Master Carcinogen List: Chemicals Not Reportable under TURA

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1 IRIS or Haematite mining Occupational Group 1 Refractory ceramic fibers Synthethic mineral Dibenz[a,j]acridine Art glass, glass containers and pressed ware (manufacture of) Androgenic (anabolic) steriods Petroleum refining (occupational exposures in) Carbon electrode manufacture Non-arsenical insecticides (occupational exposures in spraying and application of) Combustion byproduct Material Pharmaceutical Occupational Occupational Broad category pesticides Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals (1986 Frying emissions from high-temperature Lifestyle/occupational Hairdresser or barber Occupational Gamma Radiation and X Radiation Known

2 IRIS or Neutron Radiation (neutrons) Known Alcoholic beverages Diet Group 1 Known Areca nut Diet Group 1 Auramine production Occupational Group 1 Anabolic steroids Pharmaceutical Analgesic mixtures containing phenacetin Pharmaceutical Group 1 Known Aristolochic acids Pharmaceutical (herbal) Biomass fuel (primarily wood), indoor emissions from household combustion of Lifestyle Betel quid with and without tobacco Diesel engine exhaust Broad category diesel exhaust particulates dyes metabolized to 3,3'- dimethoxybenzidine Dyes metabolized to 3,3'- dimethylbenzidine Dyes metabolized to benzidine Environmental tobacco smoke Diet/Lifestyle Group 1 Known Broad category Lifestyle Group 1 Likely to be carcinogenic to humans (1999 Known Known

3 IRIS or Estrogen therapy, postmenopausal Pharmaceutical Group 1 Estrogen-progestogen menopausal therapy Pharmaceutical Group 1 (combined) Estrogen-progestogen oral contraceptives Pharmaceutical Group 1 (combined) Estrogens, nonsteroidal Pharmaceutical Group 1 Estrogens, steroidal Pharmaceutical Group 1 Known Aluminium production Occupational Group 1 Fission productions, including stontium-90 Glass wool Material Helobacter pylori (infection with) Infectious agent Group 1 Hepatitus B virus (infection with) Infectious agent Group 1 Known Hepatitis C virus (infection with) Infectious agent Group 1 Known Human immunodeficiency virus type 1 (infection Infectious agent Group 1 with) Human papillomavirus types 26, 53, 66, 67, 70, Infectious agent Group 1 Known 73, 82 Human papillomavirus type 68 Infectious agent Iron and steel founding Occupational Group 1

4 IRIS or Kaposi sarcoma herpesvirus Infectious agent Group 1 Malaria (caused by infection with Plasmodium falciparum in holoendemic Infectious agent areas) Magenta Production Occupational Group 1 Merkel cell polyomavirus (MCV) Infectious agent Mineral oils (untreated and mildly treated) Broad category Group 1 Known MOPP and other combined chemotherapy including alkylating Pharmaceutical Group 1 agents Nitrate or nitrite (ingested) under conditions that result in Diet endogenous nitrosation Leather dust Group 1 opisthorchis viverrini (infection with) Infectious agent Group 1 Oral contraceptives, combined estrogenprogestogen Pharmaceutical Group 1 Painter (occupational exposure of) Occupational Group 1 Radioiodines, including iodine-131

5 IRIS or Radionuclides, betaparticle emitting, internally deposited Rubber manufacturing Occupational Group 1 Salted fish, Chinese style Diet Group 1 Shiftwork that involves circadian disruption Lifestyle/occupational Smokeless tobacco Lifestyle Group 1 Known Soots Broad category Group 1 Known Solar radiation Lifestyle/occupational Group 1 Known Hot Mate Lifestyle/Diet Talc containing asbestiform fibers Material Group 1 Tobacco smoke (and smokeless) Lifestyle Group 1 Known Ultraviolet radiation Lifestyle/occupational Group 1 Known Chonorchis sinensis (infection with) ,2,3-Trichloropropane ,3-Dibromo-1-propanol Chloro-o - phenylenediamine Infectious agent Group 1 Likely to be carcinogenic to humans ( Iron dextran complex Pharmaceutical

