Meet-the-Expert: AML Treating older patients with AML
|
|
- Albert Chapman
- 5 years ago
- Views:
Transcription
1 Meet-the-Expert: AML Treating older patients with AML Sergio Amadori Tor Vergata University Hospital Rome Istanbul 2012
2 AML in older patients Poor prognosis Minority treated with intensive Cx Treatment less successful Outcome has not changed over the last 40 years Burnett et al, JCO 2011 Kantarjian, ASCO 2011
3 Reasons for lack of progress Poor tolerance for intensive Cx Poor PS and comorbidities Therapeutic nihilism Lack of accrual to clinical trials Inherent drug resistance Adverse biology
4 Available options Low-Int Rx Supp care Intensive Rx Investigational Rx
5 Intensive Rx: treatment of choice EORTC AML-7 (age 65+) (Lowenberg et al, JCO 1989) ECOG SWOG MDACC 6,283 pts Target: CR Prerequisite for better OS and QOL Lesser responses: limited benefit Walters et al, JCO 2010
6 Older adults are not all the same FIT Low risk UNFIT FIT Poor risk Candidate for intensive Cx? YES NO What is best strategy? What are alternatives?
7 Candidates for intensive Rx? Prognostic Risk Models
8 Intensive Rx Standard approach: DNR + Ara-C (3+7 regimen) for induction Ara-C-based consolidation (1-2 courses) CR, DFS and OS rates inferior to younger pts Age, y CR% ED % RR% Cure % <60 75 < >60 50 ~20 85 <15 Better therapies needed
9 New strategies Focus on Treatment Intensification Induction Postremiss DNR dose Add new agents RIC-SCT
10 HOVON/SAKK AML-43 Induction cycle I DNR 45 mg/m 2 x3 Ara-C 200 mg/m 2 x7 Induction cycle II Ara-C 1 g/m 2 q12 hrs x 6 days Post induction none R DNR 90 mg/m 2 x3 Ara-C 200 mg/m 2 x7 Lowenberg et al, NEJM 2009 Ara-C 1 g/m 2 q12 hrs x 6 days R RIC-SCT (optional) GO 6 mg/m 2 q 4 weeks x 3
11 Induction outcome N=813, age 60-83y DNR 45 DNR 90 P value % CR % < % CR age 60-65y % CR CBF % 30-d mortality NS
12 Survival
13 Addi5on of gemtuzumab (GO) ALFA 0701 E/G AML 17 3 RCT NCRI AML 16
14 ALFA 0701 study Induction Day 15 additional treatment* for persistent marrow blasts Consolidation (2 courses) Patients aged yrs with de novo AML (N = 278) GO 3 mg/m 2 /day on Days 1, 4, and 7 + Daunorubicin 60 mg/m 2 on Days Cytarabine 200 mg/m 2 on Days 1-7 (n = 139) Daunorubicin 60 mg/m 2 on Days Cytarabine 200 mg/m 2 on Days 1-7 (n = 139) CR/CRp GO 3 mg/m 2 /day on Day 1 + Daunorubicin 60 mg/m 2 on Day 1 (first course) or Day 1-2 (2nd course) + Cytarabine 1 g/m 2 /12 hrs on Days 1-4 Daunorubicin 60 mg/m 2 on Day 1 (first course) or Day 1-2 (2nd course) + Cytarabine 1 g/m 2 /12 hrs on Days 1-4 *Patients with persistent marrow blasts > 10% at Day 15 received additional daunorubicin 35 mg/m 2 on Days cytarabine 1 g/m 2 /12 hrs on Days 1-3. Castaigne et al, ASH 2011
15 Outcomes
16 OS by cytogenetics Fav/Int K Unfav K Benefit only in patients with fav/interm CG
17 NCRI AML16 study Age >60 Treatment Schedules DA 3+10 Dauno 50 mg/m 2 d1,3,5; Cytarabine 100 mg/m 2 d1-10 every 12h DA 3+8 Dauno 50 mg/m 2 d1,3,5; Cytarabine 100 mg/m 2 d1-8 every 12h DA 2+5 Dauno 50 mg/m 2 d1,3; Cytarabine 100 mg/m 2 d1-5 every 12h DClo Dauno 50 mg/m 2 d1,3,5; Clofarabine 20 mg/m 2 d1-5 Mylotarg Mylotarg 3mg/m 2 d1 of course 1. Azacytidine Azacytidine 75mg/m 2 daily for 5 days repeated every 6 weeks for 9 courses Burnett et al, ASH 2011
18 Outcomes CIR Surv from CR OS
19 OS by baseline features Patients with adverse CG or other poor-risk features unlikely to benefit
20 EORTC/GIMEMA AML-17 study R GOx2 MICE CR/CRp GO+ ICEx2 MICE CR/CRp ICEx2 Treatment Schedules MICE Mito 7 mg/m 2 d1,3,5; Ara- C 100 mg/m 2 d1-7; Eto 100 mg/m 2 d1-3 GO induc5on 6 mg/m 2 d 1, 15 GO consolid 3 mg/m 2 d 0 ICE Ida 8 mg/m 2 d1,3,5; Ara- C 100 mg/m 2 d1-5; Eto 100 mg/m 2 d1-3 Amadori et al, EHA 2012
21 Induction results by age Age Age Pa5ents % No GO GO No GO GO CR+CRp (%) 47,4 52,3 52,4 32,5 No resp (%) 40,8 29,4 29,8 31,3 Ind death (%) 9,9 11,8 15,5 26,5 Inev/unkn (%) 2 6,6 2,4 9,6 P=0.01
22 Survival OS (all pts) Logrank test: p= (years) O N Number of patients at risk : Treatment No GO GO OS (age 70-75y) Logrank test: p= (years) O N Number of patients at risk : Treatment No GO GO saml 61-69y OS Logrank test: p= (years) O N Number of patients at risk : Treatment No GO GO
