Can Probiotics be Treated with Allergic or Infectious Disease?

Size: px
Start display at page:

Download "Can Probiotics be Treated with Allergic or Infectious Disease?"

Transcription

1 1 Can Probiotics be Treated with Allergic or Infectious Disease? (synbiotics) 1, ,8 (antibiotic-associated diarrhea) (infectious diarrhea) (irritable bowel syndrome) (probiotics) 1-3 (prebiotics) 4,5 Lactobacillus species( L acidophilus,

2 2? L rhamnosus, L bulgaricus, L reuteri, and L casei); Bifidobacterium species; Saccharomyces boulardii ( ) (Lactobacillus acidophilus A ) (Bifidobacterium sp. B ) (Lactobacillus casei C ) (Lactobacillus bulgaricus) B lactis (Streptococcus thermophilus) C difficile. 15 S boulardii LGG L plantarum Bifidobacterium bifidus L acidophilus. rhamnosus GG 3 52% 3 (34%) 30 16,17 18 (necrotizing enterocolitis: NEC): 14 Nissle 1917 SF68 NEC NEC NEC ,14 14 bifidobacteria 22

3 (TGF- ) Lee 28 L rhamnosus (Peptidoglycan) Toll-like receptor 2 24 T IL-10 TGF- IgA T , 30, ,31, , bifidobacteria , 26 A 39 40

4 4? lactobacilli ,41 bifidobacterium 1. Floch,MH, Moussa K. Probiotics and dietary fiber. The clinical coming of age of intestinal microecology. J Clin Gastroenterol 1998; 27: Floch MH. Soluble dietary fiber and short-chain fatty acids: an advance in understanding the human bacterial flora. Am J Gastroenterol 1990; 85: Gibson GR. Prebiotics as gut microflora management tools.j Clin Gastroenterol. 2008; 42(suppl 2): S Fuller R. Probiotics in man and animals. J Appl Bacteriol 1989; 66: Cummings JH, Macfarlane GT, Englyst HN. Prebiotic digestion and fermentation. Am J Clin Nutr 2001; 73(suppl): Douglas LC, Sanders ME. Probiotics and prebiotics in dietetics practice. J Am Diet Assoc 2008; 108: Montrose D, Floch MH. Probiotics used in human studies. J Clin Gastroenterol 2005; 9: Floch M.H, Montrose DC. Use of probiotics in humans: an analysis of the literature. Gastroenterol Clin North Am 2005; 34: Kelly CP, LaMont JT. Clostridium difficile--more difficult than ever. N Engl J Med 2008; 359: Floch MH, Walker WA, Guandalini S,et al. Recommendations for probiotic use J Clin Gastroenterol 2008; 42(suppl 2):S Park J, Floch MH. Prebiotics, probiotics, and dietary fiber in gastrointestinal disease. Gastroenterol Clin North Am 2007; 36: Johnston BC, Supina AL, Vohra S.Probiotics for pediatric antibiotic-associated diarrhea: a metaanalysis of randomized placebo-controlled trials. CMAJ 2006; 175: Barclay L. Benefits of Probiotics Reviewed. Am Fam Physician 2008; 78: de Vrese M, Schrezenmeir J. Probiotics, prebiotics, and synbiotics. Adv Biochem Eng Biotechnol 2008; 111: Aas J, Gessert CE, Bakken JS.Recurrent. Clostridium difficile colitis: case series involving 18 patients treated with donor stool administered via a nasogastric tub. Clin Infect Dis 2003; 36: McFarland LV. Meta-analysis of probiotics for the prevention of antibiotic associated diarrhea and the treatment of Clostridium difficile disease. Am J Gastroenterol 2006; 101: Dendukuri N1, Costa V, McGregor M, et al: Probiotic therapy for the prevention and treatment of Clostridium difficile-associated diarrhea: a systematic review. CMAJ 2005; 173: Hookman P, Barkin JS.Clostridium difficile associated infection, diarrhea and colitis. World J Gastroenterol 2009; 15: AlFale KM, Bassler D. Probiotics for prevention of necrotizing enterocolitis in preterm infants. Cochrane Database of Systematic Reviews, Issue 1, Barclay AR, Stenson B, Simpson JH, Weaver LT, Wilson DC.Probiotics for necrotizing enterocolitis: a systematic review. J Pediatr Gastroenterol Nutr 2007; 45: Noverr MC, Huffnagle GB.The "microflora hypothesis" of allergic diseases. Clin Exp Allergy 2005; 35:

