CHEMICALS KNOWN TO THE STATE TO CAUSE CANCER OR REPRODUCTIVE TOXICITY September 30, 2016

Transcription

1 STATE OF CALIFORNIA ENVIRONMENTAL PROTECTION AGENCY OFFICE OF ENVIRONMENTAL HEALTH HAZARD ASSESSMENT SAFE DRINKING WATER AND TOXIC ENFORCEMENT ACT OF 1986 CHEMICALS KNOWN TO THE STATE TO CAUSE CANCER OR REPRODUCTIVE TOXICITY September 30, 2016 The Safe Drinking Water and Toxic Enforcement Act of 1986 requires that the Governor revise and republish at least once per year the list of chemicals known to the State to cause or reproductive toxicity. The identification number indicated in the following list is the Chemical Abstracts Service (CAS) Registry Number. No CAS number is given when several substances are presented as a single listing. The date refers to the initial appearance of the chemical on the list. For easy reference, chemicals which are shown underlined are newly added. Chemicals or endpoints shown in strikeout were placed on the Proposition 65 list on the date noted, and have subsequently been removed. Chemical Type of Toxicity CAS No. Date Listed A-alpha-C (2-Amino-9H-pyrido January 1, 1990 [2,3-b]indole) Abiraterone acetate, fe, April 8, 2016 Acetaldehyde April 1, 1988 Acetamide January 1, 1990 Acetazolamide August 20, 1999 Acetochlor January 1, 1989 Acetohydroxamic acid April 1, Acetylaminofluorene July 1, 1987 Acifluorfen sodium January 1, 1990 Acrylamide January 1, 1990 Acrylamide, February 25, 2011 Acrylonitrile July 1, 1987 Actinomycin D October 1, 1989 October 1, 1992 AF-2;[2-(2-furyl)-3-(5-nitro-2-furyl)] July 1, 1987 acrylamide Aflatoxins January 1, 1988 Alachlor Alcoholic beverages, when January 1, 1989 July 1, 1988 associated with alcohol abuse Aldrin July 1, 1988 All-trans retinoic acid January 1, 1989 Allyl chloride January 1, 1990 Delisted October 29, 1999 Aloe Vera, non-decolorized whole leaf extract Alprazolam December 4, 2015 July 1, 1990 Altretamine, August 20, 1999 Amantadine hydrochloride February 27, 2001 Amikacin sulfate July 1, Aminoanthraquinone p-aminoazobenzene October 1, 1989 January 1, 1990 o-aminoazotoluene July 1, Aminobiphenyl (4-amino February 27, 1987

2 diphenyl) 1-Amino-2,4-dibromo August 26, 1997 anthraquinone 3-Amino-9-ethylcarbazole July 1, 1989 hydrochloride 2-Aminofluorene January 29, 1999 Aminoglutethimide July 1, 1990 Aminoglycosides October 1, Amino-2-methylanthraquinone October 1, Amino-5-(5-nitro-2-furyl)-1,3, July 1, 1987 thiadiazole 4-Amino-2-nitrophenol January 29, 1999 Aminopterin, fe July 1, 1987 Amiodarone hydrochloride, fe, August 26, 1997 Amitraz March 30, 1999 Amitrole July 1, 1987 Amoxapine May 15, 1998 Amsacrine tert-amyl methyl ether August 7, 2009 December 18, 2009 Delisted December 13, 2013 Anabolic steroids fe, April 1, 1990 Analgesic mixtures containing February 27, 1987 phenacetin Androstenedione May 3, 2011 Angiotensin converting enzyme October 1, 1992 (ACE) inhibitors Aniline January 1, 1990 Aniline hydrochloride May 15, 1998 o-anisidine July 1, 1987 o-anisidine hydrochloride July 1, 1987 Anisindione October 1, 1992 Anthraquinone September 28, 2007 Antimony oxide (Antimony trioxide) October 1, 1990 Aramite July 1, 1987 Areca nut February 3, 2006 Aristolochic acids July 9, 2004 Arsenic (inorganic arsenic -- February 27, 1987 compounds) Arsenic (inorganic oxides) May 1, 1997 Asbestos Aspirin (NOTE: It is especially, fe February 27, 1987 July 1, 1990 important not to use aspirin during the last three months of pregnancy, unless specifically directed to do so by a physician because it may cause problems in the unborn child or complications during delivery.) Atenolol August 26, 1997 Atrazine, fe July 15, 2016 Auramine July 1, 1987 Auranofin January 29, 1999 Avermectin B1 (Abamectin) Azacitidine December 3, 2010 January 1, 1992 Azaserine July 1, 1987 Azathioprine February 27, Proposition 65 List of Chemicals

3 Azathioprine September 1, 1996 Azobenzene January 1, 1990 Barbiturates October 1, 1992 Beclomethasone dipropionate May 15, 1998 Benomyl, July 1, 1991 Benthiavalicarb-isopropyl July 1, 2008 Benz[a]anthracene July 1, 1987 Benzene February 27, 1987 Benzene, December 26, 1997 Benzidine [and its salts] February 27, 1987 Benzidine-based dyes October 1, 1992 Benzodiazepines October 1, 1992 Benzo[b]fluoranthene July 1, 1987 Benzo[j]fluoranthene July 1, 1987 Benzo[k]fluoranthene July 1, 1987 Benzofuran October 1, 1990 Benzophenone Benzo[a]pyrene June 22, 2012 July 1, 1987 Benzotrichloride July 1, 1987 Benzphetamine hydrochloride April 1, 1990 Benzyl chloride January 1, 1990 Benzyl violet 4B July 1, 1987 Beryllium and beryllium compounds October 1, 1987 Betel quid with tobacco January 1, 1990 Betel quid without tobacco February 3, ,2-Bis(bromomethyl)-1, May 1, 1996 propanediol Bis(2-chloroethyl)ether April 1, 1988 N,N-Bis(2-chloroethyl) February 27, 1987 naphthylamine (Chlornapazine) Bischloroethyl nitrosourea (BCNU) July 1, 1987 (Carmustine) Bischloroethyl nitrosourea (BCNU) July 1, 1990 (Carmustine) Bis(chloromethyl)ether February 27, 1987 Bis(2-chloro-1-methylethyl)ether, October 29, 1999 technical grade Bisphenol A (BPA) fe May 11, 2015 Bisphenol A (BPA) Delisted April 19, April 11, 2013 Bitumens, extracts of steam-refined January 1, 1990 and air refined Bracken fern January 1, 1990 Bromacil lithium salt May 18, 1999 Bromacil lithium salt January 17, 2003 Bromate May 31, 2002 Bromochloroacetic acid April 6, 2010 Bromodichloroacetic acid July 29, 2016 Bromodichloromethane January 1, 1990 Bromoethane December 22, 2000 Bromoform April 1, Bromopropane (1-BP) 1-Bromopropane (1-BP), fe, Bromopropane (2-BP) fe, May 31, 2005 August 5, 2016 December 7, Proposition 65 List of Chemicals

