INVESTOR & ANALYST PRESENTATION. H August 2017

Transcription

1 INVESTOR & ANALYST PRESENTATION H August 2017

2 Company disclaimer This presentation contains forward-looking statements that provide our expectations or forecasts of future events such as new product introductions, product approvals and financial performance. Such forward-looking statements are subject to risks, uncertainties and inaccurate assumptions. This may cause actual results to differ materially from expectations and it may cause any or all of our forwardlooking statements here or in other publications to be wrong. Factors that may affect future results include interest rate and currency exchange rate fluctuations, delay or failure of development projects, production problems, unexpected contract breaches or terminations, government-mandated or market-driven price decreases for Lundbeck's products, introduction of competing products, Lundbeck's ability to successfully market both new and existing products, exposure to product liability and other lawsuits, changes in reimbursement rules and governmental laws and related interpretation thereof, and unexpected growth in costs and expenses. Lundbeck undertakes no duty to update forward-looking statements. Certain assumptions made by Lundbeck are required by Danish Securities Law for full disclosure of material corporate information. Some assumptions, including assumptions relating to sales associated with products that are prescribed for unapproved uses, are made taking into account past performances of other similar drugs for similar disease states or past performance of the same drug in other regions where the products are currently marketed. It is important to note that although physicians may, as part of their freedom to practice medicine in the US, prescribe approved drugs for any use they deem appropriate, including unapproved uses, at Lundbeck, promotion of unapproved uses is strictly prohibited. 2

3 Lundbeck who are we? Danish based, global pharmaceutical company. Founded in 1915 Production sites in Denmark, France and Italy Pursuing category leadership in four disease categories in CNS: Alzheimer s, mood disorders, Parkinson s and psychotic disorders Innovative treatments for patients in diseases with high unmet medical needs Experienced management team and long history as CNS specialists 2017 financial guidance: Revenue: DKK bn and EBIT: DKK bn Market cap: DKK ~75bn (USD ~12bn) ~5,000 employees 3

4 Revenue grows 13%, EBIT doubles in H1 2017, and 2017 guidance is raised Total revenue increased by 13% to DKK 8.5 billion Key products grew 44% to DKK 4.2 billion representing 49% of revenue EBIT doubled to DKK 2.1 billion and EBIT margin significantly improved to 24.3% EPS grew 186% to DKK 6.06 Net cash improved by DKK 2.8 billion since Q Guidance raised following better operational performance and Other Operating Income Abilify Maintena approved by the US FDA for bipolar I disorder and Azilect approved in China for Parkinson s 4

5 Key products exceed DKK 4 billion in H up 44% y/y DKKm % H % FY ,114 67% DKKm % H % FY % DKKm % H % FY ,105 76% DKKm % H ,448 28% FY ,409 37% DKKm % H % FY , % 5

6 Strong revenue growth of 13% to DKK 8.5 billion, EBIT margin improved from 12.7% to 24.3% Revenue* (DKKm) Regional split* (DKKm) EBIT margin 30% Key products Other mature products Europe: (1%) Int. Markets: +8% North America: +22% H H H H % 23% 57% 17% 22% 61% 25% 20% 15% 10% 5% 0% -5% -10% -50% *) Excluding Other revenue 6

7 Abilify Maintena grew 23% to DKK 659 million in H primarily driven by non-us markets Share of total market *) Abilify Maintena (DKKm) Highlights 18% 15% 12% 9% 6% 3% RoW North America Growth mainly driven by Australia, Canada, Spain, Italy and France 10-20% value market share (LAI retail) in most markets Bipolar I disorder snda approved by the US FDA Total LAI antipsychotic market was USD ~2bn in H1 2017*) 0% Q2.15 Q2.16 Q Q2.14 Q2.15 Q2.16 Q2.17 Y/Y growth of 10% *) Based on quarterly reports from Lundbeck, Otsuka, Alkermes and Johnson & Johnson Lundbeck s share of revenue 7

