Bivariate Genetic Analysis
|
|
|
- Theodora Garrett
- 5 years ago
- Views:
Transcription
1 Bivariate Genetic Analysis Boulder Workshop 2018 Hermine H. Maes, Elizabeth Prom-Wormley, Lucia Colondro Conde, et. al.
2 Questions Univariate Analysis: What are the contributions of additive genetic, dominance/shared environmental and unique environmental factors to the variance? Bivariate Analysis: What are the contributions of genetic and environmental factors to the covariance between two traits?
3 Two Traits
4 Causes of covariation Two or more traits can be correlated because they share common genes or common environmental influences same genetic/environmental factors influencing traits? With twin data on multiple traits it is possible to partition the covariation into its genetic and environmental components Goal is to understand what factors make sets of variables correlate or co-vary
5 Bivariate Twin Data individual twin within between trait within between within-twin within-trait co(variance) (within-twin cross-trait) covariance (cross-twin within-trait) covariance cross-twin cross-trait covariance
6 Sources of Information Within-twin Cross-trait covariance: phenotypic covariance Cross-twin Cross-trait covariance: between twins MZ:DZ ratio of Cross-twin Cross-trait covariance Ratio of Cross-twin to Within-twin Cross-trait covariance
7 s Phenotype 1 (P1) P1T2 P2T2 P1T2 P2T2 P1T2
8 s Phenotype 2 (P2) P1T2 P2T2 P1T2 P2T2 P1T2 P2T2
9 Phenotypic P1-P2 Within-Twin Cross-Trait P1T2 P2T2 P1T2 P2T2 P1T2 P1T2P2T2 P1T2P2T2 P2T2
10 Cross-Twin Within-Trait P1 P1T2 P2T2 Within-Trait P1T2 P1T2 P2T2 Within-Trait P1T2 P1T2 P1T2P2T2 P1T2P2T2 P2T2
11 Cross-Twin Within-Trait P2 P1T2 P2T2 Within-Trait P1T2 Within-Trait P2T2 P1T2 P2T2 Within-Trait P1T2 Within-Trait P2T2 P1T2 P1T2P2T2 P1T2P2T2 P2T2
12 Cross-Twin Cross-Trait X1Y2 P1T2 P2T2 Within-Trait P1T2 Cross-Trait P2T2 Within-Trait P2T2 P1T2 P2T2 Within-Trait P1T2 Cross-Trait P2T2 Within-Trait P2T2 P1T2 P1T2P2T2 P1T2P2T2 P2T2
13 Cross-Twin Cross-Trait X2Y1 P1T2 P2T2 Within-Trait P1T2 Cross-Trait P1T2 Cross-Trait P2T2 Within-Trait P2T2 P1T2 P2T2 Within-Trait P1T2 Cross-Trait P2T2 Cross-Trait P1T2 Within-Trait P2T2 P1T2 P1T2P2T2 P1T2P2T2 P2T2
14 Bivariate Twin Matrix P1T2 P2T2 V C CP1T2 CP2T2 C V CP1T2 CP2T2 P1T2 CP1T2 CP1T2 VP1T2 CP1T2P2T2 P2T2 CP2T2 CP2T2 CP1T2P2T2 VP2T2
15 Within Twin s P1T2 P2T2 V C CP1T2 CP2T2 Within-Twin C V CP1T2 CP2T2 P1T2 CP1T2 CP1T2 VP1T2 CP1T2P2T2 Within-Twin P2T2 CP2T2 CP2T2 CP1T2P2T2 VP2T2
16 Cross-Twin s P1T2 P2T2 V C CP1T2 CP2T2 Within-Twin Cross-Twin C V CP1T2 CP2T2 P1T2 CP1T2 CP1T2 VP1T2 CP1T2P2T2 Cross-Twin Within-Twin P2T2 CP2T2 CP2T2 CP1T2P2T2 VP2T2
17 Two Phenotypes/Twin - Within-Twin s
18 Cross-Twin s
19 A Cross-Twin s
20 C Cross-Twin s
21 E Cross-Twin s
22 Bivariate Twin Matrix
23 Bivariate Twin Matrix VA11
24 Bivariate Twin Matrix VA11 VA21
25 Bivariate Twin Matrix VA11 VA21 VA21
26 Bivariate Twin Matrix VA11 VA21 VA21 VA22
27 Bivariate Twin Matrix VA11 + VE11 VA21 + VE21 VA21 + VE21 VA22 + VE22
28 Bivariate Twin Matrix P1T2 P2T2 Within-Trait P1T2 Cross-Trait P1T2 Cross-Trait P2T2 Within-Trait P2T2
29 Bivariate Twin Matrix P1T2 P2T2 1/0.5 * VA11 Cross-Trait P1T2 Cross-Trait P2T2 Within-Trait P2T2
30 Bivariate Twin Matrix P1T2 P2T2 1/0.5 * VA11 1/0.5 * VA21 Cross-Trait P2T2 Within-Trait P2T2
31 Bivariate Twin Matrix P1T2 1/0.5 * VA11 1/0.5 * VA21 P2T2 1/0.5 * VA21 Within-Trait P2T2
32 Bivariate Twin Matrix P1T2 1/0.5 * VA11 1/0.5 * VA21 P2T2 1/0.5 * VA21 1/0.5 * VA22
33 Predicted Twin Matrix P1T2 P2T2 VA11 + VC11 + VE11 VA21 + VC21 + VE21 VA21 + VC21 + VE21 VA22 + VC22 + VE22 1/0.5 * VA11 + VC11 1/0.5 * VA21 + VC21 1/0.5 * VA21 + VC21 1/0.5 *VA22 + VC22 P1T2 P2T2 1/0.5 * VA11 + VC11 1/0.5 * VA21 + VC21 1/0.5 * VA21 + VC21 1/0.5 *VA22 + VC22 VA11 + VC11 + VE11 VA21 + VC21 + VE21 VA21 + VC21 + VE21 VA22 + VC22 + VE22
