DiaSorin Group Company Presentation. March 2019

Transcription

1 DiaSorin Group Company Presentation March 2019

2 What we do DiaSorin develops, manufactures and markets tests for the diagnosis of infectious diseases or hormonal disorders in the patient s health status. Our offer includes Me-too tests and Specialty tests both with high technological content Our diagnostic tests are aimed at both private and hospital laboratories worldwide, in immunodiagnostic and molecular diagnostic markets.

3 DiaSorin worldwide We are an Italian multinational Group, listed on the stock exchange in the FTSE MIB. Owned by DiaSorin S.p.A., it consists of 24 Companies, 5 foreign branches, offices on the 5 Continents and 6 manufacturing facilities throughout the world. USA Stillwater UK Dartford Germany Dietzenbach Italy Gerenzano With over 50 years of experience, USA Cypress R&D Centers Manufacturing Sites Italy Saluggia South Africa Kyalami We are one of the leading hitech players in the in vitro diagnostic market and, in particular, in the immunodiagnostic and molecular diagnostic segments.

4 DiaSorin worldwide Our distribution model consists of commercial subsidiaries (Europe, USA, Mexico, Brazil, China, Australia, Israel) and a network of about 200 independent distributors in the rest of the world. We want to reach everyone, wherever they are >200 employees researchers 10 new tests every year 120 geographical footprint

5 Our History Foundation of Sorin, a nuclear energy production research site, In Saluggia (VC, Italy), with the Joint Venture between FIAT and Montecatini. The first in Vitro Diagnostic (IVD) business is developed, focused on the European market 1968 With a management buyout operation, DiaSorin returns to Italian ownership 1997 Sorin acquires American Incstar Inc., active in the in vitro diagnostics (IVD). All activities related to IVD are spun off in a company named DiaSorin Srl, then sold to American Standard Inc DiaSorin continues its growth by launching the LIAISON XL. Acquisition of Murex and Abbott's related ELISA product-line, expanding further into Europe, Asia and Africa 2007 On July 19 DiaSorin is listed on the Stock Exchange DiaSorin acquires the molecular diagnostic and immunodiagnostic business unit of Focus Diagnostic, today DiaSorin Molecular DiaSorin is the leading player in the immunodiagnostic sector with the most extensive test menu available on CLIA technology and the highest number of specialty tests. Through strategic agreements with Roche and Beckman Coulter, DiaSorin takes on a truly global dimension 2016 DiaSorin signs a strategic agreement with Meridian Bioscience to sell Helicobater Pylori Stool Antigen test in the United States and the United Kingdom 2017 With the strategic partnership with Qiagen, DiaSorin is able to offer an automated solution for the tuberculosis diagnosis 2018

6 Financial December 31, 2018 Cash flow generation and positive financial position Net Financial Position Euro millions Revenues by geography FY 18 vs.fy'17 at constant exchange rates Free Cash Flow Europe & Africa /mln 46.3% of sales +11.7% France USA +12.0% +0.7% Euro millions Total LIAISON XL worldwide: Total installed base LIAISON + LIAISON XL: 4,001 7,849 Germany +16.5% Italy +12.2% Brazil -6.2% Latin America 42.2 /mln 6.3% of sales -2.2% China +5.8% Mexico +9.6% Expansion of DiaSorin s installed base New LIAISON XL installed in 2018: USA and Canada /mln 28.1% of sales +0.8% Australia +17.4% Asia Pacific /mln 19.3% of sales +13.5% Source: Press Release FY 2018 Results

7 Immunodiagnostics

8 MENU Innovation process in the Immunodiagnostic market: Area of opportunity RIA BENCH-TOP SOLUTIONS FIRST AUTOMATED SYSTEMS AUTOMATED SYSTEMS FULL CONNECTIVITY (Immuno+Clinical Chemistry) AUTOMATION

9 Immunodiagnostics Technology based on the detection of antibodies to highlight the presence of diseases in a sample of human fluids loaded on proprietary platforms based on CLIA technology (Chemiluminescence) and ELISA technology (Colorimetry) CLIA Systems ELISA Systems Freedom AVAILABLE OUTSIDE THE UNITED STATES AND CANADA

10 LIAISON family platforms Same cartridge for each test Magnetic particles Same raw materials 100 test samples for each cartridge Calibrators Diluent New in 2019 LAS

