Dr Stephen Till s publications
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1 Dr Stephen Till s publications 1 Lam EPS, Kariyawasam H, Rana BMJ, Durham SR, McKenzie ANJ, Powell N, Orban N, Lennartz Walker M, Hopkins C, Ying S, Rimmer J, Lund VJ, Cousins DJ, Till SJ. IL 25/IL 33 responsive Th2 cells characterize nasal polyps with default Th17 signature in nasal mucosa, J Allergy Clin Immunol (in press). 2 E. Wambre, J. H. DeLong, E. A. James, N. Torres Chinn, W. Pfutzner, C. Mobs, S. R. Durham, S. J. Till, D. Robinson, and W. W. Kwok, 'Specific Immunotherapy Modifies Allergen Specific CD4(+) T Cell Responses in an Epitope Dependent Manner', J Allergy Clin Immunol, 133 (2014), e7. 3 S. J. Till, E. J. Raynsford, C. J. Reynolds, K. J. Quigley, A. Grzybowska Kowalczyk, L. R. Saggar, A. Goldstone, B. Maillere, W. W. Kwok, D. M. Altmann, S. R. Durham, and R. J. Boyton, 'Peptide Induced Immune Regulation by a Promiscuous and Immunodominant CD4t Cell Epitope of Timothy Grass Pollen: A Role of Cbl B and Itch in Regulation', Thorax, 69 (2014), A. Slovick, A. Douiri, J. Kelly, A. Guerra, R. Muir, K. Tsioulos, C. Murphy, M. H. Shamji, S. Ying, S. R. Durham, and S. J. Till, 'Protocol for a Double Blind Randomised Controlled Trial of Low Dose Intradermal Grass Pollen Immunotherapy Versus a Histamine Control on Symptoms and Medication Use in Adults with Seasonal Allergic Rhinitis (Pollenlite)', Clin Transl Allergy, 3 (2013), M. H. Shamji, J. N. Francis, P. A. Wurtzen, K. Lund, S. R. Durham, and S. J. Till, 'Cell Free Detection of Allergen IgE Cross Linking with Immobilized Phase CD23: Inhibition by Blocking Antibody Responses after Immunotherapy', J Allergy Clin Immunol, 132 (2013), e G. Rotiroti, M. Shamji, S. R. Durham, and S. J. Till, 'Repeated Low Dose Intradermal Allergen Injection Suppresses Allergen Induced Cutaneous Late Responses', J Allergy Clin Immunol, 130 (2012), e1. 7 D. I. Pritchard, D. G. Blount, P. Schmid Grendelmeier, and S. J. Till, 'Parasitic Worm Therapy for Allergy: Is This Incongruous or Avant Garde Medicine?', Clinical and Experimental Allergy, 42 (2012), S. M. Walker, S. R. Durham, S. J. Till, G. Roberts, C. J. Corrigan, S. C. Leech, M. T. Krishna, R. K. Rajakulasingham, A. Williams, J. Chantrell, L. Dixon, A. J. Frew, and S. M. Nasser, 'Immunotherapy for Allergic Rhinitis', Clinical and Experimental Allergy, 41 (2011), S. J. Till, 'Mechanisms of Immunotherapy and Surrogate Markers', Allergy, 66 Suppl 95 (2011), I. J. Skypala, M. A. Calderon, A. R. Leeds, P. Emery, S. J. Till, and S. R. Durham, 'Development and Validation of a Structured Questionnaire for the Diagnosis of Oral Allergy Syndrome in Subjects with 1 of 5
