Journal of Nephropathology
|
|
- Sheryl Cameron
- 6 years ago
- Views:
Transcription
1 DOI: /jnp J Nephropathol. 2017;6(2): Journal of Nephropathology Differences in the frequency of macrophage and T cell markers between focal and crescentic classes of antineutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis Dana Kidder 1*, Susan E Bray 2, Stewart Fleming 3 1 Renal Unit, Aberdeen, Royal Infirmary, Aberdeen, Scotland, AB25 2ZN 2 Tayside Tissue Bank, University of Dundee Medical School, Ninewells Hospital, Dundee, Scotland, DD1 9SY 3 Department of Pathology, University of Dundee Medical School, Ninewells Hospital, Dundee, Scotland, DD1 9SY ARTICLE INFO ABSTRACT Article type: Original Article Article history: Received: 7 September 2016 Accepted: 20 November 2016 Published online: 25 December 2016 DOI: /jnp Keywords: Anti-neutrophil cytoplasmic antibody Glomerulonephritis Macrophage T lymphocyte Background: Anti-neutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis (AAGN) can be classified into; focal, crescentic, mixed and sclerotic classes. Macrophages and T lymphocytes are key players in mediating renal injury. The frequency of macrophage and T lymphocytes in different histological classes is unclear. Objectives: We examined the frequency of macrophage and T lymphocyte markers in AAGN and assessed their correlation with renal function at presentation. Patients and Methods: Renal biopsies from 38 patients were included in immunohistochemistry analysis of macrophages (CD68, sialoadhesin [Sn] and mannose receptor [MR]) and T cells (CD4 and CD8) markers. The frequency of these markers in glomerular, periglomerular and interstitial compartments were measured in a blinded fashion. Biopsies were allocated a histological class of focal, crescentic, mixed or sclerotic. Scores were then matched to histological class and assessed for correlation with renal function. Results: The biopsies were crescentic 19 (50%), focal 10 (26.3%), mixed 6 (15.7%) and sclerotic 3 (8%). Interstitial CD68+ macrophages and CD8+ T lymphocytes showed best correlation with renal function at the time of presentation. CD68+ macrophages were significantly increased in crescentic compared to focal AAGN. MR+ macrophages, CD4 and CD8 T cells were also elevated in the interstitium of crescentic compared to focal group. Conclusions: In this study interstitial CD68 and CD8 showed the highest association with the renal function at presentation. Differences in the cellular infiltrate between focal and crescentic AAGN were related to CD68+ macrophages and to interstitial MR+ macrophages and T lymphocytes. Further studies are needed to assess these differences across all four histological categories. Original Article Implication for health policy/practice/research/medical education: This study highlights that in AAGN, the frequency of interstitial CD68+ macrophages and CD8+ lymphocytes show the highest correlation with renal function at presentation. Differences in the cellular infiltrate between focal and crescentic classes of AAGN are primarily related to CD68+ macrophages. Please cite this paper as: Kidder D, Bray SE, Fleming S. Differences in the frequency of macrophage and T cell markers between focal and crescentic classes of anti-neutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis. J Nephropathol. 2017;6(2): DOI: /jnp *Corresponding author: Dana Kidder, Renal Unit, Aberdeen Royal Infirmary, Aberdeen, Scotland, AB25 2ZN. Telephone: ; Fax: ; dana.kidder@nhs.net
2 Kidder D et al 1. Background Anti-neutrophil cytoplasmic antibody (ANCA)- associated vasculitis (AAV) represents a group of inflammatory diseases characterized by multiorgan dysfunction. The disease can be divided into three categories based on clinical phenotype and ANCA types. These include granulomatosis with polyangiitis (formerly called Wegener s granulomatosis), microscopic polyangiitis (MPA) and eosinophilic granulomatosis with polyangiitis (EGPA, formerly called Churg Strauss Vasculitis) (1). Kidney involvement is common, especially in GPA and MPA, and bears a significant impact on outcomes. Recently, an international working group developed a classification of renal involvement in into four different types based on glomerular pathology (2). ANCA-associated glomerulonephritis (AAGN) severity was categorised based on standard histological classification into crescentic ( 50% cellular crescents), focal ( 50% normal glomeruli), sclerotic ( 50% globally sclerosed glomeruli) and mixed. The classification was validated and confirmed to be directly associated (in ascending order of focal, crescentic, mixed and sclerotic) with renal outcomes e.g. renal function and end stage renal disease at 1 and 5 years (2). Macrophages and T lymphocytes are key players in orchestrating and inducing damage in AAGN (3-5). Sn (also known as Siglec-1, CD169) is the prototype of the family of sialic acid binding immunoglobulin-like lectins (Siglecs). Sn+ macrophages are found in the marginal zone of the spleen and subcapsular sinus of lymph nodes. However, Sn expression can be induced under inflammatory conditions, such as: proliferative glomerulonephritis and rheumatoid arthritis (6). The frequency of Sn+ macrophages was found to be correlated directly to the severity of renal injury in a murine model of systemic lupus erythematosus (7). Mannose receptor (MR) is a pattern recognition receptor implicated in the uptake of endogenous and microbial ligands. It is up-regulated on alternatively activated macrophages and is involved in antigen presentation to T cells (8). MR deficiency was found to be protective in an animal model of crescentic glomerulonephritis (9). 