HIV Informatics Service

Transcription

1 HIV Informatics Service Understanding HIV with high tech computational molecular algorithms HIV NGS data analysis Drug resistance prediction Treatment strategy suggestion Geographical movement tracking prediction Patient risk assessment 1

2 List of Contents: Introduction to HIV HIV Statistics Epidemiology of HIV/AIDS Epidemiology of HIV/AIDS in middle east & Africa Cost of HIV treatment HIV Informatics Service How HIV informatics will help HIV/AIDS NGS data analysis HIV/AIDS drug resistance prediction Clinical Strategy Suggestion Patient Risk assessment Bio Data Center Our Services Contact Us

3 Introduction to HIV HIV/AIDS: The human immunodefciency virus is a lentivirus that causes HIV infection and over time acquired immunodefciency syndrome. HIV/AIDS Threats: Acquired immunodefciency syndrome (AIDS) is a chronic, potentially life-threatening condition caused by the human immunodefciency virus (HIV). By damaging immune system, HIV interferes with body's ability to fght the organisms that cause disease. HIV/AIDS Transmission: Contact between broken skin, wounds, or mucous membranes and HIV-infected blood or blood-contaminated body fuids. Deep, open-mouth kissing if both partners have sores or bleeding gums and blood from the HIV-positive partner gets into the bloodstream of the HIV-negative partner. 3

4 HIV Statistics: Epidemiology of HIV/AIDS HIV/AIDS is a global pandemic. As of 2016, approximately 36.9 million people are living with HIV globally. In 2016, approximately half are men and half are women. There were about 1.0 million deaths from AIDS in 2016, down from 1.9 million in 2005 Epidemiology of HIV/AIDS in Middle east & Africa UNAIDS has estimated that around 230,000 people are living with HIV in the Middle East and North Africa region, an overall HIV prevalence of 0.1 percent among adults ages 15 to 49, and one of the lowest rates among world regions. But other fgures reveal a different picture 4

5 Cost of HIV/AIDS treatment: According to the Centers for Disease Control and Prevention (CDC), currently (last updated: March 8, 2017), the lifetime treatment cost of an HIV infection is estimated at $379,668, Another study estimated the discounted lifetime cost for persons who become HIV infected at age 35 is $326,500 (60% for anti retroviral medications, 15% for other medications, 25% non-drug costs). Undiscounted mean lifetime costs are estimated to be $597,300."Discounting" in this context refers to a process in which future costs and health consequences are converted to their present values, about which process there is some controversy. 5

6 HIV Informatics Service: Understanding HIV in molecular dimensions is an important issue for help patient experience a better cure method and for government to make a national decision in health and medical services. List of HIV Informatics Services: - 6 HIV NGS data analysis Drug resistance prediction Clinical strategy suggestions HIV geographical source tracking Patient risk assessment

7 How HIV informatics will help? Understanding molecular informatics of HIV virus help to have a long time vision for each patient. HIV informatics will make a better cure experience by decreasing cost and time of cure, drug resistance prediction, suggesting clinical strategies, risk ranking calculation and increase cure method effectiveness. HIV informatics create a vision to estimate risk of transmission in a country and between neighbor countries. HIV informatics also create a vision of HIV drugs and medical needs for next decade and it would be a success point for health management systems. For a country with 1200 case of HIV-infected people estimation shows about 240 million dollar saving during disease period. HIV informatics also can help immigration program to understand and control special population in an exact area in borders and control high risk societies and HIV hot point zones in cities and countries. All of these information will lead to a roadmap of HIV future in a country that can help make national and political decision easier for government. 7

8 HIV/AIDS NGS data analysis: First step for understanding HIV behavior is to analyzing its unusual whole genome content that is RNA with high mutation and change that make each virus unique. Identifying whole genome residue by residue will create a roadmap for a better medical services. NGS data can help make a wide range of cure strategies against virus in patient body and also can help understand geographical source of virus. Knowing HIV whole genome content can help us select an economic and effective drugs for a better experience of cure. NGS data analysis is not usual for RNA virus contents and need details to make it useful for medical purposes. Bio data center corporation make it happened with optimized platform that aimed to make HIV NGS data easier to understand for medical purposes. 8

9 HIV/AIDS Drug Resistance Prediction: HIV virus because of high mutational rate shows a variety of behavior against commercial drugs during cure process. Create a medical profle based on the genome contents and previous experience in similar cases can help medical systems choose a suitable strategy during period of cure. Drug resistance prediction is an important issue that can have an irreversible effect on patient body. Genotype drug resistance testing can create a roadmap and long time vision and help patient and medical services use an effective and economic solution for make a better cure experience for patient. Creating genomics profle of HIV and use high tech algorithms to predict details can lead to a large money saving. 9

10 Clinical Strategy Suggestion: Patient with HIV/AIDS usually shows a variety of symptoms and problems that make cure process complex and sometime difcult. HIV attack immunity system and other viral and bacterial disease fnd an opportunity to make a wide range of symptoms. Understanding each case condition and search for experience based databases all around the world will lead to clinical strategy suggestion that help an effective and economic solution for a patient during common period and cure process. HIV/AIDS geographical source tracking Understanding geopolitics resources of HIV/AIDS is an important issue to control HIV in society with high immigration rate. Controlling and having a geopolitical map for HIV hot points will lead to a roadmap for political decisions. Bio Data Center use a high tech optimized algorithms to track geographical resource of HIV virus in each patients and fnd experienced based databases that can result a better cure process. 10

11 Patient risk assessment: HIV-Infected patients need their own usual social life and this will increase risk of society pollution. One of main question about HIV/AIDS is that, how much is it danger to society? And what are hot points about HIV/AIDS in cities and countries? Risk assessment calculation for each patients based on the HIV Genome content and some other factors, create a simple vision to future of patients and how much he/she should be under control of medical monitoring. How much he/she will survive with cure process. Understanding risk by a simple numbers is a very important issue in medical services that is available by integrating information with a computational tools. 11

12 Bio Data Center Life variety is very beautiful and complex to understand. Computational biology try to understand life in atomic dimensions that called bioinformatics. HIV as a viral agent with unusual genome content threat human life. Bio data center as a pioneer group in RNA bioinformatics create a platform for understanding HIV in molecular dimensions and providing services that is useful for a better cure experience and medical services. Our aim is to help countries and societies for using computational biology against HIV/AIDS. 12

13 Our Services: Our aim in bio data center is to make world better place to live in. So we make our HIV informatics Service available for different aspect of HIV society, from patients to medical services, from universities to government. We are ready to make workshops and power and design HIV informatics for clinics and hospitals. Also we are ready to do large data mining for governments and countries in HIV informatics. Contact us for free consulting meeting and we are able to communicate and understand your needs and design your special services. 13

14 Contact Us: Website: Phone: