Outcomes and GRADE Summary of Findings Tables: old and new
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1 Holger Schünemann, MD, PhD Chair, Dept. of Clinical Epidemiology & Biostatistics Professor of Clinical Epidemiology & Biostatistics and of Medicine Michael Gent Chair in Healthcare Research McMaster University, Hamilton, COMET meeting, Rome, November Outcomes and GRADE Summary of Findings Tables: old and new
2 Disclosure Co-chair GRADE Working Group World Health Organization: various committees Co-director, WHO collaborating center on evidence informed policy making Cochrane Collaboration Steering group GIN Board of Directors No direct financial COI
3 C Summary of Findings Tables Prior work Updates ontent
4
5 Evidence profiles Question and source of evidence (systematic review) Population, intervention, comparator, outcomes Outcomes Methds and evaluation Effect estimates Confidence/quality by outcome: High Moderate Low Very low
6 First study of SoF Number of outcomes 7 Presenting information on all important outcomes; ordering of outcomes 20 Cochrane review authors participated (20 new or updated reviews) spent an additional 4 h (2 to 40 h) layout clear 11/17 increased accessibility 5/17 improved quality 1/17 rephrased conclusions
7 RCTs RCTs 1 EBCP workshop (N 72); 2 Cochrane entities meeting (N 33) RCT 1: easy to find results, SoF versus no: 68 vs. 40% (p = 0.02) RCT 2: SoF more correct answers to two questions re results 93% vs 44% (p = 0.003) and 87% vs. 11% (p < 0.001) SoF participants spent average of 90 seconds to find key information vs 4 minutes without SoF table
8 134 fewer 22 fewer 5 more
9 Optimal format Evidence Profiles RCT alternative testing formats of Evidence Profiles in 88 guideline panelists Preferences for: Study event rates over no (small/moderate effect) Absolute risk differences over absolute risks (large effect) more likely to correctly interpret CI around difference (58 vs 11%, p < ) Information in table cells vs footnotes (small/moderate effect) In cells more likely to get time frame right (58% vs 11%, p < ) Information EP judged easy to find, comprehend, helpful both (median 6 of 7)
10 C Summary of Findings Tables Prior work Updates ontent
11 Cochrane method innovation fund project Enhancing the acceptance and implementation of SoF tables in Cochrane reviews Initiated in 2012 Feedback from Cochrane review groups User-testing of potential solutions Formal testing of formats RCT
12 Enhancing the acceptance and implementation of SoF tables in 40 participants Cochrane reviews Cochrane review users (clinicians, guideline developers, researchers) Participants prefer simple, less crowded SoF tables Dichotomous: NNTs, Risk Difference over natural frequencies Continuous: Minimal important difference units over MD and SMD what happens column: statement of presence/direction of effect and qualitative statement of confidence U ser testing
13 Table 1. Comparison between items included in the current and alternative SoF tables formats Current formats (Table B) Alternative formats (Table A) 1 Inclusion of the Nº of participants and studies column Exclusion of the Nº of participants and studies column. Information presented in the outcomes column 2 Quality of evidence presented with symbols and labeled as High, moderate, low, or very low. Reasons for downgrading presented in the footnotes Quality of evidence presented with main reasons for downgrading in the same column (e.g. MODERATE due to imprecision) 3 Footnotes label Explanations label 4 Baseline risk and corresponding risk expressed as natural frequencies Baseline risk and corresponding risk expressed as percentages 5 No column presenting absolute risk reduction (risk difference) or mean difference Inclusion of a column presenting absolute risk reduction (risk difference) or mean difference 6 Comments column included Comments column deleted 7 No what happens column* What happens column included* 8 Description of the GRADE Working Group grades of evidence definitions below the table No description of the GRADE Working Group grades of evidence definitions
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15 300 Clinicians, guideline developers, researchers Alternative vs current formats Understanding, accessibility, satisfaction, preference R CT Design
16 R Percentage of participants that answered correctly understanding questions Concept Ability to determine risk difference Understanding of quality of evidence and treatment effect Question asked How many fewer children < 5 years will have diarrhea if they have probiotics than if they do not? Which of the following statements best represents the results informing the outcome adverse events? Alternative formats (N=122) Current formats (N=168) Difference P value 98% 35% 63% < % 26% 62% <0.001 CT Results
17 DECIDE: Interactive Summary of Findings tables
18 Diagnostic SoF Tables
19 Testing of different entry points
20
21
22
23 Multiple comparisons
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25 Tools
26 Why is this relevant for COMET Summary of Findings Tables report information for patient or population important outcomes Outcomes are determined by decisionmakers (e.g. panels): over and over again
27 Grade up Grade down Randomization raises initial quality RCTs: high Observational: low P I C O Outcome Outcome Outcome Outcome Evidence synthesis Critical Critical Important Not Summary of findings & estimate of effect for each outcome High Moderate Low Very low 1. Risk of bias 2. Inconsistency 3. Indirectness 4. Imprecision 5. Publication bias 1. Large effect 2. Dose response 3. Opposing bias & Confounders Recommendation Grade recommendations (Evidence to Recommendation) For or against (direction) Strong or conditional/weak (strength) By considering balance of consequences (evidence to recommendations): Quality of evidence Balance benefits/harms Values and preferences Feasibility, equity and acceptability Resource use (if applicable) Guideline Grade overall quality of evidence across outcomes based on lowest quality of critical outcomes Formulate Recommendations ( ) The panel recommends that.should... The panel suggests that.should... The panel suggests to not... The panel recommends to not... Transparency, clear, actionable Research?
28 longer life fewer symptoms fewer complications better quality of life sensitivity specificity
29 Why is this relevant for COMET Summary of Findings Tables report information for patient or population important outcomes Outcomes are determined by decisionmakers (e.g. panels): over and over again But we wouldn t have to (if there was a core outcome set)
30 In summary SoF tables improve systematic review users understanding and rapidity of grasping information Study showed this was using suboptimal formats big improvement in formats with testing There is no one results presentation that fits all potential users need interactive SoF SoFs are essential and should be compulsory
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Washington, DC, November 9, 2009 Institute of Medicine
Holger Schünemann, MD, PhD Chair, Department of Clinical Epidemiology & Biostatistics Michael Gent Chair in Healthcare Research McMaster University, Hamilton, Canada Washington, DC, November 9, 2009 Institute
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