4 Bromoxynil October 1, 1990 Bromoxynil octanoate May 18, 1999 Butabarbital sodium October 1, ,3-Butadiene April 1, ,3-Butadiene, fe, April 16, ,4-Butanediol dimethanesulfonate February 27, 1987 (Busulfan) 1,4-Butanediol dimethanesulfonate January 1, 1989 (Busulfan) Butylated hydroxyanisole January 1, 1990 Butyl benzyl phthalate (BBP) December 2, 2005 n-butyl glycidyl ether August 7, 2009 Delisted April 4, 2014 beta-butyrolactone July 1, 1987 Cacodylic acid May 1, 1996 Cadmium Cadmium and cadmium, May 1, 1997 October 1, 1987 compounds Caffeic acid October 1, 1994 Captafol October 1, 1988 Captan January 1, 1990 Carbamazepine January 29, 1999 Carbaryl February 5, 2010 Carbaryl, fe, August 7, 2009 Carbazole May 1, 1996 Carbon black (airborne, unbound February 21, 2003 particles of respirable size) Carbon-black extracts Carbon disulfide, fe, January 1, 1990 July 1, 1989 Carbon monoxide July 1, 1989 Carbon tetrachloride October 1, 1987 Carboplatin July 1, 1990 N-Carboxymethyl-N-nitrosourea January 25, 2002 Catechol July 15, 2003 Ceramic fibers (airborne particles July 1, 1990 of respirable size) Certain combined chemotherapy February 27, 1987 for lymphomas Chenodiol April 1, 1990 Chloral September 13, 2013 Chloral hydrate September 13, 2013 Chlorambucil February 27, 1987 Chlorambucil January 1, 1989 Chloramphenicol October 1, 1989 Delisted January 4, 2013 Chloramphenicol sodium succinate September 27, 2013 Chlorcyclizine hydrochloride July 1, 1987 Chlordane July 1, 1988 Chlordecone (Kepone) Chlordecone (Kepone) January 1, 1988 January 1, 1989 Chlordiazepoxide January 1, 1992 Chlordiazepoxide hydrochloride January 1, Proposition 65 List of Chemicals

5 Chlordimeform January 1, 1989 Chlorendic acid July 1, 1989 Chlorinated paraffins (Average July 1, 1989 chain length, C12; approximately 60 percent chlorine by weight) p-chloroaniline October 1, 1994 p-chloroaniline hydrochloride May 15, 1998 Chlorodibromomethane January 1, 1990 Delisted October 29, 1999 Chloroethane (Ethyl chloride) July 1, (2-Chloroethyl)-3-cyclohexyl January 1, nitrosourea (CCNU) (Lomustine) 1-(2-Chloroethyl)-3-cyclohexyl July 1, nitrosourea (CCNU) Lomustine) 1-(2-Chloroethyl)-3-(4-methyl October 1, 1988 cyclohexyl) -1-nitrosourea (Methyl-CCNU) Chloroform October 1, 1987 Chloroform Chloromethyl methyl ether August 7, 2009 February 27, 1987 (technical grade) 3-Chloro-2-methylpropene July 1, Chloro-4-nitrobenzene October 29, Chloro-o-phenylenediamine January 1, 1988 Chloroprene June 2, Chloropropionic acid August 7, 2009 Chlorothalonil January 1, 1989 p-chloro-o-toluidine January 1, 1990 p-chloro-o-toluidine, strong acid May 15, 1998 salts of 5-Chloro-o-toluidine and October 24, 1997 its strong acid salts Chlorotrianisene September 1, 1996 Chlorozotocin January 1, 1992 Chlorsulfuron, fe, May 14, 1999 Delisted June 6, 2014 Chromium (hexavalent compounds) February 27, 1987 Chromium (hexavalent compounds), fe, December 19, 2008 Chrysene January 1, 1990 C.I. Acid Red 114 C.I. Basic Red July 1, 1992 July 1, 1989 monohydrochloride C.I. Direct Blue August 26, 1997 C.I. Direct Blue August 26, 1997 C.I. Disperse Yellow February 8, 2013 C.I. Solvent Yellow May 15, 1998 Ciclosporin (Cyclosporin A; January 1, 1992 Cyclosporine) Cidofovir,, January 29, 1999 fe, Cinnamyl anthranilate July 1, 1989 Cisplatin October 1, 1988 Citrus Red No. 2 Cladribine October 1, 1989 September 1, 1996 Clarithromycin May 1, 1997 Clobetasol propionate, fe May 15, Proposition 65 List of Chemicals