5 5 22. B, Sepp E, Julge K, Voor T, Mikelsaar M. Allergy development and the intestinal microflora during the first year of life. J Allergy Clin Immunol 2001;108: Betsi GI, Papadavid E, Falagas ME. Probiotics for the treatment or prevention of atopic dermatitis: a review of the evidence from randomized controlled trials. Am J Clin Dermatol 2008; 9: Veckman V, Miettinen M, Pirhonen J, Siren J, Matikainen S, Julkunen I. Streptococcus pyogenes and Lactobacillus rhamnosus differentially induce maturation and production of Th1-type cytokines and chemokines in human monocyte-derived dendritic cells. J Leukoc Biol2004; 75: Kusel MM., Holt PG, de Klerk N, Sly PD.Support for 2 variants of eczema. J Allergy Clin Immunol 2005; 116: Flohr C, Johansson SG,Wahlgren CF, Williams H. How atopic is atopic dermatitis?. J Allergy Clin Immunol 2004; 114: Sistek D, Kelly R, Wickens K, Stanley T, Fitzharris P, Crane J. Is the effect of probiotics on atopic dermatitis confined to food sensitized children? Clin Exp Allergy 2006; 36: Lee J, Seto D, Bielory L.Meta-analysis of clinical trials of probiotics for prevention and treatment of pediatric atopic dermatitis, J Allergy Clin Immunol 2008; 121: Kukkonen K, Savilahti E, Haahtela T, et al. Probiotics and prebiotic galacto-oligosaccharides in the prevention of allergic diseases: A randomized, double-blind, placebo-controlled trial J Allergy Clin Immunol 2007; 119: Taylor AL, Dunstan JA, Prescott SL. Probiotic supplementation for the first 6 months of life fails to reduce the risk of atopic dermatitis and increases the risk of allergen sensitization in high-risk children: a randomized controlled trial, J Allergy Clin Immunol 2007; 119: Kopp MV, Hennemuth I, Dietschek A, et al. A randomized, double-blind, placebo-controlled trial of probiotics for primary prevention: no clinical or immunological effects of Lactobacillus GG supplementation, Pediatrics 2008; 121:e850-e Vliagoftis H, Kouranos VD, Betsi GI, Falagas ME. Probiotics for the treatment of allergic rhinitis and asthma: systematic review of randomized controlled trials.ann Allergy Asthma Immunol 2008; 101: Kopp MV, Salfeld P. Probiotics and prevention of allergic disease. Curr Opin Clin Nutr Metab Care 2009; 12: Osborn DA, Sinn JK.Probiotics in infants for prevention of allergic disease and food hypersensitivity. Cochrane Database Syst Rev. Issue 2, 2009 (Status in this issue: Unchanged), This version first published online: 2007 Oct 17; (4):CD Salfeld P, Kopp MV. Probiotics cannot be generally recommended for primary prevention of atopic dermatitis. Allergy Clin Immunol 2009 May 7. [Epub ahead of print] 36. Kukkonen K, Savilahti E, Haahtela T,et al. Longterm safety and impact on infection rates of postnatal probiotic and prebiotic (synbiotic) treatment: randomized, double-blind, placebo-controlled trial. Pediatrics 2008; 122: Shafai T. Routine supplement of prebiotics and probiotics to newborn infants is not recommended. Pediatrics 2009; 123:e Mukerji SS, Pynnonen MA, Kim HM,, Tabor M, Terrell JE.Probiotics as adjunctive treatment for chronic rhinosinusitis: a randomized controlled trial. Otolaryngologyngol Head Neck Surg 2009; 140: Hatakka K, Blomgren K, Pohjavuori S, et al. A. Treatment of acute otitis media with probiotics in otitis-prone children-a double-blind, placebo-controlled randomised study. Clin Nutr 2007; 26: Epub 2007 Mar Borchert D, Sheridan L, Papatsoris A, et al. Prevention and treatment of urinary tract infection with probiotics: Review and research perspective. Indian J Urol 2008; 24: Hammerman C, Bin-Nun A, Kaplan M. Safety of probiotics: comparison of two popular strains. BMJ 2006; 333: Borriello SP, Hammes WP, Holzapfel W, Marteau P, Schrezenmeir J,Vaara M, et al. Safety of probiotics that contain lactobacilli or bifidobacterium. Clin Infect Dis 2003; 36: ESPGHAN Committee on Nutrition. Probiotic bacteria in dietetic products for infants: a commentary by the ESPGHAN committee on nutrition. J Pediatr Gastroenterol Nutr 2004; 38: De Groote MA. Frank DN. Dowell E. Glode MP. Pace NR Lactobacillus rhamnosus GG bacteremia associated with probiotic use in a child with short gut syndrome. Pediatric Infectious Disease Journal 2005; 24: Land MH. Rouster-Stevens K. Woods CR. Cannon ML. Cnota J. Shetty AK..Lactobacillus sepsis associated with probiotic therapy. Pediatrics 2005;115: Cannon P, Lee TA, Bolanos JT, Danziger LH. Pathogenic relevance of Lactobacillus: a retrospective review of over 129 cases. Eur J Clin Microbiol Infect Dis 2005; 24: Lomax AR, Calder PC. Probiotics, immune function, infection and inflammation: a review of the evidence from studies conducted in humans. Curr Pharm Des 2009;15: Giorgi PL. Probiotics. A review. Recenti Prog Med 2009; 100:40-7.

The role of nutrition in optimum gastrointestinal health

The role of nutrition in optimum gastrointestinal health The role of nutrition in optimum gastrointestinal health Kelly A. Tappenden, Ph.D., R.D., FASPEN Kraft Foods Human Nutrition Endowed Professor University Distinguished Teacher-Scholar University of Illinois

More information

Clinical Report: Probiotics and Prebiotics in Pediatrics

Clinical Report: Probiotics and Prebiotics in Pediatrics www.medscape.com Authors and Disclosures Author(s) Dan W. Thomas, MD Professor of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, California; Head, Division of Gastroenterology

More information

ESPEN Congress Vienna Networking with your microbiota Specific evidence-based indications. H. Lochs (Germany)

ESPEN Congress Vienna Networking with your microbiota Specific evidence-based indications. H. Lochs (Germany) ESPEN Congress Vienna 2009 Networking with your microbiota Specific evidence-based indications H. Lochs (Germany) Probiotics Evidence based indications H. Lochs Medizinische Klinik mit Schwerpunkt Gastroenterologie,

More information

השפעת חיידקים פרוביוטיים

השפעת חיידקים פרוביוטיים השפעת חיידקים פרוביוטיים החיים בחלל )המעי(... על רון שאול יחידת גסטרו ילדים מרכז רפואי רמב"ם Introduction The intestinal microflora primarily in the large bowel consists mostly on benign bacterial species

More information

Probiotics in Pediatric Health. AANP Annual Convention

Probiotics in Pediatric Health. AANP Annual Convention Probiotics in Pediatric Health AANP Annual Convention Don Brown, ND July 12, 2017 Human Microbiome Richness and Metabolic Markers Human gut microbial composition was studied in 292 Danish adults Individuals

More information

Seppo Salminen Mimi Tang

Seppo Salminen Mimi Tang Koletzko B. (ed): Pediatric Nutrition in Practice. Basel, Karger, 2008, pp 80 84 1 General Aspects of Childhood Nutrition 1.8 Gut Microbiota in Infants Seppo Salminen Mimi Tang Key Words M i c r o b i

More information

9/18/2018. The Physiological Roles of the Intestinal Microbiota. Learning Objectives

9/18/2018. The Physiological Roles of the Intestinal Microbiota. Learning Objectives The Physiological Roles of the Intestinal Microbiota Kelly A. Tappenden, Ph.D., R.D., FASPEN Professor and Head, Kinesiology and Nutrition University Distinguished Teacher-Scholar University of Illinois

More information

British Journal of Nutrition

British Journal of Nutrition (2012), 107, 1 6 q The Authors 2011 doi:10.1017/s0007114511003400 Meta-analysis Impact of maternal supplementation with probiotics during pregnancy on atopic eczema in childhood a meta-analysis Katja Doege

More information

Homeopathic Products. Evidence??