34 Predicted MZ Twin P1T2 P2T2 VA11 + VC11 + VE11 VA21 + VC21 + VE21 VA21 + VC21 + VE21 VA22 + VC22 + VE22 VA11 + VC11 VA21 + VC21 VA21 + VC21 VA22 + VC22 P1T2 P2T2 VA11 + VC11 VA21 + VC21 VA21 + VC21 VA22 + VC22 VA11 + VC11 + VE11 VA21 + VC21 + VE21 VA21 + VC21 + VE21 VA22 + VC22 + VE22
35 Predicted DZ Twin P1T2 P2T2 VA11 + VC11 + VE11 VA21 + VC21 + VE21 VA21 + VC21 + VE21 VA22 + VC22 + VE * VA11 + VC * VA21 + VC * VA21 + VC *VA22 + VC22 P1T2 P2T2 0.5 * VA11 + VC * VA21 + VC * VA21 + VC *VA22 + VC22 VA11 + VC11 + VE11 VA21 + VC21 + VE21 VA21 + VC21 + VE21 VA22 + VC22 + VE22
36 Bivariate Twin Matrix P1T2 P2T2 V C CP1T2 s of CP2T2 & P2 same across twins and C V zygosity groups CP1T2 CP2T2 P1T2 CP1T2 CP1T2 VP1T2 CP1T2P2T2 P2T2 CP2T2 CP2T2 CP1T2P2T2 VP2T2
37 Bivariate Twin Matrix P1T2 P2T2 V C CP1T2 s CP2T2 of P1& P2 same across twins and C V zygosity groups CP1T2 CP2T2 P1T2 CP1T2 CP1T2 VP1T2 CP1T2P2T2 P2T2 CP2T2 CP2T2 CP1T2P2T2 VP2T2
38 Bivariate Twin Matrix P1T2 P2T2 Cross-Twin Within- V C CP1T2 CP2T2 Trait s differ by zygosity C V CP1T2 CP2T2 P1T2 CP1T2 CP1T2 VP1T2 CP1T2P2T2 P2T2 CP2T2 CP2T2 CP1T2P2T2 VP2T2
39 Bivariate Twin Matrix P1T2 P2T2 Cross-Twin Cross- V C CP1T2 CP2T2 Trait s differ by zygosity C V CP1T2 CP2T2 P1T2 CP1T2 CP1T2 VP1T2 CP1T2P2T2 P2T2 CP2T2 CP2T2 CP1T2P2T2 VP2T2
40 Example MZ Matrix P1T2 P2T P1T P2T
41 Example DZ Matrix P1T2 P2T P1T P2T
42 Cross-Trait s Within-twin Cross-trait covariances imply common etiological influences (phenotypic covariance) Cross-twin Cross-trait covariances imply familial common etiological influences MZ/DZ ratio of Cross-twin Cross-trait covariances reflects whether common etiological influences are genetic or environmental Ratio of Cross-twin to Within-twin Cross-trait covariance reflects on role of unique environment
43 Genetic to Genetic Correlation calculated by dividing genetic covariance by square root of product of genetic variances of two variables 1 r g r g 1 = 1 σ 2 A σ 2 A22 * σ 2 A11 σ 2 A21 σ 2 A12 σ 2 A22 * 1 σ 2 A σ 2 A22
44 Contribution to Phenotypic Correlation if VA21=~VA11 & VA22, then two sets of genes overlap completely if however VA11 & VA22 are near zero, genes do not contribute much to phenotypic correlation contribution to phenotypic correlation is function of both heritabilities and rg
45 OpenMx Specification P1T2 P2T2 V C CP1T2 CP2T2 C V CP1T2 CP2T2 P1T2 CP1T2 CP1T2 VP1T2 CP1T2P2T2 P2T2 CP2T2 CP2T2 CP1T2P2T2 VP2T2 OpenMx script
Path Analysis, SEM and the Classical Twin Model
Path Analysis, SEM and the Classical Twin Model Michael Neale & Frühling Rijsdijk 2 Virginia Institute for Psychiatric and Behavioral Genetics Virginia Commonwealth University 2 MRC SGDP Centre, Institute
Liability Threshold Models
Liability Threshold Models Frühling Rijsdijk & Kate Morley Twin Workshop, Boulder Tuesday March 4 th 2008 Aims Introduce model fitting to categorical data Define liability and describe assumptions of the
Univariate Twin Analysis. OpenMx Tc Hermine Maes, Elizabeth Prom-Wormley, Nick Martin
Univariate Twin Analysis OpenMx Tc26 2012 Hermine Maes, Elizabeth Prom-Wormley, Nick Martin Overall Questions to be Answered oes a trait of interest cluster among relate dividuals? an clustering be explained
Resemblance between Relatives (Part 2) Resemblance Between Relatives (Part 2)
Resemblance Between Relatives (Part 2) Resemblance of Full-Siblings Additive variance components can be estimated using the covariances of the trait values for relatives that do not have dominance effects.