6 IRIS or Bitumens occupational exposure to oxidized bitumens and their emissions during roofing Coal-tars Broad category Group Cyclosporine Pharmaceutical Group Dichloroacetic acid ,1,2,2-Tetrachloroethane MeIQx (2-Amino-3,8- dimethylimidazo[4,5- f]quinoxaline) MeIQ (2-Amino-3,4- dimethylimidazo[4,5- f]quinoline) Diet (heterocyclic amine) Diet (heterocyclic amine) Group 3 Likely to be carcinogenic to humans (1999 Likely to be carcinogenic to humans ( Phenolphthalein Pharmaceutical IQ (2-Amino-3- methylimidazo[4,5-f] Pharmaceutical quinoline) Chloral Pharmaceutical Nitrochrysene No [Secondary air pollutant- reaction w/ PAHs] Plutonium

7 IRIS or Shale-oils Broad category Group Norethisterone (Norethindrone) Pharmaceutical Erionite Mineral Group 1 Known Methyl methanesulfonate Pitch, coal tar, hightemp. Broad category Group 1 Known Coal tar, Tar, coal, hightemp. Broad category Known (N-Nitrosomethylamino)- lifestyle (nitrosamine 1-(3-pyridyl)1-butanone in cigarettes) Group Ethanol in alcoholic beverages Phenoxybenzamine hydrochloride Diet Group 1 Pharmaceutical Furmecyclox Pesticide Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals ( Cyclosporin A Pharmaceutical Known Vinyl bromide Progesterone Pharmaceutical C.I. Basic Red 9 monohydrochloride

8 IRIS or Chloramphenicol Pharmaceutical ,4-Butanediol dimethanesulfonate (Busulfan) Nitrogen mustard hydrochloride (Mechlorethamine hydrochloride) Pharmaceutical Group 1 Known Chlorozotocin Pharmaceutical Tris(1- aziridinyl)phosphine sulfide (Thiotepa) Dimethylvinylchloride, 1- Chloro-2-methylpropene Pharmaceutical Group 1 Known Research Propylthiouracil Pharmaceutical Chlornaphazine Pharmaceutical Group 1 Known Methoxypsoralen with ultraviolet A therapy NA Azathioprine Pharmaceutical Group 1 Known Metronidazole Pharmaceutical Dacarbazine Pharmaceutical Oxymetholone Pharmaceutical Procarbazine hydrochloride Pharmaceutical

9 IRIS or Etoposide (also in combination with cisplatin and bleomycin) Pharmaceutical Group Azacitidine Pharmaceutical Ochratoxin A dietary mycotoxin Choral hydrate Pharmaceutical Treosulfan Pharmaceutical Group Methoxsalen (8- methoxypsoralen) plus UV Pharmaceutical Group 1 Known A radiation Methoxypsoralen with ultraviolet A therapy Pharmaceutical Group 1 Known Teniposide Pharmaceutical Cyclopenta[cd]pyrene Butylhydroxyanisol (food preservative) Disperse Blue Captafol Fungicide Mirex Obsolete pesticide Riddelliine Pharmaceutical Adriamycin Pharmaceutical

10 IRIS or Indium phosphide Cisplatin Pharmaceutical Bromate Environmental byproduct Known/likely human carcinogen ( Bischloroethyl nitrosourea (BCNU) (Carmustine) Pharmaceutical Radium-228 and its decay products Phosphorus-32, as phosphate Aflatoxins (naturally occurring mixtures of) Aramite Pesticide Radium-226 and its decay products 1-(2-Chloroethyl)-3-(4- methylcyclohexyl)-1- nitrosourea (Methyl- CCNU) Phenazopyridine hydrochloride Diet Group 1 Known Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals (1986 Pharmaceutical Group 1 Known Pharmaceutical

11 IRIS or Diazoaminobenzene ,4'-Methylenedianiline dihydrochloride N-Nitrososarcosine Research Radium-224 and its decay products 1-(2-Chloroethyl)-3- cyclohexyl-1-nitrosourea (CCNU) (Lomustine) Pharmaceutical Dantron (Chrysazin; 1,8- Dihydroxyanthraquinone) Pharmaceutical Vinyl-1-cyclohexene diepoxide (Vinyl cyclohexenedioxide) N- Nitrosomethylethylamine PhiP(2-Amino-1-methyl-6- phenylimidazol[4,5- b]pyridine) Research Diet (heterocyclic amine) Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals ( Tamoxifen and its salts Pharmaceutical Group 1 Known

