UNIVERSITY OF KANSAS SCHOOL OF MEDICINE Faculty Curriculum Vitae

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1 UNIVERSITY OF KANSAS SCHOOL OF MEDICINE Faculty Curriculum Vitae I. PERSONAL DATA First Name Fen Last name Wang Current Academic Rank Associate Professor Department(s) Radiation Oncology Office Address 3901 Rainbow Blvd, Kansas City, Kansas, Phone Fax PROFESSIONAL DEVELOPMENT Undergraduate and Graduate Education Years (Inclusive) Degree Institution 09/79 to 08/84 Bachelor of Medicine Beijing Medical University, China 09/87 to 06/91 Doctor of Medicine Medical School of Essen University, Germany Postgraduate Education Years (Inclusive) Degree Institution 09/84 to 09/87 Resident Department of Surgery, People s Hospital, Beijing Medical University, China. 07/90 to 06/91 07/97 to 06/98 07/98 to 06/02 Fellow Intern Resident Department of Surgery, Medical School of Essen University, Germany Department of Surgery, Medical Center of University of South Alabama Department of Radiation Oncology, University of Academic and Professional Appointments and Activities Month and Year Position Institution 07/91 to 06/97 Research Scientist Mastology Center, Baton Rouge, Louisiana 07/02 to 06/04 Instructor Department of Radiation Oncology, University of 07/04 to 2010 Assistant Professor Department of Radiation Oncology, University of CV for Fen Wang, M.D., Ph.D. page 1

2 7/2010 to present 8/2006 to present Associate Professor Residency Program Director Department of Radiation Oncology, University of Department of Radiation Oncology, University of Professional Registration/Licensure Year Number State Kansas Professional Certification(s) Date Board 1997 ECFMG 06/2004 American Board of Therapeutic Radiology Professional Societies and Affiliations Date Organization (including offices held) American Association for Cancer Research 1998 present American Society for Therapeutic Radiology and Oncology American College of Radiology Present American Brachytherapy Society Committee member: Cancer fellowship Review Panel for Ladies Auxiliary Veterans of Foreign Wars 2004, 2008 Committee member: Hospital-Based Cohort Nominating Committee present Committee member: KMCRI Protocol Review and Monitoring Committee 2006 present Committee member: SOM Faculty Council, University of Kansas 2002 present Member of SWOG, GOG, POG and ACSO 2004, 2008 Committee member: Hospital-Bases Cohort Nominating Committee 2006 present Committee member: SOM Faculty Council, University of Kansas 2006 present Committee chair: Educational Committee, Department of Radiation Oncology, KUMC 2008 present Institution Principal Investor: RTOG 2009 present Member of Graduate Medical Education Committee (GMEC), KUMC present Member. International Association for the Study of Lung Cancer 1/5/2011 KUPI Board Cohorts Nominating Committee CV for Fen Wang, M.D., Ph.D. page 2

3 Additional Training 12/08 - Brain Lab Modular Courses on Stereotactic Radiotherapy and Radiosurgery Brain Lab Academy, University of Erlanger, Erlanger, Germany Activities related to Academic Societies Cancer fellowship Review Panel for Ladies Auxiliary Veterans of Foreign Wars Committee member: Annually review grant applications KMCRI Protocol Review and Monitoring Committee Committee member: Review and discuss protocols and clinical trials to be opened in KUMC Present Radiation Therapy Oncology Group Institution Principle investigator: Responsible for opening RTOG clinical trials in the institution and developing clinical trials for RTOG. Attend RTOG semiannual meeting. 