Homeopathic Products. Evidence?? Homeopathic Products Principle of analogy or Law of Similars Small or infinitesimal doses (3X-30C) Avogadro s number=6x10 23 = ~23X Succussion and potentization (see http://www.boiron.com/en/htm/02_medi_hom

More information

Probiotics for Disease Prevention and Amelioration. Neerja Hajela, PhD Yakult Danone India Pvt. Ltd.

Probiotics for Disease Prevention and Amelioration. Neerja Hajela, PhD Yakult Danone India Pvt. Ltd. Probiotics for Disease Prevention and Amelioration Neerja Hajela, PhD Yakult Danone India Pvt. Ltd. Microbiology turns inwards Human Metagenome project and Meta Hit project reveals that the gut micro flora

More information

NEERJA HAJELA, PhD Head Science Yakult Danone India Pvt. Ltd.

NEERJA HAJELA, PhD Head Science Yakult Danone India Pvt. Ltd. NEERJA HAJELA, PhD Head Science Yakult Danone India Pvt. Ltd. What we already know. Functional Foods - foods that provide a health benefit beyond the traditional nutrients it contains.. American Dietetics

More information

Shifts in the Intestinal Microbiota

Shifts in the Intestinal Microbiota Shifts in the Intestinal Microbiota Therapeutic Opportunities for Pre- and Probiotics? Kelly A. Tappenden, Ph.D., R.D., FASPEN Kraft Foods Human Nutrition Endowed Professor Editor-in-Chief, Journal of

More information

Prevention and Therapy of Antibiotic Associated Diarrhea (ADD) through Probiotics

Prevention and Therapy of Antibiotic Associated Diarrhea (ADD) through Probiotics Prevention and Therapy of Antibiotic Associated Diarrhea (ADD) through Probiotics DGMIM, 15.-16.10.2010 16.10.2010 Stuttgart Prof. Rémy Meier, MD GI-Department University Hospital Liestal, Switzerland

More information

Emerging Probiotic Research: A Guide to the Use of Probiotics in Clinical Practice

Emerging Probiotic Research: A Guide to the Use of Probiotics in Clinical Practice Emerging Probiotic Research: A Guide to the Use of Probiotics in Clinical Practice Donald Brown, ND April 13, 2010 Probiotics WHO Definition: Live microorganisms, which when administered in adequate amounts,

More information

PROBIONA. PROBIOTICS with 5 bacterial strains. Suitable during and after the use of antibiotics to restore intestinal microflora.

PROBIONA. PROBIOTICS with 5 bacterial strains. Suitable during and after the use of antibiotics to restore intestinal microflora. PROBIONA Probiotic supplement for adults PROBIOTICS with 5 bacterial strains Suitable during and after the use of antibiotics to restore intestinal microflora. 2.850 billion cfu per capsule guaranteed

More information

Developing the potential of prebiotics and probiotics as immune health ingredients

Developing the potential of prebiotics and probiotics as immune health ingredients Developing the potential of prebiotics and probiotics as immune health ingredients ARTHUR OUWEHAND ACTIVE NUTRITION DUPONT NUTRITION & HEALTH 20 th November 2014, The gut microbiome The gut microbiota

More information

Probiotics and Health

Probiotics and Health Probiotics and Health March 2015 TABLE OF CONTENTS EXECUTIVE SUMMARY... 2 BACKGROUND AND DEFINITIONS... 4 FUNCTIONAL GASTROINTESTIINAL DISORDERS... 5 Irritable bowel syndrome... 5 Constipation... 6 INFLAMMATORY

More information

PROBIOTICS IN THE FIRST 1000 DAYS

PROBIOTICS IN THE FIRST 1000 DAYS PROBIOTICS IN THE FIRST 1000 DAYS 25 TH APRIL 2018 Rocio Martin Director Danone Nutricia Research Singapore 1 OUTLINE Probiotics Relevance of the first 1000 days Microbiota and health during the 1000 days

More information

Participants. probiotic. /placebo)

Participants. probiotic. /placebo) Table S1. Demographic characteristics of trials included in the meta-analysis. Study Birth weight (mean±sd) Gestation (wk) Feeding patterns Participants (probiotic /placebo) Probiotic agents Dosage Duration

More information

What Are Probiotics? PROBIOTICS

What Are Probiotics? PROBIOTICS PROBIOTICS What Are Probiotics? Probiotics are living, microscopic (very small) organisms that can help your gut health. Most often, probiotics are bacteria, but they may also be other organisms, such

More information

2/3/2011. Adhesion of Bifidobacterium lactis HN019 to human intestinal

2/3/2011. Adhesion of Bifidobacterium lactis HN019 to human intestinal PROBIOTICS LEARNING THE WHY AND WHEN PROBIOTICS DEFINITION live micro-organisms organisms that are beneficial to the host organism WHO: Live organisms which, when administered in adequate amounts, confer

More information

Microbiome, allergy and inflammatory diseases

Microbiome, allergy and inflammatory diseases Microbiome, allergy and inflammatory diseases 1. NCDs & inflammation 2. Microbiome &GI inflammatory pathologies 3. Microbiome & autoimmunity 4. Microbiome & neurophaties 5. Microbiome & NAFLD 6. Microbiome

