Medikal Fizik Çalışmaları
|
|
- Anis West
- 5 years ago
- Views:
Transcription
1 Medikal Fizik Çalışmaları Zeynep Özen Acıbadem Altunizade Hastanesi
2 Major Themes Treatment Planning and Delivery (in SRS/SBRT) Improving Quality and Consistency in Clinical Trials via Knowledge- Based Planning, NRG Oncology RTOG 0631 (spine SRS) Imaging for Response Assessment / Outcome analysis and modeling Diffusion Imaging Biomarkers of Regional White Matter Injury Correlate with Change in Executive Function and Processing Speed after Brain Radiotherapy
3 Improving quality and consistency in clinical trials via knowledgebased planning NRG Oncology RTOG 0631 K. C. Younge 1, R. Marsh 2, D. Owen 3, H. Geng 4, Y. Xiao 5, D. E. Spratt 2, J. Foy 2, Q. R. J. Wu 6, F. F. Yin 7, S. Ryu 8, and M. M. Matuszak 1 1 Department of Radiation Oncology, University of Michigan, Ann Arbor, MI, 2 University of Michigan, Ann Arbor, MI, 3 University of Michigan, Department of Radiation Oncology, Ann Arbor, MI, 4 University of Pennsylvania, Philadelphia, PA, 5 Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA, 6 Duke Medical Center, Durham, NC, 7 Duke University Medical Center, Durham, NC, 8 Stony Brook University, Stony Brook, NY
4 Study Design / Purpose/Objective(s) Challenging consistency and standardization of radiotherapy planning quality in multi-institutional clinical trials. Variations in plan quality / compliance affect outcome Experience at an institution correlates with plan quality Aim: To utilize knowledge-based planning (KBP) to produce high quality, consistent, protocol compliant treatment plans (e.g. RTOG 0631; localized spine metastasis; phase II; effect of higher radiation dose on pain control and QOL; 16 Gy SRS).
5 Study Design / Methods Training and validation dataset KBP model applied to an validation cohort of 22 anonymized cases 16 Gy VMAT / single target Original and KBP plans compared: protocol scores, target conformity, gradient index, OAR dose, dose to surrounding normal tissues Protocol: Target: 90% coverage % coverage = acceptable (minor variation); < 80% coverage = unacceptable (major deviation) OAR: exceeding dose volume limits > % = minor variation; exceeding them by > 5 % = major deviation. Any deviation of spinal cord dose constraint = unacceptable
6 Study Design / Methods Example RTOG 0631 Volumes All OARs were grouped into a single score. Primary OAR: spinal cord, cauda equina (sometimes also esophagus and other structures). NonPTV: Ring around the target (limits for this structure are some of the most frequently violated).
7 5 plans 17 plans Results Sub: plan submitted to Model prioritizes PTV coverage (all target scores are 1). KBP model generated plans meet all protocol objectives in a single optimization when tested on both internal and external RTOG 0631 cases. 1 = meets protocol 2 = acceptable variation 3 = unacceptable deviation
8 Results Example where KBP made a significant difference. Original submitted plan had a lot of high dose spillage around the PTV. Submitted plan scored a 3 for nonptv dose, and the KBP plans scored a 2. Target volume: vertebral body, both left and right pedicles, gross paraspinal or epidural lesions.
9 Results The volume of PTV receiving prescription dose increased from 93.3 ± 3.2% to 99.5 ± 0.7% (P<0.001) when using KBP. High-dose spillage to surrounding normal tissues (V105%) showed no significant differences (2.1 ± 7.3 cc for manual plans to 1.2 ± 0.4 cc with KBP) but dosimetric outliers with large amounts of spillage were eliminated through the use of KBP.
10 Authors Conclusions Different tradeoffs are made between PTV coverage and cord sparing. These types of decisions will be institution- and physician-dependent and will vary across cases. KBP plans will consistently make the same tradeoffs, depending on how the model was designed, is both an asset and a limitation. Incorporation of KBP models into the clinical trial setting may have a profound impact on the quality of trial results due to the increase in consistency and standardization of planning, especially for treatment sites or techniques that are nonstandard.
11 Comments PRO: Inconsistency in treatment planning are affecting multi-institutional clinical trials Knowledge-based planning might become standard in multi-institutional trials to allow consistent planning CON: Number of considered plans is quite low KBP could introduce bias and needs further studies
12 Diffusion Imaging Biomarkers of Regional White Matter Injury Correlate with Change in Executive Function and Processing Speed after Brain Radiotherapy K. R. Tringale, R. Karunamuni, T. Nguyen, T. M. Seibert, K. Leyden, V. Uttarwar, V. Murzin, D. C. Marshall, D. R. Simpson, P. Sanghvi, V. Moiseenko, M. K. Gorman, N. Farid, N. White, A. M. Dale, C. McDonald, and J. A. Hattangadi University of California, San Diego, La Jolla, CA
13 Study Design / Purpose/Objective(s) White matter radiation effects: demyelination, vascular changes Aim: To analyze region specific biomarkers of white matter (WM) integrity using diffusion imaging and test associations with executive functioning and processing speed in a prospective clinical trial. Hypothesis: Regional changes in diffusion biomarkers of WM damage correlate with changes in executive function and processing speed at 6-months post-radiotherapy.