2004, 2008 Hospital-Based Cohort Nominating Committee KUMC Committee member, KUMC 2002 Present Education Committee Department of Radiation Oncology, KUMC Committee member , Chair, 2006 present Radiation Oncology Foundation Kansas City, Kansas Treasurer 2007 Present Disease Working Groups (Brain tumor, Head and Neck Cancer, Lung Cancer, GI Cancer) University of Kansas Cancer Center Member Department of Radiation Oncology Chairperson Search Committee University of Present GMEC Scholarly Publications 1 Head, J.F., Wang, F., Elliott, R.L. and McCoy, J.L. Development of a Tumor-Associated Antigen (TAA) Bacillus Calmette-Guerin (BCG) Vaccination Program for Breast Cancer Patients. Book of the New York Academy of Sciences: Specific Immunotherapy of Cancer with Vaccines. PI- 5. Jan , Head, J.F., Wang, F., Elliott, R.L. and McCoy, J.L. Assessment of Immunologic Competence and Host Reactivity Against Tumor Antigen in Breast Cancer Patients (Prognostic Value and Rationale of Immunotherapy Development) Ann. New York Acad. Sci. 690: , Head, J.F., Wang, F. and Elliott, R.L. Breast Thermography is a Noninvasive Prognostic Procedure that Predicts Tumor Growth Rate in Breast Cancer Patients. Ann. New York Acad. Sci. 698: , CV for Fen Wang, M.D., Ph.D. page 3

4 4 Elliott, R.L., Elliott, M.C., Wang, F. and Head, J.F. Breast Carcinoma and the Role of Iron Metabolism; a Cytochemical, Tissue Culture and Ultrastructural Study. Ann. New York Acad. Sci. 698: , Wang, F., Ledford, L., Head, J.F. and Elliott, R.L. A Novel Cell Culture Technique for Electron Microscopy. Microscopy Research and Technique, 26: , Head, J.F., Wang, F. and Elliott, R.L. Vaccination of Breast Cancer Patients with Autologous Tumor-Associated Antigens Results in Decreased Serum Concentrations of the Tumor marker CA Journal of Tumor Marker Oncology. 10:45, Elliott, R.L., Ledford, L.B., Head, J.F. and Wang, F. A New Method of Preparing Cultured Cells for EM. Microscopy and Analysis. 13:31-32, Head, J.F., Lipari, C.A., Wang, F., and Elliott, R.L. Cancer Risk Assessment with a Second Generation Infrared Imaging System. S.P.I.E. 3061: , Head, F.J., Wang, F. and Elliott, R.L. Antineoplastic Drugs that Interfere with Iron Metabolism in Cancer Cells. Advan. Enzyme Regul., 37: , Head, J., Lipari, C., Wang, F., and Elliott, R. Image Analysis of Digitized Infrared Images of the Breasts from a First Generation Infrared Images of the Breasts from a First Generation Infrared Imaging System. Proc. IEEE Eng. Med. Biol. 19: , Wang, F., Elliott, R.L., and Head, J.F. Inhibitory Effect of Deferoxamine Mesylate and Low Iron Diet on the 13762NF Rat Mammary Adenocarcinoma. Anticancer Res. 19: , Wang, F., Jingo, X.P, Yang, D.C., Elliott, R.L., and Head, J.F. Doxorubicin-Gallium-Transferrin Conjugate Overcomes Multidrug Resistance: Evidence for Drug Accumulation in the Nucleus of Drug Resistant MCF-7/ADR Cells. Anticancer Res. 20: , Head, J.F., Wang, F., Lipari, C.A., and Elliott, R.L. The Important Role of Infrared Imaging in Breast Cancer: New Technology Improves Applications in Risk Assessment, Detection, Diagnosis and Prognosis. IEEE Eng. Med. Biol. 19:52-57, Yang, D.C., Wang, F., Elliott, R.L., and Head, J.F.: Expression of Transferrin Receptor and Ferrritin H-chain mrna are Associated with Clinical and Histopathological Prognostic Indicators in Breast Cancer. Anticancer Res. 21: , Xian P. Jiang, Fen Wang, Ding C. Yang, Robert L. Elliott and Johnathan F. Head. Induction of apoptosis by iron depletion in the human breast cancer MCF-7 cell line and the 13762NF rat mammary adenocarcinoma in vivo. Anticancer Res. 22: , Kubicek G, Reddy EK, Kimler BF, Al-Kasspooles M, Baranda J, Wang F, Krishnan L, Jewell WR: Anal cancer: The KUMC experience. Kansas J Med. 1: 27-37, Kubicek GJ, Krishnan L, Kimler BF, Al-kasspooles M, Reddy EK, Wang F, Jewell WR: Adjuvant radiation for malignant melanoma: The KUMC experience. Kansas J Med Volume 2, Issue 1, Krishnan, L., Jewell, W., Connor, C., Tawfik, O.W., Alvarez-Farinetti, A., Wang, F., Reddy, E. and Krishnan, E.C.: Breast Conservation Therapy with Tumor Bed Brachytherapy alone in Stage I Breast Cancer: Results of a Phase II Trial. Kansas J Med, 2(2): CV for Fen Wang, M.D., Ph.D. page 4

