Neil David Woodward, Ph.D.

Transcription

1 NAME: Neil David Woodward, Ph.D. Office Address: Vanderbilt Psychiatric Hospital, Suite rd Avenue S., Nashville, TN Office Phone #: Fax #: Webpage: EDUCATION: 1999: Bachelor of Science with Specialization in Psychology, University of Alberta. Edmonton, Alberta, Canada 2004: Master of Arts in Psychology, Vanderbilt University. Nashville, Tennessee, United States 2007: Clinical Neuropsychology Resident, Edmonton Consortium Clinical Psychology Residency. Edmonton, Alberta, Canada 2007: Doctor of Philosophy in Clinical Psychology, Vanderbilt University. Nashville, Tennessee, United States 2009: Post-Doctoral Research Fellow, Psychiatric Neuroimaging Program, Dept. of Psychiatry, Vanderbilt University School of Medicine. Nashville, Tennessee, United States LICENSURE: 2012-present: Psychologist HSP, Tennessee (License #3033) ACADEMIC APPOINTMENTS: 7/2013-present: Jack Martin, M.D., Research Professor in Psychopharmacology Dept. of Psychiatry, Vanderbilt University School of Medicine /2013: Assistant Professor of Psychiatry, Dept. of Psychiatry, Vanderbilt University School of Medicine 2009-present: Vanderbilt Neuroscience Training Faculty (Tier 1) Vanderbilt Neuroscience Graduate Program, Vanderbilt University CLINICAL APPOINTMENTS: 2012-present: Clinical Neuropsychologist Dept. of Psychiatry, Vanderbilt University School of Medicine MEMBERSHIP IN PROFESSIONAL ORGANIZATIONS: 2009-present: Organization of Human Brain Mapping 2009-present: International Neuropsychological Society Page 1 of 10

2 2009-present: 2009-present: American Psychological Association Society of Biological Psychiatry PROFESSIONAL ACTIVITIES: Intramural: Committees: 2012 Luton Society Meeting Planning Committee Extramural: Grant Reviewer: 2012 Behavioral Genetics and Epidemiology (BGES) Study Section, NIH 2012 Drug Safety and Effectiveness Network Targeted Research Review Committee, Canadian Institute of Health Research (CIHR) Ad Hoc Journal Reviewer: Archives of General Psychiatry, American Journal of Psychiatry, Biological Psychiatry, Cerebral Cortex, Comprehensive Psychiatry, European Psychiatry, Expert Review of Neurotherapeutics, Harvard Review of Psychiatry, International Journal of Neuropsychopharmacology, Neuroimage, Neuropsychopharmacology, Neuroscience Letters, Progress in Neuropsychopharmacology and Biological Psychiatry, Psychological Medicine, Psychopharmacology, Schizophrenia Bulletin, Schizophrenia Research AWARDS: 2013: Travel Fellowship, 46 th Winter Conference on Brain Research 2011: Young Investigator Travel Award, 13 th International Congress on Schizophrenia Research 2009: NARSAD Young Investigator Award, Brain and Behavior Research Fund 1999: Young Scientist Award, 10 th Biennial Winter Workshop on Schizophrenia TEACHING ACTIVITIES: Medical School Courses 2011 PGY2- Guest Lecturer, Vanderbilt University School of Medicine Graduate School Courses Spring 2010: NURO 325 Neuroscience Discussions, Vanderbilt University 2010, 2011: PSY 246 Schizophrenia- Guest Lecturer, Vanderbilt University, Dept. of Psychology Psychiatric Neuroimaging Program (PNP) Didactics : PNP/VUIIS Joint Imaging Seminar Series- Coordinator with Baxter Rogers Dept. of Psychiatry, Vanderbilt University RESEARCH PROGRAM AND FUNDING (ACTIVE) 5R21 MH (Woodward) 07/01/ /30/ calendar mos. NIMH $424,520 Page 2 of 10