Quantitative Trait Analysis in Sibling Pairs. Biostatistics 666
Quantitative Trait Analsis in Sibling Pairs Biostatistics 666 Outline Likelihood function for bivariate data Incorporate genetic kinship coefficients Incorporate IBD probabilities The data Pairs of measurements
Discontinuous Traits. Chapter 22. Quantitative Traits. Types of Quantitative Traits. Few, distinct phenotypes. Also called discrete characters
Discontinuous Traits Few, distinct phenotypes Chapter 22 Also called discrete characters Quantitative Genetics Examples: Pea shape, eye color in Drosophila, Flower color Quantitative Traits Phenotype is
We expand our previous deterministic power
Power of the Classical Twin Design Revisited: II Detection of Common Environmental Variance Peter M. Visscher, 1 Scott Gordon, 1 and Michael C. Neale 1 Genetic Epidemiology, Queensland Institute of Medical
Threshold Liability Models (Ordinal Data Analysis)
Threshold Liability Models (Ordinal Data Analysis) Frühling Rijsdijk MRC SGDP Centre, Institute of Psychiatry, King s College London Boulder Twin Workshop 2014 Ordinal data Measuring instrument discriminates
Interaction of Genes and the Environment
Some Traits Are Controlled by Two or More Genes! Phenotypes can be discontinuous or continuous Interaction of Genes and the Environment Chapter 5! Discontinuous variation Phenotypes that fall into two
Discussion. were best fit by models of determination that did not include genetic effects.
A Behavior Genetic Investigation of the Relationship Between Leadership and Personality Andrew M. Johnson 1, Philip A. Vernon 2, Julie Aitken Harris 3, and Kerry L. Jang 4 1 Faculty of Health Sciences,The
It is shown that maximum likelihood estimation of
The Use of Linear Mixed Models to Estimate Variance Components from Data on Twin Pairs by Maximum Likelihood Peter M. Visscher, Beben Benyamin, and Ian White Institute of Evolutionary Biology, School of
Genetic and Environmental Contributions to Obesity and Binge Eating
Genetic and Environmental Contributions to Obesity and Binge Eating Cynthia M. Bulik,* Patrick F. Sullivan, and Kenneth S. Kendler Virginia Institute for Psychiatric and Behavioral Genetics of Virginia
Phenotypic, Genetic, and Environmental Correlations between Reaction Times and Intelligence in Young Twin Children
J. Intell. 2015, 3, 160-167; doi:10.3390/jintelligence3040160 Brief Report OPEN ACCESS Journal of Intelligence ISSN 2079-3200 www.mdpi.com/journal/jintelligence Phenotypic, Genetic, and Environmental Correlations
SEMs for Genetic Analysis
SEMs for Genetic Analysis Session 8, Lecture 4 2/3/06 Basic Genetic Analysis of Twin Samples Using SEMs SEMs and variance explained Motivating example Simple correlation test The heritability concept Structural
Psych 3102 Introduction to Behavior Genetics
Psych 3102 Introduction to Behavior Genetics Lecture 12 Quantitative analysis Covariance between relatives Sources of covariance between relatives covariance a measure of shared variance (how similar the
Combined Linkage and Association in Mx. Hermine Maes Kate Morley Dorret Boomsma Nick Martin Meike Bartels
Combined Linkage and Association in Mx Hermine Maes Kate Morley Dorret Boomsma Nick Martin Meike Bartels Boulder 2009 Outline Intro to Genetic Epidemiology Progression to Linkage via Path Models Linkage
Do genetic influences on abuse and dependence overlap? Explorations using cannabis and alcohol diagnoses
Washington University School of Medicine Digital Commons@Becker Posters 2004: Alcoholism and the Latest Genetics and Neuroscience Findings 2004 Do genetic influences on abuse and dependence overlap? Explorations
Multiple Regression Analysis of Twin Data: Etiology of Deviant Scores versus Individuai Differences
Acta Genet Med Gemellol 37:205-216 (1988) 1988 by The Mendel Institute, Rome Received 30 January 1988 Final 18 Aprii 1988 Multiple Regression Analysis of Twin Data: Etiology of Deviant Scores versus Individuai
Estimating genetic variation within families
Estimating genetic variation within families Peter M. Visscher Queensland Institute of Medical Research Brisbane, Australia peter.visscher@qimr.edu.au 1 Overview Estimation of genetic parameters Variation
Etiological Similarities Between Psychological and Physical Aggression in Intimate Relationships: A Behavioral Genetic Exploration
J Fam Viol (2007) 22:121 129 DOI 10.1007/s10896-006-9059-6 ORIGINAL ARTICLE Etiological Similarities Between Psychological and Physical Aggression in Intimate Relationships: A Behavioral Genetic Exploration
Shared genetic influence of BMI, physical activity and type 2 diabetes: a twin study
Diabetologia (2013) 56:1031 1035 DOI 10.1007/s00125-013-2859-3 SHORT COMMUNICATION Shared genetic influence of BMI, physical activity and type 2 diabetes: a twin study S. Carlsson & A. Ahlbom & P. Lichtenstein
Genetic and Environmental Influences on Literacy and Numeracy Performance in Australian School Children in Grades 3, 5, 7, and 9
Genetic and Environmental Influences on Literacy and Performance in Australian School Children in Grades 3, 5, 7, and 9 Katrina L. Grasby, William L. Coventry, Brian Byrne, Richard K. Olson & Sarah E.