5 19 Kubicek GJ, Wang F, Reddy E, Shnayder Y, Cabrera CE, Girod DA. Importance of treatment institution in head and neck cancer radiotherapy. Otolaryngol Head Neck Surg Aug;141(2): Kubicek GJ, Champ C, Fogh S, Wang F, Reddy E, Intenzo C, Dusing RW, Machtay M. FDG- PET staging and importance of lymph node SUV in head and neck cancer. Head Neck Oncol Jul 16;2: Kubicek GJ, Kimler BF, Wang F, Reddy EK, Girod DA, Williamson SK. Chemotherapy in Head and Neck Cancer: Clinical Predictors of Tolerance and Outcomes. Am J Clin Oncol Sep 24. [Epub ahead of print] 23 Wang, F., Kumar, P. The Role of Radiotherapy in Management of Pancreatic Cancer. Journal of Gastrointestinal Oncology, Vol 2, No 3, , September Published abstracts 1 Wang, F., Blank, M., Head, J.F. and Elliott, R.L. Breast Surface Temperature Cooling Behavior in the Cold Ambient. Annual Meeting of American Academy Thermology, Wang, F., Blank, M., Head, J.F. and Elliott, R.L. Thermoregulation of the Breast Surface during the Menstrual Cycle. Annual Meeting of American Academy Thermology, Head, J.F., Wang, F. and Elliott, R.L. The Relationship of Thermographic Results of Breast Cancer Patients to Clinical Pathological and Biochemical Prognostic Factors. Annual Meeting of American Academy Thermology, Head, J.F., Wang, F. and Elliott, R.L. Breast Thermography is a Noninvasive Prognostic Procedure that Predicts Tumor Growth Rate in Breast Cancer Patients. Book of the Pisa Symposia in Oncology Breast Cancer: from Biology to Therapy. 48. Oct Elliott, R.L., Elliott, M.C., Wang, F. and Head, J.F. Breast Carcinoma and the Role of Iron Metabolism (A Cytochemical, Tissue Culture and Ultrastructural Study). Book of the Pisa Symposia in Oncology Breast Cancer: from Biology to Therapy. 50. Oct, Elliott, R.L., Wang, F., Elliott, M.C., Ledford, L.B. and Head, J.F. Ultrastructural Pathology of Human Breast Carcinoma (Observation in 592 Patients). Proc. of the American Association for Cancer Research. 34, March Elliott, R.L., Wang, F., Elliott, M.C., Ledford, L. and Head, J.F. Ultrastructural Pathology of Human Breast Carcinoma (Observation in 592 Patients). Proc. of the American Association for Cancer Research, 34:191, Wang, F., Hailey, M., Elliott, R.L. and Head, J.F. Inhibitory Effect of Deferoxamine Mesylate on the Growth of Rat 13762NF Mammary Adenocarcinoma. Breast Cancer Research and Treatment, 27:151, Head, J.F., Nutt, D.R., Elliott, M.C., Wang, F. and Elliott, R.L. Phase I/II Study of Sequentially Administered Deferoxamine, Cisplatin-Transferrin Complex and FAC (5-fluorouracil, doxorubicin, cyclophosphamide) in Advanced Breast Cancer. Proc. of the American Association for Cancer Research. 85:227, CV for Fen Wang, M.D., Ph.D. page 5