14 Study Design / Methods White Matter Diffusion Imaging Biomarkers Diffusion-weighted imaging (DWI): measuring diffusion of water at the cellular level. Diffusion tensor imaging (DTI): Extension of DWI; depicts the overall motion of water as an ellipse using a tensor model. Enables measurement of changes to subcortical structures, cortex, and white matter Most common white matter diffusion measurements Mean diffusivity (MD; average amount of water diffusion l in mm 2 /s) Fractional anisotropy (FA; coherence of the orientation of water diffusion) Measur e Definition Significance in WM MD / 3 : WM disruption/edema/iq FA Degree of directional bias : Disrupted WM integrity
15 Study Design / Methods Known from previous study: MD increased consistently over time, with a greater rate of change at higher doses (linear with dose; significant at low doses only at later time points) FA decreased over time with greater rate of change at higher RT doses (linear with dose; significant even at low doses <10 Gy) This study: 56 subjects At least 2 time points with both neurocognitive score and MRI 26 subjects 54% men (n=14) Mean age 49.2 years Mean years of education % had gliomas (n=16) 46% had right-, 32% had lefthemispheric tumors (n=10, n=7) 50% had concurrent chemotherapy (n=13) 54Gy median prescription dose ( Gy) Mean dose to ROIs ranged from 11.6 Gy to 21.5 Gy
16 Diffusion Biomarkers after Radiotherapy Over Time Connor et al., Radiother Oncol 2016
17 Study Design / Methods Executive function left dorsolateral and bihemispheric anterior cingulate WM Processing Speed bihemispheric inferior parietal and total right hemispheric WM Executive Function (impulse control, emotional control, organizing, task initiation) DKEFS Letter Fluency DKEFS Category Switching Total WCST Total Errors Linear mixed effects models for all time points (3, 6, 12 months after RT) Processing Speed (speed to react to information they receive) Trail Making Number Sequencing Trail Making Letter Sequencing Software to segment regions of interest (ROIs); change in MD and FA were calculated for each ROI Linear mixed effects model with random subject intercept Neurocog ij = β 0 + β 1 x [Month] j + β 2 x Imaging + u i + e ij Neurocog ij = β 0 + β 1 x Month j + β 2 x Imaging + β 3 x Imaging x Month + u i + e ij DKEFS: Delis-Kaplan Executive Function System WCST: Wisconsin Card Sorting Test i = subject; j = visit; e ij = error; u i = subject-specific random intercept
18 Results Each subject is shown as a different color Worse Executive Function Anterior Cingulate White Matter Processing Speed Left Inferior Parietal White Matter Left Worse P=0.03 NS Better NS P=0.04 Worse Better Right Better P=0.08 P=0.01
19 Authors Conclusions Executive function (D-KEFS category switching total, mean change -.56, p=0.017; WCST mean change -.51, p=0.006) and processing speed (TM number sequencing, mean change -.40, p=.045) significantly declined post- RT. Change in executive function was positively correlated with age and years of education (r=.54, p=0.012; r=.53, p=0.013, respectively), while processing speed was negatively correlated with age (r=-.51, p=0.014). FA correlated with total right hemispheric WM (mean change.0074±.029) and all ROIs associated with executive function and processing speed. MD correlated with executive function ROIs, but remained relatively unchanged in ROIs associated with processing speed. MD of both left and right inferior parietal WM and right total hemispheric WM were positively correlated with processing speed.
20 Comments PRO: Cognitive morbidity following radiation therapy has a profound impact. Enhanced imaging techniques may enable us to detect subtle changes associated with the onset and progression of cognitive impairment. CON: Very similar to a study already published by the same group in November 2016 (Radiother. Oncol.) Unclear impact on treatment planning Limitations include censoring high-dose regions, tumor progression, confounding variables in neurocognitive performance, sample size, dynamic biologic changes post-rt
21 Overall Conclusions/Summary All 5 abstracts are about cutting edge research in radiation oncology physics aiming at Current approaches in using prior knowledge in treatment planning and delivery Outcome assessment via imaging techniques to be applied in planning and delivery
22 TEŞEKKÜRLER
Treatment Planning & IGRT Credentialing for NRG SBRT Trials
Treatment Planning & IGRT Credentialing for NRG SBRT Trials Hania Al Hallaq, Ph.D. Department of Radiation & Cellular Oncology The University of Chicago Learning Objectives Explain rationale behind credentialing
More informationCase Conference: SBRT for spinal metastases D A N I E L S I M P S O N M D 3 / 2 7 / 1 2
Case Conference: SBRT for spinal metastases D A N I E L S I M P S O N M D 3 / 2 7 / 1 2 Case 79 yo M with hx of T3N0 colon cancer diagnosed in 2008 metastatic liver disease s/p liver segmentectomy 2009
