast alike. 14

15 UC-II undenaturated collagen type 2 Finished Dosage Forms Consumer Health & Nutrition Paul Cunningham 23 August 2018

UC-II undenaturated collagen type 2: Bone & Joint Health Formula 40mg UC-II plus Vitamin C & Vit D, Manganese and Copper Allowing EFSA health claims on bones, muscles, connective tissue and cartilage formation EFSA Health Claims are in line with UC-II benefits: Vitamin C contributes to normal collagen formation for the normal function of bones and cartilage (and gums) Vitamin D contributes to the maintenance of normal bones and muscle function Copper and manganese contributes to the maintenance of normal bones and the normal formation of connective tissue 16

UC-II brand: Dosage Form: Bone & Joint Health Super-Convenience: one tiny pill once daily Vegetarian capsule Vcaps plus Small size 3 Easy to swallow Branding possible Convenience UC-II Vitamins & Minerals capsule 1500mg Glucosamin & 1200mg Chondroitin 31% of Sports supplement users have stopped taking Glucosamine because they feel it was not effective Low dose lower than GC Effective in healthy consumers Ability to combine ingredients in single dose Source: NMI SORD Research 2017 Q.23_26 17

UC-II brand Combinations and DUOCAP capsules Other possible combinations: botanical extracts with anti-inflammatory benefits like omega 3 concentrates / Krill Oil, Curcumin, Boswellia UC-II undenaturated type II collagen + curcumin extract UC-II undenaturated type II collagen + liquid Curcumin UC-II undenaturated type II collagen + Krill oil UC-II undenaturated type II collagen + fish oil 18

Key Take Aways 19

What Does this Mean for You Keep innovating Consumers want efficacious and safe products Made from natural compounds with clean labels The supplement experience is at the heart of consumer satisfaction and loyalty Convenience is important (easy to swallow, low pill burden, taste & odour, fast release or targeted release) More Competitive New Consumers, New Opportunities More Demanding Customers 20

Thank You For a sample, questions, suggestions, new projects, line extensions Challenge us Paul Cunningham at paul.cunningham@lonza.com Bianca Edwards at bianca.edwards@lonza.com 21