12 IRIS or Azobenzene Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals ( Radon-222 and its decay products Known Haematite mining Occupational Group 1 Refractory ceramic fibers Synthethic mineral Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals ( Dibenz[a,j]acridine Combustion byproduct Art glass, glass containers and pressed ware Material (manufacture of) Androgenic (anabolic) steriods Pharmaceutical Petroleum refining (occupational exposures Occupational in) Carbon electrode manufacture Occupational

13 IRIS or Non-arsenical insecticides (occupational exposures in spraying and application of) Broad category pesticides Frying emissions from high-temperature Lifestyle/occupational Hairdresser or barber Occupational Gamma Radiation and X Radiation Known Neutron Radiation (neutrons) Known Alcoholic beverages Diet Group 1 Known Areca nut Diet Group 1 Auramine production Occupational Group 1 Anabolic steroids Pharmaceutical Analgesic mixtures containing phenacetin Pharmaceutical Group 1 Known Aristolochic acids Pharmaceutical (herbal) Biomass fuel (primarily wood), indoor emissions from household combustion of Lifestyle Betel quid with and without tobacco Diesel engine exhaust Broad category Diet/Lifestyle Group 1 Known Likely to be carcinogenic to humans (1999

14 IRIS or diesel exhaust particulates Broad category dyes metabolized to 3,3'- dimethoxybenzidine Dyes metabolized to 3,3'- dimethylbenzidine Dyes metabolized to benzidine Group 1 Known Environmental tobacco smoke Lifestyle Known Estrogen therapy, postmenopausal Pharmaceutical Group 1 Estrogen-progestogen menopausal therapy Pharmaceutical Group 1 (combined) Estrogen-progestogen oral contraceptives Pharmaceutical Group 1 (combined) Estrogens, nonsteroidal Pharmaceutical Group 1 Estrogens, steroidal Pharmaceutical Group 1 Known Aluminium production Occupational Group 1 Fission productions, including stontium-90 Glass wool Material Helobacter pylori (infection with) Hepatitus B virus (infection with) Hepatitis C virus (infection with) Infectious agent Group 1 Infectious agent Group 1 Known Infectious agent Group 1 Known

15 IRIS or Human immunodeficiency virus type 1 (infection Infectious agent Group 1 with) Human papillomavirus types 26, 53, 66, 67, 70, Infectious agent Group 1 Known 73, 82 Human papillomavirus type 68 Infectious agent Iron and steel founding Occupational Group 1 Kaposi sarcoma herpesvirus Infectious agent Group 1 Malaria (caused by infection with Plasmodium falciparum in holoendemic Infectious agent areas) Magenta Production Occupational Group 1 Merkel cell polyomavirus (MCV) Infectious agent Mineral oils (untreated and mildly treated) Broad category Group 1 Known MOPP and other combined chemotherapy including alkylating Pharmaceutical Group 1 agents Nitrate or nitrite (ingested) under conditions that result in Diet endogenous nitrosation Leather dust Group 1 opisthorchis viverrini (infection with) Infectious agent Group 1

16 IRIS or Oral contraceptives, combined estrogenprogestogen Pharmaceutical Group 1 Painter (occupational exposure of) Occupational Group 1 Radioiodines, including iodine-131 Radionuclides, betaparticle emitting, internally deposited Rubber manufacturing Occupational Group 1 Salted fish, Chinese style Diet Group 1 Shiftwork that involves circadian disruption Lifestyle/occupational Smokeless tobacco Lifestyle Group 1 Known Soots Broad category Group 1 Known Solar radiation Lifestyle/occupational Group 1 Known Hot Mate Lifestyle/Diet Talc containing asbestiform fibers Material Group 1 Tobacco smoke (and smokeless) Lifestyle Group 1 Known Ultraviolet radiation Lifestyle/occupational Group 1 Known Chonorchis sinensis (infection with) Infectious agent Group 1

17 IRIS or ,2,3-Trichloropropane ,3-Dibromo-1-propanol Chloro-o - phenylenediamine Likely to be carcinogenic to humans ( Iron dextran complex Pharmaceutical Bitumens occupational exposure to oxidized bitumens and their emissions during roofing Coal-tars Broad category Group Cyclosporine Pharmaceutical Group Dichloroacetic acid ,1,2,2-Tetrachloroethane MeIQx (2-Amino-3,8- dimethylimidazo[4,5- f]quinoxaline) MeIQ (2-Amino-3,4- dimethylimidazo[4,5- f]quinoline) Diet (heterocyclic amine) Diet (heterocyclic amine) Group 3 Likely to be carcinogenic to humans (1999 Likely to be carcinogenic to humans (2005