More information

Probiotics for Primary Prevention of Clostridium difficile Infection

Probiotics for Primary Prevention of Clostridium difficile Infection Probiotics for Primary Prevention of Clostridium difficile Infection Objectives Review risk factors for Clostridium difficile infection (CDI) Describe guideline recommendations for CDI prevention Discuss

More information

Probiotics and Prebiotics: Medicine or Myth. Objectives 5/31/2013. Speaker s Disclosure Statement & Non Commercialism Agreement

Probiotics and Prebiotics: Medicine or Myth. Objectives 5/31/2013. Speaker s Disclosure Statement & Non Commercialism Agreement Probiotics and Prebiotics: Medicine or Myth Gregory Matsuura, Pharm.D., BCPS (AQ ID) Objectives Recall the differences between prebiotics and probiotics and their uses Identify the specific agents used

More information

Probiotics- basic definition

Probiotics- basic definition Haworth Press 2007 Probiotics Terms: Probiotic Probiotics are live microorganisms (bacteria or yeasts) which, when administered in adequate amounts, confer a health benefit on the host Prebiotic - nutritional

More information

7/30/2018. Nutricia North America 1. Learning Objectives

7/30/2018. Nutricia North America 1. Learning Objectives Probiotics, Prebiotics and the Role of the Infant Intestinal Microbiota in Health and Allergic Disease Kelly Tappenden, Ph.D, R.D. Kelly Tappenden, Ph.D, R.D. Professor and Department Head Department of

More information

Clinical Report Probiotics and Prebiotics in Pediatrics

Clinical Report Probiotics and Prebiotics in Pediatrics FROM THE AMERICAN ACADEMY OF PEDIATRICS Guidance for the Clinician in Rendering Pediatric Care Clinical Report Probiotics and Prebiotics in Pediatrics Dan W. Thomas, MD, Frank R. Greer, MD, and COMMITTEE

More information

Next generation of probiotics

Next generation of probiotics Session: Evaluating next generation ingredients to support digestive health Wednesday 23 rd November 2016 Next generation of probiotics Louise R Wilson RD PhD Assistant Science Manager, Yakult UK Ltd LWilson@yakult.co.uk

More information

The Global Trends in Evaluation and Regulations of Intestine related Functional Foods

The Global Trends in Evaluation and Regulations of Intestine related Functional Foods The Global Trends in Evaluation and Regulations of Intestine related Functional Foods Keun Uk Ji, M.D. Department of Human and Food Seoul National University, College of Ecology E mail : geji@bifido.com

More information

Dr Warren Hyer Consultant Paediatric Gastroenterologist

Dr Warren Hyer Consultant Paediatric Gastroenterologist Dr Warren Hyer Consultant Paediatric Gastroenterologist Probiotics a cure for all? No conflict of interest to declare Aims To change your opinion of probiotic use in children To base your decision on high

More information

Probiotics and prevention of NEC

Probiotics and prevention of NEC Probiotics and prevention of NEC Indirect evidence Innate recognition of of bacteria in in human milk is is mediated by by a milk-derived highly expressed pattern recognition receptor, soluble CD14C MO

More information

Bio Pro 365. Product Summary. Ingredients. Prebiotic Probiotic Blend. Bio Pro 365 is a comprehensive and clinically-tested pre- and probiotic blend

Bio Pro 365. Product Summary. Ingredients. Prebiotic Probiotic Blend. Bio Pro 365 is a comprehensive and clinically-tested pre- and probiotic blend Bio Pro 365 Prebiotic Probiotic Blend Product Summary Bio Pro 365 is a comprehensive and clinically-tested pre- and probiotic blend specifically designed to protect and enhance all aspects of the digestion

More information

Evaluating next generation ingredients to support immune health. Dr Carrie Ruxton Freelance Dietitian

Evaluating next generation ingredients to support immune health. Dr Carrie Ruxton Freelance Dietitian Evaluating next generation ingredients to support immune health Dr Carrie Ruxton Freelance Dietitian What is the immune system? Innate Physical barriers i.e. skin Natural killer cells Macrophages Acquired

More information

Probiotic. Prebiotics:

Probiotic. Prebiotics: Probiotic This product has been formulated using a blend of select prebiotics with a wide array of probiotics, designed to naturally strengthen the immune system. The organisms in this formula are synergistic

More information

Probiotics : What we Know and Where we are Going Next

Probiotics : What we Know and Where we are Going Next Probiotics : What we Know and Where we are Going Next Neerja Hajela, Ph.D. General Manager - Science and Regulatory Affairs Yakult Danone India Pvt. Ltd. Functional Food Market Probiotics an important

More information

Examining the effects of pre and probiotics on gut microbiota during the ageing process

Examining the effects of pre and probiotics on gut microbiota during the ageing process Session: Reviewing key ingredients shaping nutrition for healthy ageing Tuesday 22 nd November 2016 Examining the effects of pre and probiotics on gut microbiota during the ageing process Louise R Wilson

More information

Diet during pregnancy. and atopic disease

Diet during pregnancy. and atopic disease Diet during pregnancy and atopic disease 1. Elimination diet 2. Probiotics 3. LCPUFA 4. Conclusions Maternal elimination diet during pregnancy? NO! Prescription of of an an antigen avoidance diet to to

More information

Fonterra Probiotics: From guts to glory

Fonterra Probiotics: From guts to glory Fonterra Probiotics: From guts to glory James Dekker April 16, 2015 Host Institution Probiotic bacteria Live micro-organisms which, when administered in adequate amounts, confer a health benefit on the

More information

Health Benefits of Prebiotic Dietary Fiber

Health Benefits of Prebiotic Dietary Fiber Health Benefits of Prebiotic Dietary Fiber JENNIFER ERICKSON, PhD, RD Objectives Provide some background on dietary fiber To define the term "prebiotic dietary fiber" To discuss potential health effects

More information

Probiotics, Prebiotics and the Role of the Infant Intestinal Microbiota in Health and Allergic Disease. Kelly Tappenden, Ph.D, R.D.