More informationA TREATMENT PLANNING STUDY COMPARING VMAT WITH 3D CONFORMAL RADIOTHERAPY FOR PROSTATE CANCER USING PINNACLE PLANNING SYSTEM *
Romanian Reports in Physics, Vol. 66, No. 2, P. 394 400, 2014 A TREATMENT PLANNING STUDY COMPARING VMAT WITH 3D CONFORMAL RADIOTHERAPY FOR PROSTATE CANCER USING PINNACLE PLANNING SYSTEM * D. ADAM 1,2,
More informationSBRT TREATMENT PLANNING: TIPS + TRICKS. Rachel A. Hackett CMD, RT(T)
SBRT TREATMENT PLANNING: TIPS + TRICKS Rachel A. Hackett CMD, RT(T) OUTLINE Brief radiobiology review 3D CRT Tx Planning VMAT Tx Planning Protocols Other Sites Oligomets Spine Liver Kidney Adrenal Gland
More informationReview of Workflow NRG (RTOG) 1308: Phase III Randomized Trial Comparing Overall Survival after Photon versus Proton Chemoradiation Therapy for
Review of Workflow NRG (RTOG) 1308: Phase III Randomized Trial Comparing Overall Survival after Photon versus Proton Chemoradiation Therapy for Inoperable Stage II-IIIB NSCLC 1 Co-Chairs Study Chair: Zhongxing
More informationMedikal Fizik Çalışmaları
Medikal Fizik Çalışmaları 9 Kasım 2017 13.00 14.00 Vildan ALPAN Amerikan Hastanesi MDACC Kanser Merkezi, İstanbul Learning Objectives To get an overview of the main current research directions in radiation
More informationLinac or Non-Linac Demystifying And Decoding The Physics Of SBRT/SABR
Linac or Non-Linac Demystifying And Decoding The Physics Of SBRT/SABR PhD, FAAPM, FACR, FASTRO Department of Radiation Oncology Indiana University School of Medicine Indianapolis, IN, USA Indra J. Das,
More informationDisclosures. Overview 8/3/2016. SRS: Cranial and Spine
SRS: Cranial and Spine Brian Winey, Ph.D. Department of Radiation Oncology Massachusetts General Hospital Harvard Medical School Disclosures Travel and research funds from Elekta Travel funds from IBA
More informationDisclosure SBRT. SBRT for Spinal Metastases 5/2/2010. No conflicts of interest. Overview
Stereotactic Body Radiotherapy (SBRT) for Recurrent Spine Tumors Arjun Sahgal M.D., F.R.C.P.C. Assistant Professor Princess Margaret Hospital Sunnybrook Health Sciences Center University of Toronto Department
More informationOutline. Contour quality control. Dosimetric impact of contouring errors and variability in Intensity Modulated Radiation Therapy (IMRT)
Dosimetric impact of contouring errors and variability in Intensity Modulated Radiation Therapy (IMRT) James Kavanaugh, MS DABR Department of Radiation Oncology Division of Medical Physics Outline Importance
More informationTreatment Planning for Lung. Kristi Hendrickson, PhD, DABR University of Washington Dept. of Radiation Oncology
Treatment Planning for Lung Kristi Hendrickson, PhD, DABR University of Washington Dept. of Radiation Oncology Outline of Presentation Dosimetric planning strategies for SBRT lung Delivery techniques Examples
More informationThe Physics of Oesophageal Cancer Radiotherapy
The Physics of Oesophageal Cancer Radiotherapy Dr. Philip Wai Radiotherapy Physics Royal Marsden Hospital 1 Contents Brief clinical introduction Imaging and Target definition Dose prescription & patient
More informationJOURNAL OF APPLIED CLINICAL MEDICAL PHYSICS, VOLUME 17, NUMBER 6, 2016
JOURNAL OF APPLIED CLINICAL MEDICAL PHYSICS, VOLUME 17, NUMBER 6, 2016 Development and evaluation of a clinical model for lung cancer patients using stereotactic body radiotherapy (SBRT) within a knowledge-based
More informationDosimetric Analysis of 3DCRT or IMRT with Vaginal-cuff Brachytherapy (VCB) for Gynaecological Cancer
Dosimetric Analysis of 3DCRT or IMRT with Vaginal-cuff Brachytherapy (VCB) for Gynaecological Cancer Tan Chek Wee 15 06 2016 National University Cancer Institute, Singapore Clinical Care Education Research
More informationInternational RT Clinical Trial Group Membership & Quality Control BY DR YING XIAO
International RT Clinical Trial Group Membership & Quality Control BY DR YING XIAO Disclosures The Department of Radiation Oncology at Hospital of University of Pennsylvania has a research agreement with
More informationClinical Case Conference
Clinical Case Conference Palliative radiation therapy for bone metastasis Jeff Burkeen, MD, PGY2 7/20/2015 1 Overview Epidemiology Pathophysiology Common presentations and symptoms Imaging Surgery Radiation
More informationA Dosimetric Comparison of Whole-Lung Treatment Techniques. in the Pediatric Population
A Dosimetric Comparison of Whole-Lung Treatment Techniques in the Pediatric Population Corresponding Author: Christina L. Bosarge, B.S., R.T. (R) (T) Indiana University School of Medicine Department of
More informationPalliative radiotherapy in lung cancer
New concepts and insights regarding the role of radiation therapy in metastatic disease Umberto Ricardi University of Turin Department of Oncology Radiation Oncology Palliative radiotherapy in lung cancer
More informationMany vendors are beginning to allow couch motion during radiation delivery.