6 Clofibrate September 1, 1996 Clomiphene citrate May 24, 2013 Clomiphene citrate April 1, 1990 Clorazepate dipotassium October 1, 1992 CMNP (pyrazachlor) August 25, BCobalt metal powder 1B 2B BJuly 1, 1992 Cobalt [II] oxide July 1, 1992 Cobalt sulfate May 20, 2005 Cobalt sulfate heptahydrate June 2, 2000 Cocaine, fe July 1, 1989 Coconut oil diethanolamine June 22, 2012 condensate (cocamide diethanolamine) Codeine phosphate May 15, 1998 Coke oven emissions February 27, 1987 Colchicine, October 1, 1992 Conjugated estrogens February 27, 1987 Conjugated estrogens April 1, 1990 Creosotes p-cresidine October 1, 1988 January 1, 1988 Cumene April 6, 2010 Cupferron January 1, 1988 Cyanazine April 1, 1990 Cycasin January 1, 1988 Cycloate March 19, 1999 Cyclohexanol Delisted November 6, 1998 January 25, 2002 Cycloheximide January 1, 1989 Cyclopenta[cd]pyrene April 29, 2011 Cyclophosphamide (anhydrous) February 27, 1987 Cyclophosphamide (anhydrous), fe, January 1, 1989 Cyclophosphamide (hydrated) February 27, 1987 Cyclophosphamide (hydrated), fe, January 1, 1989 Cyhexatin January 1, 1989 Cytarabine January 1, 1989 Cytembena May 15, 1998 D&C Orange No. 17 D&C Red No July 1, 1990 October 1, 1990 D&C Red No July 1, 1990 D&C Red No July 1, 1990 Dacarbazine January 1, 1988 Dacarbazine January 29, 1999 Daminozide January 1, 1990 Danazol April 1, 1990 Dantron (Chrysazin; 1, January 1, 1992 Dihydroxyanthraquinone) Daunomycin January 1, 1988 Daunorubicin hydrochloride July 1, ,4-D butyric acid, June 18, 1999 DDD (Dichlorodiphenyldichloroethane) January 1, 1989 DDE (Dichlorodi January 1, 1989 phenyldichloroethylene) -6- Proposition 65 List of Chemicals

7 DDT (Dichlorodi October 1, 1987 phenyltrichloroethane) o,p -DDT, fe, May 15, 1998 p,p -DDT, fe, May 15, 1998 DDVP (Dichlorvos) January 1, 1989 Demeclocycline hydrochloride January 1, 1992 (internal use) Des-ethyl atrazine (DEA), fe July 15, 2016 Des-isopropyl atrazine (DIA), fe July 15, 2016 N,N -Diacetylbenzidine October 1, ,4-Diaminoanisole October 1, ,4-Diaminoanisole sulfate January 1, ,4-Diamino-6-chloro-s-triazine, fe July 15, 2016 (DACT) 4,4 -Diaminodiphenyl ether January 1, 1988 (4,4 -Oxydianiline) 2,4-Diaminotoluene Diaminotoluene (mixed) January 1, 1988 January 1, 1990 Delisted November 20, 2015 Diazepam January 1, 1992 Diazoaminobenzene May 20, 2005 Diazoxide February 27, 2001 Dibenz[a,h]acridine January 1, 1988 Dibenz[a,j]acridine January 1, 1988 Dibenzanthracenes December 26, 2014 Dibenz[a,c]anthracene December 26, 2014 Dibenz[a,h]anthracene January 1, 1988 Dibenz[a,j]anthracene December 26, H-Dibenzo[c,g]carbazole January 1, 1988 Dibenzo[a,e]pyrene January 1, 1988 Dibenzo[a,h]pyrene January 1, 1988 Dibenzo[a,i]pyrene January 1, 1988 Dibenzo[a,l]pyrene January 1, 1988 Dibromoacetic acid June 17, 2008 Dibromoacetonitrile May 3, ,2-Dibromo-3-chloropropane July 1, 1987 (DBCP) 1,2-Dibromo-3-chloropropane February 27, 1987 (DBCP) 2,3-Dibromo-1-propanol October 1, 1994 Dichloroacetic acid May 1, 1996 Dichloroacetic acid, August 7, 2009 p-dichlorobenzene January 1, ,3 -Dichlorobenzidine October 1, ,3 -Dichlorobenzidine May 15, 1998 dihydrochloride 1,1-Dichloro-2,2-bis(p-, March 30, 2010 chlorophenyl)ethylene (DDE) 1,4-Dichloro-2-butene January 1, ,3 -Dichloro-4,4 -diaminodiphenyl January 1, 1988 ether 1,1-Dichloroethane Dichloromethane (Methylene January 1, 1990 April 1, 1988 chloride) Dichlorophene April 27, Proposition 65 List of Chemicals

8 1,2-Dichloropropane January 1, ,3-Dichloro-2-propanol (1,3-DCP) October 8, ,3-Dichloropropene January 1, 1989 Dichlorphenamide February 27, 2001 Diclofop-methyl April 6, 2010 Diclofop methyl March 5, 1999 Dicumarol October 1, 1992 Dieldrin July 1, 1988 Dienestrol Delisted January 4, January 1, 1990 Diepoxybutane January 1, 1988 Diesel engine exhaust October 1, 1990 Diethanolamine June 22, 2012 Di(2-ethylhexyl)phthalate (DEHP) January 1, 1988 Di(2-ethylhexyl)phthalate (DEHP), October 24, ,2-Diethylhydrazine January 1, 1988 Diethylstilbestrol (DES) February 27, 1987 Diethylstilbestrol (DES) July 1, 1987 Diethyl sulfate January 1, 1988 Diflunisal Diglycidyl ether, fe January 29, 1999 August 7, 2009 Delisted April 4, 2014 Diglycidyl resorcinol ether (DGRE) July 1, 1989 Di-n-hexyl phthalate (DnHP) fe, December 2, 2005 Di-n-butyl phthalate (DBP) Dihydroergotamine mesylate, fe, December 2, 2005 May 1, 1997 Dihydrosafrole January 1, 1988 Di-isodecyl phthalate (DIDP) / April 20, Diisononyl phthalate (DINP) December 20, 2013 Diisopropyl sulfate April 1, 1993 Diltiazem hydrochloride February 27, ,3 -Dimethoxybenzidine January 1, 1988 (o-dianisidine) 3,3 -Dimethoxybenzidine October 1, 1990 dihydrochloride 3,3 -Dimethoxybenzidine-based June 11, 2004 dyes metabolized to 3,3 - dimethoxybenzidine N,N-Dimethylacetamide, May 21, Dimethylaminoazobenzene trans-2-[(dimethylamino)methyl January 1, 1988 January 1, 1988 imino]-5-[2-(5-nitro-2-furyl)vinyl]- 1,3,4-oxadiazole 7,12-Dimethylbenz(a)anthracene January 1, ,3 -Dimethylbenzidine January 1, 1988 (ortho-tolidine) 3,3 -Dimethylbenzidine-based June 11, 2004 dyes metabolized to 3,3 - dimethylbenzidine 3,3 -Dimethylbenzidine April 1, 1992 dihydrochloride Dimethylcarbamoyl chloride January 1, ,1-Dimethylhydrazine (UDMH) 1,2-Dimethylhydrazine October 1, 1989 January 1, ,6-Dimethyl-N-nitrosomorpholine (DMNM) February 8, Proposition 65 List of Chemicals