2. Objectives The aim of this study was to examine the correlation between specific macrophage and T cell markers and renal function at the time of presentation with AAGN. The second aim of this study was to assess for differences in the cellular infiltrate between focal and crescentic AAGN. 3. Patients and Methods 3.1. Study population The pathology database in Ninewells Hospital, Dundee, Scotland was used to search for all patients with AAV who had a renal biopsy between Sample identification and subsequent slide development and staining were performed by Tayside Tissue Bank (TTB) following Tenovus Scotland Grant award (Grant number T13/15) and Research Ethics Committee Approval. Forty-five cases were identified by electronic search and out of these only 38 cases had sufficient renal tissues available for analysis in this study. All biopsies were of patients with their first presentation of AAV with suspected renal involvement. Sample retrieval, processing and optimising staining were performed by SEB. The markers used in the analysis included CD68, Sn, MR, CD4 and CD8. Morphologically normal kidney specimens from 20 individual nephrectomies were used as controls Immunohistochemistry Antigen retrieval and deparaffinization was performed using DAKO EnVision FLEX Target Retrieval solution (high ph) buffer in a DAKO PT Link. Immunostaining using DAKO EnVision FLEX system on a DAKO Autostainer Link48 was carried out according to manufacturer s protocol. Sections were incubated with primary antibody for 30 minutes. The following primary antibodies were used: anti- CD68 (clone PG-M1, DAKO, dilution 1:100), anti- Sn (HPA053457, Atlas Antibodies, dilution 1:200), anti-mr (Ab64693, Abcam, dilution 1:2000), anti- CD4 (clone 4B14, Leica Biosystems, dilution 1:25) and anti-cd8 (clone C8/144B, DAKO, dilution 1:50) antibodies. DAKO substrate working solution was used as a chromogenic agent for 2 5 minutes and sections were counterstained in EnVision FLEX haematoxylin. Sections known to stain positively were included in each batch and negative controls were prepared by replacing the primary antibody with DAKO antibody diluent. Slide scoring was performed by DK in a blinded fashion. The frequency of cellular markers in the glomerular, peri-glomerular and interstitial compartments were examined. The mean of the cellular markers for the total number of glomeruli examined was used as a final glomerular score. A similar approach was used for peri-glomerular infiltrate. For interstitial scores, the frequency of the cellular markers in 8 high power microscopic fields ( 400) was calculated and the mean score was used. Histological severity grading was performed by SF in a blinded fashion. The 98 Journal of Nephropathology, Vol 6, No 2, April
3 Cellular infiltrate in ANCA glomerulonephritis immunohistochemistry and histological severity were matched following de anonymising of the data Ethical issues The research followed the tenets of the Declaration of Helsinki. The research was approved by ethical committee of University of Dundee and NHS Tayside. 3.4 Statistical analysis Data analysis was performed with GraphPad Prism version 4. One-way analysis of variance (ANOVA) with Kruskal-Wallis test was used in comparing cellular markers in histological severity groups. Mann- Whitney U was used to compare crescentic and focal groups. P values of <0.05 was considered significant. 4. Results 4.1. Patients characteristics Renal biopsies from 38 patients with ANCA-associated renal vasculitis were examined. All patients were Caucasian. The median age at the time of presentation was 66 years (range 25-76). 24 (63%) had MPA and 14 (37%) had diagnosis of GPA. 37 (97%) of patients were ANCA positive (62% MPO+ and 38% PR3+). The median serum creatinine at presentation was 297 µmol/l (Table 1). The distribution of the histological classification was as follows: crescentic 19 (50%), focal 10 (26.3%), mixed 6 (15.7%) and sclerotic 3 (8%) Correlation between histological markers and renal function The frequency of macrophage (CD68, Sn and MR) and T cells (CD4 and CD8) markers were examined in the glomerular, peri-glomerular and interstitial compartment and compared to renal function at the time of presentation as measured by egfr. Interstitial CD68+ macrophages and CD8+ T lymphocytes had a significant negative correlation with egfr (Table 2). No significant correlation was observed between the frequency of Sn+ macrophages, MR+ macrophages or CD4+ T cells and egfr. There were no significant differences in the frequency of all markers based on the clinical diagnosis of GPA versus MPA (data not shown) Differences between focal and crescentic classes We examined the frequency of the cellular markers in different histological classes and control tissues. Higher glomerular, peri-glomerular and interstitial CD68+ macrophages were found in the crescentic compared to focal class (Table 2 and Figure 1). No significant differences in glomerular or periglomerular Sn+ macrophages, MR+ macrophages, CD4+ or CD8+ T lymphocytes were observed between focal and crescentic groups. In the interstitial compartment, significant increase in the frequency of MR+ macrophages, CD4+ and CD8+ T cells was seen in the crescentic compared to focal class (Figure 1). In the mixed group, the frequency of CD68+ macrophages, MR+ macrophages, CD8 and CD4 T cells, were non-significantly lower than crescentic and higher than focal groups (Table 2). Sn+ macrophages were non-significantly higher in the mixed group (peri-glomerular and interstitial). The sclerotic group showed a significantly elevated frequency of interstitial CD68+ macrophages, MR+ macrophages and CD8 T lymphocytes compared to controls. Sn+ macrophages were present in peri-glomerular (crescentic and mixed groups) and interstitial (crescentic, mixed and sclerotic) compartments (Table 2). 5. Discussion Previous studies on pathogenesis of AAGN revealed significant contribution of cell mediated immunity to the renal and tissue injury (3-5, 10). In this study we examined the frequency of macrophage (CD68, Sn and MR) and T lymphocytes (CD8 and CD4) markers in renal biopsies of different classes of AAGN. We found that the frequency of interstitial CD68+ macrophages, followed by interstitial CD8+ T lymphocytes correlated best with the renal function at the time of presentation. We also identified the presence of significant differences in CD68+ macrophages in glomerular, periglomerular and interstitial compartments between focal and crescentic Table 1. Patients characteristics at presentation All biopsies Focal Crescentic Mixed Sclerotic Patient number (%) (26.3) 19 (50) 6 (15.7) 3 (8) Age at biopsy (range) 66 (25-76) 64 (53-85) 65 (55-79) 67 ( ) 66 Sex (M/F) 19/19 4/6 12/7 1/5 2/1 Number of glomeruli (range) 15 (9-24) 19 (8-31) 13 (8-16) 22 (13-26) 24 PR3+/MPO+ 14/23 3/7 8/11 2/4 1/1 Serum creatinine µmol/l (range) 297 ( ) 273 (99-489) 294 ( ) 292 ( ) 989 egfr ml/min/1.73 m 2 (range) 18 (10-26) 19 (12-55) 10 (10-28) 16 (11-35) 5 Journal of Nephropathology, Vol 6, No 2, April
