The Value and Complexity of Infection Studies or Why we Bug the Data Managers.
|
|
- Isabella Tate
- 5 years ago
- Views:
Transcription
1 The Value and Complexity of Infection Studies or Why we Bug the Data Managers. Marcie Tomblyn, MD, MS, Scientific Director Manisha Kukreja, MBBS, MPH, Biostatistician Infection and Immune Reconstitution Working Committee Overview Indication for infection studies in transplant patients Definitions Study data needed Supplemental data requests 1
2 Why do we need to study infections? Significant cause of morbidity and mortality after transplant Patients may have chronic infections and receive transplant Newer drugs may change outcomes of infections after transplant Causes of Death after Transplants AUTO Relapse (75%) Organ toxicity (8%) IPn (2%) Infection (6%) GVHD (14%) HLA-ID SIB Other (9%) Other (13%) Relapse (38%) GVHD (14%) UNRELATED Relapse (32%) Infection (17%) IPn (5%) Organ toxicity (13%) Other (17%) IPn (7%) Organ toxicity 11%) Infection (19%) SUM05_20.ppt 2
3 Definitions Clinically significant infection Repeated infection Prophylaxis vs Treatment Clinically Significant Infection Identified infections that result in a change of therapy Suspected infections with supporting clinical or imaging findings (i.e. pulmonary infiltrate on chest CT) 3
4 So What s NOT an Infection? Culture-negative neutropenic fever without clear source Upper respiratory infections that are presumed viral but no virus identified Stool Candida Reporting Infections 4
5 Sites of Infection **Disseminated infections must have the organism identified at 3 or more non-contiguous sites 5
6 What is the same infection? (i.e. don t t report again) Bacteria 7 days All bacteria (except Clostridium Difficile) 30 days Clostridium Difficile 365 days Helicobacter pylori Virus 14 days VZV HZV Adenovirus Enterovirus Influenza virus Parainfluenza Rhinovirus 60 days CMV HSV Polyomavirus Fungal 14 days Yeasts Candida Cryptococcus 90 days Molds Aspergillus Fusarium Mucor Prophylaxis vs Treatment Prophylaxis: started about the time of conditioning to PREVENT infections Usually includes: Antibiotics Quinolones Bactrim (TMP/SMX) Antifungals Antivirals Treatment: drugs used for MANAGEMENT of the infection Example: d/c of Acyclovir and start Ganciclovir at time of CMV infection/reactivation 6
7 Infection Prophylaxis Where are the answers? What if you can t t find them? Dates of infection Microbiology records Dates of therapy Medication Administration Record (MAR) Still can t find it????? Estimate dates Please mark unknown 7
8 Specific Infection Data Viral loads (i.e. Hepatitis, HIV) Likely checked multiple times List all values available during the reporting period Be careful of the units of measurement! From the statisticians perspective 8
9 Supplemental Data Data that is not collected on the Comprehensive Report Form Often required in Infection Studies Treatment of infection Testing for diagnosis of infection Dates Prophylaxis Treatment Diagnostic test results Creation of Supplemental Forms Confirm that the data is not already collected on CIBMTR forms Create flow chart (hopefully similar to how the data is recorded in the medical chart!) Data requests are grouped Lab data Diagnostic tests Therapy 9
10 Creation of Supplemental Forms Medications include generic and trade names on forms Explanation of codes and definitions used on the forms can be found either: On the supplemental form directly In an accompanying manual In the Data Managers manual Why are we asking you a question you ve already answered??? To confirm data that may be confusing Ex. Hepatitis B surface antigen vs surface antibody To confirm that a patient actually should be included in the study in rare situations Ex. HIV positive **We will try and pre-populate the form with your previous response** 10
11 Example: Viral Hepatitis Data Manager Torture (I mean requirements!) Minimize use of Other, specify fields Unknown Contact the study CRC if There are potential recipients who fit study criteria but data were not requested You have ANY questions! 11
12 Reporting Dates Guidelines for estimation (since MDs are notorious for being inexact or illegible!) If month and year available but no day, use 15 If season available, report best guess of month and day You must tick the ESTIMATE box Reporting Duration of Therapy Date started Date stopped If therapy held for 7 days and then restarted, DO NOT list as stopped If on treatment until death, mark therapy stopped NO 12
13 Example: Duration of Therapy Reporting Doses Form will attempt to use a standard unit Convert dose into the unit requested (i.e. mg) Consult with pharmacist if needed Report the first dose as the starting dose Report maximum dose (if asked) What if the dose changes???? Use the starting dose 13
14 Example: Hepatitis Treatment What I do with the data you send Reasons for specific dates Calculate Time to infection Survival after infection and after transplant Study effect of prophylaxis or treatment on outcomes after infections Reasons for specific drugs Identify impact of certain medications on development or outcome of infections 14
15 15
Fungal Infections: Reporting. Marcie Tomblyn, MD, MS Associate Member, Moffitt Cancer Center
Fungal Infections: Management and Reporting Marcie Tomblyn, MD, MS Associate Member, Moffitt Cancer Center February 25, 2010 Objectives Review common fungal infections in HCT patients Review current available
More informationInfection and Immune Reconstitution: The NEW Forms
Infection and Immune Reconstitution: The NEW Forms Marcie Tomblyn, MD, MS Assistant Professor, UMN Assistant Scientific Director, CIBMTR Minneapolis February 16, 2006 Why the changes? Infection data not
More informationInfection Data: Form Updates
Infection Data: Form Updates Marcie Riches, MD, MS Associate Professor University of North Carolina Scientific Director, Infection and Immune Reconstitution WC Overview Why is infection data important?
More informationChain of Infection Agent Mode of transmission Contact (direct, indirect, droplet spread) Airborne Common-vehicle spread Host
Goals Microbiology of Healthcare-associated Infections William A. Rutala, Ph.D., M.P.H. Director, Statewide Program for Infection Control and Epidemiology and Research Professor of Medicine, University
More informationHow to prevent Infections in Patients undergoing allo-hsct?
How to prevent Infections in Patients undergoing allo-hsct? Olaf Penack EBMT Course, 29 Sept 1 Oct 2014, Naples, Italy #EBMT2014 www.ebmt.org Prevention of Infections Epidemiology and risk factors for
More informationMICROBIOLOGICAL TESTING IN PICU
MICROBIOLOGICAL TESTING IN PICU This is a guideline for the taking of microbiological samples in PICU to diagnose or exclude infection. The diagnosis of infection requires: Ruling out non-infectious causes
More informationTest Requested Specimen Ordering Recommendations
Microbiology Essentials Culture and Sensitivity (C&S) Urine C&S Catheter Surgical (excluding kidney aspirates) Voided Requisition requirements o Specific method of collection MUST be indicated o Indicate
More informationBone Marrow Transplantation in Myelodysplastic Syndromes. An overview for the Myelodysplasia Support Group of Ottawa
Bone Marrow Transplantation in Myelodysplastic Syndromes An overview for the Myelodysplasia Support Group of Ottawa Objectives Provide brief review of marrow failure Re emphasize the importance of predictions
More informationAE Toxicity Grading for Transplant Patients
AE Toxicity Grading for Transplant Patients Marcie Tomblyn, MD, MS Associate Member Director, BMT Clinical Research Moffitt Cancer Center Objectives Why do we care????? Toxicity vs Adverse Event vs Serious
More informationPotential etiologies of infection in these patients are diverse, including common and uncommon opportunistic infections.
In the name of God Principles of post Tx infections 1: Potential etiologies of infection in these patients are diverse, including common and uncommon opportunistic infections. Infection processes can progress
More informationInfections after stem cell transplantation
Infections after stem cell transplantation Lidia Gil Poznan, Poland No conflict of interest Lisbon, Portugal 20/03/2018 #EBMT18 www.ebmt.or Infections after HSCT Infectious complications universal problem
More informationThe Pulmonary Pathology of Iatrogenic Immunosuppression. Kevin O. Leslie, M.D. Mayo Clinic Scottsdale
The Pulmonary Pathology of Iatrogenic Immunosuppression Kevin O. Leslie, M.D. Mayo Clinic Scottsdale The indications for iatrogenic immunosuppression Autoimmune/inflammatory disease Chemotherapy for malignant
More informationComplications after HSCT. ICU Fellowship Training Radboudumc
Complications after HSCT ICU Fellowship Training Radboudumc Type of HSCT HSCT Improved outcome due to better HLA matching, conditioning regimens, post transplant supportive care Over one-third have pulmonary
More informationDEPARTMENT OF MICROBIOLOGY IMPORTANT NOTICE TO USERS Turnaround Times (TATs) for Microbiology Investigations
Dear User, ISSUE: M008 DEPARTMENT OF MICROBIOLOGY IMPORTANT NOTICE TO USERS Turnaround Times (TATs) for Microbiology Investigations In order to comply with national quality guidance and as part of our
More informationAn Introduction to Bone Marrow Transplant
Introduction to Blood Cancers An Introduction to Bone Marrow Transplant Rushang Patel, MD, PhD, FACP Florida Hospital Medical Group S My RBC Plt Gran Polycythemia Vera Essential Thrombocythemia AML, CML,
More informationImmunohistochemical Confirmation of Infections
Immunohistochemical Confirmation of Infections Danny A. Milner, Jr, MD, MSc, FCAP The Brigham and Women s Hospital Harvard Medical School Boston, Masschusetts USA Judicious Use of Immunohistochemistry
More informationLe infezioni fungine nel trapianto di cellule staminali emopoietiche. Claudio Viscoli Professor of Infectious Disease University of Genova, Italy
Le infezioni fungine nel trapianto di cellule staminali emopoietiche Claudio Viscoli Professor of Infectious Disease University of Genova, Italy Potential conflicts of interest Received grants as speaker/moderator
More informationAn Overview of Blood and Marrow Transplantation
