Burghausen / administrative region of Altötting : Johannes-Heß Volkschule Burghausen (primary school)

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Prof. Dr. med. Diana Lüftner Curriculum vitae & Professional Qualification PERSONAL DATA Date of birth: March 1st 1967 Place of birth: Nationality: Marital status: Burghausen / administrative region of Altötting German divorced, no children SCHOOL EDUCATION 1973-1977: Johannes-Heß Volkschule Burghausen (primary school) 1977-1986: Aventinus-Gymnasium Burghausen (high school & college; final mark: 1.0) UNIVERSITY & SCHOLARSHIP 1986-1993: Medical School of the Ludwig Maximilian University at Munich 1986-1993: Study grant according to the Bayerische Hochbegabtenförderungsgesetz (federal law for the promotion of highly talented students) 06.1993: Final medical examination (mark: 1.6) THESIS FOR A DOCTORATE 10.1996: At the Ludwig Maximilian University at Munich ( cum laude ). Subject: The Adrenergic Receptor System in Cardiovascular Organs and its Alterations in Arterial Hypertension 1

INTERNSHIP AND FINAL MEDICAL CERTIFICATION 06.93-10.94: Internship at the Medical Policlinics/Inner City Hospital of the Ludwig Maximilian University at Munich (Medical Director: Prof. Dr. D. Schlöndorff) 10.94-12.94: Internship at the Medical Department and Outpatient Department of Oncology and Hematology II, Charité Central Campus, Humboldt University at Berlin (Medical Director: Prof. Dr. K. Possinger) 01.1995 Final medical certification by the Federal Medical Authority (Berlin) SCIENTIFIC GRANT AND ASSISTANT PROFESSORSHIP, FULL PROFESSORSHIP 12.97-02.98: Post-doctorate at the Department of Developmental Therapeutics, Greenebaum Cancer Center, University of Maryland (Director: Prof. Dr. M. Egorin) 12.02.2004 Assistant Professorship for Experimental Oncology; subject: The Meaning of the Serum Antigen of the Oncoprotein HER-2/neu for the Diagnostics and Therapy of Breast Cancer. Public scientific presentation: Mechanisms of Action of Hormonal Treatment Forms of Breast Cancer 30.10.2013: Conferment of the Honor of Full Professorship by the Medical Faculty of the Charité, University Medicine at Berlin MEDICAL LICENSES AND CERTIFICATIONS 01.08.97: License for Sports Medicine by the Federal Medical Authority (Berlin) 01.09.04: License for Internal Medicine by the Federal Medical Authority (Berlin) 28.02.07: License for Hematology and Medical Oncology by the Federal Medical Authority (Berlin) 21.08.07: License for Palliative Care by the Federal Medical Authority (Berlin) 2

RESPONSIBILITIES AT THE UNIVERSITY HOSPITAL CHARITÉ 01.1995: Resident at the Medical Department and Outpatient Department of Oncology and Hematology II, Charité Central Campus, Humboldt University at Berlin (Medical Director: Prof. Dr. K. Possinger) 02.2002-02.2008: Civil servant as scientific assistant 07.2005: Senior Consultant with the responsibility for the Oncological Outpatient Department and the Clinical Trials Office 05.2007: Additional responsibility for the Colorectal Cancer Center 09.2007: Additional responsibility for an oncological ward with 20 beds 02.2008: Unlimited contract with the Charité University Hospital 04.2009: Additional responsibility for the Hematological Outpatient Department, so total responsibility for the Oncological Outpatient Department, the Hematological Outpatient Department, the Clinical Trials Office, the Breast Cancer Center as well as the Colorectal Cancer Center 02.2010: Additional responsibility for the Lung Cancer Conference of the Charité Comprehensive Cancer Center (CCCC) in addition to the Oncological Outpatient Department, the Hematological Outpatient Department, the Clinical Trials Office, the Breast Cancer Center as well as the Colorectal Cancer Center 05.2010: Head of the Oncological Outpatient Department and the Clinical Trials Office, responsibility for the Breast Cancer Center -, Colorectal Cancer and Lung Cancer Center conferences 10.2011: Switch within the Charité to the Campus Benjamin Franklin into the Department of Hematology, Oncology and Tumour Immunology under the Medical Director Prof. Dr. med. A. Pezzutto (Head: Prof. B. Dörken) SCIENTIFIC WORK Clinics: All therapeutic aspects of solid tumors, especially breast cancer, lung cancer, gastrointestinal tumors as well as head-and-neck cancer. Contribution in numerous clinical trials, also as principal investigator, main focus on the integration of targeted therapies into clinical routine practice under consideration of pharmaco-economic results; conception of therapy optimization trials and supportive care in palliation. 3

Laboratory: Head of a laboratory group for the evaluation of prognostic and predictive factors in oncological diseases. Establishment of an internationally known serum-, plasma-, DNA- and urine bank of more than 50.000 samples. Anoikisis research in breast cancer cell lines with focus on changes of anoikisis under exposition with approved systemic drugs. PRESIDENCIES, BOARDS, GUIDELINES AND MEDICAL SOCIETIES 01.02-09.09: Treasurer of the Berlin Society of Internal Medicine Since 2013: Member of the commission Ovarian Cancer for the development of the so-called S3-guideline Diagnostics, therapeutics and aftercare of malignant ovarian cancers 01.10-12.14: Appointment as member of the control commission of the Institute for Medical and Pharmaceutical Examination Questions (IMPP) 2013-2015: Executive President of the German Society of Hematology and Medical Oncology (DGHO) 06.2014: Congress President of the 35 th Annual Conference of the German Society of Senology Since 2015: Since 2014: Since 2014: Since 2015: Since 2016: Since 2017: Since 2018: Member of the commission Breast Cancer for the development of the so-called S3-guideline Diagnostics, therapeutics and aftercare of breast cancer Member of the Scientific Board of the journal InFo Onkologie Member of the Scientific Board of the Wilsede School of Oncology, Hematology and Palliative Care Delegate of the DGHO for the German Society of Senology Member of the Executive Board of the German Society of Hematology and Medical Oncology DGHO Member of the Scientific Board of the BRCA e.v. network Delegate of the DGHO for the organ commission Breast of the Working Group for Gynecological Oncology (AGO) of the German Cancer Society 4

02.2018: Juror of the tendering procedure Health Care Research on behalf of the Ministry of Education, Science and Culture of Mecklenburg-Western Pomerania Berlin, den 08. Februar 2018 Prof. Dr. med. Diana Lüftner 5