4 Kidder D et al Table 2. The frequency of individual markers in different renal compartments Marker/ compartment Focal (a) Crescentic (b) Mixed (c) Sclerotic (d) Control (e) Intergroups comparison Correlation with egfr, Spearman r (P value) CD68 Glomerular 11 ± ± ± ± ± 0.21 a-b*, b-e***, c-e** (0.7) Periglomerular 8.6 ± ± ± ± ± 0.6 a-b*, b-e***, c-e** -0.24(0.1) Interstitial 39 ± ± ± ± ± 1.5 a-b*, b-e***, c-e *, d-e* (0.007) ** Sn Glomerular 0.7 ± ± ± NS (0.4) Periglomerular 2.3 ± ± ± ± b-e*, c-e** (0.1) Interstitial 17 ± ± ± ± ± 0.3 b-e***, c-e** (0.7) MR Glomerular 1.6 ± ± ± ± ± 0.6 a-e*** (0.5) Periglomerular 5.1 ± ± ± ± ± 0.2 b-e***, c-e** (0.5) Interstitial 17.6 ± ± ± ± ± 0.3 a-b*, b-e***, c-e*, d-e* (0.08) CD8 Glomerular 0.5 ± ± ± ± ± 0.11 NS 0.11 (0.5) Periglomerular 6 ± ± ± ± ± 0.06 b-e** (0.1) Interstitial 20.4 ± ± ± ± ± 0.4 a-b**, a-c*, b-e***, c-e*, d-e** (0.04)* CD4 Glomerular 3.4 ± ± ± ± ± 0.1 NS 0.06 (0.7) Periglomerular 3.8 ± ± ± ± b-e** (0.7) Interstitial 13.6 ± ± 6 25 ± ± ± 0.6 a-b*, b-e **, d-e** (0.05) NS= no significant differences. P value * 0.05, ** 0.01 and ***< classes. Further comparison between these two classes revealed higher frequency of MR+ macrophages, CD8 and CD4 T lymphocytes only in the interstitial compartment. Similar to previous studies, we showed that the only macrophage marker that consistently correlated with renal impairment and class differences was CD68 (panmacrophage marker). Despite a wealth of evidence implicating macrophages in the pathogenesis of AAV glomerulonephritis, the phenotype of these macrophages remain elusive (3-5,10,11). Ikezumi et al, found that Sn+ macrophages, a subset of CD68+ macrophages were correlated with degree of proteinuria and interstitial damage in proliferative GN (12). In our study, Sn+ macrophages were predominantly observed in the interstitial compartment, did not significantly differ between histological classes and were not an association with renal function at the time of presentation. Sn+ macrophages were present in high frequency in the sclerotic group, albeit with limited number of samples. It remains unclear whether this subset of macrophages might play a role in fibrosis. Previously, MR deficient mice were shown to be protected from experimental nephritis that was associated with a shift towards an anti-inflammatory macrophage phenotype (6). The evidence for the role MR in human AAGN is unknown. In our study, higher interstitial MR+ macrophages were found in Figure 1. The distribution of macrophage and T cell markers in glomerular, periglomerular and interstitial compartments in focal and crescentic groups. 100 Journal of Nephropathology, Vol 6, No 2, April
5 Cellular infiltrate in ANCA glomerulonephritis crescentic as compared with focal AAGN. Similar to Sn, MR did not show a significant correlation with renal function at the time of presentation. These data suggest that although the severity of tissue injury in AAGN is directly related to the overall macrophage burden and the relative contribution macrophage subsets is not clear. Recently an elegant study of MPO+ AAGN showed that MPO+ macrophages were strongly associated with tissue injury and renal impairment (13). However, the phenotype of these macrophages remains unclear. T cells have been shown in both animal models of AAV GN and human AAV to be key players in mediating inflammation (14). Our analysis is in agreement with previous studies showing significant correlation between CD8+ T cells and degree of renal impairment. We extend these observations further by the finding of higher frequency of CD8+ T cells in the interstitium in a graded fashion between focal, crescentic and mixed classes. This observation not only emphasize their role in predicting outcomes (15) but also stress on the complementary role of interstitium in addition to the glomerular compartment in defining outcomes following AAV GN. 6. Conclusions In conclusion, this study showed that among the markers studies, CD68 and CD8 showed the highest association with the renal function at the time of presentation. Differences in the cellular infiltrate between focal and crescentic AAGN were primarily related to CD68 and to a lesser extent with interstitial MR+ macrophages and T lymphocytes. Interstitial rather than glomerular or peri-glomerular cellular infiltrate correlated better with renal function at presentation. Further studies including larger number of biopsy samples are needed to asses for differences across all four histological categories of AAV. Limitations of the study The main limitation of this study is the relatively small sample size. A larger sample size with more representation in the mixed and sclerotic groups would have allowed for more robust comparison between all classes. As the study was done in a blinded fashion, the distribution of cases was not even across histological classes with majority of cases being under crescentic and focal categories. Another limitation of this study is the absence of neutrophil and B cell markers to compare their frequencies in different compartments with that of macrophages and T cells. Authors contribution DK and SF designed the study. SEB performed immunohistochemistry. DK scored and analyzed immunohistochemistry slides. SF reviewed and scored histological classes. DK, SEB and SF participated in writing the paper. Conflicts of interest The authors declare no conflict of interest. Funding/Support This study was supported by Tenovus Scotland/ Tayside grant award to DK (Grant # T13/15). References 1. Jennette JC, Falk RJ, Hu P, Xiao H. Pathogenesis of antineutrophil cytoplasmic autoantibody-associated small-vessel vasculitis. Annu Rev Pathol. 2013;8: doi: /annurev-pathol Berden AE, Ferrario F, Hagen EC, Jayne DR, Jennette JC, Joh K, et al. Histopathologic classification of ANCA-associated glomerulonephritis. J Am Soc Nephrol. 2010;21(10): doi: / ASN Rastaldi MP, Ferrario F, Crippa A, Dell Antonio G, Casartelli D, Grillo C, et al. Glomerular monocytemacrophage features in ANCA-positive renal vasculitis and cryoglobulinemic nephritis. J Am Soc Nephrol. 2000;11(11): Ferrario F, Castiglione A, Colasanti G, Barbiano di Belgioioso G, Bertoli S, D Amico G. The detection of monocytes in human glomerulonephritis. Kidney Int. 1985;28(3): doi: 10:1038/ki Cunningham MA, Huang XR, Dowling JP, Tipping PG, Holdsworth SR. Prominence of cell-mediated immunity effectors in pauci-immune glomerulonephritis. J Am Soc Nephrol. 1999;10(3): Macauley MS, Crocker PR, Paulson JC. Siglec-mediated regulation of immune cell function in disease. Nat Rev Immunol. 2014;14(10): doi: /nri Kidder D, Richards HE, Lyons PA, Crocker PR. Sialoadhesin deficiency does not influence the severity of lupus nephritis in New Zealand black x New Zealand white F1 mice. 2013;Arthritis Res Ther;15(6):R175. doi: /ar Martinez-Pomares L. The mannose receptor. J Leukoc Biol. 2012;92(6): doi: /jlb Chavele KM, Martinez-Pomares L, Domin J, Pemberton S, Haslam SM, Dell A, et al. Mannose receptor interacts with Fc receptors and is critical for the development of crescentic glomerulonephritis in mice. J Clin Invest. 2010;120(5): doi: / JCI Weidner S, Carl M, Riess R, Rupprecht HD. Histologic analysis of renal leukocyte infiltration in antineutrophil Journal of Nephropathology, Vol 6, No 2, April