23 Postremission therapy Group Study PRT Outcome MRC AML-11 1 vs 4 cycles HOVON AML-43 GO vs obs ALFA non-int vs 1 int cycle No diff No diff Better DFS and OS at 2y No proven value All large studies included PRT Poor compliance <50% of pts in CR proceeded to PRT No clear benefit Survival benefit restricted to pts with favorable CG (GOELAMS, retrosp study)* Focus on AlloSCT Goldstone et al, Blood 2001 Lowenberg et al, Blood 2010 Gardin et al, Blood 2007 * Prebet et al, JCO 2009
24 RIC-AlloSCT in elderly AML CIBMTR (1080 pts age 40-79) N=545 AML in CR1 Viable option for patients up to age years TRM comparable to pts age Prospective studies needed McClune et al, JCO 2010
25 Not candidates for intensive Rx Frail PS>2, comorbid Poor risk Multiple risk factors Toxicity Chemo resistance Low intensity Rx Supportive care Investigational Rx
26 Frail: LDAC > HU (NCRI AML 14) LDAC (N=103) HU (N=99) Early death 26% 26% CR 18% 1% Fav/Int CG Poor CG Burnett et al, Cancer 2007
27 Poor risk: Novel agents to watch CPX-351 Laromustine Clofarabine Decitabine HD-LEN CR/CRi 67% CR/CRp 32% CR/CRp 46% CR/CRi 64% CR/CRi 30% ED 3% ED 14% ED 10% ED 2% ED 24% Myelosuppressive regimens Responses in all poor risk groups Randomized trials (vs 3+7) Lancet et al, ASH 2010; Schiller et al, JCO 2010; Kantarjian et al, JCO 2010; Blum et al, PNAS 2010; Fehninger et al, Blood 2010
28 Treating elderly AML in 2012 Fit (Low Risk) Intensive Rx (even at high age) Define optimal therapy, consider RIC-SCT Fit (Poor Risk) Investigational Rx Consider RIC-SCT Unfit/Frail Less intensive Rx (LDAC) Supportive care (HU)
29 The road to progress Define who should have intensive or non-intensive treatment Novel treatments New approach to trial design Avoid therapeutic nihilism
AML in elderly. D.Selleslag AZ Sint-Jan Brugge, Belgium 14 December 2013
AML in elderly D.Selleslag AZ Sint-Jan Brugge, Belgium 14 December 2013 AML is predominantly a disease of the elderly incidence 2 3/100.000 SEER Cancer Statistics, National Cancer Institute, USA 2002 2006
More informationFrontline Induc.on Therapy in 2017 Alan K Burne+
Frontline Induc.on Therapy in 2017 Alan K Burne+ Ravenna, October 2017 Standard of Care Induc5on: 7+3 Ara-C / Daunorubicin Consolida5on: High Dose Ara-C (3g doses) Total of 4 courses. Myeloabla5ve allogral
More informationRisk-adapted therapy of AML in younger adults. Sergio Amadori Tor Vergata University Hospital Rome
Risk-adapted therapy of AML in younger adults Sergio Amadori Tor Vergata University Hospital Rome Pescara 11/2010 AML: treatment outcome Age CR % ED % DFS % OS %
More information2 Workshop Nazionale SIES Ematologia Traslazionale Nuovi Farmaci e Strategie Terapeutiche nelle LMA
2 Workshop Nazionale SIES Ematologia Traslazionale Nuovi Farmaci e Strategie Terapeutiche nelle LMA Adriano Venditti Ematologia Universita Tor Vergata, Roma Current Treatment Results in AML AGE, y CR%
More informationLeucemia Mieloide Acuta Terapie Innovative. Adriano Venditti Ematologia Universita Tor Vergata, Roma
Leucemia Mieloide Acuta Terapie Innovative Adriano Venditti Ematologia Universita Tor Vergata, Roma Leucemia Mieloide Acuta Terapie Innovative Adriano Venditti Ematologia Universita Tor Vergata, Roma AML.Current
More informationESTABLISHED AND EMERGING THERAPIES FOR ACUTE MYELOID LEUKAEMIA. Dr Rob Sellar UCL Cancer Institute, London, UK
ESTABLISHED AND EMERGING THERAPIES FOR ACUTE MYELOID LEUKAEMIA Dr Rob Sellar UCL Cancer Institute, London, UK OVERVIEW Main focus on patients fit for intensive treatment Biological and Clinical Heterogeneity
More informationInotuzumab Ozogamicin in ALL. Hagop Kantarjian M.D. May 2016 Bologna, Italy
Inotuzumab Ozogamicin in ALL Hagop Kantarjian M.D. May 2016 Bologna, Italy Immuno Oncology in ALL Monoclonals + cytotoxic agents e.g.inotuzumab Bispecific monoclonals (CD3 + CD19) e.g.blinatumomab Modified
More information39% Treated. 61% Untreated. 33% UnRx. 45% UnRx. 59% UnRx. 80% UnRx
AML in the Elderly สน น ว ส ทธ ศ กด ช ย งานประช มว ชาการกลางป สมาคมโลห ตว ทยาแห งประเทศไทย คร งท 53 25-26 ต ลาคม 2561 ณ โรงแรมเลอ เมอร เด ยน เช ยงใหม จ งหว ดเช ยงใหม 33% UnRx 45% UnRx 59% UnRx 80% UnRx
More informationAIH, Marseille 30/09/06
ALLOGENEIC STEM CELL TRANSPLANTATION FOR MYELOID MALIGNANCIES Transplant and Cellular Therapy Unit Institut Paoli Calmettes Inserm U599 Université de la Méditerranée ée Marseille, France AIH, Marseille