11 Installed base evolution LAS 2,959 3, ,872 5,272 4,740 4,206 1, , , , , ,078 6,336 7,398 6,862 2, , ,518 4, , ,880 7,849 4, ,

12 MENU MENU MENU MENU The widest CLIA menu on the market: 122 tests ONCOLOGY TUMOUR MARKERS CEA Free PSA Total PSA CA 15-3 CA 125 II CA 19-9 TPA-M NSE S100 AFP Tg Gen II HCG ß2-Microglobulin TK Calcitonin ENDOCRINOLOGY THYROID TSH (3rdGen.) Free T3 Free T4 T3 T4 Anti-Tg Tg Gen II Tg Gen Confirmatory II Anti-TPO GROWTH hgh IGF-I ADRENAL FUNCTION ACTH Cortisol DHEA-S ANAEMIA Ferritin Folate (*) Vitamin B12 ( DIABETES C-Peptide Insulin REPRODUCTIVE ENDOCRINOLOGY LH FSH Prolactin Progesterone Testosterone Estradiol HCG Androstenedione SHBG BONE & MINERAL 25-OH Vitamin D TOTAL N-TACT PTH II INFECTIOUS DISEASES EBV EBV IgM VCA IgG EBNA IgG EA IgG H.PYLORI H. Pylori IgG TREPONEMA Treponema Screen SEPSIS BRAHMS PCT II Gen TORCH Toxo IgG Toxo IgM Toxo IgG Avidity Rubella IgG Rubella IgM CMV IgG CMV IgM CMV IgG Avidity HSV-1/2 IgG HSV-1 IgG HSV-2 IgG HSV-1/2 IgM BORRELIA Borrelia burgdorferi IgG Borrelia burgdorferi IgM MEASLES & MUMPS Measles IgG Measles IgM Mumps IgG Mumps IgM VZV VZV IgG VZV IgM VIRAL HEPATITIS & RETROVIRUSES HBsAg HBsAg Quant HBsAg Confirmatory test Anti- HBs Anti- HBs plus Anti- HBc HBc IgM HBeAg Anti-Hbe Anti-HAV HAV IgM HCV Ab HCV Ab/Ag HIV Ab/Ag HT HTLV I/II CHAGAS Chagas IgG STOOL DIAGNOSTICS C. difficile GDH C. difficile Toxin A and B H. Pylori SA EHEC Rotavirus Adenovirus Calprotectin Campylobacter Elastase -1(*) INFECTIOUS DISEASES Zika IgM PARVOVIRUS Parvovirus B19 IgG Parvovirus B19IgM BORDETELLA Bordetella pertussis Toxin IgG Bordetella pertussis Toxin IgA MYCOPLASMA Mycoplasma pneumoniae IgG Mycoplasma pneumoniae IgM CHLAMYDIA Chlamydia T. IgG Chlamydia T. IgA QuantiFERON QuantiFERON TB Gold Plus AUTOIMMUNITY ANA screen ENA screen ttg IgA Cardiolipine IgG Cardiolipine IgM DsDNA CHRONIC KIDNEY DISEASES 1-84 PTH Osteocalcin BAP OSTASE 1,25 dihydroxy Vitamin D ENDOCRINOLOGY HYPERTENSION Direct Renin Aldosterone VIRAL HEPATITIS & RETROVIRUSES Anti-HDV HEV (*) CHRONIC KIDNEY DISEASES FGF-23 Ratio (Vitamin D1,25-PTH 1,84) Sclerostin (for research use only) * Under development

13 Molecular Diagnostics

14 MENU Technologies in the Molecular Diagnostics market Area of opportunity Area of opportunity AUTOMATION

15 Molecular Diagnostics Technology that allows to diagnose a pathology by detecting specific RNA and DNA sequences (nucleid acids) in patients biological fluids or abnormal cells. MOLECULAR DIAGNOSTICS

16 Our technology: Liaison MDX TECHNOLOGY Compact. Powerful. Expandable. Unique technology with no extraction required Versatile Same platform, multiple discs Direct Amplification Disc (DAD) PCR Based ASRs & Kits Universal Disc (UD) 8 reaction-wells for 96 reaction-wells for medium-low volumes high volumes

17