3 Title: Cognitive Neuroscience of Processing Speed Dysfunction in Schizophrenia This proposal will use cognitive neuroscience based methods to better understand the nature and neural basis of processing speed impairment in schizophrenia. 1RO1 MH (Zald) 07/01/ /30/ calendar mos. NIMH $1,511,954 Title: RDoC Constructs: Neural Substrates, Heritability, and Relation to Psychopathology This project proposes to test key hypotheses of the Research Domain Criteria (RDoC) initiative, which proposes that research on the neurobiological basis of psychopathology has been misled because dysfunctional brain circuits do not align one-to-one with disorders, but align with a number of functional constructs that should be the focus of study. RESEARCH PROGRAM AND FUNDING (COMPLETED) Research Grant (Woodward) 08/01/ /01/ calendar mos. Luton Society $11,197 Title: Functional Brain Network Changes Across Clinical States in Schizophrenia This study will use resting-state fmri to examine changes in functional connectivity across clinical states in schizophrenia. NARSAD Young Investigator (Woodward) calendar mos. Brain and Behavior Research Fund $60,000 Title: The Neural and Genetic Basis of Processing Speed Deficits in Schizophrenia This study examined the neural basis of processing speed deficits in schizophrenia using fmri and DTI. Luton Pilot Grant (PI: Woodward) No Effort Luton Society $4000 Title: Comparing Conscious and Unconscious Skill Learning in Schizophrenia This study examined differential deficits in procedural and declarative memory systems in schizophrenia using a novel behavioral paradigm. BIBLIOGRAPHY: Original Papers Published or In Press 1. Woodward ND, Duffy-Alberto B, Karbasforoushan H. (In Press) Prefrontal cortex activity during response selection predicts processing speed impairment in schizophrenia. Journal of the International Neuropsychological Society. 2. Samanez-Larkin G, Buckholtz JW, Cowan RL, Woodward ND, Li R, Ansari MS, Arrington CM, Baldwin RM, Smith CE, Treadway MT, Kessler RM, Zald DH. (In Press) A thalamo-corticostriatal dopamine circuit for psychostimulant-enhanced human cognitive flexibility. Biological Psychiatry. Page 3 of 10

4 3. Sheffield J, Williams LE, Woodward ND, Heckers S. (2013) Reduced grey matter volume in psychotic disorder patients with a history of childhood sexual abuse. Schizophrenia Research, 143(1): Woodward ND, Karbasforoushan H, Heckers S. (2012) Thalamocortical dysconnectivity in schizophrenia. American Journal of Psychiatry, 169(10): Treadway MT, Buckholtz JW, Cowan RL, Woodward ND, Li R, Ansari MS, Baldwin RM, Schwartzman AN, Smith CE, Bossaller NA, Shelton RC, Kessler RM, Zald DH. (2012) Dopaminergic mechanisms of individual differences in human effort-based decision making. Journal of Neuroscience, 32(18): Bobo WV, Woodward ND, Jayathilake K, Meltzer HY. (2011) The effect of armodafinil on cognitive performance and psychopathology in antipsychotic-treated patients with schizophrenia/schizoaffective disorder: A randomized, double-blind, placebo-controlled trial. Schizophrenia Research, 130(1-3): Woodward ND, Rogers B, Heckers S. (2011) Functional resting-state networks are differentially affected in schizophrenia. Schizophrenia Research, 130(1-3): Bauernfiend AL, Deitrich MS, Blackford JU, Charboneau EJ, Lillevig JG, Cannistraci CJ, Woodward ND, Cao A, Watkins C, Di lorio CR, Cascio C, Salomon R, Cowan RL. (2011) Human ecstasy use is associated with increased visual cortical excitability: an fmri study. Neuropsychopharmacology, 36(6): Woodward ND, Cowan RL, Park S, Ansari MS, Baldwin RM, Li R, Doop ML, Kessler RM, Zald DH. (2011) Correlation of individual differences in schizotypal personality traits with amphetamine-induced dopamine release in striatal and extrastriatal brain regions. American Journal of Psychiatry, 168(4): Purdon SE, Waldie B, Woodward ND, Wilman A, Tibbo P. (2011) Procedural learning in first episode schizophrenia investigated with functional magnetic resonance imaging. Neuropsychology, 25(2): Williams LE, Must A, Avery S, Woolard A, Woodward ND, Cohen NJ, Heckers S. (2010) Eye movement behaviour reveals relational memory impairment in schizophrenia. Biological Psychiatry, 68(7): Buckholtz JW, Treadway MT, Cowan RL, Woodward ND, Li R, Ansari MS, Baldwin RM, Schwartzman AN, Shelby ES, Smith CE, Kessler RM, Zald DH. (2010) Dopaminergic network differences in human impulsivity. Science, 329(5991): 532. Page 4 of 10

5 13. Woolard A, Kose S, Woodward ND, Verbruggen F, Logan G, Heckers S. (2010) Intact associative learning in patients with schizophrenia: Evidence from a Go/NoGo paradigm. Schizophrenia Research, 122(1-3): Zald DH, Woodward ND, Riccardi P, Ansari MS, Baldwin R, Cowan RL, Smith CE, Hakyemez H, Li R, Kessler RM. (2010) The interrelationship of dopamine D2-like receptor binding in striatal and extrastriatal brain regions in healthy humans. Neuroimage, 51(1): Buckholtz JW, Treadway MT, Cowan RL, Woodward ND, Benning SD, Li R, Ansari MS, Baldwin RM, Schwartzman AN, Shelby ES, Smith CE, Cole D, Kessler RM, Zald DH. (2010) Mesolimbic dopamine reward system hypersensitivity in individuals with psychopathic traits. Nature Neuroscience, 13(4): Karageorgiou I, Dietrich MS, Charboneau EJ, Woodward ND, Blackford JU, Salomon, R, Cowan RL. (2009) Prior MDMA (Ecstasy) use is associated with increased basal gangliathalamocortical circuit activation during motor task performance in humans: An fmri study. Neuroimage, 46(3): Woodward ND, Zald DH, Li R, Ding Z, Riccardi P, Ansari MS, Dawant B, Anderson S, Baldwin R, Kessler RM. (2009) Cerebral morphology and dopamine D2/D3 receptor distribution in humans: A combined [18F]fallypride and voxel-based morphometry study. Neuroimage, 46(1): Kessler RM, Woodward ND, Riccardi P, Li R, Ansari MS, Anderson S, Dawant B, Zald DH, Meltzer HY. (2009) Dopamine D2 receptor levels in striatum, thalamus, substantia nigra, limbic regions, and cortex in schizophrenia subjects. Biological Psychiatry, 65(12): Woodward ND, Waldie B, Rogers B, Seres P, Tibbo P, Purdon SE. (2009) Abnormal prefrontal cortical activity and connectivity during response selection in first episode psychosis, chronic schizophrenia, and unaffected siblings of individuals with schizophrenia. Schizophrenia Research, 109(1-3): Raj V, Liang H-C, Woodward ND, Bauernfeind AL, Lee J, Dietrich M, Park S, Cowan RL. (2010) MDMA (Ecstasy) use is associated with reduced BOLD signal change during semantic recognition in abstinent human polydrug users: A preliminary fmri study. Journal of Psychopharmacology, 24(2): Meltzer HY, Brennan MD, Woodward ND, Jayathilake K. (2008) Association of SULT4A1 SNPs with psychopathology and cognition in patients with schizophrenia or schizoaffective disorder. Schizophrenia Research, 106(2-3): Page 5 of 10