8 Brintellix/Trintellix grew 61% to DKK 778 million in H with non-us adding to growth Total R x count (US retail) Brintellix/Trintellix (DKKm) Highlights Viibryd RoW North America Q2.14 Q2.15 Q2.16 Q2.17 Growth mainly driven by Brazil, Canada, France, Italy and the US More than 1% volume share in major countries such as France, Italy, Mexico and Spain Second CRL received from US FDA on snda (cognition) Demonstrated efficacy in cognitive dysfunction and functional capacity Source: Bloomberg (monthly data ending 7/2017) 8

9 Rexulti grew 85% to DKK 574 million in H Total R x count (US retail) Rexulti sales (DKKm) Highlights Branded NR x and TR x shares of 15% and 13% respectively* More than 1% total market share (volume)* 80% of R x prescribed for MDD Vraylar Phase III study in bipolar mania to start in H Launched in Canada and recently approved in Australia Q4.15 Q2.16 Q4.16 Q2.17 European MAA submitted for schizophrenia in Q Source: Bloomberg (monthly data ending 7/2017) Lundbeck s share of revenue *) Week ending 2 July

10 Northera continues to show strong growth Total US R x Northera (DKKm) Highlights Northera grew 60% to DKK 716 million in H Northera is expected to continue to grow Source: Bloomberg (monthly data ending 7/2017) 0 Q2.15 Q2.16 Q

11 Onfi continues its solid growth momentum Total R x Count (US) Onfi (DKKm) Highlights Onfi grew 28% to DKK 1,448 million in H Onfi is expected to continue to grow Source: Bloomberg (monthly data ending 7/2017) 0 Q2.14 Q2.15 Q2.16 Q

12 North America grew 22% driven by Northera, Rexulti and Trintellix Revenue in North America (DKKm) +22% Key products # Other products Highlights North America grew 22% to DKK 5,115 million in H In Q2 2017, the region grew 23% to DKK 2,678 million Rexulti has ~1% volume share in the US Trintellix has ~0.6% and ~0.8% in volume share in the US and Canada, respectively North America s contribution*) North America 61% Rest of World 39% 0 H H #) Abilify Maintena, Northera, Onfi, Rexulti and Trintellix *) Excluding Other revenue 12

13 International Markets grew 8% with Brazil, China and Japan as major contributors Revenue in International Markets (DKKm) % Key products Other products H H Highlights International Markets constitutes 22% of total revenue Key products up 91% in H driven by Abilify Maintena and Brintellix Azilect approved in China Brintellix approval in China expected around year-end 2017 International Markets contribution*) Int. Markets 22% *) Excluding Other revenue Rest of World 78% 13

14 Europe starts to improve driven by Abilify Maintena and Brintellix Revenue in Europe (DKKm) Highlights Europe s contribution*) (1%) Key products # Other products Europe declined 1% to DKK 1,433 million in H1 2017, but was up 3% in Q and reached DKK 724 million Strong performance for Brintellix, especially in France, Italy and Spain Rxulti submitted in Europe in March 2017 (schizophrenia) Europe 17% Rest of World 83% 0 H H Market value (EU5) of our four disease areas: USD 3.7bn #) Abilify Maintena and Brintellix *) Excluding Other revenue 14

15 R&D in Lundbeck Innovation focused across four key disease areas Alzheimer s disease Mood disorders Parkinson s disease Psychotic disorders 15

16 Continued progression in our R&D pipeline with two approvals and upstart of additional trials Highlights Abilify Maintena approved by US FDA for bipolar I disorder Abilify Maintena 2-month formulation in development* Azilect approved in China New study (Anew) started with Lu AF35700** US FDA issue second CRL regarding inclusion of cognition data in Trintellix label Early pipeline progressing *) NCT **) NCT