18 IRIS or Phenolphthalein Pharmaceutical IQ (2-Amino-3- methylimidazo[4,5-f] Pharmaceutical quinoline) Chloral Pharmaceutical Nitrochrysene No [Secondary air pollutant- reaction w/ PAHs] Plutonium Shale-oils Broad category Group Norethisterone (Norethindrone) Pharmaceutical Erionite Mineral Group 1 Known Methyl methanesulfonate Pitch, coal tar, hightemp. Broad category Group 1 Known Coal tar, Tar, coal, hightemp. Broad category Known (N-Nitrosomethylamino)- lifestyle (nitrosamine 1-(3-pyridyl)1-butanone in cigarettes) Group Ethanol in alcoholic beverages Phenoxybenzamine hydrochloride Diet Group 1 Pharmaceutical

19 IRIS or Furmecyclox Pesticide Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals ( Cyclosporin A Pharmaceutical Known Vinyl bromide Progesterone Pharmaceutical C.I. Basic Red 9 monohydrochloride Chloramphenicol Pharmaceutical ,4-Butanediol dimethanesulfonate (Busulfan) Nitrogen mustard hydrochloride (Mechlorethamine hydrochloride) Pharmaceutical Group 1 Known Chlorozotocin Pharmaceutical Tris(1- aziridinyl)phosphine sulfide (Thiotepa) Dimethylvinylchloride, 1- Chloro-2-methylpropene Pharmaceutical Group 1 Known Research

20 IRIS or Propylthiouracil Pharmaceutical Chlornaphazine Pharmaceutical Group 1 Known Methoxypsoralen with ultraviolet A therapy NA Azathioprine Pharmaceutical Group 1 Known Metronidazole Pharmaceutical Dacarbazine Pharmaceutical Oxymetholone Pharmaceutical Procarbazine hydrochloride Etoposide (also in combination with cisplatin and bleomycin) Pharmaceutical Pharmaceutical Group Azacitidine Pharmaceutical Ochratoxin A dietary mycotoxin Choral hydrate Pharmaceutical Treosulfan Pharmaceutical Group Methoxsalen (8- methoxypsoralen) plus UV Pharmaceutical Group 1 Known A radiation Methoxypsoralen with ultraviolet A therapy Pharmaceutical Group 1 Known Teniposide Pharmaceutical Cyclopenta[cd]pyrene

21 IRIS or Butylhydroxyanisol Disperse Blue 1 (food preservative) Captafol Fungicide Mirex Obsolete pesticide Riddelliine Pharmaceutical Adriamycin Pharmaceutical Indium phosphide Cisplatin Pharmaceutical Bromate Environmental byproduct Known/likely human carcinogen ( Bischloroethyl nitrosourea (BCNU) (Carmustine) Radium-228 and its decay products Phosphorus-32, as phosphate Aflatoxins (naturally occurring mixtures of) Pharmaceutical Diet Group 1 Known

22 IRIS or Aramite Pesticide Diazoaminobenzene ,4'-Methylenedianiline dihydrochloride Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals (1986 Pharmaceutical Group 1 Known Pharmaceutical N-Nitrososarcosine Research Radium-224 and its decay products Radium-226 and its decay products 1-(2-Chloroethyl)-3-(4- methylcyclohexyl)-1- nitrosourea (Methyl- CCNU) Phenazopyridine hydrochloride 1-(2-Chloroethyl)-3- cyclohexyl-1-nitrosourea (CCNU) (Lomustine) Pharmaceutical Dantron (Chrysazin; 1,8- Dihydroxyanthraquinone) Pharmaceutical

23 IRIS or Vinyl-1-cyclohexene diepoxide (Vinyl cyclohexenedioxide) N- Nitrosomethylethylamine PhiP(2-Amino-1-methyl-6- phenylimidazol[4,5- b]pyridine) Research Diet (heterocyclic amine) Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals ( Tamoxifen and its salts Pharmaceutical Group 1 Known Azobenzene Radon-222 and its decay products Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals (1986 Known

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