Probiotics, Prebiotics and the Role of the Infant Intestinal Microbiota in Health and Allergic Disease. Kelly Tappenden, Ph.D, R.D. Probiotics, Prebiotics and the Role of the Infant Intestinal Microbiota in Health and Allergic Disease Kelly Tappenden, Ph.D, R.D. Kelly Tappenden, Ph.D, R.D. Professor and Department Head Department of

More information

Assessment of increase in probiotic potential of Lactobacillus strains fortified with Aloe vera

Assessment of increase in probiotic potential of Lactobacillus strains fortified with Aloe vera Original Article International Journal of Life Sciences International Peer Reviewed Open Access Refereed Journal Int. J. of Life Sciences, 2019; 7 (1):102-106 ISSN:2320-7817(p) 2320-964X(o) Open Access

More information

Study summaries L. casei 431

Study summaries L. casei 431 This binder provides you with summaries of selected publications on Lactobacillus paracasei subsp. paracasei L. casei 431. The publications are clinical studies performed in humans documenting the effects

More information

EED INTERVENTIONS 3.0

EED INTERVENTIONS 3.0 EED INTERVENTIONS 3.0 Produced by: Kidane, L.; Osterman, A.; Babigumira, J. Agenda Agenda Project Background and Objectives Approach & Rationale Methods Results Discussion and Next Steps 2 Project Background

More information

Antibiotic Resistance and Probiotics - A Metagenomic Viewpoint

Antibiotic Resistance and Probiotics - A Metagenomic Viewpoint Antibiotic Resistance and Probiotics - A Metagenomic Viewpoint Neerja Hajela, PhD General Manager-Science & Regulatory Affairs Yakult Danone India Pvt. Ltd. Outline of the Presentation Global Epidemiology

More information

Probiotics and Prebiotics: Frequently Asked Questions

Probiotics and Prebiotics: Frequently Asked Questions 1. What are probiotics? Our intestines contain over 100 trillion bacteria. This is 1,000 times the number of cells that make up the entire human body. Many of these bacteria play an important role in protecting

More information

EED INTERVENTIONS: PRE- AND PRO-BIOTIC SAFETY

EED INTERVENTIONS: PRE- AND PRO-BIOTIC SAFETY EED INTERVENTIONS: PRE- AND PRO-BIOTIC SAFETY Produced by: Dietrich, C.; Kidane, L.; Babigumira, J. Agenda Agenda Timeline Project Background and Objectives Key Takeaways Approach & Rationale Methods Results

More information

PROBIOTICS NEGATIVE ASPECTS

PROBIOTICS NEGATIVE ASPECTS PROBIOTICS NEGATIVE ASPECTS Dr Ismail Moola Department of Medical Gastroenterology CMJAH University of Witwatersrand Putative Benefits of Probiotics Modulate Immune Intestinal Function Increase secretory

More information

11/4/10. Making Sense of Infant Formulas, Milk Fortifiers and Additives. Components of infant formula. Goals of Growth.

11/4/10. Making Sense of Infant Formulas, Milk Fortifiers and Additives. Components of infant formula. Goals of Growth. Components of infant formula Making Sense of Infant Formulas, Milk Fortifiers and Additives Jae Kim, MD, PhD UCSD Medical Center Division of Neonatal-Perinatal Medicine Division of Pediatric Gastroenterology,

More information

PROSPERO International prospective register of systematic reviews

PROSPERO International prospective register of systematic reviews PROSPERO International prospective register of systematic reviews The effect of probiotics on functional constipation: a systematic review of randomised controlled trials EIRINI DIMIDI, STEPHANOS CHRISTODOULIDES,

More information

Probiotics. Wide spectrum of important health benefits

Probiotics. Wide spectrum of important health benefits Probiotics Part 1: What Are Probiotics? Probiotics are live microorganisms that inhabit the respiratory and gastrointestinal tracts and the skin. They are often referred to as friendly bacteria as they

More information

The impact of the microbiome on brain and cognitive development

The impact of the microbiome on brain and cognitive development The Gut-Brain Axis The impact of the microbiome on brain and cognitive development Diane Stadler, PhD, RD Oregon Health & Sciences University, Portland, Oregon Lao-American Nutrition Institute With acknowledgements

More information

The Gut Microbiome: 101 Justin Carlson University of Minnesota

The Gut Microbiome: 101 Justin Carlson University of Minnesota The Gut Microbiome: 101 Justin Carlson University of Minnesota Where are we now? 360 B.C. 2003 Human Gut Microbes Associated With Obesity Ley et al., Nature. 2006. Consumer Driven Science For Better of

More information

Probiotics: Implications for Pediatric Health

Probiotics: Implications for Pediatric Health Probiotics: Implications for Pediatric Health PREFACE It is no longer questioned that the interplay between our genes, nutrition, and our environment hold the keys to growth, development, and health.

More information

Center For Holistic Healthcare & Education

Center For Holistic Healthcare & Education Center For Holistic Healthcare & Education We are lemployee BENEFITS OF PROBIOTICS page!2 THE FUNCTIONS & BENEFITS OF 18 PROBIOTIC STRAINS 1. Bifidobacterium bifidum: Reduce liver enzymes Increase cell

More information

Formulations and Availability 900 BILLION 5,319 HIGH POTENCY PROBIOTIC PEDIATRIC ADULT GERIATRIC PROVEN BY RESEARCH. HIGH-POTENCY. NO SHORTCUTS.

Formulations and Availability 900 BILLION 5,319 HIGH POTENCY PROBIOTIC PEDIATRIC ADULT GERIATRIC PROVEN BY RESEARCH. HIGH-POTENCY. NO SHORTCUTS. Formulations and Availability S TU D I E S PE R D I S E A S E 39 LIVER Liver Disease, Cirrhosis, Liver Failure, Hepatic Encephalopathy S TU D I E S PE R AG E G RO U P Visbiome Regular Product Code: 693-0412-01

More information

When can infants and children benefit from probiotics?