6 Kidder D et al cytoplasmic antibody-associated vasculitis: importance of monocyte and neutrophil infiltration in tissue damage. Arthritis Rheum. 2004;50(11): doi: /art Ferrario F, Rastaldi MP, D Amico G. The crucial role of renal biopsy in the management of ANCAassociated renal vasculitis. Nephrol Dial Transplant. 1996;11(4): Ikezumi Y, Suzuki T, Hayafuji S, Okubo S, Nikolic- Paterson DJ, Kawachi H, et al. The sialoadhesin (CD169) expressing a macrophage subset in human proliferative glomerulonephritis. Nephrol Dial Transplant. 2005;20(12): doi: /ndt/ gfi O Sullivan KM, Lo CY, Summers SA, Elgass KD, McMillan PJ, Longano A, et al. Renal participation of myeloperoxidase in antineutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis. Kidney Int. 2015;88(5): doi: / ki Gan PY, Holdsworth SR, Kitching AR, Ooi JD. Myeloperoxidase (MPO)-specific CD4+ T cells contribute to MPO-anti-neutrophil cytoplasmic antibody (ANCA) associated glomerulonephritis. Cell Immunol. 2013;282(1):21-7. doi: /j. cellimm McKinney EF, Lyons PA, Carr EJ, Hollis JL, Jayne DR, Willcocks LC, et al. A CD8+ T cell transcription signature predicts prognosis in autoimmune disease. Nat Med. 2015;16(5): doi: /nm Copyright 2017 The Author(s); Published by Society of Diabetic Nephropathy Prevention. This is an open-access article distributed under the terms of the Creative Commons Attribution License ( which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. 102 Journal of Nephropathology, Vol 6, No 2, April
ANCA associated vasculitis in China
ANCA associated vasculitis in China Min Chen Renal Division, Peking University First Hospital, Beijing 100034, P. R. China 1 General introduction of AAV in China Disease spectrum and ANCA type Clinical
More informationChapter 2 Animal Models of ANCA-Associated Vasculitides
Chapter 2 Animal Models of ANCA-Associated Vasculitides Domenico Ribatti and Franco Dammacco Abstract Antibodies against neutrophil proteins myeloperoxidase (MPO) and proteinase- 3 (PR3) are responsible
More informationAN OVERVIEW OF ANCA-ASSOCIATED VASCULITIS
GRANULOMATOSIS WITH POLYANGIITIS (GPA), MICROSCOPIC POLYANGIITIS (MPA), and EOSINOPHILIC GRANULOMATOSIS WITH POLYANGIITIS (EGPA) AN OVERVIEW OF ANCA-ASSOCIATED VASCULITIS What is ANCA-associated Vasculitis?
More informationPlasma exchanges in ANCA-associated vasculitis
Plasma exchanges in ANCA-associated vasculitis Xavier Puéchal, MD, PhD Centre de Référence des Maladies auto-immunes systémiques rares d Ile de France Hôpital Cochin Université Paris Descartes http://www.vascularites.org
More information4. KIDNEYS AND AUTOIMMUNE DISEASE
How to Cite this article: Kidneys and Autoimmune Disease - ejifcc 20/01 2009 http://www.ifcc.org 4. KIDNEYS AND AUTOIMMUNE DISEASE Maksimiljan Gorenjak 4.1 Autoimmune diseases The human immune system limits
More informationImmune complex deposits in ANCA-associated crescentic glomerulonephritis: A study of 126 cases
Kidney International, Vol. 65 (2004), pp. 2145 2152 Immune complex deposits in ANCA-associated crescentic glomerulonephritis: A study of 126 cases MARK HAAS and JOSEPH A. EUSTACE Department of Pathology
More informationJournal of Nephropathology
www.nephropathol.com DOI: 10.15171/jnp.2018.24 J Nephropathol. 2018;7(3):101-105 Journal of Nephropathology Relationship of CD147 kidney expression with various pathologic lesions, biochemical and demographic
More informationHistopathology: Glomerulonephritis and other renal pathology
Histopathology: Glomerulonephritis and other renal pathology These presentations are to help you identify basic histopathological features. They do not contain the additional factual information that you
More informationRepeat protocol renal biopsy in ANCA-associated renal vasculitis
NDT Advance Access published February 26, 2014 Nephrol Dial Transplant (2014) 0: 1 5 doi: 10.1093/ndt/gfu042 Original Article Repeat protocol renal biopsy in ANCA-associated renal vasculitis Zdenka Hruskova
More informationRenal Pathology 1: Glomerulus. With many thanks to Elizabeth Angus PhD for EM photographs
Renal Pathology 1: Glomerulus With many thanks to Elizabeth Angus PhD for EM photographs Anatomy of the Kidney http://www.yalemedicalgroup.org/stw/page.asp?pageid=stw028980 The Nephron http://www.beltina.org/health-dictionary/nephron-function-kidney-definition.html
More informationEstimating Renal Survival Using the ANCA-Associated GN Classification
Estimating Renal Survival Using the ANCA-Associated GN Classification Marc Hilhorst, Benjamin Wilde, Peter van Breda Vriesman, Pieter van Paassen, and Jan Willem Cohen Tervaert, for the Limburg Renal Registry
More information29th Annual Meeting of the Glomerular Disease Collaborative Network
29th Annual Meeting of the Glomerular Disease Collaborative Network Updates on the Pathogenesis IgA Nephropathy and IgA Vasculitis (HSP) J. Charles Jennette, M.D. Brinkhous Distinguished Professor and
More informationCirculating complement activation in patients with anti-neutrophil cytoplasmic antibody associated vasculitis
http://www.kidney-international.org & 212 International Society of Nephrology see commentary on page 16 Circulating complement activation in patients with anti-neutrophil cytoplasmic antibody associated
More informationOlder patients with ANCA-associated vasculitis and dialysis dependent renal failure: a retrospective study
Manno et al. BMC Nephrology (2015) 16:88 DOI 10.1186/s12882-015-0082-9 RESEARCH ARTICLE Open Access Older patients with ANCA-associated vasculitis and dialysis dependent renal failure: a retrospective
More informationPauci-immune glomerulonephritis: does negativity of antineutrophilic cytoplasmic antibodies matters?