17 Brexpiprazole showed improvements in symptoms of agitation relative to placebo in Alzheimer s agitation Study I (NCT ) Study II (NCT ) Comments N = 413 patients 1 mg, 2 mg and placebo 12 weeks treatment duration Main recruitment centers: Russia, Ukraine and USA CMAI 1) : 2 mg statistically superior to placebo CGI-S 2) : 2 mg not statistically superior to placebo N = 270 patients Flexible dose: mg 12 weeks treatment duration Main recruitment centers: Russia, Ukraine and USA CMAI 1) : mg not superior to placebo CGI-S 2) : mg superior to placebo Geography played a major role, with US patients responding well and patients in Russia responding poorly If Russian sites are excluded from both studies, p-value for both studies on CMAI primary endpoint is <0.05 1) Primary efficacy endpoint: Cohen-Mansfield Agitation Inventory (CMAI) total score, a 29-item scale to systematically assess the symptoms of agitation 2) Key secondary efficacy endpoint: Clinical Global Impression-Severity of Illness (CGI-S) score, a 7-point scale assessing overall severity of the patient's agitation 17

18 Brexpiprazole in pivotal programme in Alzheimer s agitation The condition The studies Clinical programme >20% of individuals in a community setting and >50% of nursing home residents with dementia have agitation >1.5m dementia patients in the US with agitation / aggression Agitation in Alzheimer s is associated with increased caregiver burden, decreased functioning and earlier nursing home placement Study #1 (12 weeks) (NCT ) Study #2 (12 weeks) (NCT ) 413 patients 270 patients 1 mg and 2 mg mg (flexible dose) Study start: July 2013 Study start: June 2013 Target population: Institutionalized or noninstitutionalized setting Primary outcome: Change in the Cohen-Mansfield Agitation Inventory (CMAI) total score Type C meeting requested at US FDA Fast Track Designation granted February

19 Brexpiprazole enters Proof-of-Concept study in Post-traumatic Stress Disorder (PTSD) PTSD The PoC study* ) ~8.6m American adults affected 1), but ~80% is undiagnosed Growing economic and social burden to care for people with PTSD Inadequate response with US FDA approved SSRIs sertraline and paroxetine Polypharmacy the norm 4-arm, 12-week trial using 1-3 mg of brexpiprazole Monotherapy or in combination with sertraline ~330 patients to be enrolled Primary endpoint: Change from baseline in the CAPS-5 total score #) 1) US Census Bureau. Annual estimates of the resident population by sex and selected age groups for the United States: April 1, 2010 to July 1, 2011 (NC-EST ) *) NCT #) Clinician-Administered PTSD Scale for DSM-5 (CAPS-5) 19

20 Brexpiprazole Long-acting Injectable (LAI) entered phase I Brexpiprazole LAI More long-acting treatment options are needed Brexpiprazole has demonstrated efficacy for patients with schizophrenia without compromising safety and tolerability Dosing interval, route of administration and device presentation being evaluated LAI formulation with strong tolerability and adherence profile Validated formulation technology Brexpiprazole: Strong and evaluated safety profile The study*) Open-label trial to determine the pharmacokinetics and tolerability of brexpiprazole LAI administered subcutaneously or intramuscularly Estimated enrollment: 110 adult patients with schizophrenia Study start: January 2017 Expected completion: H *) Clinicaltrials.gov ID: NCT

21 Lu AF35700 offers significant potential in Treatment Resistant Schizophrenia (TRS) TRS Lu AF35700 Clinical programme Around 1/3 of schizophrenia patients are treatment resistant Psychiatrists readily recognize the term Treatment Resistant Schizophrenia (TRS) TRS is an inability to control symptoms of schizophrenia after a full round of two to three antipsychotics Unique mode of action. In contrast to current treatment, antipsychotic effect at low D 2 blockade Combined D 1 /D 2 and 5-HT 6 profile gives good activity combined with a benign tolerability profile Very long half-life leads to significantly reduced risk of relapse Four clinical studies have been conducted, three studies in healthy people and one in patients with schizophrenia 1) The first study (DayBreak) in the pivotal programme commenced in March ) Other key studies ongoing: Long-term safety study 3) Cardiac repolarization 4) ED or LD TRS (Anew) 5) 1) Clinicaltrials.gov identifier: NCT ) NCT ) NCT ) NCT ) NCT (early-in-disease (ED) or late-in-disease (LD) treatment-resistant schizophrenia (TRS)) 21