9 Dimethyl sulfate January 1, 1988 N,N-Dimethyl-p-toluidine May 2, 2014 Dimethylvinylchloride m-dinitrobenzene July 1, 1989 July 1, 1990 o-dinitrobenzene July 1, 1990 p-dinitrobenzene July 1, ,7-Dinitrofluoranthene August 26, ,9-Dinitrofluoranthene August 26, ,3-Dinitropyrene November 2, ,6-Dinitropyrene October 1, ,8-Dinitropyrene October 1, 1990 Dinitrotoluene (technical grade) 2,4-Dinitrotoluene fe, August 20, 1999 July 1, ,4-Dinitrotoluene August 20, ,6-Dinitrotoluene July 1, ,6-Dinitrotoluene August 20, 1999 Dinitrotoluene mixture, 2,4-/2,6- May 1, 1996 Dinocap April 1, 1990 Dinoseb Di-n-propyl isocinchomeronate, January 1, 1989 May 1, 1996 (MGK Repellent 326) 1,4-Dioxane January 1, 1988 Diphenylhydantoin (Phenytoin) January 1, 1988 Diphenylhydantoin (Phenytoin) July 1, 1987 Diphenylhydantoin (Phenytoin), January 1, 1988 sodium salt Direct Black 38 (technical grade) January 1, 1988 Direct Blue 6 (technical grade) January 1, 1988 Direct Brown 95 (technical grade) October 1, 1988 Disodium cyanodithioimido March 30, 1999 carbonate Disperse Blue October 1, 1990 Diuron May 31, 2002 Doxorubicin hydrochloride July 1, 1987 (Adriamycin) Doxorubicin hydrochloride, January 29, 1999 (Adriamycin) Doxycycline (internal use) July 1, 1990 Doxycycline calcium (internal use) January 1, 1992 Doxycycline hyclate (internal use) October 1, 1991 Doxycycline monohydrate (internal use) October 1, ,4-DP (dichloroprop) April 27, 1999 Delisted January 25, 2002 Emissions from combustion of coal August 7, 2013 Emissions from high-temperature January 3, 2014 unrefined rapeseed oil Endrin May 15, 1998 Environmental tobacco smoke June 9, 2006 (ETS) Epichlorohydrin October 1, 1987 Epichlorohydrin Epoxiconazole September 1, 1996 April 15, 2011 Ergotamine tartrate April 1, 1990 Erionite / October 1, Proposition 65 List of Chemicals

10 Estradiol 17B January 1, 1988 Estragole October 29, 1999 Estrogens, steroidal August 19, 2005 Estrogen-progestogen (combined) November 4, 2011 used as menopausal therapy Estrone January 1, 1988 Estropipate, August 26, 1997 Ethanol in alcoholic beverages April 29, 2011 Ethinylestradiol January 1, 1988 Ethionamide August 26, 1997 Ethoprop February 27, 2001 Ethyl acrylate July 1, 1989 Ethyl alcohol in alcoholic beverages October 1, 1987 Ethylbenzene June 11, 2004 Ethyl-tert-butyl ether December 18, 2009 Delisted December 13, 2013 Ethyl dipropylthiocarbamate April 27, 1999 Ethyl-4,4 -dichlorobenzilate Ethylene dibromide January 1, 1990 July 1, 1987 Ethylene dibromide, May 15, 1998 Ethylene dichloride (1, October 1, 1987 Dichloroethane) Ethylene glycol (ingested) June 19, 2015 Ethylene glycol monoethyl ether, January 1, 1989 Ethylene glycol monoethyl, January 1, 1993 ether acetate Ethylene glycol monomethyl ether, January 1, 1989 Ethylene glycol monomethyl, January 1, 1993 ether acetate Ethyleneimine (Aziridine) January 1, 1988 Ethylene oxide July 1, 1987 Ethylene oxide fe February 27, 1987 Ethylene oxide, August 7, 2009 Ethylene thiourea January 1, 1988 Ethylene thiourea January 1, Ethylhexanoic acid August 7, 2009 Delisted December 13, 2013 Ethyl methanesulfonate January 1, 1988 Etodolac, fe August 20, 1999 Etoposide Etoposide November 4, 2011 July 1, 1990 Etoposide in combination with November 4, 2011 cisplatin and bleomycin Etretinate July 1, 1987 Fenoxaprop ethyl March 26, 1999 Fenoxycarb June 2, 2000 Filgrastim February 27, 2001 Fluazifop butyl November 6, 1998 Flunisolide, fe May 15, 1998 Fluorouracil January 1, 1989 Fluoxymesterone Flurazepam hydrochloride April 1, 1990 October 1, 1992 Flurbiprofen, fe August 20, 1999 Flutamide July 1, Proposition 65 List of Chemicals

