Proyecto INNPACTO-HIVACAT para el desarrollo de vacunas preventivas y terapéuticas frente al VIH. Eduard Valentí ESTEVE
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1 Proyecto INNPACTO-HIVACAT para el desarrollo de vacunas preventivas y terapéuticas frente al VIH Eduard Valentí ESTEVE Sesión: Proyectos en cooperación público-privado de ámbito nacional y europeo VII Conferencia Anual de las Plataformas Tecnológicas de Investigación Biomédica Barcelona, 5 Marzo 2014
2 ESTEVE R&D: Pain Research and NME Drug Discovery ESTEVE R&D Network of Excellence: ESTEVE R&D Center in Parc Científic de Barcelona (University of Barcelona) Strategic Joint Units in Pain NMEs: Alliance model that allows access to talent, know-how, technologies, capacities and infrastructures in Centers of Excellence The synergistic collaborative work focuses in ESTEVE Pain projects with real implication Research Consortia for Pain Research and NME Drug Discovery in Pain: KOLs and International Scientific Groups Current and future trends Public Private Partnerships in non-pain fields: High unmet needs High societal impact Strategic Joint Units - ICIQ (Institut Català d InvestigacióQuímica) - Universidad Santiago de Compostela Research Consortia: - IMI : Europain+ 5 horizontal projects - EU FP7: NeuroPain PPPs: - Sanfilippo - HIVACAT
3 Development of therapeutic and prophylactic HIV vaccines Public-Private Partnership (PPP) Partially funded with an INNPACTO Grant
4 Impact of the research Source: repairstemcell.wordpress.com Functional cure Therapeutic vaccine Market size: 35 Millionpeople worldwide Preventive vaccine Market size: 7 Billion people worldwide
5 The long road to an HIV vaccine 1984: A vaccine in two years Margaret Heckler, Secretary, US Department of Health and Human Services, on April 23 rd, 1984, when it was announced the HIV isolation by Robert Gallo 2014: 30 yearslaterandstillno HIV vaccine! More than 200 AIDS vaccine clinical trials Data from IAVIReport, Novenber 22, 2013 HIV/AIDS is much more complex than any other viral disease for which vaccines have been successfully developed!!
6 Challenges and opportunities A therapeutic vaccine would significantly improve HIV control and quality of life A prophylactic vaccine is the ultimate objective Intended to educate the immune system to improve viral control Achieve a long-term functional cure Complete eradicationof the virus would be a desirable objective Prevention of transmission Very clean safety profile Amenable to combination therapy Can be first line of treatment (not just last line after HAART options fail) HIVACAT therapeutic can be the foundation of the prophylactic Intended to educate the immune system to prevent viral infection or to turn everyone into an elite controller Only onehiv vaccine clinical trial has demonstrated any efficacyin humans (RV144, 31%) High degree of efficacy(>80%) is critical for broad utilization Very clean safety profile Mostof the HIV vaccine consortiaare focused here The prophylactic will leverage and build onthe results of the T cell immunogen therapeutic clinical development
7 The research centres HIVACAT research program started in 2008 Two internationally renowned centres of reference More than 60 investigators Access to more than 7000 HIV patients and unique sample source created over more than 15 years Conducted more than 200 clinical trials in HIV/AIDS Well established national and international collaborations Hospital Germans Trias i Pujol (Irsicaixa), Badalona Hospital Clínic, Barcelona
8 HIVACAT has a Network of Well-established National & International Collaborations
9 Research strategy HIVACAT programme incorporates four approaches for a vaccine, each with several lines: Dendriticcell-based therapeutic vaccine Vector-based therapeutic vaccine Vector-based prophylactic vaccine Passive immunization with neutralizing antibodies L1 Cellular Immunity L4 Preventive Vaccine Vectors L7 Clinical Trials T- and B-cell Immunogen Development and Refinement L2 Humoral Immunity L5 Therapeutic Vaccine Vectors L7 Clinical Cohorts Vector Development for Therapeutic and Preventive Vaccine Candidates L3 Standardized Techniques L6 Immnunopathogenes is and animal models HIV Immune patophysiology and Clinical Trials
10 Thank you ESTEVE Pharmacy (Manresa, since 1787) ESTEVE HQ (Barcelona, since 1942) ESTEVE R & D Centre (Barcelona, since 2012) ESTEVE Pharmaceutical Plant (Martorelles, since1992) ESTEVE API Plant (Celrà, since 1986)
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