List of Actively Accruing Cancer Clinical Trials. DST Study Protocol acronym Project Title Site status detail Clinical trials gov number
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1 Breast Cardiac Biomarker (Cabot) CABOT Determining the Cardiac Biomarker Profile in Breast Cancer Patients Receiving Adjuvant Trastuzumab Therapy Breast IND.213 A Study of Reolysin For Patients With Advanced/Metastatic Breast Cancer NCT Breast LEGACY Establishment of a cohort of girls in breast cancer families The Ontario LEGACY Pilot Breast MA.33 A Randomised Phase III Study Of Radiation Doses And Fractionation Schedules For Ductal Carcinoma In Situ (Dcis) Of The Breast Breast MAC.15 (S1007) Tamoxifen Citrate, Letrozole, Anastrozole, or Exemestane With or Without Chemotherapy in Treating Patients With Invasive RxPONDER Breast Cancer NCT NCT Breast OCOG-2012-LUMINA LUMINA A Prospective Cohort Study Evaluating Risk of Local Recurrence Following Breast Conserving Surgery and Endocrine Therapy in Low Risk Luminal A Breast Cancer (LUMINA) Breast ONCOTYPE DX (BIANCO) A Prospective Cohort Study to Evaluate the Oncotype DX Test in Early Stage Breast Cancer (sub study) GI BO25114 JACOB A Double-Blind, Placebo-Controlled, Randomized, Multicenter Phase III Study Evaluating The Efficacy And Safety Of Pertuzumab In Combination With Trastuzumab And Chemotherapy In Patients With Her2-Positive Advanced Gastric Cancer NCT NCT Page 1 of 14
2 GI CO.21 CHALLENGE A Phase III Study of the Impact of a Physical Activity Program on Disease-Free Survival in Patients With High Risk Stage II or Stage III Colon Cancer: A Randomized Controlled Trial (CHALLENGE) NCT GI CO.23:BBI608 and Best Supportive Care vs Placebo and Best Supportive Care in Patients With Pretreated Advanced Colorectal Carcinoma A Phase III Randomised Study Of BBI608 And Best Supportive Care Versus Placebo And Best Supportive Care In Patients With Pretreatedadvanced Colorectal Carcinoma GI CRC.6 A Phase III Trial of 6 Versus 12 Treatments of Adjuvant FOLFOX Plus Celecoxib or Placebo for Patients With Resected Stage III Colon Cancer GI EMR (MAESTRO) Merck Maestro A Randomized, Double-Blind, Phase III Study of the Efficacy and Safety of Gemcitabine in Combination With TH-302 Compared With Gemcitabine in Combination With Placebo in Previously Untreated Subjects With Metastatic or Locally Advanced Unresectable Pancreatic Adenocarcinoma NCT NCT NCT GI IND.210 A Randomized Phase II Study of Reolysin in Combination With FOLFOX6 and Bevacizumab or FOLFOX6 and Bevacizumab Alone in Patients With Metastatic Colorectal Cancer NCT Page 2 of 14
3 GI PA.6 (PRODIGE) Multicentric Randomized Phase III Trial Comparing Adjuvant Chemotherapy With Gemcitabine Versus 5-fluorouracil, Leucovorin, Irinotecan and Oxaliplatin (mfolfirinox) in Patients With Resected Pancreatic Adenocarcinoma NCT GI YO28322 METGASTERIC A randomized, phase III, multicenter, double-blind, placebo-controlled study evaluating the efficacy and safety of onartuzumab (metmab) in combination with 5-fluorouracil, folinic acid, and oxaliplatin (mfolfox6) in patients with metastatic HER2-negative, met-positive gastroesophageal cancer. GU\RENAL CFG920X2101 A phase I/II, multicenter, open-label dose finding study of oral CFG920 in patients with metastatic castration-resistant prostate cancer GU\RENAL IMRT_ISD_JARES Randomized Study of Quality of Life in Patients with High-Risk Prostate Cancer Undergoing Radiotherapy: Role of Pelvic Nodal IMRT GU\RENAL IND.205 A Phase II Study of PX-866 in Patients With Recurrent or Metastatic Castration Resistant Prostate Cancer GU\RENAL IND.209 Reolysin Combined With Docetaxel and Prednisone or Docetaxel and Prednisone Alone in Metastatic Castration Resistant Prostate Cancer NCT NCT NCT NCT Page 3 of 14