11 Fluticasone propionate May 15, 1998 Fluvalinate November 6, 1998 Folpet January 1, 1989 Formaldehyde (gas) January 1, (2-Formylhydrazino) January 1, 1988 (5-nitro-2-furyl)thiazole Fumonisin B November 14, 2003 Furan October 1, 1993 Furazolidone January 1, 1990 Furfuryl alcohol Furmecyclox September 30, 2016 January 1, 1990 Fusarin C July 1, 1995 Gallium arsenide August 1, 2008 Ganciclovir,, August 26, 1997 Ganciclovir sodium, August 26, 1997 Gasoline engine exhaust (condensates/extracts) October 1, 1990 Gemfibrozil December 22, 2000 Gemfibrozil fe, August 20, 1999 Glass wool fibers (inhalable and biopersistent) Glu-P-1 (2-Amino-6-methyldipyrido July 1, 1990 January 1, 1990 [1,2- a:3,2 -d]imidazole) Glu-P-2 (2-Aminodipyrido January 1, 1990 [1,2-a:3,2 -d]imidazole) Glycidaldehyde January 1, 1988 Glycidol July 1, 1990 Goldenseal root powder December 4, 2015 Goserelin acetate, fe, August 26, 1997 Griseofulvin January 1, 1990 Gyromitrin (Acetaldehyde January 1, 1988 methylformylhydrazone) Halazepam July 1, 1990 Halobetasol propionate August 20, 1999 Haloperidol Halothane, fe January 29, 1999 September 1, 1996 HC Blue July 1, 1989 Heptachlor July 1, 1988 Heptachlor August 20, 1999 Heptachlor epoxide July 1, 1988 Herbal remedies containing July 9, 2004 plant species of the genus Aristolochia Hexachlorobenzene October 1, 1987 Hexachlorobenzene January 1, 1989 Hexachlorobutadiene May 3, 2011 Hexachlorocyclohexane October 1, 1987 (technical grade) Hexachlorodibenzodioxin April 1, 1988 Hexachloroethane July 1, ,4-Hexadienal (89% trans, trans March 4, Proposition 65 List of Chemicals

12 isomer; 11% cis, trans isomer) Hexafluoroacetone, August 1, 2008 Hexamethylphosphoramide January 1, 1988 Hexamethylphosphoramide October 1, ,5-Hexanedione Histrelin acetate December 4, 2015 May 15, 1998 Hydramethylnon, March 5, 1999 Hydrazine January 1, 1988 Hydrazine sulfate January 1, 1988 Hydrazobenzene January 1, 1988 (1,2-Diphenylhydrazine) Hydrogen cyanide (HCN) and July 5, 2013 cyanide salts (CN salts) 1-Hydroxyanthraquinone May 27, 2005 Hydroxyurea May 1, 1997 Idarubicin hydrochloride, August 20, 1999 Ifosfamide Iodine July 1, 1990 January 1, 1989 Imazalil May 20, 2011 Indeno[1,2,3-cd]pyrene January 1, 1988 Indium phosphide February 27, 2001 IQ (2-Amino-3-methylimidazo April 1, 1990 [4,5-f] quinoline) Iprodione May 1, 1996 Iprovalicarb June 1, Iron dextran complex January 1, 1988 Isobutyl nitrite May 1, 1996 Isoprene May 1, 1996 Isopyrazam July 24, 2012 Isosafrole Delisted October 1, 1989 December 8, 2006 Isotretinoin July 1, 1987 Isoxaflutole December 22, 2000 Kresoxim-methyl February 3, 2012 Lactofen January 1, 1989 Lasiocarpine April 1, 1988 Lead, fe, February 27, 1987 Lead and lead compounds October 1, 1992 Lead acetate January 1, 1988 Lead phosphate April 1, 1988 Lead subacetate October 1, 1989 Leather dust April 29, 2011 Leuprolide acetate, fe, August 26, 1997 Levodopa January 29, 1999 Levonorgestrel implants Lindane and other hexachlorofe May 15, 1998 October 1, 1989 cyclohexane isomers -12- Proposition 65 List of Chemicals

13 Linuron March 19, 1999 Lithium carbonate January 1, 1991 Lithium citrate January 1, 1991 Lorazepam July 1, 1990 Lovastatin October 1, 1992 Lynestrenol February 27, 2001 Malathion Malonaldehyde, sodium salt May 20, 2016 May 3, 2011 Mancozeb January 1, 1990 Maneb January 1, 1990 Marijuana smoke June 19, 2009 Me-A-alpha-C (2-Amino-3-methyl January 1, H-pyrido[2,3-b]indole) Mebendazole August 20, 1999 Medroxyprogesterone acetate January 1, 1990 Medroxyprogesterone acetate April 1, 1990 Megestrol acetate Megestrol acetate March 28, 2014 January 1, 1991 MeIQ (2-Amino-3,4-dimethyl October 1, 1994 imidazo[4,5-f]quinoline) MeIQx (2-Amino-3,8-dimethyl October 1, 1994 imidazo[4,5-f]quinoxaline) Melphalan February 27, 1987 Melphalan July 1, 1990 Menotropins April 1, 1990 Mepanipyrim July 1, 2008 Meprobamate January 1, 1992 Mercaptopurine July 1, 1990 Mercury and mercury compounds July 1, 1990 Merphalan April 1, 1988 Mestranol April 1, 1988 Metam potassium December 31, 2010 Methacycline hydrochloride January 1, 1991 Metham sodium November 6, 1998 Metham sodium May 15, 1998 Methanol March 16, 2012 Methazole December 1, 1999 Methimazole July 1, 1990 Methotrexate Methotrexate sodium January 1, 1989 April 1, Methoxypsoralen with October 1, 1988 ultraviolet A therapy 8-Methoxypsoralen with February 27, 1987 ultraviolet A therapy 2-Methylaziridine (Propyleneimine) January 1, 1988 Methylazoxymethanol April 1, 1988 Methylazoxymethanol acetate April 1, 1988 Methyl bromide, as a structural January 1, 1993 fumigant Methyl carbamate May 15, 1998 Methyl chloride March 10, 2000 Methyl chloride 3-Methylcholanthrene August 7, 2009 January 1, Methylchrysene April 1, ,4'-Methylene bis(2-chloroaniline) July 1, Proposition 65 List of Chemicals