6 22. Woodward ND, Tibbo P, Purdon SE. (2007) An fmri investigation of procedural learning in unaffected siblings of patients with schizophrenia. Schizophrenia Research, 94(1-3): Woodward ND, Jayathilake K, Meltzer HY. (2007) COMT val108/158met genotype, cognitive function, and cognitive improvement with clozapine in schizophrenia. Schizophrenia Research, 90(1-3): Woodward ND, Purdon SE, Meltzer HY, Zald DH. (2007) A meta-analysis of cognitive change with haloperidol in clinical trials of second generation antipsychotics: dose effects and comparison to practice effects. Schizophrenia Research, 89(1-3): Zedkova L, Woodward ND, Shih EM, Seres P, Purdon SE, Tibbo, PG. (2006) Procedural learning in schizophrenia investigated with functional MRI. Schizophrenia Research, 88(1-3): Riccardi P, Zald DH, Li R, Park S, Ansari MS, Dawant B, Anderson S, Woodward ND, Schmidt D, Baldwin R, Kessler R. (2006) Sex differences in amphetamine induced displacement of [18F] Fallypride in striatal and extratstriatal regions: a PET study. American Journal of Psychiatry, 163(9): Riccardi P, Li R, Ansari MS, Zald DH, Park S, Dawant B, Anderson S, Woodward ND, Schmidt D, Baldwin R, Kessler RM. (2006) Amphetamine induced displacement of [18F] Fallypride in striatum and extratstriatal brain regions. Neuropsychopharmacology, 31(5): Woodward ND, Purdon SE, Meltzer HY, Zald DH. (2005) A meta-analysis of neuropsychological change to clozapine, olanzapine, quetiapine, and risperidone in schizophrenia. International Journal of Neuropsychopharmacology, 8(3): Purdon SE, Woodward ND, David SR, Stip E. (2003) Procedural learning in schizophrenia after 6 months of double-blind treatment with olanzapine, risperidone, and haloperidol. Psychopharmacology, 169(3-4): Purdon SE, Woodward ND, LaBelle A, Mintz AR. (2002) Procedural learning improvements after 6 weeks of treatment with clozapine. Schizophrenia Research, 53(1-2): Purdon SE, Woodward ND, Flor-Henry P. (2001) Asymmetrical hand force persistence and neuroleptic treatment in schizophrenia. Journal of the International Neuropsychological Society, 7(5): Manuscripts Under Review: Treadway MT, Buckholtz JW, Cowan RL, Woodward ND, Li R, Ansari MS, Baldwin RM, Schwartzman AN, Smith CE, Kessler RM, Zald DH. Stress reactivity predicts alterations in human medial prefrontal neurochemistry. Page 6 of 10

7 Invited Review Articles: 1. Karbasforoushan H, Woodward ND. (2012) Resting-state networks in schizophrenia. Current Topics in Medicinal Chemistry, 12(21): Book Chapters: 1. Heckers S, Woodward ND, Ongur D. (2013) Neuroimaging of psychotic disorders. In Neurobiology of Mental Illness. Eds. Charney D, Buxbaum J, Sklar P, Nestler E. Oxford. 2. Woodward ND, Meltzer HY. (2010) Neuropsychology of treatment resistant schizophrenia. In Advances in Biological Psychiatry (Vol. 26): Therapy-Resistant Schizophrenia. Eds. Elkis, H and Meltzer, HY. Karger Invited Lectures: 09/14/2012 Neurocardiology Rounds. Vanderbilt University, Nashville, TN, USA 06/21/2012 Psychiatry Grand Rounds. Vanderbilt University, Nashville, TN, USA 04/22/2012 McLean Neuroscience Seminar. McLean Hospital, Belmont, MA, USA 08/21/2008 Psychiatry Grand Rounds. Vanderbilt University, Nashville, TN, USA 06/07/2007 Psychiatry Grand Rounds. Alberta Hospital Edmonton, AB, Canada 11/07/2006 Neuropsychology Grand Rounds. University of Alberta Hospital, AB, Canada 10/06/ th Edmonton Schizophrenia Conference, Edmonton, AB, Canada Peer-Reviewed Conference Symposia Talks: 01/28/2013 Thalamocortical dysconnectivity in schizophrenia. Symposium Title: The functional relevance of specific inputs to the prefrontal cortex in health and disease (Chair: Joshua Gordon). 46 th Annual Winter Conference on Brain Research. Breckenridge, CO, USA 04/03/2012 Thalamocortical dysconnectivity in schizophrenia: A biomarker of atypical brain maturation? Symposium Title: Resting-state fmri: a window into atypical neurodevelopment in psychiatric disorders (Chair: Neil D. Woodward). 67 th Annual Meeting of the Society of Biological Psychiatry. Philadelphia, PA, USA 04/22/2010 Dopaminergic function and schizotypal personality traits in healthy individuals. Symposium Title: Dopamine Dysfunction in Schizophrenia- from Human Imaging Studies to Animal Models (Chair: Neil D. Woodward). 65 th Annual Meeting of the Society of Biological Psychiatry. New Orleans, LA, USA 02/09/2008 Patients with schizophrenia and their unaffected relatives demonstrate abnormalities in fronto-subcortical circuitry during procedural learning: An fmri investigation. Symposium Title: Validation of an Endophenotype for Schizophrenia with Cross-cultural, Psychological, and Biological Correlates (Chair: Scot E. Purdon). 36 th Annual Meeting of the International Neuropsychological Society. Waikoloa, HI, USA 07/12/2006 A meta-analysis of neuropsychological change to atypical antipsychotic drugs in schizophrenia. Symposium Title: Neurocognition in Schizophrenia: Medication Page 7 of 10

