Adults with PKU Improving Quality of life through Diet
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1 Adults with PKU Improving Quality of life through Diet
2 WHAT IS PKU?? Stands for phenylketonuria is an inherited liver enzyme deficiency causes problems in protein metabolism leads to mental retardation if untreated
3 What is missing in PKU? The enzyme phenylalanine hydroxylase this converts phenylalanine to tyrosine in the liver without it, phenylalanine builds up and phenylketones form
4 Effects of Untreated PKU High levels of phenylalanine cause brain damage during development
5 Effects of Untreated PKU high levels of phenylalanine affect developing brain causes irreversible brain damage occurs from birth onwards old thinking: diet from birth to age 6 new thinking: diet for life
6 High phe levels can lead to... Hyperactivity self-abuse crying anxiety and nervousness aggressiveness low attention span motor disturbances
7 Low phe levels lead to... attention span social awareness ability to respond to behavior modification use of meds skin and odour problems feeling happier!
8 What can be done? By limiting the amount of protein eaten, the levels of phenylalanine can be normalized in the blood formula + low-protein diet = success!
9 Take home points Brain damage caused by high levels of phenylalanine during development is irreversible Intoxication effect caused by high levels of phenylalanine is reversible through diet intervention
10 Reaping the benefits of the PKU diet Monitoring effects on behavior
11 Effects of Untreated PKU High levels of phenylalanine cause an intoxication effect much like alcohol leads to decreases in mental efficiency and causes behavioral problems this is reversible!
12 Why monitor behavior?? Provides measurable evidence of the effectiveness of the PKU diet for the individual Gives an objective picture of behavior so that improvements can be made
13 Behavior assessment is... defining examining observing planning documenting
14 When is a behavior a problem? if it is harmful or disruptive to oneself, others or property if it interferes with learning new skills if it interferes with skills already learned
15 Defining the behavior Behavior is observable: it can be detected by your 5 senses Behavior is measurable: it can be measured in terms of frequency, duration and intensity Behavior is discrete: it has a definite beginning and ending.
16 Defining Behavior... Using the criteria, how would you define this person s behavior??
17 Food for thought... Beware of LABELLING Clients don t always see their behavior as being a problem Problem behaviors that may not affect peers or staff may be harmful to the client
18 Choosing a behavior record Types of behavior records mood charts sleep charts behavior analysis charts behavioral incident chart
19 Choosing a method Depends on type of behavior Depends on frequency and duration of behavior; may be easier to record absence vs. presence nurse and psychologist can work with you to determine best tool for recording behavior
20 Recording behavior Group home staff need to define 1 or 2 target behaviors and then choose the method that works best for everyone Important that tool is user-friendly so behavior is consistently recorded and takes as little time as possible
21 The ABCs of observing behavior A=antecedent situation; what is happening at the time of behavior B=behavior C=consequences of the behavior
22 Behavior modification Lowering phenylalanine levels can make the person with PKU more open to behavior modification Two ways of managing behavior are: 1) time outs 2) reinforcing good behavior
23 Remember... Be realistic in setting goals. No intervention has a 100% success rate. Give it time changes to long term behavior happen slowly Celebrate small changes that tell you the behavior is improving!
24 Take home points... The goal of the PKU diet for untreated adults is behavior improvement Recording behavior provides reliable evidence that the diet is improving the quality of life for the client
25 PKU Diet Management By Taryn Bosdet, Jennifer Branov & Annie Rosen Heath RDs
26 Outline Protein How do we remove phenylalanine from the diet? The PKU diet Case study Sick Day Plan Funding Summary
27 Protein Average protein requirements & phe intake Average Female: 55 grams protein = 2750mg phe Average Male: 70 grams protein = 3500 mg phe Classical PKU: = 300mg phe ~ 6 grams dietary protein
28 Protein cont d Role of Dietary Protein Structural proteins (e.g. muscles) Transport proteins (e.g. hemoglobin) Immune proteins (e.g. white blood cells) Energy
29 Protein cont d Amino acids the building blocks of a protein There are 20 different amino acids, which when strung together make up a wide variety of proteins Amino acids are classified as Essential and Non- Essential. Essential amino acids are amino acids that our bodies can NOT make and we must rely on dietary sources to get them. There are 9 essential amino acids phenylalanine is one of them.