Heritability. The Extended Liability-Threshold Model. Polygenic model for continuous trait. Polygenic model for continuous trait.
The Extended Liability-Threshold Model Klaus K. Holst Thomas Scheike, Jacob Hjelmborg 014-05-1 Heritability Twin studies Include both monozygotic (MZ) and dizygotic (DZ) twin
Comparing heritability estimates for twin studies + : & Mary Ellen Koran. Tricia Thornton-Wells. Bennett Landman
Comparing heritability estimates for twin studies + : & Mary Ellen Koran Tricia Thornton-Wells Bennett Landman January 20, 2014 Outline Motivation Software for performing heritability analysis Simulations
Analysis of bivariate binomial data: Twin analysis
Analysis of bivariate binomial data: Twin analysis Klaus Holst & Thomas Scheike March 30, 2017 Overview When looking at bivariate binomial data with the aim of learning about the dependence that is present,
Univariate modeling. Sarah Medland
Univariate modeling Sarah Medland Starting at the beginning Data preparation The algebra style used in Mx expects line per case/family (Almost) limitless number of families and variables Missing data Default
NIH Public Access Author Manuscript J Educ Psychol. Author manuscript; available in PMC 2009 September 14.
NIH Public Access Author Manuscript Published in final edited form as: J Educ Psychol. 2007 February 1; 99(1): 128 139. doi:10.1037/0022-0663.99.1.128. The Origins of Diverse Domains of Mathematics: Generalist
Common Genetic Components of Obesity Traits and Serum Leptin
nature publishing group articles Common Genetic Components of Obesity Traits and Serum Leptin nn L. Hasselbalch, Beben Benyamin 2, Peter M. Visscher 2, Berit L. Heitmann,3, Kirsten O. Kyvik 4 and Thorkild
A Behavior Genetic Study of the Connection Between Social Values and Personality
ARTICLE AVAILABLE ONLINE Twin Research and Human Genetics Volume 14 Number 3 pp. 233 239 A Behavior Genetic Study of the Connection Between Social Values and Personality Julie Aitken Schermer, 1 Philip
Chapter 2 Interactions Between Socioeconomic Status and Components of Variation in Cognitive Ability
Chapter 2 Interactions Between Socioeconomic Status and Components of Variation in Cognitive Ability Eric Turkheimer and Erin E. Horn In 3, our lab published a paper demonstrating that the heritability
Interaction of Genes and the Environment
Some Traits Are Controlled by Two or More Genes! Phenotypes can be discontinuous or continuous Interaction of Genes and the Environment Chapter 5! Discontinuous variation Phenotypes that fall into two
CHAPTER 6. Conclusions and Perspectives
CHAPTER 6 Conclusions and Perspectives In Chapter 2 of this thesis, similarities and differences among members of (mainly MZ) twin families in their blood plasma lipidomics profiles were investigated.