Dynamic Couch Motion Many vendors are beginning to allow couch motion during radiation delivery. Varian developer mode allows institutions to perform research using these types of treatments. Tomotherapy
More information8/2/2018. Acknowlegements: TCP SPINE. Disclosures
A Presentation for the AAPM Annual meeting, Aug 2, 2018 Nashville, TN Stereotactic Radiosurgery for Spinal Metastases: Tumor Control Probability Analyses and Recommended Reporting Standards for Future
More informationA Comparison of IMRT and VMAT Technique for the Treatment of Rectal Cancer
A Comparison of IMRT and VMAT Technique for the Treatment of Rectal Cancer Tony Kin Ming Lam Radiation Planner Dr Patricia Lindsay, Radiation Physicist Dr John Kim, Radiation Oncologist Dr Kim Ann Ung,
More informationA guide to using multi-criteria optimization (MCO) for IMRT planning in RayStation
A guide to using multi-criteria optimization (MCO) for IMRT planning in RayStation By David Craft Massachusetts General Hospital, Department of Radiation Oncology Revised: August 30, 2011 Single Page Summary
More informationRadiation Damage Comparison between Intensity Modulated Radiotherapy (IMRT) and Field-in-field (FIF) Technique In Breast Cancer Treatments
Radiation Damage Comparison between Intensity Modulated Radiotherapy () and Field-in-field (FIF) Technique In Breast Cancer Treatments Huisi Ai 1 and Hualin Zhang 2 1. Department of Radiation Oncology,
More informationAutomated Plan Quality Check with Scripting. Rajesh Gutti, Ph.D. Clinical Medical Physicist
Automated Plan Quality Check with Scripting Rajesh Gutti, Ph.D. Clinical Medical Physicist Veera.Gutti@BSWHealth.org Outline Introduction - BSW Automation in Treatment planning Eclipse Scripting API Script
More informationPitfalls in SBRT Treatment Planning for a Moving Target
Pitfalls in SBRT Treatment Planning for a Moving Target Cynthia F. Chuang, Ph.D. Department of Radiation Oncology University of California-San Francisco I have no conflicts of interests to disclose In
More informationOriginal Article. Teyyiba Kanwal, Muhammad Khalid, Syed Ijaz Hussain Shah, Khawar Nadeem
Original Article Treatment Planning Evaluation of Sliding Window and Multiple Static Segments Technique in Intensity Modulated Radiotherapy for Different Beam Directions Teyyiba Kanwal, Muhammad Khalid,
More informationTreatment Planning Evaluation of Volumetric Modulated Arc Therapy (VMAT) for Craniospinal Irradiation (CSI)
Treatment Planning Evaluation of Volumetric Modulated Arc Therapy (VMAT) for Craniospinal Irradiation (CSI) Tagreed AL-ALAWI Medical Physicist King Abdullah Medical City- Jeddah Aim 1. Simplify and standardize
More informationHow effective is current clinical trial QA
How effective is current clinical trial QA Elizabeth Miles UK National RadioTherapy Trials QA (RTTQA) group Mount Vernon Cancer Centre United Kingdom ESTRO 35 29 April 3 May Turin, Italy Contents QA processes
More informationIMRT - the physician s eye-view. Cinzia Iotti Department of Radiation Oncology S.Maria Nuova Hospital Reggio Emilia
IMRT - the physician s eye-view Cinzia Iotti Department of Radiation Oncology S.Maria Nuova Hospital Reggio Emilia The goals of cancer therapy Local control Survival Functional status Quality of life Causes
More informationReena Phurailatpam. Intensity Modulated Radiation Therapy of Medulloblastoma using Helical TomoTherapy: Initial Experience from planning to delivery
Intensity Modulated Radiation Therapy of Medulloblastoma using Helical TomoTherapy: Initial Experience from planning to delivery Reena Phurailatpam Tejpal Gupta, Rakesh Jalali, Zubin Master, Bhooshan Zade,
More information9.5. CONVENTIONAL RADIOTHERAPY TECHNIQUE FOR TREATING THYROID CANCER
9.5. CONVENTIONAL RADIOTHERAPY TECHNIQUE FOR TREATING THYROID CANCER ROBERT J. AMDUR, MD, SIYONG KIM, PhD, JONATHAN GANG LI, PhD, CHIRAY LIU, PhD, WILLIAM M. MENDENHALL, MD, AND ERNEST L. MAZZAFERRI, MD,
More informationOptimal Management of Isolated HER2+ve Brain Metastases
Optimal Management of Isolated HER2+ve Brain Metastases Eliot Sims November 2013 Background Her2+ve patients 15% of all breast cancer Even with adjuvant trastuzumab 10-15% relapse Trastuzumab does not
More informationNon-Hodgkin s Lymphomas Version
NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines ) Non-Hodgkin s Lymphomas Version 2.2015 NCCN.org Continue Principles of Radiation Therapy PRINCIPLES OF RADIATION THERAPY a Treatment with
More informationDiffusion Tensor Imaging in brain tumours
Diffusion Tensor Imaging in brain tumours @MarionSmits, MD PhD Associate Professor of Neuroradiology Dept. of Radiology, Erasmus MC, Rotterdam (NL) Honorary Consultant and Reader UCLH National Hospital
More informationThe Role of Radiation Therapy in the Treatment of Brain Metastases. Matthew Cavey, M.D.