4 GU\RENAL OGX AFFINITY A randomized phase 3 study comparing cabazitaxel/prednisone in combination with custirsen (OGX-011) to cabazitaxel/prednisone for second-line chemotherapy in men with metastatic castrate resistant prostate cancer GU\RENAL OZM-042 A Phase II, Multi-Centre, Study of the Efficacy and Safety of Sunitinib Given on an Individualized Schedule as First-Line Therapy for Metastatic Renal Cell Cancer. GU\RENAL PR.13 PR.13(Arm A) Radiation Therapy and Androgen Deprivation Therapy in Treating Patients Who Have Undergone Surgery for Prostate Cancer (RADICALS) GU\RENAL PR-02 OGX-427 in Metastatic Castrate-Resistant Prostate Cancer With Prostate-Specific Antigen Progression While Receiving Abiraterone NCT NCT NCT NCT GU\RENAL RTOG 0534:Phase III PELVIC Prostate Radiation Therapy or Short-Term Androgen Deprivation Therapy and Pelvic Lymph Node Radiation Therapy With or Without Prostate Radiation Therapy in Treating Patients With a Rising PSA After Surgery for Prostate Cancer NCT GU\RENAL RTOG 0938:Phase II Hypofractionated RT for prostate A Randomized Phase II Trial of Hypofractionated Radiotherapy for Favorable Risk Prostate Cancer NCT Page 4 of 14
5 GYNE CBKM120C2201 A Phase II, Single-arm Study of Orally Administered BKM120 as Second-line Therapy in Patients With Advanced Endometrial Carcinoma On hold NCT GYNE ASTEX SGI-110: A Randomized, Controlled, Open-Label, Phase 2 Trial of SGI-110 and Carboplatin in Subjects with Platinum- Resistant Recurrent Ovarian Cancer SGI-110 ASTEX SGI-110: A Randomized, Controlled, Open-Label, Phase 2 Trial of SGI-110 and Carboplatin in Subjects with Platinum- Resistant Recurrent Ovarian Cancer GYNE Brachytherapy-Rectal Retraction Dosimetric Comparison of Rectal Retraction Methods in Brachytherapy for Cervical Carcinoma GYNE CX.5 (SHAPE):Early Stage 1A2 and 1B1 SHAPE Radical Versus Simple Hysterectomy and Pelvic Node Dissection in Patients With Early Stage Cervical Cancer NCT GYNE INCB :biochemical recurrence only A Phase 2 Study of the IDO Inhibitor INCB Versus Tamoxifen for Subjects With Biochemical-recurrent-only EOC, PPC or FTC Following Complete Remission With First-line Chemotherapy NCT Page 5 of 14
6 GYNE MK :Platinum Sensitive p53 mutant A Study of MK-1775 in Combination With Paclitaxel and Carboplatin Versus Paclitaxel and Carboplatin Alone for Participants With Platinum-Sensitive Ovarian Tumors With the P53 Gene Mutation (MK ) GYNE PET LACE The Impact of Positron Emission Tomography (PET) Imaging in Women With Locally Advanced Cervical Cancer NCT NCT GYNE PHL-085:recurrent /metastatic HPV related PHL085 A Phase 2 Study of Ipilimumab in women with metastatic or recurrent HPV-related cervical carcinoma of either squamous cell or adenocarcinoma histologies NCT GYNE PHL-086 A Study of XL184 (Cabozantinib) in Endometrial Cancer GYNE RTOG 1174 (OUTBACK) OUTBACK A Phase III Trial of Adjuvant Chemotherapy Following Chemoradiation as Primary Treatment for Locally Advanced Cervical Cancer Compared to Chemoradiation Alone: The OUTBACK Trial NCT NCT GYNE SOLO 1(D0818C00001):Olapar ib Monotherapy in Patients With BRCA Mutated Ovarian Cancer Following First Line Platinum Based Chemotherapy A Phase III, Randomised, Double Blind, Placebo Controlled, Multicentre Study of Olaparib Maintenance Monotherapy in Patients With BRCA Mutated Advanced (FIGO Stage III-IV) Ovarian Cancer Following First Line Platinum Based Chemotherapy (SOLO 1). NCT Page 6 of 14
7 GYNE SOLO 2(D0816C00002):Olapar ib Treatment in BRCA Mutated Ovarian Cancer Patients After Complete or Partial Response to Platinum Chemotherapy A Phase III Randomised, Double Blind, Placebo Controlled Study of Olaparib Maintenance Monotherapy in Platinum Sensitive Relapsed BRCA Mutated Ovarian Cancer Patients With a Complete or Partial Response Following Platinum Based Chemotherapy(SOLO 2) NCT Head&Neck DOVE A Phase II Study of Dovitinib in Recurrent and/or Metastatic Adenoid Cystic Carcinoma of the Salivary Glands (DOVE) NCT Head&Neck MU ALTENS for Dysphagia: A Pilot Study of ALTENS in Improving Dysphagia Induced by IMRT for Head and Neck Cancers Effectiveness of Acupuncture-like Transcutaneous Nerve Stimulation (ALTENS) in Improving Dysphagla and Associated Symptoms of Current Chemotherapy and IMRT for Head and Neck Cancers: A Pilot Study NCT Hematology CAMN107A2408 (ENESTop) A phase II, single arm, open label study of treatment-free remission after achieving sustained MR4.5 on nilotinib NCT Hematology CICL670A2421:Combina tion Study of Deferasirox and Erythropoietin in Patients With Low- and Int-1-risk Myelodysplastic Syndrome. KALLISTO An open-label, phase II, randomized, pilot study to assess the effect in term of erythroid improvement of deferasirox combined with erythropoietin compared to erythropoietin alone in patients with low- and int-1-risk myelodysplastic syndrome. NCT Page 7 of 14
