HCV HIV +*+ Human immunodeficiency virus HIV hepatitis C virus HCV HIV HCV HCV HIV HIV

Transcription

1 ,**- The Japanese Society for AIDS Research The Journal of AIDS Research +0 HIV HCV , +, :HCV HIV HAART / : +*+ +*0,**- Human immunodeficiency virus HIV hepatitis C virus HCV HIV,* HCV HIV HCV HIV HCV HIV HCV highly active antiretroviral therapy HAART HIV HIV HCV HIV HCV C National Institutes of Health Consensus Development Conference C /,**, HCV HIV, HCV HIV - 1 HCV HIV HAART HCV 2 :.00 2//* 0/ Fax : */, 1..,+12,** HCV HIV HIV n +* HCV n 0* HCV HIV n,3 - n -*. HAART HCV HIV GPT, IgM, IgA, IgG, B CD. T HIV Amplicor-HIV monitor assay Roche Diagnostic Systems, Tokyo, Japan HCV Quantiplex HCV RNA Chiron, Emeryville, CA Student t test Wilcoxon test, t-test Spearman rank test P *.*/ HAART HIV HCV + HCV HCV HCV HIV HIV HCV HAART GPT, IgM, IgA, IgG, B CD. T., GPT HCV HIV HCV HCV GPT IgM B HCV HIV HCV GPT HCV CD. T HCV HIV HIV HCV HIV IgA HIV HCV HIV HIV +*+ -+

2 K Hayashi et al. : Liver Damage Related with Hepatitis C and Human Immune Deficiency Coinfection + HAART HCV HIV IgG HIV, HCV - HAART HIV HCV B CD. T HIV CD. T HCV B, HIV HCV GPT, IgM, IgA, IgG, B CD. T HAART., / HAART HCV HIV HIV HIV CD. T HCV HAART B IgM HCV HIV CD. T HCV B HIV T HCV B C HCV HCV HIV 3 HAART HIV HCV HAART HCV HAART HIV HCV HIV HAART HCV +* HAART ++ HCV HIV HCV HCV HIV +32* HIV HCV HIV HCV IFN HIV HAART IFN HCV +,, +- IFN IFN HAART HCV IFN Vento HCV IFN HAART HCV HIV IFN HCV HCV IFN +. HCV HIV IFN IFN HCV HIV HAART HCV HIV + Bica I, McGovern B, Dhar R, Stone D, McGowan K, Scheib R, Snydman DR : Increasing mortality due to end-stage liver disease in patients with human immunodeficiency virus infection. Clin Infect Dis -, :.3,.31,,**+., Thomas DL : Hepatitis C andhuman immunodeficiency virus infection. Hepatology -0 :S,*+,*3,,**,. - Pol S, Vallet-PichardA, Fontaine H : Hepatitis C and +*, -,

3 The Journal of AIDS Research Vol. / No.,,**- +*- --

4 K Hayashi et al. : Liver Damage Related with Hepatitis C and Human Immune Deficiency Coinfection +*. -.

5 The Journal of AIDS Research Vol. / No.,,**-. CD., B cell, HIV RNA, IgA human immune deficiency coinfection at the era of highly active antiretroviral therapy. J Viral Hepat 3 : + 2,,**,.. Bruno R, Sacchi P, Puoti M, Soriano V, Filice G: HCV chronic hepatitis in patients with HIV : clinical management issues. Am J Gastroenterol 31 : +/32 +0*0,,**,. / Maier I, Wu GY : Hepatitis C and HIV co-infection : a review.world J Gastroenterol 2 : /11 /13,,**,. 0 Mohsen AH, Easterbrook P, Taylor CB, Norris S : Hepatitis C and HIV-+ coinfection. Gut /+ : 0*+ 0*2,,**,. 1 Sulkowski MS, Thomas DL : Hepatitis C in the HIV- Infected Person. Ann Intern Med +-2 : +31,*1,,**-. 2 Yokozaki S, Takamatsu J, Nakano I, Katano Y, Toyoda H, Hayashi K, Hayakawa T, Fukuda Y : Immunologic dynamics in hemophiliac patients infected with hepatitis C virus and human immunodeficiency virus : influence of antiretroviral therapy. Blood 30 :.,3-.,33,,***. 3 Eyster ME, Fried MW, Di Bisceglie AM, Goedert JJ : Increasing hepatitis C virus RNA levels in hemophiliacs : Relationship to human immunodeficiency virus infection and liver disease. Blood 2. : +*,* +*,-, * Rutschmann OT, Negro F, Hirschel B, Hadengue A, Anwar D, Perrin LH : Impact of treatment with human immunodeficiency virus (HIV) protease inhibitors on hepatitis C viremia in patients coinfected with HIV. J Infect Dis +11 : 12-12/, Vento S, Garofano T, Renzini C, Casali F, Ferraro T, Concia E : Enhancement of hepatitis C virus replication and liver damage in HIV-coinfected patients on antiretroviral combination therapy. AIDS +, : , , Toyoda H, Nakano S, Kumada T, Takeda I, Sugiyama K, Osada T, Kiriyama S, Orito E, Mizokami M : Comparison of serum hepatitis C virus RNA concentration by branched DNA probe assay with competitive reverse transcription polymerase chain reaction as a predictor of response to interferon-alpha therapy in chronic hepatitis C patients. J Med Virol.2 : -/. -/3, Di Bisceglie AM, Hoofnagle JH : Optimal therapy of hepatitis C. Hepatology -0 :S+,+ +,1,,**,. +. Yoshida H, Arakawa Y, Sata M, Nishiguchi S, Yano M, Fujiyama S, Yamada G, Yokosuka O, Shiratori Y, Omata M : Interferon therapy prolonged life expectancy among chronic hepatitis C patients. Gastroenterology +,- :.2-.3+,,**,. +*/ -/

6 K Hayashi et al. : Liver Damage Related with Hepatitis C and Human Immune Deficiency Coinfection / GPT, HCV RNA, IgM, IgG +*0-0