Heritability. The concept
Heritability The concept What is the Point of Heritability? Is a trait due to nature or nurture? (Genes or environment?) You and I think this is a good point to address, but it is not addressed! What is
Bivariate Analysis of Disordered Eating Characteristics in Adolescence and Young Adulthood
CE ACTIVITY Bivariate Analysis of Disordered Eating Characteristics in Adolescence and Young Adulthood Melissa A. Munn, MPE 1,2 * Michael C. Stallings, PhD 1,2 Soo Hyun Rhee, PhD 1,2 Laura E. Sobik, PhD
Imaging Genetics: Heritability, Linkage & Association
Imaging Genetics: Heritability, Linkage & Association David C. Glahn, PhD Olin Neuropsychiatry Research Center & Department of Psychiatry, Yale University July 17, 2011 Memory Activation & APOE ε4 Risk
Predicting Offspring Conduct Disorder Using Parental Alcohol and Drug Dependence
Predicting Offspring Conduct Disorder Using Parental Alcohol and Drug Dependence Paul T. Korte, B.A. J. Randolph Haber, Ph.D. Abstract Introduction: Previous research has shown that the offspring of parents
Genetic and environmental influences on eating behaviors in 2.5- and 9-year-old children: a longitudinal twin study
Dubois et al. International Journal of Behavioral Nutrition and Physical Activity 2013, 10:134 RESEARCH Open Access Genetic and environmental influences on eating behaviors in 2.5- and 9-year-old children:
In the classic twin design, estimation of genetic and
A Test of the Equal Environment Assumption (EEA) in Multivariate Twin Studies Eske M. Derks, 1 Conor V. Dolan, 2 and Dorret I. Boomsma 1 1 Department of Biological Psychology,Vrije Universiteit,Amsterdam,
An Examination of the Developmental Pathways Model for Oppositional Defiant Disorder in a Twin Sample
University of Colorado, Boulder CU Scholar Psychology and Neuroscience Graduate Theses & Dissertations Psychology and Neuroscience Spring 1-1-2013 An Examination of the Developmental Pathways Model for
lescence and young adulthood. About 70% to almost 90% of the year-old and year-old males and between 52% and 71% of the year-old
The aim of the current thesis was to examine the etiology of individual differences in alcohol use in adolescents and young adults. In this chapter we discuss the main findings presented in this thesis.
Multiple Approaches to Studying Gene-Environment Interplay. Sara Jaffee University of Pennsylvania
Multiple Approaches to Studying Gene-Environment Interplay Sara Jaffee University of Pennsylvania What is GE Interplay? Gene-environment correlation (rge): Individual differences in exposure to environments
Preliminary Conclusion
1 Exploring the Genetic Component of Political Participation Brad Verhulst Virginia Institute for Psychiatric and Behavioral Genetics Virginia Commonwealth University Theories of political participation,
Word Reading Fluency: Role of Genome-Wide Single-Nucleotide Polymorphisms in Developmental Stability and Correlations With Print Exposure
Europe PMC Funders Group Author Manuscript Published in final edited form as: Child Dev. 2014 ; 85(3): 1190 1205. doi:10.1111/cdev.12207. Word Reading Fluency: Role of Genome-Wide Single-Nucleotide Polymorphisms
Conditional Distributions and the Bivariate Normal Distribution. James H. Steiger
Conditional Distributions and the Bivariate Normal Distribution James H. Steiger Overview In this module, we have several goals: Introduce several technical terms Bivariate frequency distribution Marginal
Keywords: classical twin study, behavioural genetics, Mx, SEM, genetic model fitting
Fruhling Rijsdijk is a lecturer in Quantitative Behavioral Genetics at the Social, Genetic & Development Psychiatry Research Centre of the Institute of Psychiatry, King s College London. She works on the
Causes of Stability of Aggression from Early Childhood to Adolescence: A Longitudinal Genetic Analysis in Dutch Twins
Behavior Genetics, Vol. 33, No. 5, September 2003 ( 2003) Causes of Stability of Aggression from Early Childhood to Adolescence: A Longitudinal Genetic Analysis in Dutch Twins C. E. M. van Beijsterveldt,
Epigenetics. Jenny van Dongen Vrije Universiteit (VU) Amsterdam Boulder, Friday march 10, 2017
Epigenetics Jenny van Dongen Vrije Universiteit (VU) Amsterdam j.van.dongen@vu.nl Boulder, Friday march 10, 2017 Epigenetics Epigenetics= The study of molecular mechanisms that influence the activity of
An Introduction to Quantitative Genetics
An Introduction to Quantitative Genetics Mohammad Keramatipour MD, PhD Keramatipour@tums.ac.ir ac ir 1 Mendel s work Laws of inheritance Basic Concepts Applications Predicting outcome of crosses Phenotype
Evidence for shared genetic influences on selfreported ADHD and autistic symptoms in young adult Australian twins
