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1 The tudy lited may include approved and non-approved ue, formulation or treatment regimen. The reult reported in any ingle tudy may not reflect the overall reult obtained on tudie of a product. Before precribing any product mentioned in thi Regiter, healthcare profeional hould conult precribing information for the product approved in their country. GSK Medicine: e Study Number: RH01690 Title: Panadol oteo PBS claim cohort tudy report Rationale: Comparion of the ue of e para with tandard doe para in a cohort of 10% ample of Autralian conceional patient with oteoarthriti (OA) Study Period: 1 Jan Dec 2010 Objective: To compare the ue of e para with tandard para 500 mg X in a cohort of Autralian conceional patient with OA, to ae difference in precribing pattern and patient compliance Indication: Oteoarthriti Study Invetigator/Center: There were no invetigator center Reearch Method: A long-term conceional cohort from the Medicare Autralia PBS claim dataet for the time period (4 year) wa ued. Epiode of treatment for OA were identified uing para ( e or ) for the period January December 2010 (2 year) to allow 1 year retropective and 1 year propective for all patient elected. Data Source: Medicare Autralia PBS claim dataet Study Deign: Participant uffering from OA who received e or, from 1 Jan Dec 2010 were elected. New uer (no hitory of OA para in previou 12 month) were eparated from previou uer (hitory of OA para in previou 12 month). Dipened precription were followed for 12 month propectively and 12 month retropectively. Study Population: Participant aged year who were precribed para for OA in the time frame 1 Jan Dec 2010 were elected. Thoe uffering from rheumatoid arthriti or any auto-immune inflammatory condition, taking immunomodulator or treatment for cancer pain were exclu from the tudy. Study Expoure, Outcome: Peritence with medication Data Analyi Method: Two ample t-tet wa ued for numerical data comparion. To compare between rate, tet for difference in two proportion wa ued. Chiquare tet wa ued to look for aociation in cro tabulation. KM treatment peritence curve were compared uing the proportional hazard mode. Limitation: Potential for election bia between patient initiated on longer acting and horter acting para product Script dipened are aumed to be taken by the patient Over-the-counter analgeic ue i not inclu Defined daily doe are ued to calculate analgeic equivalent Study Reult: The majority of conceional patient were female (64%) and aged between 70 and 85 year (61%). The majority were newly initiated to para (62%), rather than previou para uer. Table 1: Conceional patient analgeic ue characteritic All Patient Pot Patient* cript AED Patient cript AED e * Doe not include patient without a cript in the 12 month window Table 2: Patient, Script and AED by Analgeic all patient New Patient viou Uer Patient Pot Pot Patient AED cript AED Patient cript AED Patient cript AED cript 1
2 exten e Table 3: Patient, Script and AED e exten e New Patient viou Uer Pot Pot Patient cript AED Patient cript AED Patient cript AED Patient cript AED Table 4: Patient, Script and AED tab New Patient exten e viou Uer Pot Pot cript AED Patient cript AED Patient cript AED Patient cript AED Patient
3 Table 5: Comparion of Script and AED between e and in New Patient e e Pot Pot cript AED cript AED cript AED cript AED e Table 6: Comparion of Script and AED between e and Patient e e Pot Pot cript AED cript AED cript AED cript AED e Table 7: Comparion of Script and AED between e and in Pot Patient Analgeic cription Pot index event e New viou New viou Cla_Total e AED Pot index event e 3
4 New viou New viou Cla_Total e Table 8: Comparion between e and for New Patient New New New e e Pot New Pot Patient % Patient % Patient % Patient % 0 0% - 0% % 1,647 14% e % 2,665 22% % 937 8% 0 0% 0 0% % 12,175 % Table 9: Comparion between e and for viou Uer e viou viou viou viou Pot e e Pot Patient % Patient % Patient % Patient % % % % % % % 839 6% 880 6% % % % % Table 10: Comparion between e and of gatrointetinal product ue e New Patient New Patient Pot Pot Patient cript Rx/pat Patient cript Rx/pat Patient cript Rx/pat Patient cript H2- antag onit Proto n pump inhibi tor Prot aglan din e viou Uer viou Uer Rx/pat 4
5 Pot Pot Patient cript Rx/pat Patient cript Rx/pat Patient cript Rx/pat Patient cript Rx/pat H2- antag onit Proto n pump inhibi tor Prot aglan din Table 11: Treatment peritence comparion between e and Index Drug e Sample patient with >1 Rx dipened Sample interval (n) Interval per patient Mean interval per patient (day) Standard deviation (day) % interval (day) Median interval per patient (day) % interval (day) 89 5
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