The Role of Radiation Therapy in the Treatment of Brain Metastases Matthew Cavey, M.D. Objectives Provide information about the prospective trials that are driving the treatment of patients with brain
More informationReirradiazione. La radioterapia stereotassica ablativa: torace. Pierluigi Bonomo Firenze
Reirradiazione La radioterapia stereotassica ablativa: torace Pierluigi Bonomo Firenze Background Stage III NSCLC isolated locoregional recurrence in 25% of pts mostly unresectable; low RR with 2 nd line
More informationSilvia Pella, PhD, DABR Brian Doozan, MS South Florida Radiation Oncology Florida Atlantic University Advanced Radiation Physics Boca Raton, Florida
American Association of Medical Dosimetrists 2015 Silvia Pella, PhD, DABR Brian Doozan, MS South Florida Radiation Oncology Florida Atlantic University Advanced Radiation Physics Boca Raton, Florida Most
More informationLung Spine Phantom. Guidelines for Planning and Irradiating the IROC Spine Phantom. MARCH 2014
Lung Spine Phantom Guidelines for Planning and Irradiating the IROC Spine Phantom. MARCH 2014 The study groups are requesting that each institution keep the phantom for no more than 2 week. During this
More informationNew Technologies for the Radiotherapy of Prostate Cancer
Prostate Cancer Meyer JL (ed): IMRT, IGRT, SBRT Advances in the Treatment Planning and Delivery of Radiotherapy. Front Radiat Ther Oncol. Basel, Karger, 27, vol. 4, pp 315 337 New Technologies for the
More informationImplementing SBRT Protocols: A NRG CIRO Perspective. Ying Xiao, Ph.D. What is NRG Oncology?
Implementing SBRT Protocols: A NRG CIRO Perspective Ying Xiao, Ph.D. What is NRG Oncology? One of five new NCI-supported National Clinical Trials Network (NCTN) groups. NCTN officially started March 1,
More informationStereotactic MR-guided adaptive radiation therapy (SMART) for locally advanced pancreatic tumors
Stereotactic MR-guided adaptive radiation therapy (SMART) for locally advanced pancreatic tumors Anna Bruynzeel, Radiation Oncologist VU University Medical Center, Amsterdam, The Netherlands Current standard
More informationVariable Dose Rate Dynamic Conformal Arc Therapy (DCAT) for SABR Lung: From static fields to dynamic arcs using Monaco 5.10
Variable Dose Rate Dynamic Conformal Arc Therapy (DCAT) for SABR Lung: From static fields to dynamic arcs using Monaco 5.10 Simon Goodall Radiation Oncology Physicist Genesis Care Western Australia Introduction
More informationM P---- Ph.D. Clinical Psychologist / Neuropsychologist
M------- P---- Ph.D. Clinical Psychologist / Neuropsychologist NEUROPSYCHOLOGICAL EVALUATION Name: Date of Birth: Date of Evaluation: 05-28-2015 Tests Administered: Wechsler Adult Intelligence Scale Fourth
More informationIndra J. Das/ Small Fields (Page-1)
Indra J. Das/ Small Fields (Page-1) Improving Dose Prescriptions for Safety, Reporting, and Clinical Guideline Consistency Jean Moran, Univ of Michigan, Ann Arbor Mark Langer, Indianian Univeristy, Indianapolis
More informationDisclosure. Paul Medin teaches radiosurgery courses sponsored by BrainLAB Many animals (and humans) were harmed to make this presentation possible!
Disclosure The tolerance of the nervous system to SBRT: dogma, data and recommendations Paul Medin, PhD Paul Medin teaches radiosurgery courses sponsored by BrainLAB Many animals (and humans) were harmed
More informationProtocol of Radiotherapy for Small Cell Lung Cancer
107 年 12 月修訂 Protocol of Radiotherapy for Small Cell Lung Cancer Indication of radiotherapy Limited stage: AJCC (8th edition) stage I-III (T any, N any, M0) that can be safely treated with definitive RT
More informationVOLUMETRIC-MODULATED ARC THERAPY VS. 3D-CONFORMAL RADIOTHERAPY FOR BREAST CANCER
Romanian Reports in Physics, Vol. 67, No. 3, P. 978 986, 2015 VOLUMETRIC-MODULATED ARC THERAPY VS. 3D-CONFORMAL RADIOTHERAPY FOR BREAST CANCER D. ADAM 1, 2, M.D. SUDITU 1, 2, R. POPA 1, 2, V. CIOCALTEI
More informationEfficient SIB-IMRT planning of head & neck patients with Pinnacle 3 -DMPO
Investigations and research Efficient SIB-IMRT planning of head & neck patients with Pinnacle 3 -DMPO M. Kunze-Busch P. van Kollenburg Department of Radiation Oncology, Radboud University Nijmegen Medical
More informationStereotactic Body Radiotherapy (SBRT) For HCC T A R E K S H O U M A N P R O F. R A D I A T I O N O N C O L O G Y N C I, C A I R O U N I V.
Stereotactic Body Radiotherapy (SBRT) For HCC T A R E K S H O U M A N P R O F. R A D I A T I O N O N C O L O G Y N C I, C A I R O U N I V. Hepatocellular carcinoma (HCC), is a major health problem worldwide.