22 Study set-up in first study (DayBreak) in pivotal programme using lu AF35700 in Treatment Resistant Schizophrenia First study in pivotal programme Oral, once daily Approximately 1,000 patients Expected completion by H Primary endpoint Change in PANSS total score Secondary endpoints Clinical Global Impression Severity scale (CGI-S) Personal and Social Performance (PSP) total score Clinicaltrials.gov ID: NCT

23 Our path to category leadership Current products Pipeline Mood disorders Research projects LCM projects Psychotic Disorders LCM projects Research projects Lu AF35700 Alzheimer s Brexpiprazole Lu AF20513 Lu AF66432 TauAb Parkinson s Lu AF82422 LRRK2 23

24 Higher degree of transparency in future revenue drivers than Lundbeck has had historically >2030 Launched products Pipeline Lu AF35700 (Treatment Resistant Schizophrenia) Lu AF20513 (Alzheimer s) Lu AF66432 (Alzheimer s) Brexpiprazole LAI (schizophrenia) TauAb (Alzheimer s) Lu AF82422 (Parkinson s) LRRK2 (Parkinson s) 24

25 Finance & other 25

26 Strong growth in revenue and significant improvement in both gross margin and EBIT margin Financial results Q and H Q Q % DKKm H H % 4,283 3,751 14% Revenue 8,494 7,521 13% 76.8% 72.5% - Gross margin 76.9% 72.1% - 1, % EBIT 2, % 24.5% 12.5% - EBIT margin 24.3% 12.7% - 1, % Core EBIT 2,500 1,475 69% % Net profit 1, % % EPS % 26

27 Continued focus on cost discipline COS and SG&A ratio Highlights Headcount (FTEs) 70% 60% 50% 40% 30% 20% 10% SG&A ratio (%) COS ratio (%) Slight reduction in total costs while growing topline by 13% in H Lowest FTE level in close to 15 years CAPEX stable around DKK million per year % Q2.15 Q4.15 Q2.16 Q4.16 Q Q2.15 Q4.15 Q2.16 Q4.16 Q

28 Continued improvement in net cash Free cash flow (DKKm) Net cash position (DKKm) Highlights Substantial positive cash flow from operations Q2.15 Q4.15 Q2.16 Q4.16 Q Q2.14 Q4.15 Q2.16 Q4.16 Q Cash flow impacted by: Quarterly fluctuations in working capital Paid income tax Investments in securities Repayment of loans and dividend pay-out Net cash expected to reach around 3 billion in

29 Lundbeck on track to achieve an all-time high revenue and EBIT 2017 financial guidance raised DKKbn 2016 Previous 2017 guidance Revised 2017 guidance ~ % (y/y) Revenue % EBIT % EBIT margin 14.7% ~21-24% ~22-26%* - Assumptions 2017 will be impacted by additional generic erosion but also continued growth of key products EBIT for 2017 includes around DKK 240 million from divestiture of properties recognized as Other operating income No new one-off income and/or expenses included Unchanged currencies from beginning of August 2017 *) Excluding DKK ~240 million in total gains from divestiture of properties which are recognized as Other Operating Income 29

30 Key priorities Sustain sales momentum of key products Realize full benefits from restructuring programme Deliver on innovation Cash reallocation 30