Washington University School of Medicine Digital Commons@Becker Open Access Publications 2008 Evidence for shared genetic influences on selfreported ADHD and autistic symptoms in young adult Australian
Generalist Genes and Learning Disabilities
Psychological Bulletin Copyright 2005 by the American Psychological Association 2005, Vol. 131, No. 4, 592 617 0033-2909/05/$12.00 DOI: 10.1037/0033-2909.131.4.592 Generalist Genes and Learning Disabilities
Separation Anxiety Disorder and Adult Onset Panic Attacks Share a Common Genetic Diathesis
Separation Anxiety Disorder and Adult Onset Panic Attacks Share a Common Genetic Diathesis Roxann Roberson-Nay, PhD Virginia Commonwealth University Department of Psychiatry The SAD PD link Don Klein proposed
NeuroImage 60 (2012) Contents lists available at SciVerse ScienceDirect. NeuroImage. journal homepage:
NeuroImage 60 (2012) 1686 1695 Contents lists available at SciVerse ScienceDirect NeuroImage journal homepage: www.elsevier.com/locate/ynimg Full Length Article Genetic and environmental influences of
Flexible Mx specification of various extended twin kinship designs
Washington University School of Medicine Digital Commons@Becker Open Access Publications 2009 Flexible Mx specification of various extended twin kinship designs Hermine H. Maes Virginia Commonwealth University
Quantitative genetics: traits controlled by alleles at many loci
Quantitative genetics: traits controlled by alleles at many loci Human phenotypic adaptations and diseases commonly involve the effects of many genes, each will small effect Quantitative genetics allows
A Twin-Family Study of Suicidality and Illicit Drug Use in Young People
A Twin-Family Study of Suicidality and Illicit Drug Use in Young People Qiang (John) Fu, 1,2 Andrew C. Heath, 2 Kathleen K. Bucholz 2 1 Saint Louis University School of Public Health 2 Midwest Alcoholism
Examining Genetic and Environmental Effects on Social Aggression: A Study of 6-Year-Old Twins
Child Development, July/August 2005, Volume 76, Number 4, Pages 930 946 Examining Genetic and Environmental Effects on Social : A Study of 6-Year-Old Twins Mara Brendgen Université du Québec à Montréal
BRIEF REPORT. Introduction
BRIEF REPORT Genetic and Environmental Associations between Body Dissatisfaction, Weight Preoccupation, and Binge Eating: Evidence for a Common Factor with Differential Loadings Across Symptom Type Shannon
A Twin Study Examining the Development of Rumination and its Role as a Transdiagnostic Risk Factor for Psychopathology
University of Colorado, Boulder CU Scholar Psychology and Neuroscience Graduate Theses & Dissertations Psychology and Neuroscience Spring 1-1-2015 A Twin Study Examining the Development of Rumination and
Kuja-Halkola, Ralf; Lichtenstein, Paul; D'Onofrio, Brian; Larsson, Henrik
This is an author produced version of a paper published by Journal of child psychology and psychiatry. This paper has been peer-reviewed but does not include the final publisher proof-corrections or journal
Does Black Birthweight Reach Genetic Potential?
Does Black Birthweight Reach Genetic Potential? Genetic Epidemiology Model is Sensitive to Twin Sex-Composition and Mortality Muriel Zheng Fang October 7, 2012 I examine the relative importance of environmental
The Genetic and Environmental Contributions to Oppositional Defiant Behavior: A Multi-informant Twin Study
The Genetic and Environmental Contributions to Oppositional Defiant Behavior: A Multi-informant Twin Study JAMES J. HUDZIAK, M.D., ESKE M. DERKS, M.A., ROBERT R. ALTHOFF, M.D., PH.D., WILLIAM COPELAND,
The Influence of Genetic and Environmental Factors on Quit Attempt in Adolescent and Young Adult Twins
Virginia Commonwealth University VCU Scholars Compass Theses and Dissertations Graduate School 2017 The Influence of Genetic and Environmental Factors on Quit Attempt in Adolescent and Young Adult Twins
Common and unique genetic contributions to conduct disorder and two stages of alcohol dependence development in women
Washington University School of Medicine Digital Commons@Becker Posters 2007: Alcohol Use Across the Lifespan 2007 Common and unique genetic contributions to conduct disorder and two stages of alcohol
Heritability of Health-Related Quality of Life: SF-12 Summary Scores in a Population-Based Nationwide Twin Cohort
Twin Research and Human Genetics Volume 16 Number 3 pp. 670 678 C The Authors 2013 doi:10.1017/thg.2013.21 Heritability of Health-Related Quality of Life: SF-12 Summary Scores in a Population-Based Nationwide
The SAGE Encyclopedia of Educational Research, Measurement, and Evaluation Multivariate Analysis of Variance
The SAGE Encyclopedia of Educational Research, Measurement, Multivariate Analysis of Variance Contributors: David W. Stockburger Edited by: Bruce B. Frey Book Title: Chapter Title: "Multivariate Analysis
An Introduction to Quantitative Genetics I. Heather A Lawson Advanced Genetics Spring2018