14 4,4'-Methylene bis(n,n-dimethyl) October 1, 1989 benzenamine 4,4'-Methylene bis(2-methylaniline) April 1, ,4'-Methylenedianiline January 1, ,4'-Methylenedianiline January 1, 1988 dihydrochloride Methyleugenol November 16, 2001 Methylhydrazine and its salts July 1, Methylimidazole June 22, Methylimidazole January 7, 2011 Methyl iodide April 1, 1988 Methyl isobutyl ketone November 4, 2011 Methyl isobutyl ketone (MIBK) March 28, 2014 Methyl isocyanate (MIC), fe November 12, 2010 Methyl isopropyl ketone February 17, 2012 Delisted April 4, 2014 Methyl mercury July 1, 1987 Methylmercury compounds May 1, 1996 Methyl methanesulfonate April 1, 1988 Methyl-n-butyl ketone August 7, 2009 December 4, 2015 April 1, Methyl-1-nitroanthraquinone (of uncertain purity) N-Methyl-N'-nitro-N April 1, 1988 nitrosoguanidine N-Methylolacrylamide July 1, 1990 N-Methylpyrrolidone June 15, 2001 α-methyl styrene (alpha November 2, 2012 Methylstyrene) α-methyl styrene fe July 29, 2011 Delisted April 4, 2014 Methyltestosterone April 1, 1990 Methylthiouracil October 1, 1989 Metiram January 1, 1990 Metiram March 30, 1999 Metronidazole January 1, 1988 Michler's ketone January 1, 1988 Midazolam hydrochloride July 1, 1990 Minocycline hydrochloride January 1, 1992 (internal use) Mirex Misoprostol January 1, 1988 April 1, 1990 Mitomycin C April 1, 1988 Mitoxantrone hydrochloride January 23, 2015 Mitoxantrone hydrochloride July 1, 1990 Molinate, fe, December 11, 2009 MON 4660 (dichloroacetyl March 22, 2011 oxa-4-azaspiro(4,5)-decane) MON (furilazole) March 22, Monochloropropane-1, October 8, 2010 diol (3-MCPD) Monocrotaline April 1, 1988 MOPP (vincristine-prednisonenitrogen mustard-procarbazine mixture) November 4, (Morpholinomethyl) April 1, Proposition 65 List of Chemicals

15 [(5-nitrofurfuryl-idene)- amino]-2-oxazolidinone Mustard Gas February 27, 1987 MX (3-chloro-4-(dichloromethyl) December 22, hydroxy-2(5H)-furanone) Myclobutanil, April 16, 1999 beta-myrcene March 27, 2015 Nabam March 30, 1999 Nafarelin acetate April 1, 1990 Nafenopin April 1, 1988 Nalidixic acid May 15, 1998 Naphthalene April 19, Naphthylamine October 1, Naphthylamine February 27, 1987 Neomycin sulfate (internal use) October 1, 1992 Netilmicin sulfate July 1, 1990 Nickel (Metallic) Nickel acetate October 1, 1989 October 1, 1989 Nickel carbonate October 1, 1989 Nickel carbonyl October 1, 1987 Nickel carbonyl September 1, 1996 Nickel compounds May 7, 2004 Nickel hydroxide ; October 1, Nickelocene October 1, 1989 Nickel oxide October 1, 1989 Nickel refinery dust from the October 1, 1987 pyrometallurgical process Nickel subsulfide October 1, 1987 Nicotine April 1, 1990 Nifedipine, fe, January 29, 1999 Nimodipine April 24, 2001 Niridazole April 1, 1988 Nitrapyrin October 5, 2005 Nitrapyrin March 30, 1999 Nitrilotriacetic acid January 1, 1988 Nitrilotriacetic acid, trisodium April 1, 1989 salt monohydrate 5-Nitroacenaphthene April 1, Nitro-o-anisidine October 1, 1989 Delisted December 8, 2006 o-nitroanisole October 1, 1992 Nitrobenzene August 26, 1997 Nitrobenzene March 30, Nitrobiphenyl April 1, Nitrochrysene October 1, 1990 Nitrofen (technical grade) January 1, Nitrofluorene October 1, 1990 Nitrofurantoin April 1, 1991 Nitrofurazone January 1, [(5-Nitrofurfurylidene)-amino]- 2-imidazolidinone April 1, 1988 N-[4-(5-Nitro-2-furyl)-2-thiazolyl] April 1, 1988 acetamide -15- Proposition 65 List of Chemicals

16 Nitrogen mustard January 1, 1988 (Mechlorethamine) Nitrogen mustard January 1, 1989 (Mechlorethamine) Nitrogen mustard hydrochloride April 1, 1988 (Mechlorethamine hydrochloride) Nitrogen mustard hydrochloride July 1, 1990 (Mechlorethamine hydrochloride) Nitrogen mustard N-oxide April 1, 1988 Nitrogen mustard N-oxide April 1, 1988 hydrochloride Nitromethane May 1, Nitropropane January 1, Nitropyrene October 1, Nitropyrene October 1, 1990 N-Nitrosodi-n-butylamine October 1, 1987 N-Nitrosodiethanolamine January 1, 1988 N-Nitrosodiethylamine October 1, 1987 N-Nitrosodimethylamine p-nitrosodiphenylamine October 1, 1987 January 1, 1988 N-Nitrosodiphenylamine April 1, 1988 N-Nitrosodi-n-propylamine January 1, 1988 N-Nitroso-N-ethylurea October 1, (N-Nitrosomethylamino) April 1, 1990 propionitrile 4-(N-Nitrosomethylamino) April 1, 1990 (3-pyridyl)1-butanone N-Nitrosomethyl-n-butylamine December 26, 2014 N-Nitrosomethyl-n-decylamine December 26, 2014 N-Nitrosomethyl-n-dodecylamine December 26, 2014 N-Nitrosomethylethylamine October 1, 1989 N-Nitrosomethyl-n-heptylamine December 26, 2014 N-Nitrosomethyl-n-hexylamine December 26, 2014 N-Nitrosomethyl-n-nonylamine December 26, 2014 N-Nitrosomethyl-n-octylamine December 26, 2014 N-Nitrosomethyl-n-pentylamine December 26, 2014 N-Nitrosomethyl-n-propylamine December 26, 2014 N-Nitrosomethyl-n-tetradecylamine December 26, 2014 N-Nitrosomethyl-n-undecylamine December 26, 2014 N-Nitroso-N-methylurea October 1, 1987 N-Nitroso-N-methylurethane N-Nitrosomethylvinylamine April 1, 1988 January 1, 1988 N-Nitrosomorpholine January 1, 1988 N-Nitrosonornicotine January 1, 1988 N-Nitrosopiperidine January 1, 1988 N-Nitrosopyrrolidine October 1, 1987 N-Nitrososarcosine January 1, 1988 o-nitrotoluene May 15, 1998 Nitrous oxide, fe August 1, 2008 Norethisterone (Norethindrone) 4B 5B BOctober 1, 1989 Norethisterone (Norethindrone) April 1, 1990 Norethisterone acetate October 1, 1991 (Norethindrone acetate) Norethisterone (Norethindrone) /Ethinyl estradiol / April 1, 1990 Norethisterone / April 1, 1990 (Norethindrone)/Mestranol Proposition 65 List of Chemicals