8 Effects and Biological Markers (Chair: Tomiki Sumiyoshi). 24 th CINP Congress. Chicago, IL, USA. Peer-Reviewed Conference Talks: Woodward ND, Rogers B, Heckers SH. Resting-state networks are differentially affected in schizophrenia. 13 th International Congress on Schizophrenia Research, April 2-6, Colorado Springs, CO, USA. Woodward ND, Waldie B, Rogers B, Seres P, Tibbo P, Purdon SE. The neural basis of response selection in schizophrenia: A potential endophenotype International Congress on Schizophrenia Research, March 29-April 1, San Diego, CA, USA Woodward ND, Tibbo P, Purdon SE. An fmri investigation of procedural learning in unaffected siblings of patients with schizophrenia International Congress on Schizophrenia Research. March 28-April 1, Colorado Springs, CO, USA Woodward ND, Purdon SE, David SR & Stip E. Procedural learning and neuroleptic treatment in schizophrenia. 29 th Annual Meeting of the International Neuropsychological Society. Feb , Chicago, IL, USA Peer-Reviewed Conference Poster Presentations: Karbasforoushan H, Duffy-Alberto B, Rogers B, Woodward ND. Functional dysconnectivity in schizophrenia transcends cognitive state. 68 th Annual Meeting of the Society of Biological Psychiatry. May 16-18, San Francisco, CA, USA Woodward ND, Duffy-Alberto B, Karbasforuoshan H. Prefrontal cortex activity during response selection predicts processing speed impairment in schizophrenia. 14 th International Congress on Schizophrenia Research. April 21-25, Orlando Grand Lakes, FL, USA. Karbasforoushan H, Heckers S, Woodward ND. Interhemispheric functional connectivity during resting-state is reduced in schizophrenia. 67 th Annual Meeting of the Society of Biological Psychiatry. May 3-5, Philadelphia, PA, USA Woodward ND, Heckers SH. A functional network approach to understanding structural brain changes in schizophrenia. 66 th Annual Meeting of the Society of Biological Psychiatry, May 12-14, San Francisco, CA, USA Woodward ND, Zald DH, Riccardi P, Ansari MS, Baldwin R, Cowan RL, Li R, Kessler RM. Sex differences in striatal and extra-striatal dopamine D2/D3 receptor distribution in humans: An [18F]fallypride study. 15 th Annual Meeting of the Organization for Human Brain Mapping, June 18-23, San Francisco, CA, USA Page 8 of 10