An Introduction to Quantitative Genetics I Heather A Lawson Advanced Genetics Spring2018 Outline What is Quantitative Genetics? Genotypic Values and Genetic Effects Heritability Linkage Disequilibrium
Journal of Research in Personality
Journal of Research in Personality 43 (2009) 737 746 Contents lists available at ScienceDirect Journal of Research in Personality journal homepage: www.elsevier.com/locate/jrp Temperament in middle childhood:
The role of conduct disorder in explaining the comorbidity between alcohol and illicit drug dependence in adolescence
Drug and Alcohol Dependence 87 (2007) 46 53 The role of conduct disorder in explaining the comorbidity between alcohol and illicit drug dependence in adolescence Tanya M.M. Button a,, Soo Hyun Rhee a,b,
Mendelian & Complex Traits. Quantitative Imaging Genomics. Genetics Terminology 2. Genetics Terminology 1. Human Genome. Genetics Terminology 3
Mendelian & Complex Traits Quantitative Imaging Genomics David C. Glahn, PhD Olin Neuropsychiatry Research Center & Department of Psychiatry, Yale University July, 010 Mendelian Trait A trait influenced
Genetic and environmental influences on juvenile antisocial behaviour assessed on two occasions
Psychological Medicine, 2000, 30, 1315 1325. 2000 Cambridge University Press Printed in the United Kingdom Genetic and environmental influences on juvenile antisocial behaviour assessed on two occasions
EXPLORING THE ROLE OF NEGATIVE URGENCY IN THE ETIOLOGY OF BINGE EATING: GENETIC/ENVIRONMENTAL ASSOCIATIONS AND INTERACTIONS WITH OVARIAN HORMONES
EXPLORING THE ROLE OF NEGATIVE URGENCY IN THE ETIOLOGY OF BINGE EATING: GENETIC/ENVIRONMENTAL ASSOCIATIONS AND INTERACTIONS WITH OVARIAN HORMONES By Sarah Elizabeth Racine A DISSERTATION Submitted to Michigan
Prediction of Breeding Value Using Bivariate Animal Model for Repeated and Single Records
Journal of Animal Research: v.5 n.2, p. 311-315. June 2015 DOI Number: 10.5958/2277-940X.2015.00053.4 Prediction of Breeding Value Using Bivariate Animal Model for Repeated and Records Shakti Kant Dash
Twin studies have shown heritabilities from 39% (10)
Epidemiology Multivariate Genetic Analysis of Lifetime Exercise and Environmental Factors RIITTA SIMONEN 1, ESKO LEVÄLAHTI 1, JAAKKO KAPRIO 1,2, TAPIO VIDEMAN 3, and MICHELE C. BATTIÉ 4 1 Department of
The genetics of complex traits Amazing progress (much by ppl in this room)
The genetics of complex traits Amazing progress (much by ppl in this room) Nick Martin Queensland Institute of Medical Research Brisbane Boulder workshop March 11, 2016 Genetic Epidemiology: Stages of
Mx Scripts Library: Structural Equation Modeling Scripts for Twin and Family Data
Behavior Genetics, Vol. 35, No. 4, July 2005 (Ó 2005) DOI: 10.1007/s10519-005-2791-5 Mx Scripts Library: Structural Equation Modeling Scripts for Twin and Family Data D Posthuma 1 and D. I. Boomsma 1 Received
10-1 MMSE Estimation S. Lall, Stanford
0 - MMSE Estimation S. Lall, Stanford 20.02.02.0 0 - MMSE Estimation Estimation given a pdf Minimizing the mean square error The minimum mean square error (MMSE) estimator The MMSE and the mean-variance
UC San Diego UC San Diego Previously Published Works
UC San Diego UC San Diego Previously Published Works Title Genetic and environmental contributions to regional cortical surface area in humans: A magnetic resonance imaging twin study Permalink https://escholarship.org/uc/item/04z9z371
Genetic influences on disordered eating behaviour are largely independent of body mass index
Acta Psychiatr Scand 2008: 117: 348 356 All rights reserved DOI: 10.1111/j.1600-0447.2007.01132.x Copyright Ó 2007 The Authors Journal Compilation Ó 2007 Blackwell Munksgaard ACTA PSYCHIATRICA SCANDINAVICA
ETIOLOGIC RELATIONSHIPS BETWEEN ANXIETY AND DIMENSIONS OF MALADAPTIVE PERFECTIONISM IN YOUNG ADULT FEMALE TWINS
Research Article DEPRESSION AND ANXIETY 29: 47 53 (2012) ETIOLOGIC RELATIONSHIPS BETWEEN ANXIETY AND DIMENSIONS OF MALADAPTIVE PERFECTIONISM IN YOUNG ADULT FEMALE TWINS Jason S. Moser, Ph.D., Jennifer
The present study investigated the location of trait
Phenotypic and Genetic Relations Between the HEXACO Dimensions and Trait Emotional Intelligence Livia Veselka, 1 K. V. Petrides, 2 Julie Aitken Schermer, 3 Lynn F. Cherkas, 4 Tim D. Spector 4 and Philip
Twins and the Study of Rater (Dis)agreement
Psychological Methods 2007, Vol. 12, No. 4, 451 466 CORRECTED APRIL 10, 2008; SEE LAST PAGE Copyright 2007 by the American Psychological Association 1082-989X/07/$12.00 DOI: 10.1037/1082-989X.12.4.451
Methodology for Genetic Studies of Twins and Families
Methodology for Genetic Studies of Twins and Families Michael C. Neale Department of Psychiatry Virginia Institute for Psychiatric and Behavioral Genetics Virginia Commonwealth University Hermine H. M.