More informationSBRT I: Overview of Simulation, Planning, and Delivery
Disclosure SBRT I: Overview of Simulation, Planning, and Delivery I have received research funding from NIH, the Golfers Against Cancer (GAC) foundation, and Philips Health System. Jing Cai, PhD Duke University
More informationTreating Multiple. Brain Metastases (BM)
ESTRO 36 5-9 May 2017, Vienna Austria, Accuray Symposium Treating Multiple Brain Metastases (BM) with CyberKnife System Frederic Dhermain MD PhD, Radiation Oncologist Gustave Roussy University Hospital,
More informationAdvances in external beam radiotherapy
International Conference on Modern Radiotherapy: Advances and Challenges in Radiation Protection of Patients Advances in external beam radiotherapy New techniques, new benefits and new risks Michael Brada
More informationThe Evolution of SBRT and Hypofractionation in Thoracic Radiation Oncology
The Evolution of SBRT and Hypofractionation in Thoracic Radiation Oncology (specifically, lung cancer) 2/10/18 Jeffrey Kittel, MD Radiation Oncology, Aurora St. Luke s Medical Center Outline The history
More informationDose escalation for NSCLC using conformal RT: 3D and IMRT. Hasan Murshed
Dose escalation for NSCLC using conformal RT: 3D and IMRT. Hasan Murshed Take home message Preliminary data shows CRT technique in NSCLC allows dose escalation to an unprecedented level maintaining cancer
More informationCollection of Recorded Radiotherapy Seminars
IAEA Human Health Campus Collection of Recorded Radiotherapy Seminars http://humanhealth.iaea.org The Management of Brain Metastases Dr. Luis Souhami Professor Department of Radiation Oncology University,
More informationQuality management for Breast Brachytherapy.
Quality management for Breast Brachytherapy. DORIN TODOR, Ph.D. Medical College of Virginia Campus Department of Radiation Oncology New England AAPM Chapter 2012 Summer Meeting, Providence, RI Quality
More informationEvaluation of Monaco treatment planning system for hypofractionated stereotactic volumetric arc radiotherapy of multiple brain metastases
Evaluation of Monaco treatment planning system for hypofractionated stereotactic volumetric arc radiotherapy of multiple brain metastases CASE STUDY Institution: Odette Cancer Centre Location: Sunnybrook
More informationAshley Pyfferoen, MS, CMD. Gundersen Health Systems La Crosse, WI
Ashley Pyfferoen, MS, CMD Gundersen Health Systems La Crosse, WI 3 Radiation Oncologists 3 Physicists 2 Dosimetrists 9 Radiation Therapists o o o o o o o o o Brachial Plexus Anatomy Brachial Plexopathy
More informationEvaluation of Whole-Field and Split-Field Intensity Modulation Radiation Therapy (IMRT) Techniques in Head and Neck Cancer
1 Charles Poole April Case Study April 30, 2012 Evaluation of Whole-Field and Split-Field Intensity Modulation Radiation Therapy (IMRT) Techniques in Head and Neck Cancer Abstract: Introduction: This study
More informationDevelopment of an Expert Consensus Target Delineation Atlas for Thymic Cancers: Initial Quantitative Analysis of an Expert Survey.
Development of an Expert Consensus Target Delineation Atlas for Thymic Cancers: Initial Quantitative Analysis of an Expert Survey. Charles R. Thomas, Jr., MD, Jayashree Kalpathy-Cramer, PhD, Jehee Choi,
More informationLocally advanced disease & challenges in management
Gynecologic Cancer InterGroup Cervix Cancer Research Network Cervix Cancer Education Symposium, February 2018 Locally advanced disease & challenges in management Carien Creutzberg Radiation Oncology, Leiden
More information8/2/2017. Improving Dose Prescriptions for Safety, Reporting, and Clinical Guideline Consistency. Part III
Improving Dose Prescriptions for Safety, Reporting, and Clinical Guideline Consistency Part III I Das, J Moran, M Langer Keeping Guidelines On Track: The Effect On Clinical Practice of Neglecting Guidelines
More informationHot topics in Radiation Oncology for the Primary Care Providers
Hot topics in Radiation Oncology for the Primary Care Providers Steven Feigenberg, MD Professor Chief, Thoracic Oncology Vice Chair of Clinical Research April 19, 2018 Disclosures NONE 2 Early Stage Disease
More informationImpact of Contouring Variability on Dose- Volume Metrics used in Treatment Plan Optimization of Prostate IMRT
Open Access Original Article DOI: 10.7759/cureus.144 Impact of Contouring Variability on Dose- Volume Metrics used in Treatment Plan Optimization of Prostate IMRT Arvand Barghi, Carol Johnson 2, Andrew
More informationNormal tissue dose in pediatric VMAT Piotr Zygmanski
Normal tissue dose in pediatric VMAT Piotr Zygmanski Department of Radiation Oncology Brigham and Women s Hospital Radiation induced effects in children Risk of inducing 2 nd cancers higher than for adults
More informationJean Pouliot, PhD Professor and Vice Chair, Department of Radiation Oncology, Director of Physics Division
IMRT / Tomo / VMAT / Cyberknife / HDR Brachytherapy: Jean Pouliot, PhD Professor and Vice Chair, Department of Radiation Oncology, Director of Physics Division Should Choices be Based on Dosimetric and