More informationAcute Myeloid Leukemia Progress at last
Acute Myeloid Leukemia Progress at last Bruno C. Medeiros, MD September 9, 217 Introduction Mechanisms of leukemogenesis Emerging therapies in AML Previously untreated AML Relapsed and refractory patients
More informationRemission induction in acute myeloid leukemia
Int J Hematol (2012) 96:164 170 DOI 10.1007/s12185-012-1121-y PROGRESS IN HEMATOLOGY How to improve the outcome of adult acute myeloid leukemia? Remission induction in acute myeloid leukemia Eytan M. Stein
More informationTreatment of Low-Blast Count AML. Maria Teresa Voso Dipartimento di Biomedicina e Prevenzione Università di Roma Tor Vergata
Treatment of Low-Blast Count AML Maria Teresa Voso Dipartimento di Biomedicina e Prevenzione Università di Roma Tor Vergata Definition of Low-Blast Count AML Blast counts 20-30%, or > 10%? v Retrospective
More informationHow the Treatment of Acute Myeloid Leukemia is Changing in 2019
How the Treatment of Acute Myeloid Leukemia is Changing in 2019 Guido Marcucci, M.D. Director, Gehr Family Center for Leukemia Research Chair, Dept. Hematologic Malignancies Translational Science City
More informationOncology Highlights: Leukemia & Myelodysplastic Syndromes
Oncology Highlights: Leukemia & Myelodysplastic Syndromes Jorge Cortes, MD Department of Leukemia The University of Texas, M.D. Anderson Cancer Center Highlights of the Day Leukemia & MDS AML: The field
More informationAcute Myeloid Leukemia: State of the Art in 2018
Acute Myeloid Leukemia: State of the Art in 2018 Harry P. Erba, MD, PhD Professor, Department of Medicine Director, Leukemia Program Duke University Durham, NC Treatment Paradigm of Adults with AML Fit
More informationAcute Myeloid Leukemia
Acute Myeloid Leukemia Pimjai Niparuck Division of Hematology, Department of Medicine Ramathibodi Hospital, Mahidol University Outline Molecular biology Chemotherapy and Hypomethylating agent Novel Therapy
More informationKevin Kelly, MD, Phd Acute Myeloid and Lymphoid Leukemias
Kevin Kelly, MD, Phd Acute Myeloid and Lymphoid Leukemias Relevant financial relationships in the past twelve months by presenter or spouse/partner. Speakers bureau: Novartis, Janssen, Gilead, Bayer The
More informationIndication for unrelated allo-sct in 1st CR AML
Indication for unrelated allo-sct in 1st CR AML It is time to say! Decision of allo-sct: factors to be considered Cytogenetic risk status Molecular genetics FLT3; NPM1, CEBPA. Response to induction Refractoriness
More informationNew concepts in the management of elderly patients with AML
New concepts in the management of elderly patients with AML Martha L. Arellano, MD Associate Professor of Hematology/Oncology Director, Hematology & Medical Oncology Fellowship Program Winship Cancer Institute
More informationAML IN OLDER PATIENTS Whenever possible, intensive induction therapy should be considered
AML IN OLDER PATIENTS Whenever possible, intensive induction therapy should be considered Charles A. Schiffer, M.D. Karmanos Cancer Institute Wayne State University School of Medicine Detroit, MI WHY ARE
More informationEvolving Targeted Management of Acute Myeloid Leukemia
Evolving Targeted Management of Acute Myeloid Leukemia Jessica Altman, MD Robert H. Lurie Comprehensive Cancer Center of Northwestern University Learning Objectives Identify which mutations should be assessed
More informationTools for MRD in AML: flow cytometry
ACUTE MYELOID LEUKEMIA MEETING Ravenna - October 27, 2017 Tools for MRD in AML: flow cytometry Francesco Buccisano Can MRD improve outcome determina3on? No. of leukemic cells 10 12 10 10 10 8 10 6 10 4
More informationAcute Myeloid Leukemia
Acute Myeloid Leukemia Guido Marcucci, M.D. Director, Gehr Family Center for Leukemia Research Hematologic Malignancies and Stem Cell Transplantation Institute City of Hope Acute Myeloid Leukemia Gene
More informationTreating Higher-Risk MDS. Case presentation. Defining higher risk MDS. IPSS WHO IPSS: WPSS MD Anderson PSS
Treating Higher-Risk MDS Eyal Attar, M.D. Massachusetts General Hospital Cancer Center eattar@partners.org 617-724-1124 Case presentation 72 year old man, prior acoustic neuroma WBC (X10 3 /ul) 11/08 12/08