International Journal of Rheumatic Diseases 2016; 19: 74 81 ORIGINAL ARTICLE Pauci-immune glomerulonephritis: does negativity of antineutrophilic cytoplasmic antibodies matters? Aman SHARMA, 1, * Ritambra
More informationANCA-associated vasculitis. Vladimir Tesar Department of Nephrology, General University Hospital, Prague, Czech Republic
ANCA-associated vasculitis Vladimir Tesar Department of Nephrology, General University Hospital, Prague, Czech Republic Disclosure of Interests Abbvie, Amgen, Baxter, Bayer, Boehringer-Ingelheim, Calliditas,
More informationEnd-stage renal disease in ANCA-associated vasculitis
Nephrol Dial Transplant (2017) 32: 248 253 doi: 10.1093/ndt/gfw046 Advance Access publication 6 April 2016 End-stage renal disease in ANCA-associated vasculitis Sergey Moiseev 1, Pavel Novikov 1, David
More informationSmall Vessel Vasculitis
Small Vessel Vasculitis Paul A Brogan Professor of Vasculitis and Consultant Paediatric Rheumatologist Department of Rheumatology Institute of Child Health and Great Ormond St Hospital, London UK P.brogan@ucl.ac.uk
More informationTell me more about vasculitis. Lisa Willcocks Consultant in Nephrology and Vasculitis, Addenbrooke s Hospital
Tell me more about vasculitis Lisa Willcocks Consultant in Nephrology and Vasculitis, Addenbrooke s Hospital Talk overview Case study ANCA-associated vasculitis What is ANCA vasculitis? What causes ANCA
More informationRENAL BIOPSIES in patients with the clinical
RENAL BIOPSY TEACHING CASE Crescentic Glomerulonephritis With a Paucity of Glomerular Immunoglobulin Localization Alexis A. Harris, MD, Ronald J. Falk, MD, and J. Charles Jennette, MD RENAL BIOPSIES in
More informationEDITORIAL. Issue Seventeen, October Editorial Team. Issue Seventeen. Info link
EDITORIAL, October 2004 Welcome to the Spring 2004 Edition of InfoLink. The feature article in this edition has been written by Dr Rodger Laurent, Head of Department, PaLMS Rheumatology Laboratory. The
More informationComplement in vasculitis and glomerulonephritis. Andy Rees Clinical Institute of Pathology Medical University of Vienna
Complement in vasculitis and glomerulonephritis Andy Rees Clinical Institute of Pathology Medical University of Vienna 41 st Heidelberg Nephrology Seminar March 2017 The complement system An evolutionary
More informationJournal of Nephropathology
www.nephropathol.com DOI: 10.12860/jnp.2014.22 J Nephropathol. 2014; 3(3): 115-120 Journal of Nephropathology Clinicopathological correlations in lupus nephritis; a single center experience Hamid Nasri
More informationSupplementary Appendix
Supplementary Appendix This appendix has been provided by the authors to give readers additional information about their work. Supplement to: Jones RB, Cohen Tervaert JW, Hauser T, et al. Rituximab versus
More informationCitation for published version (APA): Chen, M. (2009). Pathogenetic and clinical aspects of ANCA-associated vasculitis Groningen: s.n.
University of Groningen Pathogenetic and clinical aspects of ANCA-associated vasculitis Chen, Min IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite
More informationSHO Teaching. Dr. Amir Bhanji Consultant Nephrologist, Q.A hospital, Portsmouth
SHO Teaching Vasculitis Renal medicine Dr. Amir Bhanji Consultant Nephrologist, Q.A hospital, Portsmouth OUTLINE What is vasculitis Causes Classification Brief look into ANCA Associated Vasculitis (AAV)
More informationAnnual Rheumatology & Therapeutics Review for Organizations & Societies
Annual Rheumatology & Therapeutics Review for Organizations & Societies Update on Granulomatosis with Polyangiitis (Wegener s) Learning Objectives Identify the clinical features of granulomatosis with
More informationDr Ian Roberts Oxford
Dr Ian Roberts Oxford Oxford Pathology Course 2010 for FRCPath Present the basic diagnostic features of the commonest conditions causing renal failure Highlight diagnostic pitfalls. Crescentic GN: renal
More informationRenal outcome of kidney-transplantation in Korean recipients with ANCA-associated vasculitis
Renal outcome of kidney-transplantation in Korean recipients with ANCA-associated vasculitis E.S. Park, S.S. Ahn, S.M. Jung, J.J. Song, Y.-B. Park, S.-W. Lee Division of Rheumatology, Department of Internal
More informationSeverity of tubulointerstitial inflammation and prognosis in immunoglobulin A nephropathy
http://www.kidney-international.org & 2007 International Society of Nephrology original article Severity of tubulointerstitial inflammation and prognosis in immunoglobulin A nephropathy JM Myllymäki 1,
More informationSimultaneous comprehensive multiplex autoantibody analysis by CytoBead technology for Rapidly Progressive Glomerulonephritis.
Simultaneous comprehensive multiplex autoantibody analysis by CytoBead technology for Rapidly Progressive Glomerulonephritis l Assays Indirect Immunofluorescence Goldstandard for Diagnosis of Autoimmune
More informationApproach to Glomerular Diseases: Clinical Presentation Nephrotic Syndrome Nephritis
GLOMERULONEPHRITIDES Vivette D Agati Jai Radhakrishnan Approach to Glomerular Diseases: Clinical Presentation Nephrotic Syndrome Nephritis Heavy Proteinuria Renal failure Low serum Albumin Hypertension
More informationVasculitis of the peripheral nervous system
4 rd Congress of the European Academy of Neurology Lisbon, Portugal, June 16-19, 2018 Teaching Course 5 Acute emergencies in neuromuscular disease - Level 2 Vasculitis of the peripheral nervous system
More informationGlucocorticoids and Relapse and Infection Rates in Anti-Neutrophil Cytoplasmic Antibody Disease
Article Glucocorticoids and Relapse and Infection Rates in Anti-Neutrophil Cytoplasmic Antibody Disease JulieAnne G. McGregor, Susan L. Hogan, Yichun Hu, Caroline E. Jennette, Ronald J. Falk, and Patrick
More informationanti-neutrophil cytoplasmic antibody, myeloperoxidase, microscopic polyangiitis, cyclophosphamide, corticosteroid
Online publication June 24, 2009 ANCA JMAAV 1 2 ANCA JMAAV MPO-ANCA 18 17 50 J Jpn Coll Angiol, 2009, 49: 53 61 anti-neutrophil cytoplasmic antibody, myeloperoxidase, microscopic polyangiitis, cyclophosphamide,
More informationDiagnostic Procedures for Vasculitis
Diagnostic Procedures for Vasculitis Toshiharu Matsumoto, MD Clinical Professor of Department of Diagnostic Pathology Juntendo University Nerima Hospital, Tokyo, Japan Introduction In 1994, the International
More informationSMALL TO MEDIUM VASCULITIS: RENAL ASPECT RATANA CHAWANASUNTORAPOJ UPDATE IN INTERNAL MEDICINE 2018
SMALL TO MEDIUM VASCULITIS: RENAL ASPECT RATANA CHAWANASUNTORAPOJ UPDATE IN INTERNAL MEDICINE 2018 OUTLINE Renal involvement in vasculitis Curr Rheumatol Rep 2013 Renal involvement in ANCA vasculitis GN***:
More informationAntineutrophil cytoplasm antibody associated vasculitis: recent developments
mini review http://www.kidney-international.org & 2013 International Society of Nephrology Antineutrophil cytoplasm antibody associated vasculitis: recent developments Shunsuke Furuta 1 and David R.W.