8 Hematology IND.193 IND.193 A Phase II Study of AT7519M, a CDK Inhibitor, in Patients With Relapsed and/or Refractory Chronic Lymphocytic Leukemia. Hematology IND.194 A Phase II Study of AT7519M, a CDK Inhibitor, in Patients With Relapsed Mantle Cell Lymphoma Hematology MDC.1 (S1117) S1117 A Randomized Phase II Study of Azacitidine in Combination With Lenalidomide (NSC ) vs. Azacitidine Alone vs. Azacititdine in Combination With Vorinostat (NSC ) for Higher-Risk Myelodysplastic Syndromes (MDS) and Chronic Myelomonocytic Leukemia (CMML) NCT NCT NCT Hematology MO28457 Pref-Mab A Randomized, Open-label, Multicenter Study to Evaluate Patient Preference With Subcutaneous Administration of Rituximab Versus Intravenous Rituximab in Previously Untreated Patients With CD20+ Diffuse Large B-cell Lymphoma or CD20+ Follicular Non-Hodgkin's Lymphoma Grades 1, 2 or 3a NCT Page 8 of 14
9 Hematology PCI-32765CLL3001 (HELIOS) PCI CLL3001 Randomized, Double-blind, Placebocontrolled Phase 3 Study of Ibrutinib, a Bruton's Tyrosine Kinase (BTK) Inhibitor, in Combination with Bendamustine and Rituximab (BR) in Subjects With Relapsed or Refractory Chronic Lymphocytic Leukemia / Small Lymphocytic Lymphoma (The HELIOS trial). NCT Hematology PHL-090 Phase 2 Trial of Single-agent Ibrutinib (PCI ) in Relapsed or Refractory Follicular Lymphoma Lung STA A Single Arm, Phase 2 Study of Ganetespib On hold in Subjects with Advanced Non-Small-Cell Lung Cancer with Anaplastic Lymphoma Kinase Gene Rearrangement (ALK-Positive NSCLC) NCT NCT Lung CA A Multi-arm Phase I study of BMS in combination with Gemcitabine/Cisplatin, Pemetrexed/Cisplatin, or Carboplatin/Paclitaxel in subjects with Chemotherapy-Naive Stage IIIB/IV Nonsmall Cell Lung Cancer (NSCLC) Lung I4X-MC-JFCK A Single-Arm, Multicenter, Open-Label, Phase 2 Study of Gemcitabine-Cisplatin Chemotherapy Plus Necitumumab (IMC- 11F8) in the First-Line Treatment of Patients With Stage IV Squamous Non- Small Cell Lung Cancer (NSCLC) NCT NCT Page 9 of 14
10 Lung IMGN IMGN901 A Phase 1/2 Study to Assess the Safety and Efficacy of Lorvotuzumab Mertansine (IMGN901) in Combination with Carboplatin/Etoposide in Patients with Advanced Solid Tumors including Extensive Stage Small Cell Lung Cancer NCT Lung IND.207 A Phase II Study of PF in Patients With Advanced Malignant Pleural Mesothelioma Lung IND.211 A Randomized Phase II Study Of Reolysin In Patients With Previously Treated Advanced Or Metastatic, Non Small Cell Lung Cancer Receiving Standard Salvage Therapy Lung IND.215:Study of Selumetinib in Patients With Previously Treated or Untreated Advanced/Metastatic NSCLC IND.215 A Phase Ib Study of Selumetinib in Patients With Previously Treated or Untreated Advanced/Metastatic NSCLC Who Are Receiving Standard Chemotherapy Regimens. NCT NCT NCT Lung OCOG-2011-BRACHY Brachy A Trial to Evaluate the Improvement in Lung Cancer Patients Receiving Radiation With or Without Brachytherapy (BRACHY) Lung OCOG-2012-DOVE-M A Phase II Study of Single-agent DOVitinib in Advanced Malignant PlEural Mesothelioma Which Has Progressed Following Prior Platinum-Antifolate Chemotherapy (DOVE-M) NCT NCT Page 10 of 14