17 Norethynodrel February 27, 2001 Norgestrel April 1, 1990 Ochratoxin A July 1, 1990 Oil Orange SS April 1, 1988 Oral contraceptives, combined October 1, 1989 Oral contraceptives, sequential October 1, 1989 Oryzalin September 12, 2008 Oxadiazon July 1, 1991 Oxadiazon May 15, 1998 Oxazepam October 1, 1994 Oxazepam October 1, 1992 p,p -Oxybis(benzenesulfonyl August 7, 2009 hydrazide) Delisted December 13, 2013 Oxydemeton methyl fe, November 6, 1998 Oxymetholone January 1, 1988 Oxymetholone Oxytetracycline (internal use) May 1, 1997 January 1, 1991 Oxytetracycline hydrochloride October 1, 1991 (internal use) Oxythioquinox (Chinomethionat) August 20, 1999 Oxythioquinox (Chinomethionat) November 6, 1998 Paclitaxel, fe, August 26, 1997 Palygorskite fibers (> 5 m in length) December 28, 1999 Panfuran S January 1, 1988 Paramethadione July 1, 1990 Parathion Penicillamine May 20, 2016 January 1, 1991 Pentachlorophenol January 1, 1990 Pentobarbital sodium July 1, 1990 Pentosan polysulfate sodium April 18, 2014 Pentostatin September 1, 1996 Phenacemide July 1, 1990 Phenacetin October 1, 1989 Phenazopyridine January 1, 1988 Phenazopyridine hydrochloride Phenesterin January 1, 1988 July 1, 1989 Phenobarbital January 1, 1990 Phenolphthalein May 15, 1998 Phenoxybenzamine April 1, 1988 Phenoxybenzamine hydrochloride April 1, 1988 Phenprocoumon October 1, 1992 o-phenylenediamine and its salts May 15, 1998 Phenyl glycidyl ether October 1, 1990 Phenyl glycidyl ether August 7, 2009 Delisted April 4, 2014 Phenylhydrazine and its salts July 1, 1992 o-phenylphenate, sodium January 1, 1990 o-phenylphenol Phenylphosphine August 4, 2000 August 7, 2009 PhiP(2-Amino-1-methyl October 1, 1994 phenylimidazol[4,5-b]pyridine) -17- Proposition 65 List of Chemicals

18 Pimozide, fe August 20, 1999 Pioglitazone April 18, 2014 Pipobroman July 1, 1990 Pirimicarb July 1, 2008 Plicamycin April 1, 1990 Polybrominated biphenyls January 1, 1988 Polybrominated biphenyls October 1, 1994 Polychlorinated biphenyls October 1, 1989 Polychlorinated biphenyls January 1, 1991 Polychlorinated biphenyls January 1, 1988 (containing 60 or more percent chlorine by molecular weight) Polychlorinated dibenzo-p-dioxins October 1, 1992 Polychlorinated dibenzofurans October 1, 1992 Polygeenan January 1, 1988 Ponceau MX April 1, 1988 Ponceau 3R April 1, 1988 Potassium bromate January 1, 1990 Potassium dimethyldithiocarbamate Pravastatin sodium March March 3, 2000 Prednisolone sodium phosphate August 20, 1999 Primidone August 20, 1999 Procarbazine January 1, 1988 Procarbazine hydrochloride January 1, 1988 July 1, 1990 Procymidone October 1, 1994 Progesterone January 1, 1988 Pronamide May 1, 1996 Propachlor February 27, ,3-Propane sultone January 1, 1988 Propargite October 1, 1994 Propargite June 15, 1999 Propazine, fe July 15, 2016 beta-propiolactone January 1, 1988 Propoxur August 11, 2006 Propylene glycol mono-t-butyl ether June 11, 2004 Propylene oxide October 1, 1988 Propylthiouracil January 1, 1988 Propylthiouracil July 1, 1990 Pulegone April 18, 2014 Pymetrozine Pyridine March 22, 2011 May 17, 2002 Pyrimethamine January 29, 1999 Quazepam August 26, 1997 Quinoline and its strong acid salts October 24, 1997 Quizalofop-ethyl December 24, 1999 Radionuclides July 1, 1989 Reserpine October 1, 1989 Residual (heavy) fuel oils October 1, 1990 Resmethrin Resmethrin July 1, 2008 November 6, 1998 Retinol/retinyl esters, when in July 1, 1989 daily dosages in excess of 10, Proposition 65 List of Chemicals

19 IU, or 3,000 retinol equivalents. (NOTE: Retinol/retinyl esters are required and essential for maintenance of normal reproductive function. The recommended daily level during pregnancy is 8,000 IU.) Ribavirin April 1, 1990 Ribavirin February 27, 2001 Riddelliine December 3, 2004 Rifampin, fe February 27, 2001 Saccharin Delisted April 6, October 1, 1989 Saccharin, sodium January 1, 1988 Delisted January 17, 2003 Safrole January 1, 1988 Salted fish, Chinese-style April 29, 2011 Secobarbital sodium Sedaxane October 1, 1992 July 1, 2016 Selenium sulfide October 1, 1989 Sermorelin acetate August 20, 1999 Shale-oils April 1, 1990 Silica, crystalline (airborne particles October 1, 1988 of respirable size) Simazine, fe July 15, 2016 Sodium dimethyldithiocarbamate March Sodium fluoroacetate November 6, 1998 Soots, tars, and mineral oils February 27, 1987 (untreated and mildly treated oils and used engine oils) Spirodiclofen October 8, 2010 Spironolactone May 1, 1997 Stanozolol May 1, 1997 Sterigmatocystin April 1, 1988 Streptomycin sulfate January 1, 1991 Streptozocin (streptozotocin), fe, August 20, 1999 Streptozotocin (streptozocin) January 1, 1988 Strong inorganic acid mists March 14, 2003 containing sulfuric acid Styrene Styrene oxide April 22, 2016 October 1, 1988 Sulfallate January 1, 1988 Sulfasalazine May 15, 1998 (Salicylazosulfapyridine) Sulfasalazine January 29, 1999 (Salicylazosulfapyridine) Sulfur dioxide July 29, 2011 Sulindac, fe January 29, 1999 Talc containing asbestiform fibers April 1, 1990 Tamoxifen and its salts Tamoxifen citrate September 1, 1996 July 1, 1990 Temazepam April 1, 1990 Teniposide September 1, Proposition 65 List of Chemicals

