REPORTS. Externally Funded Research Programs CANCER COUNCIL QLD. New research grants. Cancer Council charitable funding amount 2016

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1 CANCER COUNCIL QLD Externally Funded Programs New research grants Other grant Prof Mark Smyth - QIMR Checkpoint blockade and denosumab in the treatment of established primary and metastatic s. Skin & Dr Eloise Dray - Deciphering the role of the protein phosphatase EYA4 in genomic maintenance and breast avoidance. A/Prof Raymond Steptoe - Diamantina Does lymphoma avoid immune destruction by inducing T-cell tolerance? Lymphoma Dr Dominic Ng - The University of Mitotic spindle regulation by a novel Aurora A control mechanism. Prevention Dr Stacey Edwards - QIMR Identifying new breast genes from GWAS. Dr Bryan Day - QIMR Advancing a novel therapy to target brain stem cells. Brain A/Prof Vicki Whitehall - QIMR Sessile serrated adenoma prevention in a preclinical study. Bowl prevention Dr Michael Piper - The Regulation of stem cell differentiation during cerebella development and medulloblastoma. Childhood Brain Prof Rajiv Khanna - QIMR Impact of immune contexture on clinical outcome of adoptive immunotherapy Prevention 93

2 grant Other Prof Lisa Chopin - The ghrelin receptor antisense long non-coding RNA, GHSROS, as a potential target for prostate therapy. Dr Mathias Francois - The SOX18-VEGF cross-regulation during angiogenesis and blood vascular development. Basic Science Prof George Muscat - The Elucidating the role of the nuclear hormone receptor RORy1 in breast. Prof Judith Clements - Targeting kallikrein proteases to improve treatment options for ovarian. Ovarian Dr Kate Gartlan - QIMR RORyt inhibition as a novel therapeutic for the prevention of graft-versus-host disease after allogeneic stem cell transplantation. Leukemia Dr Fares Al-Ejeh - QIMR The MEK5-ERK5 pathway in triple negative breast : progression and therapy. Travelling fellowships Provision for special projects By invitation $65,000 $0 $65,000 All s By invitation $56,306 $0 $56,306 All s RESEARCH FUNDED (new ) $1,621,306 $0 $1,621,306 Continuing research grants Prof Geoffrey Hill - QIMR Understanding and optimizing Graft-versus-Myeloma effects after bone marrow transplantation. Blood Prof Kum Kum Khanna - QIMR The role of PC4 in the tumorigenesis and metastasis of breast. 94 Forum Volume 40 Number 2 July

3 grant Other A/Prof Amanda Spurdle -QIMR Clinical classification of BRCA1/2 gene variants. Prof Andreas Suhrbier - QIMR Regulation of mtorc2 and Ras signalling by Sin1 isoforms in pancreatic. Pancreatic Prof Mark Smyth - QIMR A new checkpoint of immunotherapy. Immunotherapy Dr Michele Teng - QIMR The role of IL-23 associated cytokines in immunology. Skin Dr Roberta Mazzieri - The Targeting the proangiogenic and immunosuppressive tumour microenvironment in primary and metastatic breast. Dr Murugan Kalimutho - The Cep55 is a determinant of aneuploidy cell fate in breast. Dr Lachlan Coin - The University of Using somatic copy number and methylation profiling of circulating tumour DNA to monitor heterogeneous tumour development in breast. Prof Thomas Gonda - The A small molecule screen for inhibitors of the MYB oncoprotein. Leukemia A/Prof Richard Sturm - The Human pigmentation pathway in UV-protection and mechanisms of melanoma risk. Skin Prof Brandon Wainwright - The University of A synthetic lethal based approach for the treatment of medulloblastoma. Childhood Brain 95

4 grant Other A/Prof Helen Blanchard - Griffith University Development of inhibitors targeting the promoting protein galectin - 3. All s Prof Judith Clements - PSA coding variants: functional analysis, multiethnic association and risk models for prostate. Dr Elke Hacker - New technologies in skin prevention. Skin A/Prof John Hooper - Mater, Targeting CDCP1 to reduce tumour burden and ascites in clear cell ovarian. Ovarian Prof Peter Koopman, Nodal/Cripto signalling in germ cell development and tumorigenesis. Testicular Prof Nigel McMillan, Griffith University Novel therapeutic targets for HPV-driven s. $97,000 $0 $97,000 HPV s Prof Colleen Nelson, Development of YB-1 as a therapeutic target in advanced prostate. Prof Kenneth O Byrne, MyRIP and exosomes function to control genomic stability. Basic science Dr Allison Pettit, Mater, Macrophages facilitate prostate bone metastasis. Dr Pamela Pollock, Understanding FGFR2 activation in endometrial : Novel mutations, differences in spatio-temporal signaling and alternative activating spliceforms. Endometrial 96 Forum Volume 40 Number 2 July

5 grant Other Prof Alpha Yap, Controlling the Rho off-switch: a novel target in breast. PhD Scholarship Miss Arabella Youing, QIMR Targeted therapy and immunotherapy in breast. $30,000 $0 $30,000 PhD Scholarship Dr Matthew Roberts, Improving the early detection of prostate : a noninvasive, systems biology approach. $30,000 $0 $30,000 Senior Fellowship Prof Nicholas Saunders - Translating basic science into better treatments. $159,845 $0 $159,845 Basic science Senior Fellowship A/Prof Sandi Hayes - Exercise is medicine: a nonpharmacological approach to care. $138,627 $0 $138,627 All s Chair of Prevention Prof Michael Kimlin - the Sunshine Coast CCQ/Univ. Sunshine Coast Joint Professor of Prevention. Prevention CCQ/QCOG Clinical Trial Data Manager Grants Gold Coast University Hospital Icon Care - HOCA Centre Mater Health Services - Oncology & Palliative Care Nambour Hospital Oncology Australia Genesis Care Princess Alexandra Hospital - (Surgery,Haematology & Oncology, Radiation Oncology) Radiation Oncology Services - Mater Centre $459,051 $764,063 $1,223,114 All s Royal Brisbane and Women s Hospital - Gynaecological, Oncology, Radiation Oncology, Brisbane Colorectal Group Lady Cilento Children s Hospital Townsville Hospital Wesley RESEARCH FUNDED (continuing ) $3,214,523 $764,063 $3,978,586 EXTERNAL FUNDED RESEARCH PROGRAMS (including new and continuing research grants) $4,835,829 $764,063 $5,599,892 97

6 grant Other Internally Funded Programs Continuing research grants Viertel Centre $4,319,683 $1,150,925 $5,470,608 Epidemiology - in Indigenous Australians - in Children - Outcomes - UV Exposure, Vitamin D and Melanoma - Analysis and reporting of statistics and patterns $134,989 $144,172 $279,161 Psycho-oncology - Developing accessible and effective supportive care interventions - Identifying needs for patients and carers $89,350 $305,754 $395,104 Community Engagement - Building capacity for control agencies - Meeting the needs of regional and rural communities $373,125 $37,106 $410,231 Australian Paediatric Registry $57,032 $63,924 $120,956 Registry $396,779 $939,000 $1,335,779 INTERNALLY FUNDED RESEARCH PROGRAMS (continuing research grants) $5,370,958 $2,640,881 $8,011,839 RESEARCH FUNDED CANCER COUNCIL QLD $10,206,787 $3,404,944 $13,611, Forum Volume 40 Number 2 July