An Overview of Blood and Marrow Transplantation October 24, 2009 Stephen Couban Department of Medicine Dalhousie University Objectives What are the types of blood and marrow transplantation? Who may benefit
More informationForm 2046 R3.0: Fungal Infection Pre-HSCT Date
Key Fields Sequence Number: Date Received: - - CIBMTR Center Number: CIBMTR Recipient ID: Today's Date: - - Date of HSCT for which this form is being completed: - - HSCT type: (check all that apply) Autologous
More informationCommon Fungi. Catherine Diamond MD MPH
Common Fungi Catherine Diamond MD MPH Birth Month and Day & Last Four Digits of Your Cell Phone # BEFORE: http://tinyurl.com/kvfy3ts AFTER: http://tinyurl.com/lc4dzwr Clinically Common Fungi Yeast Mold
More informationAtul Humar, MD, MSc Director, Transplant Program, University Health Network, University of Toronto
TIME PROGRAM TITLE 7:30 8:15 Registration and Continental Breakfast 8:15 8:30 Welcoming Remarks TOPIC: VIRUSES Session Chair: Shahid Husain CMV: What is New, What s Hot Atul Humar, MD, MSc Director, Transplant
More informationSample Selection- Vignettes
Sample Selection- Vignettes Rangaraj Selvarangan, BVSc, PhD, D(ABMM) Professor, UMKC School of Medicine Director, Microbiology, Virology and Molecular Infectious Diseases Laboratory Director, Laboratory
More informationThe Myrtle Road site, near Bristol Royal Infirmary, houses the Mycology reference services.
Microbiology Handbook: Royal united Hospitals Bath 1. Background The Public Health England (PHE) Bristol Laboratory is the Public Health Laboratory for the South West. It is one of the largest Microbiology
More informationIP Lab Webinar 8/23/2012
2 What Infection Preventionists need to know about the Laboratory Anne Maher, MS, M(ASCP), CIC Richard VanEnk PhD, CIC 1 Objectives Describe what the laboratory can do for you; common laboratory tests
More information& VIRAL EYE PATHOGENS
FUNGAL, MYCOBACTERIAL, & VIRAL EYE PATHOGENS Dr. WILLIAM J. BENJAMIN Eye Physiology & Ocular Prosthetics Laboratory University of Alabama at Birmingham School of Optometry Presented at the UAB School of
More informationCauses of Death. J. Douglas Rizzo, MD MS February, New11_1.ppt
Causes of Death J. Douglas Rizzo, MD MS February, 2012 New11_1.ppt Overview Attribution of COD important for research purposes Frequently not correctly coded or completely reported Source of confusion
More informationPATHOGEN DETECTION WITH THE FILMARRAY
PATHOGEN DETECTION WITH THE FILMARRAY The System Sample-to-Answer in an Hour Single sample Multiple samples The FilmArray integrates sample preparation, amplification, detection, and analysis all into
More informationMontgomery County Community College BIO 241 Clinical Microbiology II 4-3-3
Montgomery County Community College BIO 241 Clinical Microbiology II 4-3-3 AY16-17 COURSE DESCRIPTION: A course that introduces Immunology, Virology, Mycology, and Parasitology as well as the immunological
More informationPrimary prophylaxis of invasive fungal infection in patients with haematological diseases
Primary prophylaxis of invasive fungal infection in patients with haematological diseases Tunis, May 24 2012 Important questions for antifungal prophylaxis Who are the patients at risk? Which is the risk:
More informationProficiency Testing Materials for use with BioFire FilmArray Panels
Proficiency Materials for use with BioFire FilmArray Panels Introduction This document provides a listing of proficiency testing materials that have been tested at BioFire and are compatible with the BioFire
More informationFungal Infection Pre-Infusion Data
Fungal Infection Pre-Infusion Data Registry Use Only Sequence Number: Date Received: CIBMTR Center Number: Event date: / / CIBMTR Form 2046 revision 5 (page 1 of 5). Last Updated May, 2018. Infection Episode
More informationEMERGING FUNGAL INFECTIONS IN IMMUNOCOMPROMISED PATIENTS
EMERGING FUNGAL INFECTIONS IN IMMUNOCOMPROMISED PATIENTS DR LOW CHIAN YONG MBBS, MRCP(UK), MMed(Int Med), FAMS Consultant, Dept of Infectious Diseases, SGH Introduction The incidence of invasive fungal
More informationESCMID Online Lecture Library. by author. CASE PRESENTATION ECCMID clinical grand round May Anat Stern, MD Rambam medical center Haifa, Israel
CASE PRESENTATION ECCMID clinical grand round May 2014 Anat Stern, MD Rambam medical center Haifa, Israel An 18 years old Female, from Ukraine, diagnosed with acute lymphoblastic leukemia (ALL) in 2003.