20 Terbacil May 18, 1999 Teriparatide August 14, 2015 Terrazole October 1, 1994 Testosterone and its esters April 1, 1988 Testosterone cypionate October 1, 1991 Testosterone enanthate April 1, ,3,4,4 -Tetrachloroazobenzene July 24, ,3,7,8-Tetrachlorodibenzo-p January 1, 1988 dioxin (TCDD) 2,3,7,8-Tetrachlorodibenzo-p April 1, 1991 dioxin (TCDD) 1,1,1,2-Tetrachloroethane September 13, ,1,2,2-Tetrachloroethane July 1, 1990 Tetrachloroethylene April 1, 1988 (Perchloroethylene) p-a,a,a-tetrachlorotoluene January 1, 1990 Tetrachlorvinphos Tetracycline (internal use) May 20, 2016 October 1, 1991 Tetracyclines (internal use) Tetracycline hydrochloride October 1, 1992 January 1, 1991 (internal use) Tetrafluoroethylene May 1, 1997 Tetranitromethane July 1, 1990 Thalidomide July 1, 1987 Thioacetamide January 1, ,4'-Thiodianiline April 1, 1988 Thiodicarb August 20, 1999 Thioguanine July 1, 1990 Thiophanate methyl fe, May 18, 1999 Thiouracil June 11, 2004 Thiourea January 1, 1988 Thorium dioxide February 27, 1987 Titanium dioxide (airborne, September 2, 2011 unbound particles of respirable size) Tobacco, oral use of April 1, 1988 smokeless products Tobacco smoke April 1, 1988 Tobacco smoke (primary), fe, April 1, 1988 Tobramycin sulfate Toluene July 1, 1990 January 1, 1991 fe August 7, 2009 Toluene diisocyanate October 1, 1989 o-toluidine January 1, 1988 o-toluidine hydrochloride January 1, 1988 para-toluidine January 1, 1990 Delisted October 29, 1999 Topiramate Toxaphene (Polychlorinated November 27, 2015 January 1, 1988 camphenes) Toxins derived from Fusarium August 7, 2009 Moniliforme (Fusarium verticillioides) Treosulfan February 27, 1987 Triadimefon, fe, March 30, Proposition 65 List of Chemicals

21 Triamterene April 18, 2014 Triazolam April 1, 1990 S,S,S-Tributyl phosphorotrithioate February 25, 2011 (Tribufos, DEF) Tributyltin methacrylate December 1, 1999 Trichlormethine (Trimustine January 1, 1992 hydrochloride) Trichloroacetic acid September 13, 2013 Trichloroethylene April 1, 1988 Trichloroethylene, January 31, ,4,6-Trichlorophenol January 1, ,2,3-Trichloropropane October 1,1992 Trientine hydrochloride February 27, 2001 Triforine June 18, ,3,5-Triglycidyl-s-triazinetrione August 7, 2009 Delisted December 13, 2013 Trilostane April 1, 1990 Trimethadione January 1, ,4,5-Trimethylaniline and its strong acid salts October 24, 1997 Trimethyl phosphate May 1, 1996 Trimetrexate glucuronate August 26, ,4,6-Trinitrotoluene (TNT) December 19, 2008 Triphenyltin hydroxide July 1, 1992 Triphenyltin hydroxide March 18, 2002 Tris(aziridinyl)-p-benzoquinone October 1, 1989 (Triaziquone) Delisted December 8, 2006 Tris(1-aziridinyl)phosphine January 1, 1988 sulfide (Thiotepa) Tris(2-chloroethyl) phosphate April 1, 1992 Tris(2,3-dibromopropyl)phosphate January 1, 1988 Tris(1,3-dichloro-2-propyl) October 28, 2011 phosphate (TDCPP) Trp-P-1 (Tryptophan-P-1) April 1, 1988 Trp-P-2 (Tryptophan-P-2) April 1, 1988 Trypan blue (commercial grade) October 1, 1989 Unleaded gasoline (wholly April 1, 1988 vaporized) Uracil mustard April 1, 1988, fe, January 1, 1992 Urethane (Ethyl carbamate) January 1, 1988 October 1, 1994 Urofollitropin April 1, 1990 Valproate (Valproic acid) July 1, 1987 Vanadium pentoxide (orthorhombic February 11, 2005 crystalline form) Vinblastine sulfate Vinclozolin July 1, 1990 August 20, 1999 May 15, 1998 Vincristine sulfate July 1, Proposition 65 List of Chemicals

22 Vinyl bromide October 1, 1988 Vinyl chloride February 27, Vinylcyclohexene May 1, Vinyl-cyclohexene fe, August 7, Vinyl-1-cyclohexene diepoxide July 1, 1990 (Vinyl cyclohexene dioxide) Vinyl cyclohexene dioxide fe, August 1, 2008 (4-Vinyl-1-cyclohexene diepoxide) Vinyl fluoride May 1, 1997 Vinyl trichloride (1,1, October 1, 1990 Trichloroethane) Warfarin July 1, 1987 Wood dust December 18, ,6-Xylidine (2,6-Dimethylaniline) January 1, 1991 Zalcitabine August 7, 2009 Zidovudine (AZT) December 18, 2009 Zileuton,, December 22, 2000 fe Zineb Delisted October 29, 1999 Date: September 30, Proposition 65 List of Chemicals