30 Protein cont d Where do you find protein/amino acids (phe)? Meat, poultry, fish Milk and dairy- cheese, yogurt, ice cream Eggs Beans, legumes, nuts/seeds Tofu and other soy-based products
31 Protein cont d Where else can Phe be found? Regular starches: Phe (mg) Bread 150mg ½ cup Pasta 160mg ½ cup Rice 200mg 1 bagel 270mg 1 flour tortilla 189mg 1 cup cornflakes 120mg 1 cup Lucky Charms 114mg
32 Phenylalanine in Foods Phenylalanine (mg) Chicken, 1 ounce Egg, 1 medium Wheat Bread, 1 slice Carrot
33 Hidden Phe - how do we find it? Label Reading Look for key words indicating protein Lentils/beans Flour (malt, wheat, rye, barley, rice) Soy/soy protein isolate/soy sauces Rice Whey or Casein (Dairy) Semolina Egg Textured or hydrolyzed vegetable protein Gelatin Yeast, yeast extract Nuts Carob
34 PKU diet Vegetarian Diet Many vegetarian foods are still very high in protein Veggie burgers and tofu/soy products Nut spreads Bean or lentil dishes Cheese/yogurt Eggs Too many starchy foods
35 Label Reading cont d Use the 5% rule to estimate phe in a product (Approximately 0.05% of protein is phenylalanine) Look on the nutrition information panel and find the grams of protein per serving Multiply grams protein x 50= mg phe Measure how much you eat Look for artificial sweeteners (aspartame/ Nutrasweet/Equal)
36 Label Reading Note the order of ingredients. Protein information is rounded. 0g protein listed on label doesn t mean protein free Up to.49g protein can be present Assume 25mg phe if a label says 0g protein unless you know exactly how much phe is in the product Bottom line: any food with less than.5g protein may have a label reading 0g protein
37 Label Reading cont d Nutrition Label: #3
38 Label Reading cont d Nutrition Facts / List of Ingredients ACTIVITY Frozen Peaches and Cream Corn Whole Kernel Corn (canned) Ingredients: whole kernel corn Ingredients: corn, water, salt for taste #A11a
39 Label Reading cont d Nutrition Facts are based on a specific amount of food. Compare this to the amount you eat Label (1 cup dry (88 g)) 2 cups of cooked pasta At home or at a restaurant Pasta side dish or main meal? #S7c
40 Removing phe from the diet Phenylalanine is an amino acid that is part of a complete protein package. We can not just remove phe from food sources like meat/ poultry/fish/starches. How do we remove phe from the diet? Eliminate all high protein food sources from the diet: Beef, pork, poultry, fish, eggs, dairy, nuts, legumes, soy, etc Limit the amount of regular starches in the diet: Rice, pasta, bread, crackers, potatoes
41 Removing phe from the diet Canada s Food Guide to Healthy Eating #16 Cont d
42 Removing phe from the diet? cont d Is there a problem with eliminating all protein from the diet? What does this mean for our PKU clients? How are they going to meet their protein needs without eating dietary protein? If Phe is an essential amino acid and we are avoiding high phe foods how will our PKU clients get it in their diet?