More informationAntimicrobial prophylaxis in liver transplant A multicenter survey endorsed by the European Liver and Intestine Transplant Association
Antimicrobial prophylaxis in liver transplant A multicenter survey endorsed by the European Liver and Intestine Transplant Association Els Vandecasteele, Jan De Waele, Dominique Vandijck, Stijn Blot, Dirk
More informationCase 3: what grew? BA Gram stain morphology Mucoid colonies on BA
Case 3: what grew? BA Gram stain morphology Mucoid colonies on BA 43 Case 3: probability split! Gram variable, grows on BA, MAC, barely on CHOC Oxidase positive Vitek: probability split, Acinetobacter
More informationAnswer Key: ARS Questions Presented in Live Course Presentations (Non Board Review or Photo Opportunity)
Answer Key: ARS Questions Presented in Live Course Presentations (Non Board Review or Photo Opportunity) Contents Volume I... 2 Online Only Lectures... 2 Saturday, August 24, 2013 (Lectures 1 10)... 3
More informationSchedule of Accreditation issued by United Kingdom Accreditation Service 2 Pine Trees, Chertsey Lane, Staines-upon-Thames, TW18 3HR, UK
2 Pine Trees, Chertsey Lane, Staines-upon-Thames, TW18 3HR, UK Luton and Dunstable University Hospital NHS Foundation Trust Lewsey Road Luton Bedfordshire LU4 0DZ Contact: Pauline Philip Tel: +44 (0)1582
More informationMANAGEMENT OF SUSPECTED VIRAL ENCEPHALITIS IN CHILDREN
MANAGEMENT OF SUSPECTED VIRAL ENCEPHALITIS IN CHILDREN OVERVIEW 1980s: dramatically improved by aciclovir HSV encephalitis in adults Delays treatment(> 48h after hospital admission): associated with a
More informationBMTCN REVIEW COURSE POST-TRANSPLANT ISSUES I
BMTCN REVIEW COURSE POST-TRANSPLANT ISSUES I Jennifer Shamai MS, RN, AOCNS, BMTCN Professional Practice Leader Department of Clinical Practice And Professional Education Click How to edit the Master Experts
More informationPUO in the Immunocompromised Host: CMV and beyond
PUO in the Immunocompromised Host: CMV and beyond PUO in the immunocompromised host: role of viral infections Nature of host defect T cell defects Underlying disease Treatment Nature of clinical presentation
More informationDr. Cristina Gutierrez, Laboratory Director, CARPHA SARI/ARI SURVEILLANCE IN CARPHA MEMBER STATES
Dr. Cristina Gutierrez, Laboratory Director, CARPHA SARI/ARI SURVEILLANCE IN CARPHA MEMBER STATES SARI/ARI Surveillance in CARPHA Member States* Objectives of SARI Surveillance: To detect unusual or unexpected
More informationApproach to the Transplant Patient. Amy Musiek, MD AAD Annual Meeting 2018
Approach to the Transplant Patient Amy Musiek, MD AAD Annual Meeting 2018 Disclosures Actelion: speaker, advisory board, investigator Elorac: investigator Kyowa: investigator, advisory board Seattle genetics:
More informationECMM Excellence Centers Quality Audit
ECMM Excellence Centers Quality Audit Person in charge: Department: Head of Department: Laboratory is accredited according to ISO 15189 (Medical Laboratories Requirements for quality and competence) Inspected
More informationDr. Joseph McGuirk Professor of Medicine, BMT Medical Director, Interim Director, Division of Hematology/Oncology
Advances in Autologous and Allogeneic Stem Cell Transplantation Dr. Joseph McGuirk Professor of Medicine, BMT Medical Director, Interim Director, Division of Hematology/Oncology April 12, 2014 Disclosures
More informationNeutropenic Sepsis Guideline
Neutropenic Sepsis Guideline Neutropenic Sepsis Guideline - definitions Suspected or proven infection in a neutropenic patient is a MEDICAL EMERGENCY and is an indication for immediate assessment and prompt
More informationClinical Aspect and Application of Laboratory Test in Herpes Virus Infection. Masoud Mardani M.D,FIDSA
