Improve medication safety for patients Build a community of patients for clinical research

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Egbert Henderson
5 years ago
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2 Challenge - October 2007 Improve medication safety for patients Build a community of patients for clinical research heavy touch light touch disease specific general?

3 Patients are Increasingly Using the Internet to Seek Health Information In 2009, million U.S. adults went online for prescription drug information; more than 2x the number in 2004 (45.7 million) 1 Drivers of the rapid growth include: Older consumers becoming more comfortable with the Internet An increase in the number of U.S. adults taking one or more medication Health care costs/cost sharing 30 million people in the UK access the internet every day (60%) ~40% seeking health related information ~50% of French people go regularly on the web to find medical information Each month, 1 out of 3 internet users goes to a website dedicated to health, wellbeing, or nutrition Office of National Statistics: Internet Access 2010: 3. Jupiter Research 2008; Benchmark Group 2008.

4 Internet Growth has Fueled the Emergence of On-line Patient Pools General networking sites Facebook Linked In Health-related social networks WeAre Patientslikeme TalkHealth Partnership General on-line panels My points Harris Interactive On-line health services iguard.org Microsoft HealthVault (PHR) All of these on-line patient pools differ from health information portals that post information, but do not have a consented, on-going relationship with patients

5 MediGuard is The largest medication monitoring service The largest patient-centric research platform in the world 2.4M Oct 07 Sep 10

MediGuard users get http://au.mediguard.

6 MediGuard users get FREE medication safety checks RAPID medication safety alerts and recalls ACCESS to feedback from thousands of patients

7 Patients join by REFERRAL through Quintiles partner sites OUTREACH in Quintiles clinical clusters REFERRAL though MediGuard s API partners Healthcare providers, hospitals, pharmacies E-Prescribing platforms, PHRs Patient advocacy groups Online properties / health portals

8 Rapid Access to Targeted Patients Feb 10: Oct 10: UK France Germany Spain Australia 8

9 UK Coverage of Almost All Chronic Medicines - 1,000 2,000 3,000 4,000 5,000 6,000 Hypertension Cholesterol lowering Antidepressants Non-narcotic Pain H2/PPI Antidiabetics Anticoagulants Antiepileptics Atypical antipsychotics Respiratory Antihistamines Opioids Osteoporosis Insomnia ADHD Thyroid DMARDs OAB Migraine AD/Dementia ,785 1,671 1,584 1,540 1,456 1,350 2,615 2,598 2,430 2,416 2,361 3,314 3,281 5,527 October, For more information visit: uk.mediguard.org 9

Celebrating 3 Years of Working with Patients 10/07 website launch 2008 build to 1 million

information arises Scan for interactions and personalized risk ratings Feedback from other

2010 Clinical Recruitment + Int l Expansion 200+ Surveys ~25,000 people UK, FR, DE, ES, AU

10 Celebrating 3 Years of Working with Patients 10/07 website launch 2008 build to 1 million Safety alerts Safety checks Patient reviews Medication list updates as new safety information arises Scan for interactions and personalized risk ratings Feedback from other members on side effects and other information Printable list of medications 2009 Surveys 2010 Clinical Recruitment + Int l Expansion 200+ Surveys ~25,000 people UK, FR, DE, ES, AU 2011 Patient Centric Studies! Clinical: Observational Studies Commercial: Adherence Programs

11 Single US-based Platform, Global Footprint Exploring: India South Africa Others o China o Japan o Brazil Dec 2009: UK launched Oct 2010: France, Germany, Australia launched as MediGuard; UK name switch Nov 2010: Spain Dec 2010: Conversion of US to MediGuard name 11

12 Improving Research Efficiency

13 What s New: QuickStart Being Piloted Through AZ EPMT Model QuickStart Quintiles unique clinical trial acceleration that delivers 3 to 5 pre-qualified iguard.org patients to a site at the time site activation Faster protocol operational feedback Faster site performance feedback More efficient initial CRA site visits Faster time to first randomization Patient referral service Supplements recruitment by referring pre-qualified patients to a site Quintiles/Sponsor can select sites/geographies and control the rate of referrals 13

What s New: iguard Patient Story (1) Meet Joanne: Age 54 with Rheumatoid Arthritis Joanne was diagnosed by a rheumatologist about 5 years ago and is currently treated with methotrexate.

I have a hard time dealing with the flares as I sometimes can't do all of the things I want to do when I'm in pain or my joints are stiff. Sometimes it is even difficult to drive or do my job.

14 What s New: iguard Patient Story (1) Meet Joanne: Age 54 with Rheumatoid Arthritis Joanne was diagnosed by a rheumatologist about 5 years ago and is currently treated with methotrexate. Although she only has RA, several of her friends with RA also have fibromyalgia RA has a significant impact on Joanne s daily life. RA makes me very tired. I have a hard time dealing with the flares as I sometimes can't do all of the things I want to do when I'm in pain or my joints are stiff. Sometimes it is even difficult to drive or do my job. I do the best I can, and take my medication every day. I'd be lost without my medication. Joanne says that she is satisfied with her current RA medication, but like the majority of community-based RA patients, she self-reports at least 6 painful joints and may benefit from more advanced treatment. She has never been in a clinical trial before, but is somewhat interested in a study. Her primary concerns are related to the need for injections/infusions and the time off work required for the study. Reimbursement for time and travel is also important to Joanne Specifically, she recommended the following to facilitate participation: Number 1 - Make sure that off work hours are the primary time for appointments. It's bad enough having to miss work for the disease itself, and the normal doctor visits. Having them after normal work hours would be fantastic. Number 2 - A higher stipend for participating. Profile developed based on an iguard.org survey of 50 RA patients treated with oral DMARDs.

15 What s New: Surveys Contain Question to Collect Data for Concept Development (e.g., Crohn s) Makes my life miserable - constantly watching my diet - embaressed to be out in public during flare ups When my Crohn's is active I'm miserable. I'm afraid to go anywhere away from my house, and if I do go somewhere, I try not to eat or drink anything well before I leave and while I'm out of the house. The high volume of liquid stools can be very distressing and messy; definitely professionally awkward at times. I've had episodes on planes where I've had to argue with a stewardess about using the bathroom when seatbelt light was on. The most difficult issue is the lack of predictability. Symptoms come & go without warning. It is impossible to go anywhere without preplanning - available bathrooms, change of clothing, etc. Social activities are stressful. You never realize the unavailability of clean, accessible bathrooms until you are met with these symptoms. The accompanying Crohn's arthritis is painful and deters many activities, as does the extreme fatigue. It is a constant battle to keep it under control. It never ends. I miss events with family and friends and sometimes work due to the symptoms. It is embarasing to have to run to the bathroom and fear you won't make it and I will not go campimg anymore because I am afraid to go places with little or no access to restrooms

16 For More Information, Please Contact

Engaging Patients in Research to Increase Efficiency and Generate Real-World Data

Engaging Patients in Research to Increase Efficiency and Generate Real-World Data Chris Kula-Przezwanski Partnering Director Quintiles Digital Patient Unit 2 THE ENVIRONMENT Research Challenges 2005: PRNewswire