43 The PKU Diet Phenylalanine-free formula is the cornerstone of the PKU diet Fruits and Vegetables Low protein food products Limited amounts regular starches Free foods- sugars and fats
44 The PKU Diet PKU formula is the cornerstone of the diet It provides: Protein (will meet their daily requirement) Energy (calories) Vitamins and Minerals Calcium/Vit D Iron Folate B12 Zinc Tyrosine
45 The PKU Diet cont d Types of formulas: Different flavors Plain, vanilla, strawberry, orange etc. Different calorie levels Different protein levels
46 The PKU Diet cont d Formula Timing: Before other foods 3 to 4 times per day am, afternoon, pm & hs snack spreading formula throughout the day helps to ensure adequate absorption and stability of phe levels
47 The PKU Diet cont d Low protein food products: Baking - egg replacer, baking mixes Imitation Pasta/rice/cookies/crackers Ready made breads Bread machine bread (using wheat starch) Low protein cheese/peanut butter Ready to serve low protein frozen products Other low protein foods: Milk alternatives Rice milk, Almond milk ( some brands), Coconut milk and coconut milk-based products Some gluten free products must read label for protein content Rice noodles, mung bean noodles Vegan cheese (Daiya brand)
48 The PKU Diet cont d Watch serving sizes Free Foods Salad dressing/oils/lactose-free margarine Syrups/jam/sugar Kool-Aid/Regular Pop Fruit drinks Candy
49 Where to get low protein foods? Special Products Distribution Center (At BC Children s Hospital) Phone: Cambrooke Foods ( Taste Connections ( PKU Perspectives ( Ener-G Foods ( Nutricia North America ( Dietary Specialties ( Applied Nutrition ( Can find products in local grocery stores (eg. Rich s RichWhip, Okanagan Choice and Daiya cheeses, gluten free products, Coconut, Rice and Almond milks) try specialty stores like Whole Foods and Choices (see food list in education package)
50 Target Phe Levels (<6) To achieve target levels clients must stick with the PKU diet. ü Formula ü Low protein foods and limited regular starches ü Fruits ü Vegetables ü Free Foods ü Adequate calories/energy balance
51 PKU Client: Amy Noacid Meal Plan Breakfast Calories Protein Phe (mg) Formula - 73g slices low pro bread ½ tbsp. Margarine cinnamon and sugar banana Lunch Formula 73g piece of regular bread tomato, lettuce, cukes tbsp mayonnaise small apple Dinner Formula 73g oz dry low pro pasta margarine ½ tbsp Fried mushrooms and peppers
52 PKU Client: Amy Noacid cont d Phe tolerance: 300mg Calorie needs: 2000kcal Protein needs: 48g 1.) Where will Amy get her protein from? 2.) What other nutrients are found in the PKU formula? 3.) What 2 food groups should Amy avoid? 4.) What foods can Amy eat? 5.) How many regular starches can Amy eat while keeping her phe levels in the goal range? 6.) How would you increase Amy s calorie intake if she was sick (without increasing her phe intake)?
53 PKU Client: Amy Noacid cont d 7.) What would happen to Amy s phe intake if she ate a hotdog and French fries at her day program? 1 hot dog wiener = 220mg phe 1 hot dog bun = 180mg phe Regular order French fries = 127mg phe Total = 527mg phe (remember her daily phe tolerance is 300mg)
54 Sick Day Management Goal is to prevent muscle breakdown and maintain phenylalanine levels in target by: Cautious intake of phe Continue with formula Provide adequate energy sources/calories and fluids Muscles are made of protein (including phe). If muscles breakdown, phe released in to blood stream.
55 Funding the PKU Diet All formula is covered by a government grant As of Jan 1, 2014 all patients with PKU are eligible for up to $250 per month in low protein foods (they can order these from Special Products Distribution Center) Clients on Income Assistance can apply for a $40 per month low protein diet allowance. There is no funding to cover cost of scales, blenders, or bread makers
56 Summary Phenylalanine is found in all natural proteins Low Phe diet = low protein diet Phe is required in small amounts - requirement met with daily intake of starches, fruits/veg People with PKU have normal Protein needs Formula supplies Phe-free protein along with necessary vitamins and minerals Ensure adequate calories Calories are boosted with free foods and low protein products Regular starches are moderately high in phe and should be limited
57 Resources Canadian PKU and Allied Disorders National PKU Alliance (US) New England Connection for Allied Disorders PKU News
58 Resources cont d Cook Books Apples to zucchini, Family-friendly PKU recipes, Internal PKU recipe book Recipes Sign-up with for free and get PKU recipes
59 That s All Folks! Call with any questions at any time We look forward to working with you!
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