2 Seasonal Allergic Rhinitis During the UK Birch Pollen Season', Clinical and Experimental Allergy, 41 (2011), L. K. James, M. H. Shamji, S. M. Walker, D. R. Wilson, P. A. Wachholz, J. N. Francis, M. R. Jacobson, I. Kimber, S. J. Till, and S. R. Durham, 'Long Term Tolerance after Allergen Immunotherapy Is Accompanied by Selective Persistence of Blocking Antibodies', J Allergy Clin Immunol, 127 (2011), e G. Banfield, H. Watanabe, G. Scadding, M. R. Jacobson, S. J. Till, D. A. Hall, D. S. Robinson, C. M. Lloyd, K. T. Nouri Aria, and S. R. Durham, 'Cc Chemokine Receptor 4 (CCR4) in Human Allergen Induced Late Nasal Responses', Allergy, 65 (2010), S. J. Till, and S. R. Durham, 'Immunologic Responses to Subcutaneous Allergen Immunotherapy', Clin Allergy Immunol, 21 (2008), J. N. Francis, I. Sabroe, C. M. Lloyd, S. R. Durham, and S. J. Till, 'Elevated CCR6+ CD4+ T Lymphocytes in Tissue Compared with Blood and Induction of Ccl20 During the Asthmatic Late Response', Clin Exp Immunol, 152 (2008), J. N. Francis, L. K. James, G. Paraskevopoulos, C. Wong, M. A. Calderon, S. R. Durham, and S. J. Till, 'Grass Pollen Immunotherapy: IL 10 Induction and Suppression of Late Responses Precedes IgG4 Inhibitory Antibody Activity', J Allergy Clin Immunol, 121 (2008), e2. 16 J. N. Francis, C. M. Lloyd, I. Sabroe, S. R. Durham, and S. J. Till, 'T Lymphocytes Expressing Ccr3 Are Increased in Allergic Rhinitis Compared with Non Allergic Controls and Following Allergen Immunotherapy', Allergy, 62 (2007), S. J. Till, and S. R. Durham, 'Immunological Responses to Allergen Immunotherapy', Clin Allergy Immunol, 18 (2004), C. Pilette, J. N. Francis, S. J. Till, and S. R. Durham, 'Ccr4 Ligands Are up Regulated in the Airways of Atopic Asthmatics after Segmental Allergen Challenge', Eur Respir J, 23 (2004), K. T. Nouri Aria, P. A. Wachholz, J. N. Francis, M. R. Jacobson, S. M. Walker, L. K. Wilcock, S. Q. Staple, R. C. Aalberse, S. J. Till, and S. R. Durham, 'Grass Pollen Immunotherapy Induces Mucosal and Peripheral IL 10 Responses and Blocking Igg Activity', Journal of Immunology, 172 (2004), J. N. Francis, M. R. Jacobson, C. M. Lloyd, I. Sabroe, S. R. Durham, and S. J. Till, 'CXCR1+CD4+ T Cells in Human Allergic Disease', Journal of Immunology, 172 (2004), P. A. Wachholz, N. K. Soni, S. J. Till, and S. R. Durham, 'Inhibition of Allergen IgE Binding to B Cells by Igg Antibodies after Grass Pollen Immunotherapy', J Allergy Clin Immunol, 112 (2003), E. M. Varga, K. Nouri Aria, S. J. Till, and S. R. Durham, 'Immunomodulatory Treatment Strategies for Allergic Diseases', Curr Drug Targets Inflamm Allergy, 2 (2003), of 5
3 23 A. C. Rimaniol, S. J. Till, G. Garcia, F. Capel, V. Godot, K. Balabanian, I. Durand Gasselin, E. M. Varga, G. Simonneau, D. Emilie, S. R. Durham, and M. Humbert, 'The CXCR3 Chemokine Fractalkine in Allergic Asthma and Rhinitis', J Allergy Clin Immunol, 112 (2003), A. C. Rimaniol, G. Garcia, S. J. Till, F. Capel, G. Gras, K. Balabanian, D. Emilie, and M. Humbert, 'Evaluation of CD4+ T Cells Proliferating to Grass Pollen in Seasonal Allergic Subjects by Flow Cytometry', Clin Exp Immunol, 132 (2003), J. N. Francis, S. J. Till, and S. R. Durham, 'Induction of IL 10+CD4+CD25+ T Cells by Grass Pollen Immunotherapy', J Allergy Clin Immunol, 111 (2003), D. R. Wilson, T. G. Merrett, E. M. Varga, L. Smurthwaite, H. J. Gould, M. Kemp, J. Hooper, S. J. Till, and S. R. Durham, 'Increases in Allergen Specific IgE in Bal after Segmental Allergen Challenge in Atopic Asthmatics', Am J Respir Crit Care Med, 165 (2002), P. A. Wachholz, K. T. Nouri Aria, D. R. Wilson, S. M. Walker, A. Verhoef, S. J. Till, and S. R. Durham, 'Grass Pollen Immunotherapy for Hayfever Is Associated with Increases in Local Nasal but Not Peripheral Th1:Th2 Cytokine Ratios', Immunology, 105 (2002), K. T. Nouri Aria, D. Wilson, J. N. Francis, L. A. Jopling, M. R. Jacobson, M. R. Hodge, D. P. Andrew, S. J. Till, E. M. Varga, T. J. Williams, J. E. Pease, C. M. Lloyd, I. Sabroe, and S. R. Durham, 'Ccr4 in Human Allergen Induced Late Responses in the Skin and Lung', European Journal of Immunology, 32 (2002), S. J. Till, M. R. Jacobson, F. O'Brien, S. R. Durham, A. KleinJan, W. J. Fokkens, S. Juliusson, and O. Lowhagen, 'Recruitment of CD1a+ Langerhans Cells to the Nasal Mucosa in Seasonal Allergic Rhinitis and Effects of Topical Corticosteroid Therapy', Allergy, 56 (2001), N. Powell, S. J. Till, A. B. Kay, and C. J. Corrigan, 'The Topical Glucocorticoids Beclomethasone Dipropionate and Fluticasone Propionate Inhibit Human T Cell Allergen Induced Production of IL 5, IL 3 and GM CSF mrna and Protein', Clinical and Experimental Allergy, 31 (2001), N. Powell, S. Till, J. Bungre, and C. Corrigan, 'The Immunomodulatory Drugs Cyclosporin a, Mycophenolate Mofetil, and Sirolimus (Rapamycin) Inhibit Allergen Induced Proliferation and IL 5 Production by Pbmcs from Atopic Asthmatic Patients', J Allergy Clin Immunol, 108 (2001), K. T. Nouri Aria, A. M. Irani, M. R. Jacobson, F. O'Brien, E. M. Varga, S. J. Till, S. R. Durham, and L. B. Schwartz, 'Basophil Recruitment and IL 4 Production During Human Allergen Induced Late Asthma', J Allergy Clin Immunol, 108 (2001), E. M. Varga, P. Wachholz, K. T. Nouri Aria, A. Verhoef, C. J. Corrigan, S. J. Till, and S. R. Durham, 'T Cells from Human Allergen Induced Late Asthmatic Responses Express IL 12 Receptor Beta 2 Subunit MRNA and Respond to IL 12 in Vitro', Journal of Immunology, 165 (2000), S. Laberge, S. Pinsonneault, E. M. Varga, S. J. Till, K. Nouri Aria, M. Jacobson, W. W. Cruikshank, D. M. Center, Q. Hamid, and S. R. Durham, 'Increased Expression of IL 16 Immunoreactivity in 3 of 5
4 Bronchial Mucosa after Segmental Allergen Challenge in Patients with Asthma', J Allergy Clin Immunol, 106 (2000), S. R. Durham, S. J. Till, and C. J. Corrigan, 'T Lymphocytes in Asthma: Bronchial Versus Peripheral Responses', J Allergy Clin Immunol, 106 (2000), S E. M. Varga, M. R. Jacobson, S. J. Till, K. Masuyama, F. O'Brien, S. Rak, V. Lund, G. K. Scadding, Q. A. Hamid, and S. R. Durham, 'Cellular Infiltration and Cytokine mrna Expression in Perennial Allergic Rhinitis', Allergy, 54 (1999), E. M. Varga, M. R. Jacobson, K. Masuyama, S. Rak, S. J. Till, Y. Darby, Q. Hamid, V. Lund, G. K. Scadding, and S. R. Durham, 'Inflammatory Cell Populations and Cytokine mrna Expression in the Nasal Mucosa in Aspirin Sensitive Rhinitis', Eur Respir J, 14 (1999), S. R. Durham, S. M. Walker, E. M. Varga, M. R. Jacobson, F. O'Brien, W. Noble, S. J. Till, Q. A. Hamid, and K. T. Nouri Aria, 'Long Term Clinical Efficacy of Grass Pollen Immunotherapy', N Engl J Med, 341 (1999), S. J. Till, S. R. Durham, K. Rajakulasingam, M. Humbert, D. Huston, R. Dickason, A. B. Kay, and