More informationVasculitis (Polyarteritis Nodosa, Microscopic Polyangiitis, Wegener s Granulomatosis, Henoch- Schönlein Purpura)
Vasculitis (Polyarteritis Nodosa, Microscopic Polyangiitis, Wegener s Granulomatosis, Henoch- Schönlein Purpura) J. Charles Jennette Ronald J. Falk The kidneys are affected by a variety of systemic vasculitides
More informationMICROSCOPIC HEMATURIA AND DIFFUSE NECROTIZING GLOMERULONEPHRITIS
MICROSCOPIC HEMATURIA AND DIFFUSE NECROTIZING GLOMERULONEPHRITIS Hatim Q. AlMaghrabi, MD, FRCPC Consultant at King Abdulaziz Medical City (NGHA) Jeddah Case Presentation 70 years old female Known hypertensive
More informationElevated Expression of Pentraxin 3 in Anti-neutrophil Cytoplasmic Antibody-associated Glomerulonephritis with Normal Serum C-reactive Protein
CASE REPORT Elevated Expression of Pentraxin 3 in Anti-neutrophil Cytoplasmic Antibody-associated Glomerulonephritis with Normal Serum C-reactive Protein Risa Ishida 1,KentaroNakai 1, Hideki Fujii 1, Shunsuke
More informationThe role of pathology in the diagnosis of systemic vasculitis
Clinical and Experimental Rheumatology 2007; 25: S52-S56 The role of pathology in the diagnosis of systemic vasculitis J.C. Jennette 1, R.J. Falk 2 1 Brinkhous Distinguished Professor and Chair of Pathology
More informationCase # 2 3/27/2017. Disclosure of Relevant Financial Relationships. Clinical history. Clinical history. Laboratory findings
Case # 2 Christopher Larsen, MD Arkana Laboratories Disclosure of Relevant Financial Relationships USCAP requires that all planners (Education Committee) in a position to influence or control the content
More informationAnti-neutrophil Cytoplasmic Antibody-associated Pauci-immune Crescentic Glomerulonephritis Complicating Sjögren s Syndrome
Volume 110 Number 7 July 2011 Enterovirus 71 vaccine: When will it be available? GRP78 in embryonic development and neurological disorders Directly observed therapy for Tuberculosis patients in Taiwan
More informationPR3/MPO-ANCA is as effective as immunofluorescence as a first-line test in AAV screening
PR3/MPO-ANCA is as effective as immunofluorescence as a first-line test in AAV screening Stephen Holding PhD FRCPath Consultant Clinical Scientist Hull & East Yorkshire Hospitals steve.holding@hey.nhs.uk
More informationANCA Associated vasculitis presenting as bilateral pleural effusion: A rare case report
International Journal of Current Research in Medical Sciences ISSN: 2454-5716 P-ISJN: A4372-3064, E -ISJN: A4372-3061 www.ijcrims.com Case Report Volume 3, Issue 10-2017 DOI: http://dx.doi.org/10.22192/ijcrms.2017.03.10.015
More informationSCOTTISH REAL BIOPSY REGISTRY: SURVEY OF NATIVE KIDNEY BIOPSY IN SCOTLAND 2015
Scottish Renal Registry Report SECTION N SCOTTISH REAL BIOPSY REGISTRY: SURVEY OF NATIVE KIDNEY BIOPSY IN SCOTLAND All centres in Scotland were able to provide date of birth, sex (except centre), indication
More informationWegener s Granulomatosis JUN-KI PARK
Wegener s Granulomatosis JUN-KI PARK Definition History Epidemiology Clinical symptoms Pathophysiology Treatment Wegener granulomatosis (WG) is a complex, immunemediated disorder, which along with microscopic
More informationImproved prognosis in Norwegian patients with glomerulonephritis associated with anti-neutrophil cytoplasmic antibodies
Nephrol Dial Transplant (2015) 30: i67 i75 doi: 10.1093/ndt/gfv008 Advance Access publication 17 February 2015 Original Article Improved prognosis in Norwegian patients with glomerulonephritis associated
More informationC1q nephropathy the Diverse Disease
C1q nephropathy the Diverse Disease Danica Galešić Ljubanović School of Medicine, University of Zagreb Dubrava University Hospital Zagreb, Croatia Definition Dominant or codominant ( 2+), mesangial staining
More informationJournal of Nephropathology
www.nephropathol.com DOI: 10.12860/jnp.2015.04 J Nephropathol. 2015; 4(1): 19-23 Journal of Nephropathology Association of glomerular C4d deposition with various demographic data in IgA nephropathy patients;
More informationDr Rodney Itaki Lecturer Anatomical Pathology Discipline. University of Papua New Guinea School of Medicine & Health Sciences Division of Pathology
Vasculitis Dr Rodney Itaki Lecturer Anatomical Pathology Discipline University of Papua New Guinea School of Medicine & Health Sciences Division of Pathology Disease Spectrum Hypersensitivity vasculitis/microscopic
More informationEarly plasma exchange improves outcome in PR3-ANCA-positive renal vasculitis
Early plasma exchange improves outcome in PR3-ANCA-positive renal vasculitis J.W. Gregersen 1, T. Kristensen 1, S.R.P. Krag 2, H. Birn 1, P. Ivarsen 1 1 Department of Nephrology, 2 Department of Pathology,
More informationManaging Acute Medical Problems, Birmingham Vasculitis. David Jayne. University of Cambridge
Managing Acute Medical Problems, Birmingham 2016 Vasculitis David Jayne University of Cambridge Disclosures Astra Zeneca, Aurinia, BIOGEN, Boehringer, Chemocentryx, Genzyme/Sanofi, GSK, Lilly, Medimmune,
More informationA clinical syndrome, composed mainly of:
Nephritic syndrome We will discuss: 1)Nephritic syndrome: -Acute postinfectious (poststreptococcal) GN -IgA nephropathy -Hereditary nephritis 2)Rapidly progressive GN (RPGN) A clinical syndrome, composed
More informationEULAR/ERA-EDTA recommendations for the management of ANCAassociated
EULAR/ERA-EDTA recommendations for the management of ANCAassociated vasculitis Dr. Meharunnisha Syed III year DNB Resident (General Medicine) Narayana Health-MSH Fifteen recommendations were developed,
More informationNew biomarkers for ANCA-associated Vasculitis? Juliana Bordignon Draibe
New biomarkers for ANCA-associated Vasculitis? Juliana Bordignon Draibe Summary Introduction Antibodies: ANCAs, Anti-LAMP-2, Anti-moesin B and T lymphocytes Markers of vascular activation: complement,
More informationAnti-Neutrophil Cytoplasmic Antibody (ANCA)-Negative Small Vessel Vasculitis: A Rare Cause of Pulmonary Renal Syndrome
CASE REPORT Anti-Neutrophil Cytoplasmic Antibody (ANCA)-Negative Small Vessel Vasculitis: A Rare Cause of Pulmonary Renal Syndrome Boudhayan Das Munshi, Sarbani Sengupta, Abhijeet Sharan, Sarmishtha Mukhopadhyay,
More informationInteresting case seminar: Native kidneys Case Report:
Interesting case seminar: Native kidneys Case Report: Proximal tubulopathy and light chain deposition disease presented as severe pulmonary hypertension with right-sided cardiac dysfunction and nephrotic
More informationSmall Vessel Vasculitis
Banff- Rocky Mountain Barry Kassen, MD, FRCPC,FACP Head, Division of Internal Medicine UBC/VGH/SPH Acting Head, Division of Community Internal Medicine November, 2009 Objectives 1. To understand small
More informationVasculitis local: systemic