When can infants and children benefit from probiotics? When can infants and children benefit from probiotics? The latest studies indicate that probiotics can help with colic, eczema, and certain types of diarrhea. They may also help with upper respiratory

More information

Probiotics and Allergic Rhinitis G.A.Richards

Probiotics and Allergic Rhinitis G.A.Richards Probiotics and Allergic Rhinitis G.A.Richards MBBCh PhD FCP(SA) FRCP Academic Head Critical Care University of the Witwatersrand Director Critical care CMJAH The Microbiome Microbial species & their associated

More information

The Gut Factor. Probiotics, the gut microbiome and human health. Thursday November 10, 2016 l 12:00 pm

The Gut Factor. Probiotics, the gut microbiome and human health. Thursday November 10, 2016 l 12:00 pm The Gut Factor Probiotics, the gut microbiome and human health Thursday November 10, 2016 l 12:00 pm Dr. Elena Comelli is an Assistant Professor and holds the Lawson Family Chair in Microbiome Nutrition

More information

What do Cochrane systematic reviews say about probiotics as preventive interventions?

What do Cochrane systematic reviews say about probiotics as preventive interventions? COCHRANE HIGHLIGHT DOI: 10.1590/1516-3180.2017.0310241017 What do Cochrane systematic reviews say about probiotics as preventive interventions? Vinícius Lopes Braga I, Luana Pompeu dos Santos Rocha II,

More information

Issue 3, September usio

Issue 3, September usio Issue 3, September 2014 usio 1 Lactobacillus casei strain Shirota Research Update IMPROVEMENT IN INTESTINAL HEALTH 1. A probiotic fermented milk drink containing Lactobacillus casei strain Shirota improves

More information

Role of Food Matrix for Probiotic Effects

Role of Food Matrix for Probiotic Effects Role of Food Matrix for Probiotic Effects W. Kneifel Department of Food Science and Technology BOKU University of Natural Resources and Life Sciences Vienna Hohenheim, 15 Oct.. 2010 wolfgang.kneifel@boku.ac.at

More information

Cynthia Belew, CNM, WHNP C Associate Clinical Professor University of California San Francisco

Cynthia Belew, CNM, WHNP C Associate Clinical Professor University of California San Francisco Cynthia Belew, CNM, WHNP C Associate Clinical Professor University of California San Francisco cynthia.belew@ucsf.edu Be educated about and have index of suspicion for gluten sensitivity disorders Be alert

More information

LET S TALK BUGS! THE ROLE OF PROBIOTICS IN PATIENT HEALTH AND DISEASE PREVENTION. Dragana Skokovic-Sunjic RPh BScPhm NCMP

LET S TALK BUGS! THE ROLE OF PROBIOTICS IN PATIENT HEALTH AND DISEASE PREVENTION. Dragana Skokovic-Sunjic RPh BScPhm NCMP LET S TALK BUGS! THE ROLE OF PROBIOTICS IN PATIENT HEALTH AND DISEASE PREVENTION Dragana Skokovic-Sunjic RPh BScPhm NCMP OUTLINE After the presentation, pharmacists will be able to: 1. Review and discuss

More information

11/2/2016. Objectives. Definition of probiotics. What is and what is not a probiotic? What is and what is not a probiotic?

11/2/2016. Objectives. Definition of probiotics. What is and what is not a probiotic? What is and what is not a probiotic? A Consumer s Guide to Probiotics and Health Wellness Wednesday November 2, 2016 Wendy Dahl RD PhD FDC Associate Professor, Food Science and Human Nutrition, UF/IFAS Objectives To outline current evidence

More information

PROBIOTIC RESEARCH REVIEW

PROBIOTIC RESEARCH REVIEW Probiotics in the Prevention of Eczema: A Randomised Controlled Trial (Allen at al. 2014) The probiotic formula that is used in GENESTRA BRANDS HMF Baby B and HMF Baby F was found to safely and effectively

More information

Probiotic yoghurt and supplements: Retail sales in the EU Supplements and yoghurts to record 4%, and -1% growth over

Probiotic yoghurt and supplements: Retail sales in the EU Supplements and yoghurts to record 4%, and -1% growth over Probiotic yoghurt and supplements: Retail sales in the EU Supplements and yoghurts to record 4%, and -1% growth over 217-218 1 Probiotic yoghurt and supplements in the EU, retail sales, 29-218 7 1% 6 8%

More information

PROBIOTICS: WHO S WHO AND WHAT S WHAT IN THE GUT PROBIOTICS: WHAT ARE THEY, AND HOW DO THEY WORK? Karen Jensen, (Retired ND)

PROBIOTICS: WHO S WHO AND WHAT S WHAT IN THE GUT PROBIOTICS: WHAT ARE THEY, AND HOW DO THEY WORK? Karen Jensen, (Retired ND) PROBIOTICS: WHO S WHO AND WHAT S WHAT IN THE GUT Karen Jensen, (Retired ND) Today many people are aware of the benefits of maintaining a healthy gut. As a result, probiotic use is becoming ever more popular.

More information

Probiotics & prebiotics in disease - relevance for clinical practice

Probiotics & prebiotics in disease - relevance for clinical practice Probiotics & prebiotics in disease - relevance for clinical practice Ian Rowland Department of Food and Nutritional Sciences University of Reading UK i.rowland@reading.ac.uk What is a probiotic? Probiotics

More information

PROBIOTICS. what they are and what they can do for you. A patient s guide from your doctor and

PROBIOTICS. what they are and what they can do for you. A patient s guide from your doctor and PROBIOTICS what they are and what they can do for you A patient s guide from your doctor and Probiotics Products containing probiotics have flooded the market in recent years. As more people seek natural

More information

The Intestinal Microbiota and the Developing Immune System

The Intestinal Microbiota and the Developing Immune System The Intestinal Microbiota and the Developing Immune System 4 Feb 2016 The Intestinal Microbiota 10 fold more bacterial cells than human cells 100-1000 fold more bacterial genes than human genes Why does

More information

Bringing Synbiotic Interventions in Cancer to Practice: from bench to bedside The UC Davis Foods for Health Institute

Bringing Synbiotic Interventions in Cancer to Practice: from bench to bedside The UC Davis Foods for Health Institute Bringing Synbiotic Interventions in Cancer to Practice: from bench to bedside The UC Davis Foods for Health Institute Jennifer T. Smilowitz, PhD Associate Director, Human Studies Research jensm@ucdavis.edu

More information

Q What are Probiotics?