More informationNeuropsychology in Spina Bifida. Dr Ellen Northcott Clinical Neuropsychologist Kids Rehab, CHW
Neuropsychology in Spina Bifida Dr Ellen Northcott Clinical Neuropsychologist Kids Rehab, CHW Who are neuropsychologists? Undergraduate Degree (eg. BPsych, BSc, BA) Honours in Psychology Master or Doctor
More informationIMRT Planning Basics AAMD Student Webinar
IMRT Planning Basics AAMD Student Webinar March 12, 2014 Karen Chin Snyder, MS Senior Associate Physicist Department of Radiation Oncology Disclosures The presenter has received speaker honoraria from
More informationCorporate Medical Policy
Corporate Medical Policy Intensity Modulated Radiation Therapy (IMRT) of the Chest File Name: Origination: Last CAP Review: Next CAP Review: Last Review: intensity_modulated_radiation_therapy_imrt_of_the_chest
More informationa Phase II Randomised Controlled Trial Matthias Guckenberger
Dose-intensified Image-guided Fractionated Stereotactic Body Radiation Therapy for Painful Spinal Metastases (DOSIS) versus Conventional Radiation Therapy: a Phase II Randomised Controlled Matthias Guckenberger
More informationNeuropsychological Evaluation of
Neuropsychological Evaluation of Alzheimer s Disease Joanne M. Hamilton, Ph.D. Shiley-Marcos Alzheimer s Disease Research Center Department of Neurosciences University of California, San Diego Establish
More informationUncertainties and Quality Assurance of Localization and Treatment in Lung SBRT Jing Cai, PhD Duke University Medical Center
Uncertainties and Quality Assurance of Localization and Treatment in Lung SBRT Jing Cai, PhD Duke University Medical Center 2013 AAPM 55 th Annual Meeting, Educational Course, Therapy Track, MOC SAM Program
More informationRadiobiological Considerations
Stereotactic Body Radiation Therapy III: Radiobiological Considerations Brian D. Kavanagh, MD, MPH Department of Radiation Oncology University of Colorado Comprehensive Cancer Center LAST YEAR S AGENDA
More informationAutomatic Definition of Planning Target Volume in Computer-Assisted Radiotherapy
Automatic Definition of Planning Target Volume in Computer-Assisted Radiotherapy Angelo Zizzari Department of Cybernetics, School of Systems Engineering The University of Reading, Whiteknights, PO Box
More informationVaginal Sparing with Volumetric Modulated Arc Therapy (VMAT) for Rectal Cancer. Scott Boulet BSc, RT(T)
Vaginal Sparing with Volumetric Modulated Arc Therapy (VMAT) for Rectal Cancer Scott Boulet BSc, RT(T) Outline Background Objectives Design Results Discussion Conclusion Acknowledgements Questions Background
More informationA dosimetric comparison between volumetric-modulated arc therapy and dynamic conformal arc therapy in SBRT
JBUON 2019; 24(2): 838-843 ISSN: 1107-0625, online ISSN: 2241-6293 www.jbuon.com E-mail: editorial_office@jbuon.com ORIGINAL ARTICLE A dosimetric comparison between volumetric-modulated arc therapy and
More informationDepartment of Radiotherapy & Nuclear Medicine, National Cancer Institute, Cairo University, Cairo, Egypt.
Original article Res. Oncol. Vol. 12, No. 1, Jun. 2016:10-14 Dosimetric comparison of 3D conformal conventional radiotherapy versus intensity-modulated radiation therapy both in conventional and high dose
More informationCPT code semantics 8/18/2011. SBRT Planning Case Studies. Spectrum of applications of SBRT. itreat
Spectrum of applications of SBRT EDUCATIONAL COURSE Physics and Dosimetry of SBRT Part III: Planning Case Studies Brian D. Kavanagh, MD, MPH Department of Radiation Oncology University of Colorado School
More informationA treatment planning study comparing Elekta VMAT and fixed field IMRT using the varian treatment planning system eclipse
Peters et al. Radiation Oncology 2014, 9:153 RESEARCH Open Access A treatment planning study comparing Elekta VMAT and fixed field IMRT using the varian treatment planning system eclipse Samuel Peters
More information8/3/2017. Spine SBRT: A Clinician's Update On Techniques and Outcomes. Disclosures. Outline
Spine SBRT: A Clinician's Update On Techniques and Outcomes Chia-Lin (Eric) Tseng, MD FRCPC Radiation Oncologist Sunnybrook Health Sciences Centre University of Toronto August 3, 2017 Disclosures I have
More informationFuture upcoming technologies and what audit needs to address
Future upcoming technologies and what audit needs to address Dr R.I MacKay History of audit Absolute dose - Simple phantom standard dose measurement Point doses in beams - Phantoms of relatively simple
More informationDefining Target Volumes and Organs at Risk: a common language
Defining Target Volumes and Organs at Risk: a common language Eduardo Rosenblatt Section Head Applied Radiation Biology and Radiotherapy (ARBR) Section Division of Human Health IAEA Objective: To introduce
More informationThe Influence of Sleep on Cognition in Breast Cancer
The Influence of Sleep on Cognition in Breast Cancer Sonia Ancoli-Israel, PhD Professor of Psychiatry and Medicine University it of California i San Diego Fatigue by Rodin Supported by NIC CA112035, UL1RR031980