Vasculitis Inflammation of the vessel wall. Signs and symptoms: 1- local: according to the involved tissue 2- systemic:(fever, myalgia, arthralgias, and malaise) Pathogenesis 1- immune-mediated 2- infectious
More informationClassification of Glomerular Diseases and Defining Individual Glomerular Lesions: Developing International Consensus
Classification of Glomerular Diseases and Defining Individual Glomerular Lesions: Developing International Consensus Mark Haas MD, PhD Department of Pathology & Laboratory Medicine Cedars-Sinai Medical
More informationGlomerular diseases mostly presenting with Nephritic syndrome
Glomerular diseases mostly presenting with Nephritic syndrome 1 The Nephritic Syndrome Pathogenesis: proliferation of the cells in glomeruli & leukocytic infiltrate Injured capillary walls escape of RBCs
More informationAnnette Bruchfeld, 1 Mårten Wendt, 1 Johan Bratt, 2 Abdul R Qureshi, 1 Sangeeta Chavan, 3 Kevin J Tracey, 3 Karin Palmblad, 4 and Iva Gunnarsson 2
High-Mobility Group Box-1 Protein (HMGB1) Is Increased in Antineutrophilic Cytoplasmatic Antibody (ANCA)-Associated Vasculitis with Renal Manifestations Annette Bruchfeld, 1 Mårten Wendt, 1 Johan Bratt,
More informationA Dual-Fixed Neutrophil Substrate Improves Interpretation of Antineutrophil Cytoplasmic Antibodies by Indirect Immunofluorescence
AJCP / Original Article A Dual-Fixed Neutrophil Substrate Improves Interpretation of Antineutrophil Cytoplasmic Antibodies by Indirect Immunofluorescence Ming-Wei Lin, MBBS, 1,2 Roger A. Silvestrini, 1
More informationDr Ian Roberts Oxford. Oxford Pathology Course 2010 for FRCPath Illustration-Cellular Pathology. Oxford Radcliffe NHS Trust
Dr Ian Roberts Oxford Oxford Pathology Course 2010 for FRCPath Plan of attack: Diagnostic approach to the renal biopsy Differential diagnosis of the clinical syndromes of renal disease Microscopy Step
More informationOutcome of Kidney Transplant in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis
ARTIcLe Outcome of Kidney Transplant in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis Jesmar Buttigieg, 1 Lorna Henderson, 2 Dana Kidder 1 Abstract From the 1 Renal Unit, Aberdeen Royal Infirmary,
More informationWillcocks et al.,
ONLINE SUPPLEMENTAL MATERIAL Willcocks et al., http://www.jem.org/cgi/content/full/jem.20072413/dc1 Supplemental materials and methods SLE and AASV cohorts The UK SLE cohort (n = 171) was obtained from
More informationCitation for published version (APA): Chen, M. (2009). Pathogenetic and clinical aspects of ANCA-associated vasculitis Groningen: s.n.
University of Groningen Pathogenetic and clinical aspects of ANCA-associated vasculitis Chen, Min IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite
More informationCase Rep Nephrol Urol 2013;3: DOI: / Published online: January 27, 2013
Published online: January 27, 2013 1664 5510/13/0031 0016$38.00/0 This is an Open Access article licensed under the terms of the Creative Commons Attribution- NonCommercial-NoDerivs 3.0 License (www.karger.com/oa-license),
More informationVASCULITIS. Case Presentation. Case Presentation
VASCULITIS Case Presentation The patient is a 24 year old woman who presented to the emergency room with left-sided weakness. She was confused and complained of a severe headache. She was noted to have
More informationMohammad Reza Shakibi M.D Kerman university of medical sciences (KMU) Shafa Hospital, Rheumatology ward
VASCULITIS SYNDROMES Mohammad Reza Shakibi M.D Kerman university of medical sciences (KMU) Shafa Hospital, Rheumatology ward ILLUSTRATED CASE 1 A 56 years old lady refered me for prolonged fever, arthritis
More informationJournal of Nephropathology
www.nephropathol.com DOI: 10.15171/jnp.2016.12 J Nephropathol. 2016;5(2):72-78 Journal of Nephropathology Effect of hematuria on the outcome of immunoglobulin A nephropathy with proteinuria Chihiro Iwasaki
More informationProtocol Version 2.0 Synopsis
Protocol Version 2.0 Synopsis Title Short Title Plasma exchange and glucocorticoid dosing in anti-neutrophil cytoplasm antibody associated vasculitis: a randomized controlled trial. PEXIVAS PEXIVAS Clinical
More informationPhysiopathologie des vascularites associées aux ANCA
Physiopathologie des vascularites associées aux ANCA Benjamin Terrier Centre de Référence pour les Maladies AutoImmunes Systémiques Rares Hôpital Cochin, Université Paris Descartes Paris, France Fibrinoid
More informationDr Ian Roberts Oxford. Oxford Pathology Course 2010 for FRCPath Illustration-Cellular Pathology. Oxford Radcliffe NHS Trust
Dr Ian Roberts Oxford Oxford Pathology Course 2010 for FRCPath Present the basic diagnostic features of the commonest conditions causing proteinuria & haematuria Highlight diagnostic pitfalls Nephrotic
More informationPathogenetic features of severe segmental lupus nephritis
Nephrol Dial Transplant (2010) 25: 153 159 doi: 10.1093/ndt/gfp424 Advance Access publication 23 August 2009 Pathogenetic features of severe segmental lupus nephritis Venkata Y. Behara 1, William L. Whittier
More informationCrescentic Glomerulonephritis (RPGN)
Crescentic Glomerulonephritis (RPGN) Background Rapidly progressive glomerulonephritis (RPGN) is defined as any glomerular disease characterized by extensive crescents (usually >50%) as the principal histologic
More informationFIBRILLARY GLOMERULONEPHRITIS DIAGNOSTIC CRITERIA, PITFALLS, AND DIFFERENTIAL DIAGNOSIS
FIBRILLARY GLOMERULONEPHRITIS DIAGNOSTIC CRITERIA, PITFALLS, AND DIFFERENTIAL DIAGNOSIS Guillermo A. Herrera MD Louisiana State University, Shreveport Fibrils in bundles 10-20 nm d Diabetic fibrillosis
More informationIndex. electron microscopy, 81 immunofluorescence microscopy, 80 light microscopy, 80 Amyloidosis clinical setting, 185 etiology/pathogenesis,
A Acute antibody-mediated rejection (Acute AMR) clinical features, 203 clinicopathologic correlations, 206 pathogenesis, 205 206 204 205 light microscopy, 203 204 Acute cellular rejection (ACR) clinical
More informationVasculitis local: systemic
Vasculitis Inflammation of the vessel wall. Signs and symptoms: 1- local: according to the involved tissue 2- systemic:(fever, myalgia, arthralgias, and malaise) Pathogenesis 1- immune-mediated inflammation
More informationPathology of Complement Mediated Renal Disease
Pathology of Complement Mediated Renal Disease Mariam Priya Alexander, MD Associate Professor of Pathology GN Symposium Hong Kong Society of Nephrology July 8 th, 2017 2017 MFMER slide-1 The complement
More informationRisk Factors for Renal Survival in Chinese Patients with Myeloperoxidase-ANCA Associated GN
Article Risk Factors for Renal Survival in Chinese Patients with Myeloperoxidase-ANCA Associated GN Yinghua Chen, Hao Bao, Zhengzhao Liu, Xia Liu, Erzhi Gao, Caihong Zeng, Haitao Zhang, Zhihong Liu, and
More informationPersistent hematuria in patients with. vasculitis during clinical remission: chronic glomerular lesion or low-grade active renal vasculitis?