6 10 Elliott, R.L., Wang, F. and Head, J.F. Ultrastructural Observation Confirm Malignant Epithelium to be the Source of Tissue Ferritin in Breast Carcinoma. Proc. of the American Association for Cancer Research, 85:228, Wang, F., Hailey, M., Ward, K., Elliott, R,L., Head, J.F. Growth Inhibition of Rat 13762NF Mammary Adenocarcinoma by Deferoxamine Mesylate. Proc. of the American Association for Cancer Research, 85:406, Elliott, R.L., Elliott, M.C., Wang, F. and Head, J.F. The Role of Iron Metabolism in Metastatic Breast Carcinoma (Synergistic Action of Cisplatin-Transferrin Complex and Doxorubicin). Proc. of the American Society of Clinical Oncology, 13:80, Head, J.F., Wang, F. and Elliott, R.L. Lymphocyte Blastogenesis Assay (LBA) Monitoring of Breast Cancer Patients (PTs) Vaccinated with Autologous and Allogeneic Tumor-Associated Antigens. Proc. of the American Society of Clinical Oncology, 13:301, Head, J.F., Nutt, D.R., Elliott, M.C., Wang, F. and Elliott, R.L. Phase I-II Trial in Advanced Breast Cancer Patients of Sequential Combination Chemotherapy with Deferoxamine, Cisplatin- Transferrin Complex and FAC (5-Fluorouracil, Doxorubicin, cyclophosphamide). Annals of Oncology. 5:169, Elliott, R.L., Elliott, M.C., Wang, F. and Head, J.F. Innovative Chemotherapy in Breast Cancer by Modulation of Transferrin Receptors: Transferrin as a Carrier of Cytotoxic Agents. Annuals of Oncology. 5:972, Head, J.F., Wang, F. and Elliott, R.L. Lymphocyte Blastogenesis Assay Monitoring of Changes In the Immune Status of Breast Cancer Patients Vaccinated with Autologous and Allogeneic Tumor- Associated Antigens. Breast Cancer Res. and Treat. 32:133, Head, J.F., Wang, F., Hailey, M. and Elliott, R.L. Vaccination of Breast Cancer Patients with Autologous Tumor-associated Antigens Results in Increased Lymphocyte Blastogenesis Assay Ratios and Decreased Serum Concentrations of the Tumor Marker CA rd Annual Scientific Meeting of Southeastern Surgical Congress, Feb. 6-8, Head, J.F., Brewer, M.M., Ledford, L.B., Wang, F. and Elliott, R.L. Breast Tumor Ferritin Concentrations Determined By Microparticle Enzyme Immunoassay, Immunocytochemical Analysis and Electron Microscopy. Breast Cancer Research and Treatment. 33:103, Wang, F., Head, J.F., and Elliott, R.L. The Upregulation of Transferrin Receptors by Deferoxamine Enhances the Growth Inhibitory Effect of Gallium-Transferrin on MCF-7 cells Proc. Amer. Assoc. Cancer Res. 36:355, Head, J.F., Lipari, C.A., Wang, F., Davidson, J.E., and Elliott, R.L. Application of Second Generation Infrared Imaging and Computerized Image Analysis to Breast Cancer Risk Assessment. IEEE Eng. Med. Biol. 18:1019, Suyder, W., Wang, C., Wang, F., Elliott, R.L., and Head, J.F. Improving the resolution of Infrared Images of the Breast. IEEE Eng. Med. Biol. 18:1058, Yang, D.C., Head, J.F., Wang, F., Elliott, R.L. Transferrin Receptor mrna and Ferritin H-chain mrna Expression are Associated with Prognostic Indicators for Breast Cancer. Proc. Amer. Assoc. Cancer Res. 38:419, CV for Fen Wang, M.D., Ph.D. page 6

7 23 Wang, F., Jingo, X.P., Yang, D.C., Elliott, R.L., and Head, J.F. Effects of Gallium and Gallium- Transferrin on DNA Synthesis, Ferritin Gene Expression and Cellular Ferritin Synthesis in MCF-7 Cells. Proc. Amer. Assoc. Cancer Res. 38:601, Wang, F., Jiang, X.P., Yang, D.C., Elliott, R.L., and Head, J.F.: Doxorubicin-Gallium-Transferrin Conjugate Overcomes Multidrug Resistance: Evidence for nuclear Drug Accumulation in Resistant Cells MCF-7/ADR. Breast Cancer Res. Treat. 46:236, Jiang, X.P., Wang, F., Head, J.F., Yang, D.C., and Elliott, R.L.: The Deprivation of Iron Induces Apoptosis in MCF-7 Human Breast Cancer Cell Line and 13762NF Rat mammary Adenocarcinoma Tumor. Breast Cancer Res. Treat. 