More informationRTTs role in lung SABR
RTTs role in lung SABR Bart van Baaren Lineke van der Weide VU Medical Centre SBRT symposium VUMC 16 December 2017 Flow chart lung SABR Pre-treatment imaging Treatment planning On-line imaging Treatment
More informationEvaluation of three APBI techniques under NSABP B-39 guidelines
JOURNAL OF APPLIED CLINICAL MEDICAL PHYSICS, VOLUME 11, NUMBER 1, WINTER 2010 Evaluation of three APBI techniques under NSABP B-39 guidelines Daniel Scanderbeg, a Catheryn Yashar, Greg White, Roger Rice,
More informationChapters from Clinical Oncology
Chapters from Clinical Oncology Lecture notes University of Szeged Faculty of Medicine Department of Oncotherapy 2012. 1 RADIOTHERAPY Technical aspects Dr. Elemér Szil Introduction There are three possibilities
More informationCorporate Medical Policy
Corporate Medical Policy Intensity Modulated Radiation Therapy (IMRT) of Abdomen and File Name: Origination: Last CAP Review: Next CAP Review: Last Review: intensity_modulated_radiation_therapy_imrt_of_abdomen_and_pelvis
More informationA VMAT PLANNING SOLUTION FOR NECK CANCER PATIENTS USING THE PINNACLE 3 PLANNING SYSTEM *
Romanian Reports in Physics, Vol. 66, No. 2, P. 401 410, 2014 A VMAT PLANNING SOLUTION FOR NECK CANCER PATIENTS USING THE PINNACLE 3 PLANNING SYSTEM * M. D. SUDITU 1,2, D. ADAM 1,2, R. POPA 1,2, V. CIOCALTEI
More informationIntensity modulation techniques for spinal treatments and on-line VolumeView TM guidance
IMAGE GUIDED RADIATION THERAPY Elekta Synergy Intensity modulation techniques for spinal treatments and on-line VolumeView TM guidance Institution: U.O. Radiobiologia Clinica, Universita Di Firenze Casa
More informationJonathan D Grant *, Angela Sobremonte, Evangeline Hillebrandt, Pamela K Allen and Daniel R Gomez *
Grant et al. Radiation Oncology (2015) 10:32 DOI 10.1186/s13014-015-0332-9 RESEARCH Open Access The impact of induction chemotherapy on the dosimetric parameters of subsequent radiotherapy: an investigation
More informationDemands and Perspectives of Hadron Therapy
Demands and Perspectives of Hadron Therapy Alexander Lin, M.D. Assistant Professor University of Pennsylvania Direction of Operations Roberts Proton Therapy Center Disclosures Teva Pharmaceuticals: Advisory
More informationFor Protocol Amendment 3 of: NRG-BR001, A Phase 1 Study of Stereotactic Body Radiotherapy (SBRT) for the Treatment of Multiple Metastases
For Protocol Amendment 3 of: NRG-BR001, A Phase 1 Study of Stereotactic Body Radiotherapy (SBRT) for the Treatment of Multiple Metastases NCI/Local Protocol #: NRG-BR001/NRG BR001 NCI Protocol Version
More informationRadiotherapy Planning (Contouring Lung Cancer for Radiotherapy dose prescription) Dr Raj K Shrimali
Radiotherapy Planning (Contouring Lung Cancer for Radiotherapy dose prescription) Dr Raj K Shrimali Let us keep this simple and stick to some basic rules Patient positioning Must be reproducible Must be
More informationIMRT - Intensity Modulated Radiotherapy
IMRT - Intensity Modulated Radiotherapy Advanced product in the RT technology Aims to deliver radiation more precisely to the tumor, while relatively limiting dose to the surrounding normal tissues 7 position
More informationInstitute of Oncology & Radiobiology. Havana, Cuba. INOR
Institute of Oncology & Radiobiology. Havana, Cuba. INOR 1 Transition from 2-D 2 D to 3-D 3 D conformal radiotherapy in high grade gliomas: : our experience in Cuba Chon. I, MD - Chi. D, MD - Alert.J,
More informationSBRT fundamentals. Outline 8/2/2012. Stereotactic Body Radiation Therapy Quality Assurance Educational Session
Stereotactic Body Radiation Therapy Quality Assurance Educational Session J Perks PhD, UC Davis Medical Center, Sacramento CA SBRT fundamentals Extra-cranial treatments Single or small number (2-5) of
More informationMRI Based treatment planning for with focus on prostate cancer. Xinglei Shen, MD Department of Radiation Oncology KUMC
MRI Based treatment planning for with focus on prostate cancer Xinglei Shen, MD Department of Radiation Oncology KUMC Overview How magnetic resonance imaging works (very simple version) Indications for
More informationICRU Report 91 Was ist neu, was ändert sich?
DEGRO Stereotaxie Meeting 21.10.2017 ICRU Report 91 Was ist neu, was ändert sich? Lotte Wilke, Stephanie Tanadini-Lang, Matthias Guckenberger Klinik für Radio-Onkologie, Universitätsspital Zürich History
More information11/28/2018. Proton Therapy for Liver Cancer: Who, Why, and How. Disclosures. Michael Chuong, MD. None
Proton Therapy for Liver Cancer: Who, Why, and How Michael Chuong, MD Disclosures None 1 Rationale for proton therapy Hepatic toxicity Biliary toxicity GI toxicity Potentially significant benefit especially
More informationA dosimetric evaluation of VMAT for the treatment of non-small cell lung cancer
JOURNAL OF APPLIED CLINICAL MEDICAL PHYSICS, VOLUME 14, NUMBER 1, 2013 A dosimetric evaluation of VMAT for the treatment of non-small cell lung cancer Caitlin E. Merrow, a Iris Z. Wang, Matthew B. Podgorsak
More information