Lv et al. BMC Nephrology (2017) 18:354 DOI 10.1186/s12882-017-0763-7 RESEARCH ARTICLE Open Access Persistent hematuria in patients with antineutrophil cytoplasmic antibodyassociated vasculitis during clinical
More informationDC were seeded into tissue culture dishes in IMDM 2% FCS, and added with PMN. (1:1; PMN: DC) for 16h also in the presence of DNAse (100 U/ml); DC were
Supplementary methods Flow cytometric analysis of DCs. DC were seeded into tissue culture dishes in IMDM 2% FCS, and added with PMN (1:1; PMN: DC) for 16h also in the presence of DNAse (100 U/ml); DC were
More informationLeukocyte and serum S100A8/S100A9 expression reflects disease activity in ANCA-associated vasculitis and glomerulonephritis
http://www.kidney-international.org & 213 International Society of Nephrology OPEN Leukocyte and serum S1A8/S1A9 expression reflects disease activity in ANCA-associated vasculitis and glomerulonephritis
More informationSponsored document from American Journal of Kidney Diseases
Sponsored document from American Journal of Kidney Diseases Prediction of ESRD in Pauci-immune Necrotizing Glomerulonephritis: Quantitative Histomorphometric Assessment and Serum Creatinine Clara J. Day
More informationANCA-associated systemic vasculitis (AASV)
PAPER 2007 Royal College of Physicians of Edinburgh ANCA-associated systemic vasculitis (AASV) 1 DC Kluth, 2 J Hughes 1 Reader in Nephrology, MRC Centre for Inflammation Research, University of Edinburgh,
More informationJ Renal Inj Prev. 2018; 7(1): Journal of Renal Injury Prevention
J Renal Inj Prev. 2018; 7(1): 22-26. Journal of Renal Injury Prevention DOI: 10.15171/jrip.2018.05 Comparison of clinical and histopathological findings in patients with lupus nephritis having IgG deposits
More informationArticle. M2 Macrophage Infiltrates in the Early Stages of ANCA-Associated Pauci-Immune Necrotizing GN
Article M2 Macrophage Infiltrates in the Early Stages of ANCA-Associated Pauci-Immune Necrotizing GN Lei Zhao,* Michael Z. David, Elizabeth Hyjek, Anthony Chang,* and Shane M. Meehan* Abstract Background
More informationWe are IntechOpen, the world s leading publisher of Open Access books Built by scientists, for scientists. International authors and editors
We are IntechOpen, the world s leading publisher of Open Access books Built by scientists, for scientists 4,000 116,000 120M Open access books available International authors and editors Downloads Our
More information29 Glomerular disease: an overview
29 Glomerular : an overview Renal Extra-renal Neurological changes Clinical syndromes pressure Sore throat (streptococcal) Rash Cardiac valve lesions Hemoptysis Asymptomatic or Acute Glomerulonephritis
More informationCitation for published version (APA): Chen, M. (2009). Pathogenetic and clinical aspects of ANCA-associated vasculitis Groningen: s.n.
University of Groningen Pathogenetic and clinical aspects of ANCA-associated vasculitis Chen, Min IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite
More informationRevised 2017 international consensus on testing of ANCAs in granulomatosis with polyangiitis and microscopic polyangiitis.
Revised 2017 international consensus on testing of ANCAs in granulomatosis with polyangiitis and microscopic polyangiitis. Bossuyt X, Cohen Tervaert JW, Arimura Y, Blockmans D, Flores-Suárez LF, Guillevin
More informationRenal manifestations of IgG4-related systemic disease
Renal manifestations of IgG4-related systemic disease Lynn D. Cornell, M.D. Mayo Clinic Rochester, MN While autoimmune pancreatitis (AIP) has been recognized since the first description by Sarles et al
More informationAutoimmune diagnostics. A comprehensive product line for the detection of autoantibodies
Autoimmune diagnostics A comprehensive product line for the detection of autoantibodies Autoimmune diagnostics Autoimmune diseases are chronic inflammatory processes with an indeterminate etiology. They
More informationCorresponding and offprint requests to: Gerjan J. Dekkema; Twitter
Nephrol Dial Transplant (2018) 1 9 doi: 10.1093/ndt/gfy018 Urinary and serum soluble CD25 complements urinary soluble CD163 to detect active renal anti-neutrophil cytoplasmic autoantibody-associated vasculitis:
More informationYear 2004 Paper one: Questions supplied by Megan
QUESTION 53 Endothelial cell pathology on renal biopsy is most characteristic of which one of the following diagnoses? A. Pre-eclampsia B. Haemolytic uraemic syndrome C. Lupus nephritis D. Immunoglobulin
More informationMembranoproliferative Glomerulonephritis
Membranoproliferative Glomerulonephritis MPGN is characterizedby alterations in the GBM and mesangium and by proliferation of glomerular cells. 5% to 10% of cases of 1ry nephrotic syndrome in children
More informationAtypical IgA Nephropathy
Atypical IgA Nephropathy Richard J. Glassock, MD, MACP Geffen School of Medicine at UCLA XXXIII Chilean Congress of Nephrology, Hypertension and Transplantation Puerto Varas, Chile October 6, 2016 IgA
More information