31 31

32 CNS market overview Value USDbn Market size (2015) Market leaders (2015) Value Growth Volume Growth # of patients* Unmet medical needs Compound Total pharma % +2% Total CNS 134-3% +1% Share value Anti- Alzheimer s (N7D) % +3% >7 million Disease modifying treatment Disease slowing agents Improved symptomatic treatments Longer lasting symptomatic treatments 1. Memantine 2. Rivastigmine 3. Donepezil 4. Galantamine 50% 23% 21% 6% Antidepressants (N6A) % +5% ~40 million Drugs with higher remission rates Increased onset of action Current therapies are relatively well-tolerated but still room for improvement especially on sexual side effects 1. Duloxetine 2. Escitalopram 3. Bupropion 4. Venlafaxine 16% 10% 10% 9% Anti- Parkinson s (N4A) % +3% >3 million Therapies that provide neuroprotection and/or neurorestoration An optimal trial design for demonstrating neuroprotection and/or neurorestoration Control of levodopa-induced motor response complications 1.Rasagiline 2.Levodopa 3.Pramipexole 4.Rotigotine 16% 14% 14% 10% Antipsychotics (N5A) % +3% Approx 1% of global population Source: IMS Health Analytics Link 2016 (Audited sales), Growth, USD % y/y Improved treatment of cognitive dysfunction Improved treatment of negative symptoms Improved treatment of co-morbid depression and anxiety Early stage, definitive diagnostics 1.Aripiprazole 2.Quetiapine 3.Paliperidone Palmitate 4.Olanzapine 35% 14% 10% 9% 32

33 Lundbeck is a global, CNS-focused pharmaceutical company H sales* by product H sales* by region Largest markets for Lundbeck (H1 2017) USA Other pharma 50% Abilify Maintena 8% Brintellix/ Trintellix 9% Northera 9% Onfi 17% Int. Markets 22% Europe 17% North America 61% China Canada Japan Italy Rexulti 7% France *) Excluding Other revenue 33

34 Lundbeck is active in the investigation of various novel treatment concepts in Alzheimer s Reduce formation of Aβ by inhibition of BACE1 BACEi Aβ 1-42 γ-secretase inhibitors may have unwanted effects and are not pursued by Lundbeck APP* Lu AF20513 Reduce levels of Aβ by increased clearance TauAb Prevent spreading of misfoldet Tau Reduce levels of Tau protein tangles 34 *) APP : Amyloid Precursor Protein

35 Lu AF20513 an active therapeutic vaccine against β-amyloid Phase I study Study design 1) Wanted from study Low level of ARIA-E and ARIA-H 2) No meningo-encephalitis High antibody responder rate Fast antibody response (< 6 months) High affinity Aβ specific antibodies (for CNS clearance) Not wanted from study Aβ specific T-cells High IgM over IgG ratio Very low responder rate Purpose: 35 patients from centres in Europe Patients with mild Alzheimer s (MMSE 19-26) Four injections of Lu AF20513 Evaluate safety and tolerability Measure Aβ-specific antibody titter Phase I commenced in Q Expected completion: mid ) NCT ) Amyloid Related Imaging Abnormalities (ARIA): ARIA-E refers to the MR signal alterations thought to represent vasogenic edema (VE) and related extravasated fluid phenomena. ARIA-H refers to the MR signal alterations on attributable to micro hemorrhages (mh) and hemosiderosis 35

36 BACE-1 inhibition to stop the production of β-amyloid, aimed at slowing the disease progression BACE 1) BACE was identified in ) Enzyme that initiates the production of the Alzheimer s associated peptide Aβ Lu AF66432 NCE targeting inhibition of BACE1 enzyme Disease modifying treatment that fits well with Lundbeck s Alzheimer s portfolio 1) β-amyloid precursor protein site cleaving enzyme (BACE). 2) Vassar, R. et al. b-secretase cleavage of Alzheimer s amyloid precursor protein by the transmembrane aspartic protease BACE. Science 286, (1999). Nature Reviews Neuroscience 8, (July 2007) 36

37 Increasing evidence suggests abnormal tau and amyloid work together to cause nerve cell death TAU Tau, a microtubuleassociated protein first discovered in 1975 TauAb Tau aggregation inhibition for the treatment of Alzheimer s In a healthy brain, tau has an important function, acting as a form of scaffolding to keep cells stable, but in Alzheimer s, tau loses its normal form and breaks away from the cell 37

38 Alpha-synuclein a potential therapeutic Parkinson s vaccine α-synuclein A role for α-synuclein in PD was first suggested in 1997 Propagation of α-synuclein misfolding and aggregation seems to be at the heart of most types of Parkinson s Many preclinical studies suggest that α-synuclein can behave in a prion-like fashion, with misfolding and aggregation, and propagation from neuron to neuron Lu AF82422 Collaboration with Genmab entered in 2010 Clearance of pathological α- synuclein via antibody objective to delay disease progression in symptomatic PD A treatment that could slow or stop Parkinson s progression Nature Reviews Neuroscience 4, (September 2003) 38