9 Woodward ND, Jayathilake K, Meltzer HY. Neuropsychological functioning in schizophrenia patients with average or below average intellectual abilities. 63 rd Annual Meeting of the Society of Biological Psychiatry, May 1-3, Washington, DC, USA Woodward ND, Zald DH, Li R, Riccardi P, Ansari MS, Dawant B, Anderson S, Baldwin R, Kessler RM. Cerebral morphology and dopamine D2/D3 receptor distribution in humans: A combined 18F fallypride and voxel-based morphometry study. 63 rd Annual Meeting of the Society of Biological Psychiatry, May 1-3, Washington, DC, USA Cabaniss B, Woodward ND, Bauernfiend AL, Cowan RL. Cerebral morphological changes in human MDMA (Ecstasy) polydrug users: a voxel-based morphometry study. 63 rd Annual Meeting of the Society of Biological Psychiatry, May 1-3, Washington, DC, USA Kessler RM, Woodward N, Riccardi P, Ansari S, Li R, Zald D, Jayathilake K, Meltzer HY. Dopamine D2 receptor levels in the substantia nigra, cortex, limbic regions, thalamus, and basal ganglia in off medication schizophrenic subjects. 45 th Annual Meeting of the American College of Neuropsychopharmacology, December 3-7, Hollywood, FL, USA Kessler RM, Riccardi P, Zald D, Park S, Woodward N, Dawant B, Baldwin R, Salomon R. PET imaging of extrastriatal dopamine release and baseline levels of extracellular dopamine. 45 th Annual Meeting of the American College of Neuropsychopharmacology, December 3-7, Hollywood, FL, USA Ertugrul E, Anil Yagcioglu AE, Woodward ND, Jayathilake K, Meltzer HY. Genetic predictors of cognitive function and response to treatment in schizophrenia. 19 th European College of Neuropsychopharmacology Congress. September 16-20, Paris, France. Doop ML, Park S, Zald D, Li R, Riccardi P, Ansari MS, Dawant B, Anderson S, Gibson C, Woodward N, Schmidt D, Baldwin R, Kessler R. D-Amphetamine induced attenuation of attentional inhibition: Implications for schizophrenia. 12 th Annual Meeting of the Organization for Human Brain Mapping. June 11-15, Florence, Italy. Yang E, Doop ML, Park S, Li R, Zald D, Riccardi P, Ansari MS, Dawant B, Gibson C, Anderson S, Woodward N, Schmidt D, Baldwin R, Kessler RM. Dopamine modulation of attentional shift and inhibition: a PET study. 12 th Annual Meeting of the Organization for Human Brain Mapping. June 11-15, Florence, Italy. Zald DH, Riccardi P, Sib Ansari M, Li R, Woodward ND, Kessler, RM. The interrelationship of dopamine D2/D3 receptor levels in striatal and extratstriatal brain regions in healthy humans. 35 th Annual Meeting of the Society for Neuroscience. November 12-16, Washington DC, USA Grant M, Woodward N, Logan G, Hollon S, Shelton R. Cognitive control and self-regulation of emotion in major depressive disorder: is there a relationship between spatial localization and Page 9 of 10

10 efficiency of processing in anterior cingulate? 20 th Annual Meeting of the Society for Research in Psychopathology. October 27-30, Miami, FL, USA Zald DH, Riccardi P, Woodward ND, Li R, Ansari MS, Schoenberg E, Park S, Kessler RM. Differential association between verbal fluency and regional D2/D3 binding in healthy humans. Human Brain Mapping 2005, June 12-16, Toronto, ON, Canada. Zedkova L, Woodward ND, Shih EM, Seres P, Purdon SE, Tibbo PG. Procedural learning in schizophrenia investigated with fmri International Congress on Schizophrenia Research. April 2-6, Savannah, GA, USA Woodward ND, Purdon SE, Zald DH. Neuropsychological change to second generation antipsychotic treatment in schizophrenia: a meta-analysis. 9 th International Congress on Schizophrenia Research and 6 th Annual Mt. Sinai Conference on Cognition in Schizophrenia. Colorado Springs, CO, USA Purdon SE, Klein S, Woodward ND, Reed BD & Flor-Henry H. Menstrual effects on asymmetrical olfactory acuity. Annual Meeting of the International Neuropsychological Society. Feb , Chicago, IL, USA Purdon SE, Woodward ND, Mintz AR & Labelle A. Procedural learning improvements following 6 weeks of treatment with clozapine. 29 th Annual Meeting of the International Neuropsychological Society. Feb , Chicago, IL, USA Purdon SE & Woodward ND. Neuroleptic effects on atypical sensory and motor asymmetries in schizophrenia. 29 th Annual Meeting of the International Neuropsychological Society. Feb , Chicago, IL, USA Woodward ND & Purdon SE. Gender differences in cerebral volume reductions in schizophrenia. 29 th Annual Meeting of the International Neuropsychological Society. Feb , Chicago, Illinois; Biennial Meeting of the International Congress on Schizophrenia Research, April 28-May 2, 2001, Whistler, BC, Canada. Woodward ND, Purdon SE & Flor-Henry P. Asymmetrical hand force persistence and neuroleptic treatment in schizophrenia. 10 th Biennial Winter Workshop on Schizophrenia. Davos, Switzerland Purdon SE, Flor-Henry P, Waldie BD, Woodward ND & Reed BD. Asymmetrical olfactory acuity and neuroleptic treatment in schizophrenia. 10 th Biennial Winter Workshop on Schizophrenia. Davos, Switzerland. Page 10 of 10