Q What are Probiotics? Q What are Probiotics? The word PROBIOTIC was originated from Latin and means For Life. Probiotics are good bacteria usually found in food products or supplements which play very important roles in regulating

More information

BJD. Summary. British Journal of Dermatology PAEDIATRIC DERMATOLOGY

BJD. Summary. British Journal of Dermatology PAEDIATRIC DERMATOLOGY PAEDIATRIC DERMATOLOGY BJD British Journal of Dermatology Lactobacillus salivarius plus fructo-oligosaccharide is superior to fructo-oligosaccharide alone for treating children with moderate to severe

More information

Update on Probiotic Use in Children with Diarrhoea

Update on Probiotic Use in Children with Diarrhoea Update on Probiotic Use in Children with Diarrhoea Ahmed Laving Paediatric Gastroenterologist and Senior Lecturer, University of Nairobi KPA Annual Scientific Meeting, Kisumu 2017 Outline Physiology of

More information

Sunday, May 1, 16.

Sunday, May 1, 16. http://6abc.com/health/healthcheck-foodsthat-may-improve-your-digestion/547915/ The world of probiotics rajiv K sharma md Dr. RAJIV SHARMA is a Board Certified Physician. He is a practicing Gastroenterologist

More information

Safety of Saccharomyces boulardii (Florastor) in Solid Organ Transplant Patients

Safety of Saccharomyces boulardii (Florastor) in Solid Organ Transplant Patients Butler University Digital Commons @ Butler University Undergraduate Honors Thesis Collection Undergraduate Scholarship 5-12-2012 Safety of Saccharomyces boulardii (Florastor) in Solid Organ Transplant

More information

Lactobacillus bulgaricus

Lactobacillus bulgaricus probiotic Lactobacillus bulgaricus Danone " : : * * * * * Bifidobacterium (LactobacillusCG) (Saccharomyce) (Bifidobacterium) (Antibiotic related diarrhea) GG L (Cytoprotection) B IgA lgg Probiotics -

More information

Probiotics: Their Role in Medicine Today. Objectives. Probiotics: What Are They? 11/3/2017

Probiotics: Their Role in Medicine Today. Objectives. Probiotics: What Are They? 11/3/2017 Probiotics: Their Role in Medicine Today Viki Barr Pharm.D., BCPS AQ ID Assistant Professor, Pharmacy Practice Rosalind Franklin University of Medicine and Science Clinical Pharmacist, Infectious Diseases

More information

Probiotics. Gastrointestinal Health & Disease. in conjunction with American College of Gastroenterology Annual Scientific Meeting

Probiotics. Gastrointestinal Health & Disease. in conjunction with American College of Gastroenterology Annual Scientific Meeting X E C U E T I V E P R O C E E D I N G S Symposium in conjunction with American College of Gastroenterology Annual Scientific Meeting Probiotics Applications in Gastrointestinal Health & Disease Made Possible

More information

Probiotic Use in Neonates

Probiotic Use in Neonates a 28 D YS Probiotic Use in Neonates p Julie Zupancic, RN, MSN, CNP NEC is the most common gastrointestinal emergency in premature infants http://nwh.awhonn.org Premature infants are in the unique situation

More information

International Journal of Food and Allied Sciences

International Journal of Food and Allied Sciences International Journal of Food and Allied Sciences ISSN: 2415-0290 (Print) ISSN: 2413-2543 (Online) DOI:10.21620/ijfaas.2017120-26 Research Article History The Role of Saccharomyces boulardii in the Treatment

More information

ROLE OF THE GUT BACTERIA

ROLE OF THE GUT BACTERIA ROLE OF THE GUT BACTERIA Our Good Bacteria In a perfect world, we would all have a proper ratio of good bacteria And what could this proper ratio do for us? The knowledge of the connections between our

More information

B. lactis LAFTI B94 DOCUMENTED PROBIOTIC STRAIN. DEDICATED TO HEARTY KIDS. B. lactis. Health claims. References. White paper

B. lactis LAFTI B94 DOCUMENTED PROBIOTIC STRAIN. DEDICATED TO HEARTY KIDS. B. lactis. Health claims. References. White paper White paper Health claims Natural and Non-prescription Health Products Directorate (NNHPD), the regulatory agency for natural health products in Canada, has approved health claims for, such as: Helps support

More information

THE MISSING PIECE IN AUTISM DIAGNOSIS: COULD WE BE OVERLOOKING THE GUT MICROBIOME?

THE MISSING PIECE IN AUTISM DIAGNOSIS: COULD WE BE OVERLOOKING THE GUT MICROBIOME? THE MISSING PIECE IN AUTISM DIAGNOSIS: COULD WE BE OVERLOOKING THE GUT MICROBIOME? ALTERNATIVEMEDICINE.COM SUBCONSCIOUS SUGGESTION: WE TRY HYPNOTHERAPY The Color Run: 5 TIPS TO BEAT THE BUGS HORSES THAT

More information

Rapid Recovery Hyperbarics 9439 Archibald Ave. Suite 104 Rancho Cucamonga CA,

Rapid Recovery Hyperbarics 9439 Archibald Ave. Suite 104 Rancho Cucamonga CA, Clinical Gastroenterology and Hepatology Gastroenterologist's Guide to Probiotics Matthew a. Ciorba, MD Posted: 09/13/2012; Clin Gastroenterol Hepatol. 2012;10(9):960-968. 2012 G Institute bstract and