Clinical Aspect and Application of Laboratory Test in Herpes Virus Infection Masoud Mardani M.D,FIDSA Shahidhid Bh BeheshtiMdi Medical lui Universityit Cytomegalovirus (CMV), Epstein Barr Virus(EBV), Herpes
More informationSniffs and Sneezes can Spread Diseases: Year- Round Protection. Jim Gauthier, MLT, CIC Senior Clinical Advisor, Infection Prevention
Sniffs and Sneezes can Spread Diseases: Year- Round Protection Jim Gauthier, MLT, CIC Senior Clinical Advisor, Infection Prevention Objectives Look at various viral respiratory illnesses Discuss year-round
More informationLaboratory Evidence of Human Viral and Selected Non-viral Infections in Canada
Canada Communicable Disease Report ISSN 1188-4169 Date of publication: October 1998 Volume 24S7 Supplement Laboratory Evidence of Human Viral and Selected Non-viral Infections in Canada 1989 to 1996 Our
More informationSchedule of Accreditation issued by United Kingdom Accreditation Service 2 Pine Trees, Chertsey Lane, Staines-Upon-Thames TW18 3HR
Schedule of ccreditation United Kingdom ccreditation Service 2 Pine Trees, Chertsey Lane, Staines-Upon-Thames TW18 3HR Issue No: 007 Issue date: 20 pril 2018 ccredited to Medical Microbiology Ninewells
More informationFILMARRAY: CAN IT MAKE A DIFFERENCE FOR CSF TESTING L O U I S E O S U L L I V A N, M M U H O S U L L I V A N M A T E R. I E
FILMARRAY: CAN IT MAKE A DIFFERENCE FOR CSF TESTING L O U I S E O S U L L I V A N, M M U H O S U L L I V A N L @ M A T E R. I E Level 4 teaching hospital based in Dublin s north inner city Over 600 in-patient
More informationInfections in immunocompromised host
Infections in immunocompromised host Immunodeficiencies Primary immunodeficiencies Neutrophil defect Humoral: B cell defect Humoral: Complement Cellular: T cells Combined severe immunodeficiency Secondary
More informationCNS Infections in the Pediatric Age Group
CNS Infections in the Pediatric Age Group Introduction CNS infections are frequently life-threatening In the Philippines, bacterial meningitis is one of the top leading causes of mortality in children
More informationINFECTIOUS DISEASE. Page 2
Infectious disease Advantages OF TESTING INFECTIOUS DISEASE We are in the middle of a paradigm shift in infectious disease diagnostic testing. As we move from targeted infectious disease testing to a syndromic
More informationRSV Surveillance in the U.S.
RSV Surveillance in the U.S. Susan I. Gerber, MD Respiratory Virus Program Division of Viral Diseases National Center for Immunization and Respiratory Diseases Centers for Disease Control and Prevention
More informationSyndromic Testing for Infectious Diseases
Syndromic Testing for Infectious Diseases Part 3: Central Nervous System Infections HOT TOPIC / 2017 Presenter: Elitza S. Theel, Ph.D., D(ABMM) Director of Infectious Diseases Serology Department of Laboratory
More informationJourney to Decreasing Clostridium Difficile and the Unexpected Twist. Jackie Morton, Infection Prevention Cortney Swiggart, Medication Safety Officer
Journey to Decreasing Clostridium Difficile and the Unexpected Twist Jackie Morton, Infection Prevention Cortney Swiggart, Medication Safety Officer 4/13/2018 Objectives Discuss the organism and clinical
More informationUpdate on the development of clinical diagnostic run controls at NIBSC. Neil Almond Division of Virology
Update on the development of clinical diagnostic run controls at NIBSC Neil Almond Division of Virology BACKGROUND Molecular techniques are increasingly being used for microbiological diagnoses Assays
More informationIsolation Precautions in Clinics
Purpose Audience General principles Possible Exposures To define isolation precautions in a clinic setting. Clinics Isolation status should be determined primarily by the suspected disease and/or pathogen.