More informationLeukemia. Andre C. Schuh. Princess Margaret Cancer Centre Toronto
Leukemia Andre C. Schuh Princess Margaret Cancer Centre Toronto AGENDA Ø Overview Ø Key News This Year Ø Key News out of ASH 2016 Sessions Abstracts Ø Canadian Perspective Ø Overview 2015- Stone, R. et
More informationLAM 20-30% Cristina Papayannidis, MD, PhD DIMES, Istituto di Ematologia L. e A. Seràgnoli Università di Bologna
LAM 20-30% Cristina Papayannidis, MD, PhD DIMES, Istituto di Ematologia L. e A. Seràgnoli Università di Bologna FAB CLASSIFICATION OF MYELODYSPLASTIC SYNDROME Subtype % Blood Myeloblasts Bone Marrow Myeloblasts
More informationMolecularly Targeted Therapies - Strategies of the AMLSG
Molecularly Targeted Therapies - Strategies of the AMLSG Richard Schlenk Department of Internal Medicine III Ulm University, Germany Genotype-adapted Leukemia Program NAPOLEON GIMEMA/AMLSG/SAL APL [t(15;17)]
More informationTherapeutic landscape in AML
Therapeutic landscape in AML Andrew Wei 1955: From the sea to Ara-C Cryptotethya crypta Werner Bergman Robert Feeney Bergmann W. & Burke D. C. 1955. Marine products. The nucleosides of sponges. 3: Spongothymidine
More informationAcute promyelocytic leukemia
Acute promyelocytic leukemia Laura Cicconi University Tor Vergata Rome, Italy Acute Myeloid Leukemia Meeting Ravenna, Italy (October 2017) APL. From highly fatal to curable disease Fatal outcome if not
More informationSummary of Key AML Abstracts Presented at the European Hematology Association (EHA) June 22-25, 2017 Madrid, Spain
Summary of Key AML Abstracts Presented at the European Hematology Association (EHA) June 22-25, 2017 Madrid, Spain EHA 2017 ANNUAL MEETING: ABSTRACT SEARCH PAGE: https://learningcenter.ehaweb.org/eha/#!*listing=3*browseby=2*sortby=1*media=3*ce_id=1181*label=15531
More informationWe are IntechOpen, the world s leading publisher of Open Access books Built by scientists, for scientists. International authors and editors
We are IntechOpen, the world s leading publisher of Open Access books Built by scientists, for scientists 3,500 108,000 1.7 M Open access books available International authors and editors Downloads Our
More informationProgress in the treatment of acute promyelocytic leukemia. Lionel Adès, MD PhD Hopital Saint Louis, Paris Diderot University
Progress in the treatment of acute promyelocytic leukemia Lionel Adès, MD PhD Hopital Saint Louis, Paris Diderot University 대한혈액학회 Korean Society of Hematology COI disclosure Name of author : Lionel Adès
More informationAll patients with FLT3 mutant AML should receive midostaurin-based induction therapy. Not so fast!
All patients with FLT3 mutant AML should receive midostaurin-based induction therapy Not so fast! Harry P. Erba, M.D., Ph.D. Professor, Internal Medicine Director, Hematologic Malignancy Program University
More informationDisrupting the Cell Cycle to Treat AML and MDS Rodman & Renshaw Conference
CYC 682 Disrupting the Cell Cycle to Treat AML and MDS Rodman & Renshaw Conference September 2014 Disclaimer This presentation contains forward-looking statements within the meaning of the safe harbor
More informationASCO 2011: Leukemia. Disclosures
ASCO 2011: Leukemia E.J. Feldman M.D Weill-Cornell Medical College Disclosures Speaker does not report any affiliations 1 V617F JAK2 mutation in MPDs JAK STAT PATHWAY Signal transducers and activators
More informationMinimal Residual Disease as a Surrogate Endpoint in Acute Myeloid Leukemia Clinical Trials
Minimal Residual Disease as a Surrogate Endpoint in Acute Myeloid Leukemia Clinical Trials Fda.gov Adriano Venditti Hematology, University Tor Vergata, Rome, Italy Minimal Residual Disease 10 12 Relapse
More informationTREATMENT UPDATES IN ACUTE LEUKEMIA. Shannon McCurdy, MD University of Pennsylvania
TREATMENT UPDATES IN ACUTE LEUKEMIA Shannon McCurdy, MD University of Pennsylvania TIMELINE FOR FDA APPROVED AGENTS FOR AML Midostuarin Enasidenib Cytarabine + Daunorubicin (7+3) Gemtuzumab Ozogamicin
More informationThe Evolving Treatment Landscape in AML
The Evolving Treatment Landscape in AML Elias Jabbour, MD Associate Professor Section Chief, Acute Lymphocytic Leukemia Department of Leukemia Division of Cancer Medicine The University of Texas MD Anderson
More informationIII. AML IN OLDER ADULTS: ARE WE LISTENING?