39 The role of leucine-rich repeat kinase 2 (LRRK2) or dardarin in Parkinson s LRRK2 Discovered in 2004 Inhibition of LRRK2 kinase to delay disease progression in early stage PD with focus on genetic identified patients LRRK2 is widely expressed in many organs and tissues including the brain LRRK2 might act upstream of α- synuclein and its aggregation in Lewy bodies Drug discovery collaborations In December 2010, Lundbeck signed agreements with Zenobia Therapeutics and Vernalis plc Lundbeck utilizes Zenobia's expertise in protein expression and x-ray crystallography for the LRRK2 target The Vernalis agreement focus on a drug discovery collaboration utilising Vernalis' fragment and structure-based drug discovery platform Mark R. Cookson; The Lancet Neurology; December 2010, vol. 11. Nature Reviews Neuroscience 11, (December 2010) 39

40 Financial terms and territory structure of the Otsuka alliance entered in November 2011 Milestone payments Lundbeck s share of revenue and costs Payment to: Development milestones/upfront Abilify Maintena Rexulti Selincro USD 200m USD 600m 3) EUR 105m* Abilify Maintena Rexulti Selincro USA 20% 45% - Approval milestones USD 275m 1) USD 300m 2) Undisclosed EU-5, Nordic and Canada 50% 50% - Sales milestones Up to USD 425m depending on sales development Other Lundbeck territories 65%** 65%** Undisclosed Undisclosed 1) USD 100m upon US approval, USD 75m upon EU approval in schizophrenia, and USD 50m US and EU for a second indication. 2) USD 100m (US) and USD 50m (EU) for each of the two first indications 3) Development milestones of up to USD 600m after which shared development costs between parties. 4) USD 125m, USD 25m and USD 50m for first indication in the US, EU and Japan respectively. Second indication gives USD 50m, USD 25m and USD 25m, respectively. * Includes sales milestones ** All regions except Asia, Turkey and Egypt *** All regions except Thailand and Vietnam Selincro for Japan added to the alliance in October

41 Cash flow priorities: Increasing dividends linked to long-term performance Lundbeck s extended actions to return cash to shareholders demonstrate our conviction in our future Debt reduction Net cash positive already in 2016 Repay remaining debt Increase strategic cash reserve Dividends Pay-out ratio of 40% for 2016 Dividend policy revised: Pay-out ratio raised to 60-80% from 2017 Business development and/or additional cash reallocation Maintain investment grade status i.e. NIBD/EBITDA <2.0x 41

42 Financial targets Targets within the period Achievements on targets H EBIT margin 24.3% 14.7% (46.7%) ROIC (annualized) 26.6% 13.2% (45.4%) Cash-to-Earnings 58.6% 230.3% N/A EBIT margin ROIC Cash-to-earnings 25% 25% >90% Dividend pay-out Net debt/ebitda Dividend Pay-out N/A 40% 0% 60-80% <2x Net debt/ebitda (0.4) (0.1) 10.7 Financial policies 42

43 H and FY Product distribution of revenue DKKm FY 2016 FY 2015 H H Growth Growth in local currencies % of total TOTAL: Abilify Maintena 1, % 24% 8% Brintellix/Trintellix 1, % 60% 9% Cipralex/Lexapro 2,518 2,591 1,286 1,333 (4%) (3%) 15% Northera 1, % 59% 8% Onfi 2,409 1,757 1,448 1,128 28% 27% 17% Rexulti % 84% 7% Sabril 1, % 25% 9% Xenazine 1,571 2, (34%) (35%) 6% Other pharmaceuticals 3,337 4,652 1,579 1,663 (5%) (4%) 19% Other revenue (30%) (30%) 2% Total revenue 15,634 14,594 8,494 7,521 13% 13% 100% 43