More informationAntiviral Treatment and Prophylaxis for seasonal Influenza QRG 2017/18
Antiviral Treatment and Prophylaxis for seasonal Influenza QRG 2017/18 Selection of antiviral therapy for treatment of influenza (definitions + doses on p.2) When indicated, treatment should be started
More informationSchedule of Accreditation
Schedule of Accreditation Organisation Name National Virus Reference Laboratory INAB Reg No 326MT Contact Name Eimear Malone Address University College Dublin, Belfield, Dublin Contact Phone No 01-7161319
More informationSkin Pathway Group Alemtuzumab in Cutaneous Lymphoma
Skin Pathway Group Alemtuzumab in Cutaneous Lymphoma Indication: Treatment of patients with Cutaneous Lymphoma (Unlicensed use) Disease control prior to Reduced Intensity Conditioning Stem Cell Transplant
More informationDisclosures. Investigator-initiated study funded by Astellas
Disclosures Investigator-initiated study funded by Astellas 1 Background Widespread use of preemptive therapy strategies has decreased CMV end-organ disease to 5-8% after HCT. Implications for development
More informationAntimicrobial Management of Febrile Neutropenic Sepsis
Antimicrobial Management of Febrile Neutropenic Sepsis Written by: Dr J Joseph, Consultant Haematologist Dr K Gajee, Consultant Microbiologist Amended by: Larissa Claybourn, Antimicrobial Pharmacist Date:
More informationHerpes virus reactivation in the ICU. M. Ieven BVIKM
Herpes virus reactivation in the ICU M. Ieven BVIKM 07.04.2011 Introduction: Viruses identified in critically ill ICU patients Viral diseases have recently been the subject of numerous investigations in
More information1. Diagnosis: 2. Co-Morbidities: Allergies: NKDA Allergic to:
BMT NON -HODGKIN S LYMPHOMA Autologous Stem Cell Transplant Routine Plan 1. Diagnosis: 2. Co-Morbidities: Allergies: NKDA Allergic to: 3. Attending Physician: Notify on call Resident/Fellow Consult: Social
More information5/9/2018. Bone marrow failure diseases (aplastic anemia) can be cured by providing a source of new marrow
5/9/2018 or Stem Cell Harvest Where we are now, and What s Coming AA MDS International Foundation Indianapolis IN Luke Akard MD May 19, 2018 Infusion Transplant Conditioning Treatment 2-7 days STEM CELL
More informationPediatric influenza-associated deaths in Arizona,
Pediatric influenza-associated deaths in Arizona, 2004-2012 (Poster is shared here as an 8.5 x11 document for easier viewing. All content is identical, though graphs and tables are formatted differently.)
More informationMolecular Diagnostics Overview JAN A. NOWAK, PHD, MD PATHOLOGY AND LABORATORY MEDICINE MOLECULAR DIAGNOSTICS LABORATORY FEBRUARY 15, 2018
Molecular Diagnostics Overview JAN A. NOWAK, PHD, MD PATHOLOGY AND LABORATORY MEDICINE MOLECULAR DIAGNOSTICS LABORATORY FEBRUARY 15, 2018 Some Key Points Molecular Testing has applications in every section
More informationProficiency Testing Materials for use with FilmArray Panels
Proficiency Testing Materials for use with FilmArray Panels Introduction This document provides a listing of proficiency testing materials that have been tested at BioFire and are compatible with the FilmArray
More informationFungal infection in the immunocompromised patient. Dr Kirsty Dodgson
Fungal infection in the immunocompromised patient Dr Kirsty Dodgson Aims Discuss different types of fungi Overview of types of clinical infections Clinical Manifestations Fungus Includes Moulds Aspergillus
More informationTarrant County Influenza Surveillance Weekly Report CDC Week 10: March 04-10, 2012
Tarrant County Public Health Division of Epidemiology and Health Information Tarrant County Influenza Surveillance Weekly Report CDC Week 10: March 04-10, 2012 Influenza Activity Code, County and State
More informationMichael Grimley 1, Vinod Prasad 2, Joanne Kurtzberg 2, Roy Chemaly 3, Thomas Brundage 4, Chad Wilson 4, Herve Mommeja-Marin 4
Twice-weekly Brincidofovir (BCV, CMX1) Shows Promising Antiviral Activity in Immunocompromised Transplant Patients with Asymptomatic Adenovirus Viremia Michael Grimley 1, Vinod Prasad, Joanne Kurtzberg,