III. AML IN OLDER ADULTS: ARE WE LISTENING? Mikkael A. Sekeres, MD, MS* AML is a disease of older adults. In the US, the median age is 68 years and the age-adjusted population incidence is 17.6 per 100,000
More informationMRD detection in AML. Adriano Venditti Hematology Fondazione Policlinico Tor Vergata Rome
MRD detection in AML Adriano Venditti Hematology Fondazione Policlinico Tor Vergata Rome Determinants of Treatment Response Leukemia Tumor burden Growth potential Drug resistance Karyotype Genetics Host
More informationManagement of low and high risk MDS
Management of low and high risk MDS D.Selleslag AZ Sint-Jan Brugge, Belgium Brussels, 4th October 2014 Low / int 1 risk MDS Improve QOL Improve cytopenia Int 2 / high risk MDS Delay progression To AML
More informationLA LEUCEMIA SECONDARIA: QUALI OPZIONI TERAPEUTICHE. Livio Pagano Istituto di Ematologia Università Cattolica S. Cuore Roma
LA LEUCEMIA SECONDARIA: QUALI OPZIONI TERAPEUTICHE Livio Pagano Istituto di Ematologia Università Cattolica S. Cuore Roma saml: Incidence In USA, NCI / SEER data - 1998 10,600 new patients with AML / year
More informationFront-line treatment in young. Role of maintenance therapy. Rome 2017 Prof Le Gouill S.
Front-line treatment in young patients with MCL: Role of maintenance therapy Rome 2017 Prof Le Gouill S. Is there a need for maintenance for young MCL patients? Is there a need for maintenance for young
More informationMantle cell lymphoma Allo stem cell transplantation in relapsed and refractory patients
Mantle cell lymphoma Allo stem cell transplantation in relapsed and refractory patients Olivier Hermine MD, PhD Department of Hematology INSERM and CNRS, Imagine Institute Necker Hospital Paris, France
More informationDepartment of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, Texas; 2 Sunesis Pharmaceuticals, Inc, South San Francisco
Phase I/II Study of Vosaroxin and Decitabine in Newly Diagnosed Older Patients with Acute Myeloid Leukemia (AML) and High Risk Myelodysplastic Syndrome (MDS) Naval Daver 1, Hagop Kantarjian 1, Guillermo
More informationChemotherapeutic treatment of acute myeloid leukemia: incorporating the results of recent clinical trials
d Chemotherapeutic treatment of acute myeloid leukemia: incorporating the results of recent clinical trials Better outcomes for patients with acute myeloid leukemia over the last 30 years have been largely
More informationWednesday, November 30, 2011 University of Michigan
Wednesday, November 30, 2011 University of Michigan Presenter Gary J. Schiller, MD, FACP Professor, Department of Medicine, Hematology/Oncology Director, Hematological Malignancies/Stem Cell Transplantation
More informationANCO Hematological Malignancies Update: The year in review. Midostaurin Vyxeos Gemtuzumab ozogamicin Enasidenib. The year in preview
ANCO Hematological Malignancies Update: Gabriel Mannis, MD Assistant Professor, and Marrow Co-Director, Cancer Immunotherapy Clinic Acute Leukemia Sacramento, CA June 16, 2018 OVERVIEW Overview The year
More informationMyelodysplastic Syndromes. Post-ASH meeting 2014 Marie-Christiane Vekemans
Myelodysplastic Syndromes Post-ASH meeting 2014 Marie-Christiane Vekemans Agenda New biological developments Risk assessment and prognostic factors New therapeutic options Agenda New biological developments
More informationAML:Transplant or ChemoTherapy?