44 H and FY Geographic distribution of revenue - 1 DKKm FY 2016 H H Growth Growth in local currencies % of total NORTH AMERICA: Abilify Maintena % 15% 6% Trintellix % 41% 9% Northera 1, % 59% 14% Onfi 2,409 1,448 1,128 28% 27% 28% Rexulti % 84% 11% Sabril 1, % 25% 15% Xenazine 1, (35%) (36%) 10% Other pharmaceuticals % 6% 7% Total revenue 9,122 5,115 4,190 22% 21% 100% 44

45 H and FY Geographic distribution of revenue - 2 DKKm FY 2016 H H Growth Growth in local currencies % of total EUROPE: Abilify Maintena % 31% 23% Brintellix % 83% 13% Cipralex (11%) (13%) 23% Other pharmaceuticals 1, (19%) (18%) 41% Total revenue 2,912 1,433 1,453 (1%) (1%) 100% INTERNATIONAL MARKETS: Abilify Maintena % 36% 3% Brintellix % 109% 9% Cipralex/Lexapro 1, % 1% 47% Ebixa % 7% 15% Other pharmaceuticals % 5% 26% Total revenue 3,275 1,810 1,683 8% 9% 100% 45

46 H Cash generation DKKm H H FY 2016 FY 2015 Cash flows from operating activities 1, , Cash flows from investing activities (517) (96) (337) (2,842) Cash flows from operating and investing activities ,789 (2,645) Cash flows from financing activities (1,442) (674) (2,006) 501 Net cash flow for the period (742) (2,144) Cash, bank balances and securities, end of period 1,961 1,453 2,217 1,521 Interest-bearing debt (909) (3,231) (1,891) (3,770) Net cash/(net debt) 1,052 (1,778) 326 (2,249) 46

47 H and FY Balance sheet and dividend DKKm Dividend (DKK) Intangible assets 7,880 8,839 Other non-current assets 3,311 3, Dividend Yield (r.h.s.) 4% 3% Current assets 8,008 7,524 Assets 19,199 20,210 Equity 10,695 9, % 1% Non-current liabilities 1,861 2,740 Current liabilities 6,643 7,776 Equity and liabilities 19,199 20,210 Cash and bank balances 1,443 2,200 Securities Interest-bearing debt (909) (1,891) Interest-bearing debt, cash, bank balances and securities, net end of period 1, % Dividend of DKK 2.45 per share for 2016, corresponding to a payout ratio of 40% A total of DKK 484 million and a yield of 0.9%* Dividend policy: From 2017 and onwards the pay-out ratio will be 60-80% *Based on the share price of DKK

48 Costs Full year figures DKKm ( %) 2015 ( %) Revenue 15,634 14,594 13,468 7% 8% Cost of sales 4,082 5,395 4,160 (24%) 30% Sales & Distribution costs 5,488 6,706 5,164 (18%) 30% Administrative expenses 805 1,160 1,134 (31%) 2% R&D costs 2,967 8,149 2,911 2) (64%) 180% Total costs 13,342 21,410 1) 13,369 (38%) 60% EBIT 2,292 (6,816) Core EBIT 3, , % (31%) Cost of sales 26% 37% 31% - - Sales & Distribution costs 35% 46% 38% - - Administrative expenses 5% 8% 8% - - R&D costs 19% 56% 22% - - EBIT margin 15% (47%) 1% - - Included are 1) Restructuring costs and impairment of product rights of around DKK 7bn. 2) Writedown of desmoteplase of DKK 309m 48

49 For more information please contact Investor Relations Share information Lundbeck s shares are listed on the stock exchange in Copenhagen under the symbol LUN. Lundbeck has a sponsored Level 1 ADR programme listed in the US (OTC) under the symbol HLUYY. For additional company information, please visit Lundbeck at: Contact information Palle Holm Olesen VP; Head of Investor Relations Mobile: palo@lundbeck.com or polesen3@bloomberg.net Financial calendar Q November 2017 Q February

50 Thank you! 50