More information

The Egyptian Journal of Hospital Medicine (Apr. 2017) Vol.67 (2), Page

The Egyptian Journal of Hospital Medicine (Apr. 2017) Vol.67 (2), Page The Egyptian Journal of Hospital Medicine (Apr. 2017) Vol.67 (2), Page 666-671 The Prophylactic Role of Probiotics for Preterm Infants/Neonates Abdulrahman Mohammedsaeed Baqasi 1, Ali Hussain ALAbdullah

More information

Objectives. The Uses and Dangers of Probiotics 9/23/2014

Objectives. The Uses and Dangers of Probiotics 9/23/2014 The Uses and Dangers of Probiotics Megan Koyle, Pharm.D. Anthony Nelson, Pharm.D. PGY1 residents Boise VAMC Objectives Describe and define probiotics List common products on the market Review possible

More information

The role of gut microbiome in IBS

The role of gut microbiome in IBS The role of gut microbiome in IBS Chung Owyang, MD H. Marvin Pollard Professor of Internal Medicine Professor of Molecular and Integrative Physiology Chief, Division of Gastroenterology Director, Pollard

More information

PROBIOTICS. The Ultimate Flora Difference

PROBIOTICS. The Ultimate Flora Difference In the Refrigerator Section! PROBIOTICS High-Potency Daily, Critical Care and Targeted Probiotic Formulas to Improve Regularity, Strengthen Natural Defenses and Promote Overall Digestion * The ReNew Life

More information

JMSCR Vol 05 Issue 11 Page November 2017

JMSCR Vol 05 Issue 11 Page November 2017 www.jmscr.igmpublication.org Impact Factor 5.84 Index Copernicus Value: 71.58 ISSN (e)-2347-176x ISSN (p) 2455-0450 DOI: https://dx.doi.org/10.18535/jmscr/v5i11.139 The Effect of Synbiotics on the Duration

More information

PROFESSIONAL FORMULATION. ProBiotic & ProBiotic Multi. Probiotics: A Common Sense Discussion

PROFESSIONAL FORMULATION. ProBiotic & ProBiotic Multi. Probiotics: A Common Sense Discussion PROFESSIONAL FORMULATION ProBiotic & ProBiotic Multi ProBiotic (V-PB) 25 Billion C.F.U/gram 90 capsules per bottle Non-Dairy ProBiotic Multi (V-PBM) 15 Billion C.F.U./gram 45 capsules per bottle Non-Dairy

More information

The effect of probiotics on animal health: a focus on host s natural intestinal defenses

The effect of probiotics on animal health: a focus on host s natural intestinal defenses The effect of probiotics on animal health: a focus on host s natural intestinal defenses Guillaume Tabouret Animal Health Dept. Joint Unit 1225 Host Pathogens Interactions History of probiotics and definition

More information

Index. B Bacitracin Lactobacillus acidophilus, 70 pyelonephritis, 246 Antifungals

Index. B Bacitracin Lactobacillus acidophilus, 70 pyelonephritis, 246 Antifungals A AAD, see Antibiotic-associated diarrhea Absorption Bifidobacterium species animals,67 humans,67 biotherapeutic agents, 47 Lactobacillus species, 61 Saccharomyces boulardii animals, 50, 51 humans,57 Absorption,

More information

WHAT IS THE EVIDENCE FOR PROBIOTIC SUPPLEMENTATION?

WHAT IS THE EVIDENCE FOR PROBIOTIC SUPPLEMENTATION? WHAT IS THE EVIDENCE FOR PROBIOTIC SUPPLEMENTATION? Roger F. Soll, MD H. Wallace Professor of Neonatology University of Vermont President Vermont Oxford Network 19 th International Symposium on Neonatology

More information

Original Article. Introduction Antibiotic associated diarrhoea

Original Article. Introduction Antibiotic associated diarrhoea 24 Journal of the association of physicians of india october 2013 VOL. 61 Original Article Randomised Placebo-controlled Double Blind Multicentric Trial on Efficacy and Safety of Lactobacillus acidophilus

More information

Is It Possible to Prevent Necrotizing Enterocolitis?

Is It Possible to Prevent Necrotizing Enterocolitis? Is It Possible to Prevent Necrotizing Enterocolitis? Ravi Mangal Patel, MD MSc Associate Professor of Pediatrics Emory University School of Medicine, Atlanta, GA, USA @institutopgg @ravimpatelmd Disclosures

More information

Management of Diarrhea in Critical Ill Patients CCSSA Congress Sun City 20. October 2017

Management of Diarrhea in Critical Ill Patients CCSSA Congress Sun City 20. October 2017 Management of Diarrhea in Critical Ill Patients CCSSA Congress Sun City 20. October 2017 Prof. em Rémy Meier MD University of Basel Gastro-Center Obach Solothurn, Switzerland Outline Definition of diarrhea

More information

Pthaigastro.org. Drugs Used in Acute Diarrhea: Cons. Nipat Simakachorn, M.D. Department of Pediatrics Maharat Nakhon Ratchasima Hospital.

Pthaigastro.org. Drugs Used in Acute Diarrhea: Cons. Nipat Simakachorn, M.D. Department of Pediatrics Maharat Nakhon Ratchasima Hospital. Drugs Used in Acute Diarrhea: Cons Nipat Simakachorn, M.D. Department of Pediatrics Maharat Nakhon Ratchasima Hospital 27-Apr-2012 Optimistic Pessimistic Global percentage of children

More information

More than a gut feeling: How the microbiota improves health

More than a gut feeling: How the microbiota improves health More than a gut feeling: How the microbiota improves health Amanda Ramer-Tait, PhD Harold and Esther Edgerton Assistant Professor of Immunology and Microbiology Department of Food Science, University of

More information

!Microbiology Profile, stool

!Microbiology Profile, stool LAB #: F000000-0000-0 PATIENT: Sample Patient ID: P12345 SEX: Female AGE: 37 CLIENT #: 12345 DOCTOR: Doctor's Data, Inc. 3755 Illinois Ave. St. Charles, IL 60174!Microbiology Profile, stool BACTERIOLOGY

More information