AML:Transplant or ChemoTherapy? 1960 s: Importance of HLA type in Animal Models Survival of Dogs Given 1000 RAD TBI and a Marrow Infusion from a Littermate Matched or Mismatched for Dog Leucocyte Antigens
More informationArecent source data meta-analysis of randomized trials in adults
ARTICLE Acute Myeloid Leukemia EUROPEAN HEMATOLOGY ASSOCIATION Ferrata Storti Foundation Defining the dose of gemtuzumab ozogamicin in combination with induction chemotherapy in acute myeloid leukemia:
More informationANCO 2015: Treatment advances in acute leukemia
ANCO 2015: Treatment advances in acute leukemia Michaela Liedtke, MD Stanford, CA September 12, 2015!" Disclosures Research Support/P.I. Employee Consultant Major Stockholder Speakers Bureau Steering Committee
More informationControversies in Treatment of AML: Case-based Discussion
Controversies in Treatment of AML: Case-based Discussion Wendy Stock Treatment of acute myeloid leukemia (AML) in older adults remains a tremendous challenge. Standard approaches to treatment have resulted
More informationUpdate on Optimal Management of Acute Myeloid Leukemia
Update on Optimal Management of Acute Myeloid Leukemia Fuad El Rassi, Emory University Martha Arellano, Emory University Journal Title: Clinical Medicine Insights: Oncology Volume: Volume 7 Publisher:
More informationTargeting CD20 and CD22 in B-cell ALL Daniel J. DeAngelo, MD, PhD
Targeting CD20 and CD22 in B-cell ALL Daniel J. DeAngelo, MD, PhD Harvard/Dana-Farber Cancer Institute Boston, MA Disclosures for Daniel J. DeAngelo, MD, PhD Royalty Receipt of intellectual property/ Patent
More informationStem cell transplantation for patients with AML in Republic of Macedonia: - 15 years of experience -
Stem cell transplantation for patients with AML in Republic of Macedonia: - 15 years of experience - R E S E A R C H A S S O C I A T E P R O F. D - R Z L A T E S T O J A N O S K I Definition Acute myeloid
More informationSystemic Treatment of Acute Myeloid Leukemia (AML)
Guideline 12-9 REQUIRES UPDATING A Quality Initiative of the Program in Evidence-Based Care (PEBC), Cancer Care Ontario (CCO) Systemic Treatment of Acute Myeloid Leukemia (AML) Members of the Acute Leukemia
More informationObjectives. I do not have anything to disclose.
Treatment of APL Objectives I do not have anything to disclose. Objectives 1. Urgency of early recognition and treatment 2. Treatment based on risk stratification 3. Monitoring for relapse 4. Treatment
More informationWhat s new in Blood and Marrow Transplant? Saar Gill, MD PhD Jan 22, 2016
What s new in Blood and Marrow Transplant? Saar Gill, MD PhD Jan 22, 2016 Division of Hematology-Oncology University of Pennsylvania Perelman School of Medicine 1 Who should be transplanted and how? Updates
More information2/10/2017. Updates in Acute Leukemia Therapy Blood Cancer Incidence in the United States, Leukemia Incidence in the Unites States, 2016
Updates in Acute Leukemia Therapy 2017 Aaron Logan, MD, PhD UCSF Division of Malignant Hematology and Blood and Marrow Transplantation aaron.logan@ucsf.edu @hemedoc Blood Cancer Incidence in the United
More informationInduction Therapy & Stem Cell Transplantation for Myeloma
Induction Therapy & Stem Cell Transplantation for Myeloma William Bensinger, MD Professor of Medicine, Division of Oncology University of Washington School of Medicine Director, Autologous Stem Cell Transplant
More informationAcute Myeloid Leukemia: Targets and Curability, so Close But a Journey So Far
Acute Myeloid Leukemia: Targets and Curability, so Close But a Journey So Far Martin S. Tallman, M.D. Chief, Leukemia Service Memorial Sloan Kettering Cancer Center Professor of Medicine Weill Cornell
More informationAcute Myeloid and Lymphoid Leukemias
Acute Myeloid and Lymphoid Leukemias Hugo F. Fernandez, MD Department of Malignant Hematology & Cellular Therapy Moffitt at Memorial Healthcare System April 29, 2018 15 th Annual Miami Cancer Meeting Objectives
More informationNational Institute for Health and Care Excellence. Single Technology Appraisal (STA)
Single Technology Appraisal (STA) Gemtuzumab ozogamacin for untreated de novo acute myeloid leukaemia Response to consultee and commentator comments re-scope Please note: Comments received in the course
More informationTreatment of APL. M a tth e w M e i, M.D. A s s is ta n t P ro fe s s o r C ity o f H o p e C o m p re h e n s iv e C a n c e r C e n te r
Treatment of APL M a tth e w M e i, M.D. A s s is ta n t P ro fe s s o r C ity o f H o p e C o m p re h e n s iv e C a n c e r C e n te r Disclosures I have nothing to disclose Objectives 1. Urgency of
More informationBest of ASH: Acute leukemia. Frédéric Baron
Best of ASH: Acute leukemia Frédéric Baron I Acute Myeloid Leukemia Flt3 inhibitors (ratify, sorafenib after HCT) 5 other important abstracts (in brief) Mutated genes in AML FLT3: The Cancer Genome Atlas
More informationThe case for maintenance rituximab in FL
New-York, October 23 rd 2015 The case for maintenance rituximab in FL Pr. Gilles SALLES For FL patients, progression-free survival still needs to be improved Median R-CHVP-I 66 months P
More informationPET-adapted therapies in the management of younger patients (age 60) with classical Hodgkin lymphoma
PET-adapted therapies in the management of younger patients (age 60) with classical Hodgkin lymphoma Ryan Lynch MD Assistant Professor, University of Washington Assistant Member, Fred Hutchinson Cancer
More informationManaging Newly Diagnosed Multiple Myeloma
Managing Newly Diagnosed Multiple Myeloma 26 Jan 2018 Alfred Garfall, MD Assistant Professor of Medicine Diagnosis of Multiple Myeloma Traditional criteria: Monoclonal plasma cells + attributable CRAB
More informationEmerging Treatment Options for Myelodysplastic Syndromes
Emerging Treatment Options for Myelodysplastic Syndromes James K. Mangan, MD, PhD Assistant Professor of Clinical Medicine Abramson Cancer Center, University of Pennsylvania Please note that some of the
More informationROB LOWN SOUTHAMPTON HODGKIN LYMPHOMA IN THE ELDERLY
ROB LOWN SOUTHAMPTON HODGKIN LYMPHOMA IN THE ELDERLY EPIDEMIOLOGY HODGKIN LYMPHOMA - INCIDENCE EPIDEMIOLOGY HODGKIN LYMPHOMA - MORTALITY EPIDEMIOLOGY HODGKIN LYMPHOMA - MORTALITY BY AGE NUMBER OF PEOPLE
More informationPETHEMA; 2 HOVON; 3 PLAG and 4 GATLA Groups.