C. J. Corrigan, 'Allergen Induced Proliferation and Interleukin 5 Production by Bronchoalveolar Lavage and Blood T Cells after Segmental Allergen Challenge', Am J Respir Crit Care Med, 158 (1998), K. Rajakulasingam, S. Till, S. Ying, M. Humbert, J. Barkans, M. Sullivan, Q. Meng, C. J. Corrigan, J. Bungre, J. A. Grant, A. B. Kay, and S. R. Durham, 'Increased Expression of High Affinity IgE (Fcepsilonri) Receptor Alpha Chain MRNA and Protein Bearing Eosinophils in Human Allergen Induced Atopic Asthma', Am J Respir Crit Care Med, 158 (1998), K. Masuyama, S. J. Till, M. R. Jacobson, A. Kamil, L. Cameron, S. Juliusson, O. Lowhagen, A. B. Kay, Q. A. Hamid, and S. R. Durham, 'Nasal Eosinophilia and IL 5 RNA Expression in Seasonal Allergic Rhinitis Induced by Natural Allergen Exposure: Effect of Topical Corticosteroids', J Allergy Clin Immunol, 102 (1998), M. Larche, S. J. Till, B. M. Haselden, J. North, J. Barkans, C. J. Corrigan, A. B. Kay, and D. S. Robinson, 'Costimulation through CD86 Is Involved in Airway AntIgEn Presenting Cell and T Cell Responses to Allergen in Atopic Asthmatics', Journal of Immunology, 161 (1998), O. M. Kon, B. S. Sihra, S. J. Till, C. J. Corrigan, A. B. Kay, and J. A. Grant, 'Unstimulated Basophils in Atopic and Nonatopic Subjects Express Intracellular Interleukin 4: Detection by Flow Cytometry', Allergy, 53 (1998), S. R. Durham, and S. J. Till, 'Immunologic Changes Associated with Allergen Immunotherapy', J Allergy Clin Immunol, 102 (1998), S. Till, S. Walker, R. Dickason, D. Huston, F. O'Brien, J. Lamb, A. B. Kay, C. Corrigan, and S. Durham, 'IL 5 Production by Allergen Stimulated T Cells Following Grass Pollen Immunotherapy for Seasonal Allergic Rhinitis', Clin Exp Immunol, 110 (1997), of 5
5 46 S. Till, S. Durham, R. Dickason, D. Huston, J. Bungre, S. Walker, D. Robinson, A. B. Kay, and C. Corrigan, 'IL 13 Production by Allergen Stimulated T Cells Is Increased in Allergic Disease and Associated with IL 5 but not IFN Gamma Expression', Immunology, 91 (1997), S. Till, R. Dickason, D. Huston, M. Humbert, D. Robinson, M. Larche, S. Durham, A. B. Kay, and C. Corrigan, 'IL 5 Secretion by Allergen Stimulated CD4+ T Cells in Primary Culture: Relationship to Expression of Allergic Disease', J Allergy Clin Immunol, 99 (1997), S. Till, 'Immunotherapy: Readdressing the Balance between Th2 and Th1 Cells', Clinical and Experimental Allergy, 27 (1997), M. Humbert, C. J. Corrigan, P. Kimmitt, S. J. Till, A. B. Kay, and S. R. Durham, 'Relationship between IL 4 and IL 5 mrna Expression and Disease Severity in Atopic Asthma', Am J Respir Crit Care Med, 156 (1997), S. Till, B. Li, S. Durham, M. Humbert, B. Assoufi, D. Huston, R. Dickason, P. Jeannin, A. B. Kay, and C. Corrigan, 'Secretion of the Eosinophil Active Cytokines Interleukin 5, Granulocyte/Macrophage Colony Stimulating Factor and Interleukin 3 by Bronchoalveolar Lavage CD4+ and CD8+ T Cell Lines in Atopic Asthmatics, and Atopic and Non Atopic Controls', European Journal of Immunology, 25 (1995), of 5
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