More informationNeutrophil Recovery: The. Posttransplant Recovery. Bus11_1.ppt
Neutrophil Recovery: The First Step in Posttransplant Recovery No conflicts of interest to disclose Bus11_1.ppt Blood is Made in the Bone Marrow Blood Stem Cell Pre-B White cells B Lymphocyte T Lymphocyte
More informationPneumonia in the Immunocompromised Host
SIOP PODC Supportive Care Education Presentation Date: 26 th October 2015 Recording Link at www.cure4kids.org: https://www.cure4kids.org/ums/home/conference_rooms/enter.php?room=p1bk39ernlb Pneumonia in
More informationFungal Infection Post-Infusion Data
Fungal Infection Post-Infusion Data Registry Use Only Sequence Number: Date Received: CIBMTR Center Number: Event date: / / Visit: 100 day 6 months 1 year 2 years >2 years. Specify: CIBMTR Form 2146 revision
More informationLate Complications. Objectives. Long-term Survival after HCT. Long-term Survival and Late Complications after HCT. Long-term Survival after HCT
Objectives Late Complications Navneet Majhail, MD, MS Review late complications in hematopoietic cell transplant (HCT) recipients Review screening and prevention guidelines for HCT survivors Review upcoming
More informationLate Complications. Navneet Majhail, MD, MS
Late Complications Navneet Majhail, MD, MS Medical Director, Health Services Research, NMDP Assistant Scientific Director, CIBMTR Adjunct Associate Professor of Medicine University of Minnesota Objectives
More informationOne Day BMT Course by Thai Society of Hematology. Management of Graft Failure and Relapsed Diseases
One Day BMT Course by Thai Society of Hematology Management of Graft Failure and Relapsed Diseases Piya Rujkijyanont, MD Division of Hematology-Oncology Department of Pediatrics Phramongkutklao Hospital
More informationTarrant County Influenza Surveillance Weekly Report CDC Week 17: April 22-28, 2012
Tarrant County Public Health Division of Epidemiology and Health Information Tarrant County Influenza Surveillance Weekly Report CDC Week 17: April 22-28, 2012 Influenza Activity Code, County and State
More informationPNEUMONIA IN CHILDREN. IAP UG Teaching slides
PNEUMONIA IN CHILDREN 1 INTRODUCTION 156 million new episodes / yr. worldwide 151 million episodes developing world 95% in developing countries 19% of all deaths in children
More informationFecal microbial transplantation
Version 09/16 Consent Form For Fecal microbial transplantation Fecal transplant is an operation in which liquid produced from a healthy human being (as per a survey questionnaire and blood and feces tests)
More informationPerform Gram stain only. Select Survey D5, Gram Stain
www.cap.org Bacteriology This flowchart is provided as a guide for ordering the appropriate Bacteriology Surveys for your laboratory s testing menu. In order to meet CLIA requirements for the subspecialty
More information11/20/2015. Post Transplant. Problems and limitations of SCT. Bone Marrow Transplant for SAA: Managing Post BMT Health and Support.
Transplant 11/20/2015 Bone Marrow Transplant for SAA: Managing Post BMT Health and Support Richard W. Childs, M.D. Clinical Director NHLBI Chief, Laboratory of Transplantation Immunotherapy Senior Investigator,
More informationAppendix E1. Epidemiology
Appendix E1 Epidemiology Viruses are the most frequent cause of human infectious diseases and are responsible for a spectrum of illnesses ranging from trivial colds to fatal immunoimpairment caused by
More information2046: Fungal Infection Pre-Infusion Data
2046: Fungal Infection Pre-Infusion Data Fungal infections are significant opportunistic infections affecting transplant patients. Because these infections are quite serious, it is important to collect
More informationTop 5 papers in clinical mycology
Top 5 papers in clinical mycology Dirk Vogelaers Department of General Internal Medicine University Hospital Ghent Joint symposium BVIKM/BSIMC and SBMHA/BVMDM Influenza-associated aspergillosis in critically
More informationIs pre-emptive therapy a realistic approach?