GENETICAL, ENVIRONMENTAL AND PERSONALITY FACTORS INFLUENCING THE AGE OF FIRST SEXUAL INTERCOURSE IN TWINS
J. biosoc. Sci. (1977) 9, 91-97 GENETICAL, ENVIRONMENTAL AND PERSONALITY FACTORS INFLUENCING THE AGE OF FIRST SEXUAL INTERCOURSE IN TWINS N. G. MARTIN*, L. J. EAVES* AND H. J. EYSENCKt * Department of
Bias in Correlations from Selected Samples of Relatives: The Effects of Soft Selection
Behavior Genetics, Vol. 19, No. 2, 1989 Bias in Correlations from Selected Samples of Relatives: The Effects of Soft Selection M. C. Neale, ~ L. J. Eaves, 1 K. S. Kendler, 2 and J. K. Hewitt 1 Received
CHAPTER 6 A TWIN-SIBLING STUDY AND META-ANALYSIS ON THE HERITABILITY OF MAXIMAL OXYGEN CONSUMPTION
CHAPTER A TWIN-SIBLING STUDY AND META-ANALYSIS ON THE HERITABILITY OF MAXIMAL OXYGEN CONSUMPTION PUBLISHED AS Schutte NM, Nederend I, Hudziak JJ, Bartels M, de Geus EJC (201) A twin-sibling study and meta-analysis
Associations Between Reading Achievement and Independent Reading in Early Elementary School: A Genetically Informative Cross-Lagged Study
Child Development, November/December 2011, Volume 82, Number 6, Pages 2123 2137 Associations Between Reading Achievement and Independent Reading in Early Elementary School: A Genetically Informative Cross-Lagged
Effects of Social Attitude Change on Smoking Heritability
DOI 10.1007/s10519-017-9871-1 ORIGINAL RESEARCH Effects of Social Attitude Change on Smoking Heritability Laura Mezquita 1,2 Juan F. Sánchez Romera 3,4 Manuel I. Ibáñez 1,2 José J. Morosoli 3 Lucía Colodro
Juvenile IGF-I: an update
Juvenile IGF-I: an update Kim Bunter and Uwe Wuensch Animal Genetics and Breeding Unit (AGBU), a joint venture of NSW Agriculture and the University of New England, University of New England, Armidale,
Multiple trait model combining random regressions for daily feed intake with single measured performance traits of growing pigs
Genet. Sel. Evol. 34 (2002) 61 81 61 INRA, EDP Sciences, 2002 DOI: 10.1051/gse:2001004 Original article Multiple trait model combining random regressions for daily feed intake with single measured performance
Addictive Behaviors 65 (2017) Contents lists available at ScienceDirect. Addictive Behaviors
Addictive Behaviors 65 (2017) 137 146 Contents lists available at ScienceDirect Addictive Behaviors journal homepage: www.elsevier.com/locate/addictbeh Internet addiction and its facets: The role of genetics
The Genetic and Environmental Sources of Resemblance Between Normative Personality and Personality Disorder Traits
Virginia Commonwealth University VCU Scholars Compass Psychiatry Publications Dept. of Psychiatry 2017 The Genetic and Environmental Sources of Resemblance Between Normative Personality and Personality
Genetic and Cultural Transmission of Smoking Initiation: An Extended Twin Kinship Model
Behav Genet (2006) 36:795 808 DOI 0.007/s059-006-9085-4 ORIGINAL PAPER Genetic and ultural ransmission of Smoking Initiation: An Extended win Kinship Model Hermine H. Maes Æ Michael. Neale Æ Kenneth S.
Learning Abilities and Disabilities
CURRENT DIRECTIONS IN PSYCHOLOGICAL SCIENCE Learning Abilities and Disabilities Generalist Genes, Specialist Environments Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry,
Frequency of church attendance in Australia and the United States: models of family resemblance
Twin Research (1999) 2, 99 107 1999 Stockton Press All rights reserved 1369 0523/99 $12.00 http://www.stockton-press.co.uk/tr Frequency of church attendance in Australia and the United States: models of
Personalized Media: A Genetically Informative Investigation of Individual Differences in Online Media Use
RESEARCH ARTICLE Personalized Media: A Genetically Informative Investigation of Individual Differences in Online Media Use Ziada Ayorech 1, Sophie von Stumm 2, Claire M. A. Haworth 3, Oliver S. P. Davis
A twin study of the relationship between inhibitory control and behavior problems
Available online at www.sciencedirect.com ScienceDirect Procedia - Social and Behavioral Sciences 233 ( 2016 ) 165 169 Annual International Scientific Conference Early Childhood Care and Education, ECCE
Cassandra L. Scanlan 1,2, Austin M. Putz 1, Kent A. Gray 3 and Nick V. L. Serão 1,2*
Scanlan et al. Journal of Animal Science and Biotechnology (2019) 10:22 https://doi.org/10.1186/s40104-019-0330-0 RESEARCH Genetic analysis of reproductive performance in sows during porcine reproductive
Genetic Architecture of the Delis-Kaplan Executive Function System Trail Making Test: Evidence for Distinct Genetic Influences on Executive Function
Neuropsychology 2011 American Psychological Association 2012, Vol. 26, No. 2, 238 250 0894-4105/12/$12.00 DOI: 10.1037/a0026768 Genetic Architecture of the Delis-Kaplan Executive Function System Trail
Introduction to Quantitative Genetics
Introduction to Quantitative Genetics 1 / 17 Historical Background Quantitative genetics is the study of continuous or quantitative traits and their underlying mechanisms. The main principals of quantitative