46:468, Yang, D.C., Head, J.F., Wang, F., Jiang, X.P., Ferris, J., and Elliott, R.L.: Growth Inhibition of Multidrug-Sensitive and Multidrug-Resistant Human Breast Cancer Cell Lines by Gallium-Transferrin. Proc. Amer. Assoc. Cancer Res. 39:1760, Wang, F., Krishnan, L., Tawfik, O., Ren, Y.F., Kimler, B.F., Miller, R.D., Chapman, J.A. and Weed, J.C. Prognostic Significant of Apoptosis in Cancer of the Cervix. Forty-seventh Annual Meeting of the Radiation Research Society, April 29-May 3:74, Head, J.F., Bruce, T.L., Wang, F., and Elliott, R.L. Gallium Loaded Transferrin as a Specific Carrier of Paclitaxel into Breast Cancer Cells. Proc. Amer. Assoc. Cancer Res. 42:2019, Kubicek, G.J., Kimler, B., Bell, M. and Wang, F.: Changes in Breast Cavity contours After Lumpectomy. Proc. ASTRO, 66(3): 222, Wang F.: Tumor and lung volume changes in thorax during respiration. Abstract LL-R04110-L06, RSNA, Chicago, IL, Thatikonda S, Krishnan L, Wang F, Reddy, EK, Myers CP, Badkul RK. To analyze skin dose measurements using one dose Mosfet detector: An in vivo dosimetry to verify skin doses in breast cancer patients during high dose rate brachytherapy. Abstract, LL-RO4083-B08, RSNA, Chicago, IL, G.J. Kubicek, C. Champ, F. Wang, B.F. Kimler, D. Girod, E. Reddy, W. Keane, C. Intenzo, R.W. Dusing, M. Machtay: Role of FDG-PET for Staging in Head and Neck Cancer International Journal of Radiation Oncology Biology Physics 1 September 2008 (Vol. 72, Issue 1, Page S99) 33 Ethan Foster, Fen Wang. The impact of heterogeneity dose correction and beam energy on planning tumor volume (PTV) and percent dose coverage in thoracic tumors. Abstract and poster presentation ASTRO Chicago. 34 Srivani Thatikonda, Fen Wang. Long-Term Results of Concomitant Boost Radiation Plus Concurrent Cisplatin for Advanced Head and Neck Carcinomas. Abstract and poster presentation. ASTRO Chicago. 35 F. Wang, J. Park, M.P. Mitchell, E.K. Reddy, M. Al-Kassppoles, J. Baranda, S.K. Williamson, B. F. Kimler. Prognostic Value of PET in Patients with Esophageal Cancer. Abstract and poster presentation. "Translational Advances in Radiation Oncology and Cancer Imaging" in St. Louis, September Fen Wang, Srivani Thatikonda, Eashwer K. Reddy, Stephen K. Williamson, Douglas A. Girod, Terry T. Tsue, Bruce F. Kimler. Concurrent Chemotherapy and Accelerated Fractionation with Concomitant Boost Radiotherapy for Locally Advanced Head and Neck Cancer: Does CV for Fen Wang, M.D., Ph.D. page 7

8 Disease Site Matter? Abstract. Multidisciplinary Head & Neck Cancer Symposium, February 25-27, 2010 at Chandler, Ariz. 37 Fen Wang, John Park, Rajeev K. Badkul. Stereotactic Body Radiotherapy for Lung Cancer Using ExacTrac X-Ray 6D and Four-Dimensional Cone Beam CT Image Guidance. Abstract and poster presentation. 14 th World Conference on Lung Cancer, July 3-7, Amsterdam, The Netherland Invited speaker Chemoradiation Therapy for Rectal Cancer. People s Hospital, Beijing Medical University, China. June 2004 Intensity-modulated radiation therapy for Head and Neck cancer. ENT Department, KUMC Radiotherapy For Lymphoma -ASTRO 2005 REVIEW KUMC. Jan Radiotherapy For Adult Brain Tumor Neurology Department, KUMC Radiotherapy for Local Advanced NSCCL Xian, China Stereotactic Radiosurgery for Intracranial and Extracranial lesions. Pittsburg, Kansas. 4/18/2009 STEREOTACTIC RADIOSURGERY FOR EXTRACRANIAL LESIONS. CME COURSE. Planning Committee. Topeka Kansas, Nov Sereotactic Body Radiotherapy. CME course, KUMC. Kansas City, 11/16/2009 Stereotactic Radiotherapy for GI Malignance. CME course, Advanced Treatment options for Gastrointestinal Cancers. KUMC. June 10, Stereotactic Radiotherapy for Lung Cancer. Expert panel discussion. The 2 nd SANTRO Symposium and 2010 CSTRO/SANTRO Symposium, Oct. Zhejiang, China Management of Brain Metastases, 24 th Annual Coffeyville Cancer Symposium. Pittsburg, Kansas. September 10, 2011 Multidisciplinary Care in the Neuro-Oncology Patient Management of Brain Metastases. Westwood, Kansas. September 22, Fen Wang, MD, PhD Date CV for Fen Wang, M.D., Ph.D. page 8