Is pre-emptive therapy a realistic approach? J Peter Donnelly PhD, FRCPath Department of Haematology Radboud University Nijmegen Medical Centre Nijmegen, The Netherlands Is pre-emptive therapy a realistic
More informationAntimicrobial prophylaxis for transplant recipients. Peter Chin-Hong, MD MAS February 4, 2015
Antimicrobial prophylaxis for transplant recipients Peter Chin-Hong, MD MAS February 4, 2015 Objective To list and understand the approach to three prevention strategies used to prevent infections in transplant
More information4100: Cellular Therapy Essential Data Follow-Up Form
4100: Cellular Therapy Essential Data Follow-Up Form Registry Use Only Sequence Number: Date Received: Key Fields CIBMTR Center Number: Event date: Visit: 100 day 6 months 1 year 2 years >2 years, Specify:
More informationNeutropenic Fever. CID 2011; 52 (4):e56-e93
Neutropenic Fever www.idsociety.org CID 2011; 52 (4):e56-e93 Definitions Fever: Single oral temperature of 101 F (38.3 C) Temperature 100.4 F (38.0 C) over 1 hour Neutropenia: ANC < 500 cells/mm 3 Expected
More informationMicrobiology Laboratory Directors, Infection Preventionists, Primary Care Providers, Emergency Department Directors, Infectious Disease Physicians
MEMORANDUM DATE: October 1, 2009 TO: FROM: SUBJECT: Microbiology Laboratory Directors, Infection Preventionists, Primary Care Providers, Emergency Department Directors, Infectious Disease Physicians Michael
More informationHuman infection with pandemic (H1N1) 2009 virus: updated interim WHO guidance on global surveillance
Human infection with pandemic (H1N1) 2009 virus: updated interim WHO guidance on global surveillance 10 July 2009 Background This document updates the interim WHO guidance on global surveillance of pandemic
More informationViral Threat on Respiratory Failure
Viral Threat on Respiratory Failure Younsuck Koh, MD, PhD, FCCM Department of Pulmonary and Critical Care Medicine Asan Medical Center University of Ulsan College of Medicine Seoul, Korea No Conflict of
More informationInnovations in nucleic acid amplification technologies. Automated platforms for NAT. Microfluidics Digital PCR Innovations in nucleic acid microarrays
About the author Disclaimer EXECUTIVE SUMMARY Molecular diagnostic technologies Healthcare-associated infections Sexually transmitted HPVs HIV and hepatitis viruses Market outlook and forecasts Molecular
More informationSchedule of Accreditation issued by United Kingdom Accreditation Service 2 Pine Trees, Chertsey Lane, Staines-upon-Thames, TW18 3HR, UK
Schedule of Accreditation 2 Pine Trees, Chertsey Lane, Staines-upon-Thames, TW18 3HR, UK National Infection Service, Public Health England Colindale 61 Colindale Avenue London NW9 5EQ Contact: Dr Sanjiv
More informationIsolation precautions. Patama Suttha M.D. 15 Dec 2015 Bamrasnaradura Infectious diseases Institute
Isolation precautions Patama Suttha M.D. 15 Dec 2015 Bamrasnaradura Infectious diseases Institute Isolation precautions: Aim Reduce direct or indirect transmission of HAI 3 mechanisms: - Contact transmission
More informationRecurring and Emerging Questions Related to Management of HIV-Related Opportunistic Infections. Objectives. Henry Masur MD
Recurring and Emerging Questions Related to Management of HIV-Related Opportunistic Infections Henry Masur MD Clinical Professor of Medicine George Washington University School of Medicine Objectives To
More information8/11/2015. Febrile neutropenia Bone marrow transplant Immunosuppressant medications
Dean Van Loo Pharm.D. Febrile neutropenia Bone marrow transplant Immunosuppressant medications Steroids Biologics Antineoplastic Most data from cancer chemotherapy Bone marrow suppression Fever is the
More informationMINUTES AND OVERVIEW PLAN CIBMTR WORKING COMMITTEE FOR INFECTION AND IMMUNE RECONSTITUTION San Diego, CA Thursday, February 12, 2015, 12:15 2:15 pm
MINUTES AND OVERVIEW PLAN CIBMTR WORKING COMMITTEE FOR INFECTION AND IMMUNE RECONSTITUTION San Diego, CA Thursday, February 12, 2015, 12:15 2:15 pm Co-Chair: Michael Boeckh, MD, Fred Hutchinson Cancer
More informationCRITICAL VALUES, SIGNIFICANT FINDINGS LIST and STAT RESULTS
Page 1 of 6 Affected Sites: X Enterprise Chandler Good Samaritan CRITICAL VALUES: s are defined as an analytic result that suggests a clinical condition that may be lifethreatening and may require immediate
More information