Perspectives on Ensuring Access to Vaccines in Lower Income Countries
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1 Perspectives on Ensuring Access to Vaccines in Lower Income Countries Greg Widmyer Deputy Director, Vaccine Delivery Foundation Merieux January 20, 2015 Bill & Melinda Gates Foundation
2 BMGF GLOBAL PROGRAMS WORK THROUGH A MATRIX Global Health Functional Areas Global Program Strategies Global Development Functional Areas HIV Tuberculosis Discovery & Translational Sciences Malaria Pneumonia Vaccine Delivery Vaccine Development Enteric & Diarrheal Diseases Polio Neglected Infectious Diseases Agricultural Development Integrated Delivery Integrated Development Family Planning Family Health Water, Sanitation & Hygiene Life Sciences Partnerships Global Libraries Emergency Relief Financial Services for the Poor Multilateral Partnerships Global Policy & Advocacy Geographies 2014 Bill & Melinda Gates Foundation 2
3 BMGF VACCINE DELIVERY TEAM STRUCTURE Vaccine Delivery Vaccine Introduction & Market Dynamics Immunization Systems Country Programs & Partnerships Strategy, Planning, & Management Bill & Melinda Gates Foundation 3
4 BMGF VACCINE DELIVERY GOALS 2020 Goal Statement By 2020, prevent 11 million deaths, 3.8 million disabilities and 230 million illnesses 1, through high, equitable, sustainable vaccine coverage and supporting polio eradication 3-5 year Short-term Strategic Goals (STSGs) Accelerating access to new vaccines Supporting polio eradication Ensuring sustainable, predictable financing for immunization 4 Improving the affordability and supply of vaccines 5 Improving the efficiency of data-driven vaccination systems 6 7 Increasing immunization coverage equity between and within countries Improving immunization coverage for older children and adults 1 Projected health impact from GAVI-supported vaccination from From Sept update to DOVE model (SDF 7) Bill & Melinda Gates Foundation 4
5 U5 MORTALITY AND INCOME LEVEL GAVI eligible countries have U5 mortality rate 2-50x most MICs and above. This drives our programming. Note: Only non-paho countries with >250,000 annual birth cohort included. Source: World Bank GNI 2013, UNPD Population Prospects 2012 Edition, GAVI Website, September Bill & Melinda Gates Foundation 5
6 Projected GAVI Spend (US$M) PRIORITY IS ON HIGHEST IMPACT AND COST VACCINES Deaths averted through use in 73 poorest countries, * $2 500 GAVI Procurement Hep B Hib PCV MeaslesHPV $2 000 Pneumo Penta Rota Rubella Mening $ % 19% 16% 11% 5% 4% 3% 2% YF JE(<1%) $1 000 $500 1% Typhoid HPV Rota Our NVI focus is ~80% on vaccines that account for highest deaths Additional focus on pipeline vaccines including dengue, typhoid, maternal immunization program, and malaria $0 MSD MenA YF 0 JE Projected Procurement Volumes (million doses) Source: DOVE (Decade of Vaccine Economics) analysis, Johns Hopkins, 2013 GAVI Investment Case and Internal BMGF Analysis
7 OUR MARKET DYNAMICS INITIATIVES Affordable vaccines Cross-cutting initiatives Partnerships Make vaccine specific investments to ensure adequate supply and lower prices. Invest in technology, platforms and information to find cross-vaccine solutions and bolster our thinking in specific technical areas. Strengthen partnerships with other actors that contribute to meeting Gavi s market goals Bill & Melinda Gates Foundation 7
8 TYPES OF VACCINE MARKET ENGAGEMENTS The foundation supports existing vaccine schedules, new vaccine introduction and new vaccinepreventable disease initiatives Market Objectives Existing Schedule New Vaccines for Introduction Nearer Term Candidate Vaccines Secure continued supply Lower weighted average price Look for system-enhancing innovation Enable affordability Support/generate country demand Secure availability Promote product development Determine efficacy and cost effectiveness Manage scheduling /financing Investment Strategy Promote competition Offer price incentives Close cooperation with UNICEF and GAVI Enable new entrants (push funding) Close cooperation with UNICEF and GAVI for effective procurement Promote rapid uptake R&D grants Product Development Partnerships Effectiveness studies Vaccines of Specific BMGF Investment Interest Penta OPV Yellow Fever (potential) PCV Rota IPV HPV JE Meningitis MR Cholera Malaria Dengue Typhoid Other antigens in maternal immunization platform Bill & Melinda Gates Foundation 8
9 UNICEF SD GAVI BMGF HOW BMGF, GAVI AND UNICEF WORK TOGETHER BMGF, GAVI and UNICEF SD work in close cooperation across the vaccine market dynamics lifecycle, but with different mandates and toolsets Upstream Pre-tender Incentives BMGF Procurement Operations Support Product Innovation Market Analytics Alternative Investment Tools Roadmap Process Other Market Incentives PRG Process Analytics & Supplier Briefings Tender Process Supply Chain Operations Bill & Melinda Gates Foundation 9
10 FOUNDATION INVESTMENT TOOLS BMGF tools span upstream and incentives opportunities and include grants, contract management and programrelated investments Not Exhaustive Upstream Tools (Product Development) Incentives Tools (Product Delivery) Product Development Funding, including PDPs Early Stage Equity Stakes Technical Assistance Grants Capacity Scale-up Loans and Contracts Supply Volume Guarantees Purchase Pre-payments Key: Grants PRIs 2014 Bill & Melinda Gates Foundation 10
11 SOME EARLY LESSONS FROM BMGF Start with the end in mind Interventions must be driven by a longer view of how market dynamics will play out today s investment can be quickly obsolete given cycle times We can be doing more to make clear and to enforce preferred characteristics from TPPs Investmetns exit strategies must be an explicit part of the planning, investment and market evaluation Coordination is key as the context becomes more complicated Gavi product roadmaps represent a positive step in aligning different key actors More actors entering including multiple donors and intermediaries Tools + Transparency = Transaction Match the investment tool to the situation and the only way to do that is thru information sharing Bill & Melinda Gates Foundation 11
12 AND LOOKING FORWARD. A set of considerations that may not even be in play with today s new vaccines will come into play and BMGF s (and Gavi s) approach may need to shift Defining what healthy markets mean in a more concrete sense How do we think more quantitatively about supply security? How do we balance incentives for innovation with price pressure? Incorporating a broader set of product attributes into our markets objectives Evolution of a total system effectiveness lens vs. cost-per-dose Gavi graduation and middle income country issues Sustaining financing and programs Disease control strategies where burden does not align with income status Will today s global efforts for MICs lead to a sustainable solution? Re-examining combination vaccine development in light of the current pipeline and existing EPI touchpoints Bill & Melinda Gates Foundation 12
13 MOVING TOWARDS SYSTEMS THINKING Total system cost-effectiveness analysis provides a framework for evaluating trade-offs of any intervention. Illustrative output Improvement radiates outward Coverage Vaccine availability Willingness to administer Reach Efficacy Potency Correct administration Multi-dose vial Safety Frequency, severity of adverse events 1-dose vial Operational cost per administered dose Transport and storage Vaccine administration (incl. HR) Product cost per administered dose Product investment Vaccine purchase Wastage 2014 Bill & Melinda Gates Foundation 13
14 REALISTIC FOR THE FAMILY OR THE HEALTH SYSTEM? Bill & Melinda Gates Foundation 14
15 THANK YOU! 2014 Bill & Melinda Gates Foundation 15
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