Clinical significance of complex karyotype at diagnosis in Pa7ents with Acute Promyelocy7c Leukemia Treated with ATRA and chemotherapy based PETHEMA trials Labrador J 1, Montesinos P 1, Bernal T 1, Vellenga
More informationPh+ALL : a new era. Said Y Mohamed KFSHRC, Riyadh Ain Shams University, Cairo, Egypt
Ph+ALL : a new era Said Y Mohamed KFSHRC, Riyadh Ain Shams University, Cairo, Egypt A 30 Y/O patient with Ph+ ALL What would you start as an induction? 1. BFM/CALGB/UKALL Plus TKI? 2. Some chemo + TKI.
More informationallosct and CLL in the BCRi era time for a study
allosct and CLL in the BCRi era time for a study Patient characteristics in BCRi studies and allosct candidates DIFFER Facts on BCRi no Cure Risk factors for shorter BCRi efficacy in MV analysis? PA-refractory
More informationIPSS Modified 7/27/2011. WHO-Based Prognostic Scoring System (WPSS)
Advances in MDS Treatment: What s on the Horizon? New Prognostic Models and Therapies Jason Gotlib, MD, MS Assistant Professor of Medicine (Hematology) Stanford Cancer Center AA&MDSIF July 3, 011 WHO-Based
More informationRole of consolidation therapy in Multiple Myeloma. Pieter Sonneveld. Erasmus MC Cancer Institute Rotterdam The Netherlands
Role of consolidation therapy in Multiple Myeloma Pieter Sonneveld Erasmus MC Cancer Institute Rotterdam The Netherlands Disclosures Research support : Amgen, Celgene, Janssen, Karyopharm Advisory Boards/Honoraria:
More informationStandard of care for patients with newly diagnosed multiple myeloma who are not eligible for a transplant
Standard of care for patients with newly diagnosed multiple myeloma who are not eligible for a transplant Pr Philippe Moreau University Hospital, Nantes, France MP: Standard of care until 2007 J Clin Oncol
More informationClinical Overview on Measurable Residual Disease (MRD) in Acute Myeloid Leukemia(AML)
Clinical Overview on Measurable Residual Disease (MRD) in Acute Myeloid Leukemia(AML) Konstanze Döhner Department of Internal Medicine III, University Hospital of Ulm, Ulm Germany DISCLOSURES OF COMMERCIAL
More informationContemporary and Future Approaches in CML. Emory Meeting; Sea Island August 2014 Hagop Kantarjian, M.D.
Contemporary and Future Approaches in CML Emory Meeting; Sea Island August 2014 Hagop Kantarjian, M.D. 1 CML. Historical vs. Modern Perspective Parameter Historical Modern Course Fatal Indolent Prognosis
More informationMantle Cell Lymphoma: Update in Diego Villa, MD MPH FRCPC Medical Oncologist BC Cancer Agency
Mantle Cell Lymphoma: Update in 2015 Diego Villa, MD MPH FRCPC Medical Oncologist BC Cancer Agency Disclosures Research funding: Roche provides research funding to support the Centre for Lymphoid Cancer
More informationReduced-intensity Conditioning Transplantation
Reduced-intensity Conditioning Transplantation Current Role and Future Prospect He Huang M.D., Ph.D. Bone Marrow Transplantation Center The First Affiliated Hospital Zhejiang University School of Medicine,
More informationInduction therapy for elderly patients with acute myeloid leukemia
Blood Reviews (2008) 22, 311 320 www.elsevier.com/locate/blre REVIEW Induction therapy for elderly patients with acute myeloid leukemia Mike G. Martin*, Camille N. Abboud Section of Bone Marrow Transplantation
More informationHighlights in acute myeloid leukemia (AML): what is going to change?
