ADHD Foundation National Conference Environmental Factors: Their effect on the incidence of ADHD, ASD, Dyslexia and Dyspraxia

Size: px

Start display at page:

Download "ADHD Foundation National Conference Environmental Factors: Their effect on the incidence of ADHD, ASD, Dyslexia and Dyspraxia"

Abel Oliver
5 years ago
Views:

1 ADHD Foundation National Conference 2017 Environmental Factors: Their effect on the incidence of ADHD, ASD, Dyslexia and Dyspraxia Dr Madeleine Portwood Clinical Director Witherslack Group

2 Studies of the effects of nutrition on brain development Information based on a multi-centre study from Cambridge and East Anglia carried out by Professor Alan Lucas 1990 Pre-term vs term formula. Period of nutritional intervention. 4 weeks showed significant developmental advantages at 18 months 1992 Lucas reported 8.3 IQ advantage in 7 ½ - 8 year old children born pre-term when fed mothers milk by tube vs donor breastmilk and formula. Hypothesis : Since human milk is lower in most nutrients compared with formula milk it must contain something more specific which helps the development of the C.N.S Donor breastmilk vs pre-term formula reports no difference In developmental outcome at 18 months Maureen Hack, Nancy Klein and Gerry Taylor (Semin Neonatal 1996:1: ) studies of school-age outcomes In children of low birthweight and gestational age. M Makrides and R Gibson (Recent developments in Infant Nutrition ) defining the LCPUFA (long chain polyunsaturated fatty acids) requirement of term infants. Suggested that LCPUFAs are the probable explanation for the substance in breastmilk responsible for the results observed by Lucas.

4 12 Willatts Et Al Infant Habituation Test (Fagan) 10 Looking Time in Seconds High levels of DHA Low Levels of DHA LOOK

5 Maternal Malnutrition Is the Most Significant Factor for Adverse Outcomes in Pregnancy

Synthesis of HUFA from EFA The omega-6 EFA s The omega-3 EFA s Linoleic acid (LA) Gamma-linolenic acid (GLA) Dihomogammalinolenic acid (DGLA) Arachidonic acid (AA) Adrenic acid (AdrA)

6 Synthesis of HUFA from EFA The omega-6 EFA s The omega-3 EFA s Linoleic acid (LA) Gamma-linolenic acid (GLA) Dihomogammalinolenic acid (DGLA) Arachidonic acid (AA) Adrenic acid (AdrA) Docosapentaenoic acid (ω6-dpa) Alpha-linolenic acid (ALA) Stearidonic acid (SA) Eicosatetraenoic acid (ETA) Eicosapentaenoic acid (EPA) Docosapentaenoic acid (ω3-dpa) Docosahexaenoic acid (DHA)

7 Formula Vs Breastmilk LA AA ALA DHA Formula Breastmilk

8 Symptoms of EFA Deficiency Dry itchy skin Coarse bumpy patches particularly at the back of the arms Soft broken nails Frequent urination Excessive thirst Dull dry hair Allergies

LA to ALA Ratios of Foods OILS LA ALA LA/ALA Rapeseed 13.02 6.50 Soybean 51.50 7.

9 LA to ALA Ratios of Foods OILS LA ALA LA/ALA Rapeseed Soybean Olive Corn Sesame Sunflower

10 LA to ALA Ratios of Foods FATS LA ALA LA/ALA Butter Cream Chocolate Ice Cream Fat Spread (70% fat, polyunsaturated)

11 Study Design This was a randomised, double-blind placebo-controlled trial, with a total duration of 6 months. On recruitment, children were allocated at random to either the active treatment (the HUFA supplement or an identical-looking placebo. At the three-month point there was a one-way treatment crossover (placebo to active treatment) and all children were then followed up for a further 3 months. Assessments at: baseline 3 months 6 months. Group 1 (N=50) active active. Group 2 (N=50) placebo active. Exclusion criteria. Study Design Significant neurological psychiatric, or other medical problems,current medication (unless this is judged irrelevant by the GP). NB: GP consent was required for all participants, but we excluded a priori children receiving treatment for major health problems e.g. Cerebral palsy, epilepsy, MS. ME or any other major physical condition.

12 Effect size of Active and Placebo treatments on ADHD Global Scales (CTRS-R:L) ADHD Index Restless-Impulsive DSM Inattention Global Total DSM Global Total SM Hyperactive -Impulsive Emotional Lability placebo LC-PUFA

13 The Durham Trial

14 What we discovered less excitability greater memory and concentration improved reading and spelling

15 The Durham Trial We need to remember that this is not about chemistry. This is about children.

16 Research Through ESPA Education and Services for People with Autism Urinary analysis in Autism Marker: Indolyl-3-acryloylglycine (IAG) Blood samples

17 A2 Milk Study The chemicals which come from milk (casomorphins) is derived differently from 20/ 30 years ago. Along with other peptides, they may be involved in certain aspects of autism. Some of these compounds have been reported in the urine of people with autism (Reichelt & Knivsberg, 2003)

18 Pilot Study Based in the North-Eeast of England 40 males aged 4 10 Diagnoses of ASD + ADHD Urinary and blood samples taken at baseline, midway and end-point Cognitive profile (WISC), Conners profile, and CARS

19 The Sunderland Protocol for Dietary Intervention rotocol.pdf

20 Once Upon a Winter Time The South Wind will rest and the North Wind will blow Crashes of mountains all full with snow. Nothing will crash, Nothing will float Nothing s exciting, Nothing like boat. I heard a sound first a crash Then was a clatter, last was a smash. Seven hundred years or so, Seven thousand years ago, Windows, curtains, chimney, roof It s Christmas time I m telling the truth. I have made a little rhyme Once upon a winter time No, candle, no light, no dirt, no bin No sparrows, no birds, no robins they sing. All of the pigeons have gone to their nest The children are sleeping they re doing their best. Now every time I read a book The faster I ran, the candle I shook I marked myself with biro or pen It s Christmas time now and then Sing and sing, song and song Learning you were right, learning you were wrong All is right no not crime Once upon a winter time

21 References Portwood et al (2014) The role of essential fatty acids in improving language skills in children with ASD Durham University International Conference Portwood M: (2011) The Co-ordination Conundrum. SEN Magazine (September / October) Portwood M: (2008) Movement Difficulties in the early years: a planned programme of support in The Dyslexia Handbook 2208/2009, British Dyslexia Association, Bracknall Portwood M: (2006) Effect of Diet on children s behaviour and learning. Br. Journal Nutrition & Health Vol. 18, pp Portwood M: (2006) Essential Fatty Acids (EFAs) and their effect on children s behaviour and learning. Journal of the Dyslexia Institute 14. (2) 4-7 Portwood M: (2005) Dyspraxia in Special Teaching for Special Children: A Pedagogy for Inclusion? Eds Lewis & Norwich McGraw & Hill Open University Press Portwood M: (2004) Children with movement difficulties an epidemic Professional Journal of the Dyspraxia Foundation (Oct) Portwood M. (2003) Dyslexia and P.E. BDA/ David Fulton, London Portwood M. (2000) Understanding Developmental Dyspraxia A Textbook for Students and Professionals, David Fulton London Portwood M. (2000) Dyspraxia, British Journal of Teaching Physical Education 31(1), Portwood M. (1999) Developmental Dyspraxia: Identification and Intervention. David Fulton London

Role of DHA in Early Life Nutrition in the First 1000 days

Role of DHA in Early Life Nutrition in the First 1000 days Role of DHA in Early Life Nutrition in the First 1000 days Professor Barbara School of Medicine, University of Wollongong, NSW, Australia Docosahexaenoic