MATERIAL SAFETY DATA SHEET
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1 MATERIAL SAFETY DATA SHEET 1. PRODUCT AND COMPANY IDENTIFICATION Product Part No: Supplier Emergency telephone number Endotoxin (E.coli) strain(s) O55:B5, O111:B4 N-185, N-186, E , E L, 7360L, 7460L Lonza Walkersville, Inc Biggs Ford Road Walkersville, MD (Chemtrec) Product use Product Identification Number Control Standard for endotoxin detection kit 2. COMPOSITION/INFORMATION ON INGREDIENTS Hazardous components Name CAS Number Other components Name CAS Number Lipopolysaccharide See Section 15 of this MSDS for OSHA Regulatory Status 3. HAZARDS IDENTIFICATION Emergency overview White, odorless powder [or solid]. May irritate the eye or skin. Breathing dust may irritate the respiratory tract. May be harmful if swallowed. May be combustible. In case of fire, use water spray, chemical foam, dry chemical or CO 2. Primary route(s) of entry Breathing dust (inhalation). Eye and skin contact. Symptoms of exposure Inhalation Eye contact Skin contact Ingestion May cause difficulty in breathing, wheezing, or shortness of breath.. May cause irritation, experienced as pain, redness, or tearing. May cause irritation, experienced as redness or swelling. May cause irritation to gastro-intestinal tract, nausea and/or vomiting, drowsiness, or other adverse health effects. Lonza Walkersville, Inc. Endotoxin (E. coli) Page 1 of 5
2 Medical conditions aggravated by exposure Listed as carcinogen or potential carcinogen known. Not listed by OSHA, the International Agency for Research on Cancer (IARC), or the National Toxicology Program (NTP) 4. FIRST AID Inhalation Eye contact Skin contact Ingestion Note to physician Remove from area to fresh air. Seek medical attention if respiratory irritation develops or if breathing becomes difficult. Hold eye open and flush slowly and gently with plenty of water for several minutes. Remove any contact lenses, and continue flushing for several more minutes. Seek medical attention if irritation develops and persists. Clean contacts before reuse. Wash affected areas with plenty of water, and soap if available, for several minutes. Seek medical attention if irritation develops and persists. Give 3-4 glasses of water, but DO NOT induce vomiting. If vomiting occurs, give fluids again. Get medical attention to determine whether vomiting or evacuation of stomach is necessary. Do not give anything by mouth to an unconscious or convulsing person. The toxicological properties of this product have not been determined. 5. FIRE FIGHTING MEASURES Flash Point and Method General hazard May be combustible. Dust may be explosive. Extinguishing media Use water spray, chemical foam, dry chemical or CO 2.. Extinguishing media to avoid Special firefighting instructions Firefighting equipment Move containers from area if it can be done without risk. As in any fire, wear NIOSH approved, positive-pressure, self-contained breathing apparatus and full protective gear. 6. ACCIDENTAL RELEASE MEASURES Personal precautions Environmental precautions Clean-up methods Wear appropriate protective equipment (See Section 8). Avoid contact with eyes, skin or clothing. Avoid breathing dusts. Keep out of sewers or waterways. Sweep up and place in a compatible container for disposal. Avoid creating dusts. Use non-sparking tools for handling and clean-up. Lonza Walkersville, Inc. Endotoxin (E. coli) Page 2 of 5
3 7. HANDLING AND STORAGE Handling Storage Wear appropriate protective equipment (See Section 8). Avoid contact with eyes, skin or clothing. Avoid breathing dusts. Wash thoroughly after handling. Store in a cool, dry place. Keep container tightly sealed. 8. EXPOSURE CONTROLS/PERSONAL PROTECTION Engineering controls Personal Protection Respirator Eye Protection Gloves Clothing Other Hygiene practices Exposure controls Use in a laboratory exhaust hood. General dilution ventilation system should be adequate. required under normal use conditions. In operations that generate dust, wear a respirator selected by a technically qualified person. If respirators are worn, comply with OSHA s respiratory protection standard (40 CFR ). Wear safety glasses or vented safety goggles. Rubber gloves are recommended as a minimum when handling chemicals. Long sleeved laboratory coats or jackets are recommended as a minimum when handling chemicals. Eye wash. Wash hands thoroughly after handling. N/E 9. PHYSICAL AND CHEMICAL PROPERTIES Form Color Odor Properties Solid White ph: Bulk density (20 C): No information available Solidification point: No information available Water solubility: Incomplete, opalescent solution 10. STABILITY AND REACTIVITY Reactivity Materials to avoid Conditions to avoid Stable Strong oxidizing agents. Heat, open flames, sparks. Lonza Walkersville, Inc. Endotoxin (E. coli) Page 3 of 5
4 Hazardous decomposition products Carbon dioxide, carbon monoxide 11. TOXICOLOGICAL INFORMATION Acute Toxicity Chronic Toxicity 12. ECOLOGICAL INFORMATION Ecotoxicity Persistence/degradability Movement/partitioning 13. DISPOSAL CONSIDERATIONS RCRA hazardous waste code Special instructions Observe all federal, state and local laws and regulations. 14. TRANSPORT INFORMATION DOT hazard class TDG hazard class 15. REGULATORY INFORMATION OSHA regulatory status (29 CFR ) CERCLA reportable quantity (40 CFR 117, 302) Not hazardous Name Reportable quantity (lbs) SARA extremely hazardous substances (40 CFR 355) SARA hazard categories (40 CFR 370) SARA toxic chemicals (40 CFR 372) Name Threshold planning quantity (lbs) Reportable quantity (lbs) Name CAS Number Percentage Lonza Walkersville, Inc. Endotoxin (E. coli) Page 4 of 5
5 Inventory Status Toxic Substance Control Act Controlled Products Regulations WHMIS classification The chemicals in this product are subject to the FDA exemption under TSCA as per 40 CFR 720 (a)(1). This product is an FDA regulated product and exempted from TSCA as per 40 CFR 720 (a)(1). This product has been classified according to the hazard criteria of the Canadian Controlled Products Regulations, Section 33, and the MSDS contains all required information. Not a controlled product. 16. OTHER INFORMATION Abbreviations C - Ceiling limit ERG Emergency Response Guidebook LC 50 - The concentration of a substance in air that will kill 50% of test animals within a certain exposure period. LD 50 - The dose that causes death in 50% of test animals. - Not applicable N/D - Not determined N/E - Not established N/K - Not known ERG - Emergency Response Guidebook RQ - Reportable Quantity TPQ - Threshold Planning Quantity WHMIS Workplace Hazardous Materials Information System Preparation information Prepared by Regulatory Affairs MSDS number W Date prepared September 9, 2009 Replaces February 7, 2007 Revision Information Section 1: added additional part numbers to document Disclaimer This information is furnished without warranty, expressed or implied, except that it is accurate to the best knowledge of Lonza Walkersville, Inc. The data on this sheet relate only to the specific materials designated herein. Lonza Walkersville, Inc. assumes no legal responsibility for the use or reliance upon these data. Lonza Walkersville, Inc. Endotoxin (E. coli) Page 5 of 5
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