29 Highlights in acute myeloid leukemia (AML): what is going to change? C. Graux, MD, PhD SUMMARY The decision making process in AML integrates clinical features, an increasing amount of genetic information
More informationBendamustine, Bortezomib and Rituximab in Patients with Relapsed/Refractory Indolent and Mantle-Cell Non-Hodgkin Lymphoma
Bendamustine, Bortezomib and Rituximab in Patients with Relapsed/Refractory Indolent and Mantle-Cell Non-Hodgkin Lymphoma Friedberg JW et al. Proc ASH 2009;Abstract 924. Introduction > Bendamustine (B)
More informationWho should get what for upfront therapy for MCL? Kami Maddocks, MD The James Cancer Hospital The Ohio State University
Who should get what for upfront therapy for MCL? Kami Maddocks, MD The James Cancer Hospital The Ohio State University Treatment Challenges Several effective options, improve response durations, none curable
More informationALLOGENEIC STEM CELL TRANSPLANTATION FOR ACUTE MYELOBLASTIC LEUKEMIAS
ALLOGENEIC STEM CELL TRANSPLANTATION FOR ACUTE MYELOBLASTIC LEUKEMIAS Didier Blaise, MD Transplant and Cellular Therapy Unit (U2T) Department of Hematology Centre de Recherche en Cancérologie, Inserm U891
More informationWhich is the best treatment for relapsed APL?
Which is the best treatment for relapsed APL? 7th International Symposium on Acute Promyelocytic Leukemia, Rome, September 24 27, 2017 Eva Lengfelder Department of Hematology and Oncology University Hospital
More informationMantle cell lymphoma An update on management
Mantle cell lymphoma An update on management Dr Kim Linton Consultant Medical Oncologist The Christie NHS Foundation Trust 6 th October 2016 This educational meeting is organised and sponsored by Janssen-Cilag
More informationASCO 2009 Leukemia MDS -Transplant
ASCO 2009 Leukemia MDS -Transplant Ruben A. Mesa, MD Professor of Medicine Mayo Clinic College of Medicine Scottsdale, AZ, USA mesa.ruben@mayo.edu American Society of Hematology State-of-the-Art Symposium
More informationUpdate in Acute Lymphoblastic Leukemia Richard M, Stone, M.D.
Update in Acute Lymphoblastic Leukemia Richard M, Stone, M.D. Director, Adult Leukemia Program Dana-Farber Cancer Institute Professor of Medicine Harvard Medical School Boston, MA Disclosure Information
More informationNovel Induction and Targeted Strategies in Acute Myeloid Leukemia
Novel Induction and Targeted Strategies in Acute Myeloid Leukemia Eytan M. Stein, MD Leukemia Service Memorial Sloan Kettering Cancer Center Weill Cornell Medical College New York, New York Current Paradigms
More informationLa lenalidomide: meccanismo d azione e risultati terapeutici. F. Ferrara
La lenalidomide: meccanismo d azione e risultati terapeutici F. Ferrara MDS: new treatment goals Emerging treatment options expected to facilitate shift from supportive care to active therapy in MDS New
More informationAnthracycline dose intensification improves molecular response and outcome of patients treated for core binding factor acute myeloid leukemia
Published Ahead of Print on June 27, 2014, as doi:10.3324/haematol.2014.109827. Copyright 2014 Ferrata Storti Foundation. Anthracycline dose intensification improves molecular response and outcome of patients
More informationRisk stratification in the older patient; what are our priorities?
Risk stratification in the older patient; what are our priorities? Sonja Zweegman MD PhD Amsterdam The Netherlands Negative impact of age on survival Meta-analysis of European trials (MP vs MPT, VMP vs
More informationMeasurable/Minimal Residual Disease in Patients with Acute Myeloid Leukemia Undergoing Transplantation
Measurable/Minimal Residual Disease in Patients with Acute Myeloid Leukemia Undergoing Transplantation June 9, 2018 Dave Sanford The Leukemia/Bone Marrow Transplant Program of British Columbia Disclosures
More informationMatthew Mei, M.D. Assistant t Professor City of Hope Comprehensive Cancer Center
Treatment of APL Matthew Mei, M.D. Assistant t Professor City of Hope Comprehensive Cancer Center Objectives 1. Urgency of early recognition and treatment 2. Treatment based on risk stratification 3. Monitoring
More informationFirst Clinical Trial Day: Update on AML and CML trials. Barbara De Moerloose Brussels, June 20 th 2014
First Clinical Trial Day: Update on AML and CML trials Barbara De Moerloose Brussels, June 20 th 2014 Update on CML trials I-CML-Ped Study StopImaPed Study Nilotinib Phase 2 Study Guidelines for the management
More informationDr. Nicolas Ketterer CHUV, Lausanne SAMO, May 2009
Treatment of DLBCL Dr. Nicolas Ketterer CHUV, Lausanne SAMO, May 2009 Non-hodgkin lymphomas DLBCL Most common NHL subtype throughout the world many other types of lymphoma with striking geographic variations
More informationBackground CPX-351. Lancet J, et al. J Clin Oncol. 2017;35(suppl): Abstract 7035.
Overall Survival (OS) With Versus in Older Adults With Newly Diagnosed, Therapy-Related Acute Myeloid Leukemia (taml): Subgroup Analysis of a Phase 3 Study Abstract 7035 Lancet JE, Rizzieri D, Schiller
More information