11 Lung TIDAL Study of a Tiotropium Inhaler For Shortness of Breath in Advanced Non- Small Cell Lung Cancer (TIDAL) Melanoma BRF COMBI-AD: A phase III randomized double blind study of dabrafenib (GSK ) in COMBInation with trametinib (GSK ) versus two placebos in the ADjuvant treatmentof high-risk BRAF V600 mutation-positive melanoma after surgical resection. NCT NCT Melanoma COBRIM - GO28141 cobrim: A Phase 3 Study Comparing GDC (Cobimetinib), a MEK Inhibitor, in Combination With Vemurafenib vs Vemurafenib Alone in Patients With Metastatic Melanoma NCT Melanoma OZM-049/TH-CR-413 A Phase 2 Biomarker-Enriched Study of TH- 302 in Subjects with Advanced Melanoma NCT Neuro CBKM120E2101 A Phase I Dose Escalation Study of BKM120 With Radiation Therapy and Temozolomide in Patients With Newly Diagnosed Glioblastoma Neuro CDX (ACT IV) ACT IV An International, Randomized, Double- Blind, Controlled Study of Rindopepimut/GM-CSF with Adjuvant Temozolomide in Patients with Newly Diagnosed, Surgically Resected, EGFRvIIIpositive Glioblastoma (The ACT IV Study) NCT NCT Page 11 of 14
12 Neuro CE.6 Radiation Therapy With or Without Temozolomide in Treating Older Patients With Newly Diagnosed Glioblastoma Multiforme Neuro CEC.3/N107C A Phase III Trial of Post-Surgical Stereotactic Radiosurgery (SRS) Compared with Whole Brain Radiotherapy (WBRT) for Resected Metastatic Brain Disease NCT NCT Neuro EF-14:Effect of NovoTTF- 100A Together With Temozolomide in Newly Diagnosed Glioblastoma Multiforme (GBM) EF-14 A Prospective, Multi-center Trial of NovoTTF-100A Together With Temozolomide Compared to Temozolomide Alone in Patients with Newly Diagnosed GBM NCT Neuro JNG-001(TRICK) TRICK A Randomized Trial of Robotic Compared to Fixed Gantry Radiosurgery for Brain Metastases. Neuro N0574(RTOG 0671) Stereotactic Radiation Therapy With or Without Whole-Brain Radiation Therapy in Treating Patients With Brain Metastases Neuro SABR-COMET SABR-COMET Stereotactic Ablative Radiotherapy for Comprehensive Treatment of Oligometastatic Tumors (SABR-COMET): A Randomized Phase II Trial Other (TasQ) TasQ (OZM-047) A Multicentre, Open Label, Early Stopping Design, Proof Of Concept Study With Tasquinimod In Treating Patients With Advanced Or Metastatic Hepatocellular, Ovarian, Renal Cell And Gastric Carcinomas NCT NCT NCT NCT Page 12 of 14
13 Other IND.206 A Phase II Study of Sunitinib or Temsirolimus in Patients With Advanced Rare Tumours Other Other PROUD Study (PAL-ABST- PROUD/Abstral 401) Program RTOG 0631:Phase II/III Radiosurg for spine METs Abstral Drug Utilization Study - Observational Study Evaluating "Real World" Utilization of Abstral in Canada Image-Guided Radiosurgery or Stereotactic Body Radiation Therapy in Treating Patients With Localized Spine Metastasis Phase I BAY /16653 A Phase I, multi-center, non-randomized, open label, parallel-group study evaluating the pharmacokinetics and safety of regorafenib (BAY ) in cancer subjects with severe renal impairment compared to a control group NCT NCT NCT Phase I BI An open label phase I dose finding study of BI administered orally in a continuous dosing schedule in patients with various advanced or metastatic nonhematologic malignancies Phase I PJC-008 A Phase I Trial of AMG 386 and Temsirolimus in Advanced Solid Tumors with an Expansion Cohort in Uterine Cancer, Renal Cell Carcinoma and Carcinoid Tumor NCT NCT Page 13 of 14
14 Phase I SOR-C13 01 A Phase I, Open-Label, Dose Escalation Study To Assess Safety and Tolerability of Sor-C13 in Subjects with Advanced Solid Tumors Commonly Known to Express The Trpv6 Ion Channel NCT Sarcoma CAMN107A2409:Study to Allow Access to Nilotinib for Patients Who Are on Nilotinib Treatment in a Novartissponsored Study An open label, multi-center nilotinib rollover protocol for patients who have completed a previous Novartis sponsored nilotinib study and are judged by the investigator to benefit from continued nilotinib treatment NCT Sarcoma SR.6 SARC021 A Trial of TH-302 in Combination With Doxorubicin Versus Doxorubicin Alone to Treat Patients With Locally Advanced Unresectable or Metastatic Soft Tissue Sarcoma NCT * You can search the trial details by putting the clnical trial gov number in the website: or search for key words at Updated Oct.15, 2013 Page 14 of 14
List of Actively Accruing Cancer Clinical Trials. DST Study Protocol acronym Project Title Site status detail Clinical trials gov number
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