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1 International Journal of Health Sciences and Research ISSN: Original Research Article A Retrospective Analysis of 1000 Cases of Cervical Pap Smears Sabina Shrestha 1, Kricha Pande 2 1 Consultant Pathologist, Department of Pathology, Norvic International Hospital 2 Lecturer, Department of Pathology, Nepal Medical College and Teaching Hospital. Corresponding Author: Sabina Shrestha Received: 23/12/2016 Revised: 09/01/2017 Accepted: 17/01/2017 ABSTRACT Introduction: Carcinoma of the cervix is the most common cancer of women in developing countries including Nepal. The Pap smear screening is an effective method for identifying intra epithelial lesions of cervix. Aims and Objectives: To determine the type and prevalence of abnormal cervical epithelial lesions in patients presenting with abnormal uterine bleeding at Patan Hospital. Materials and Methods: This is a retrospective study of all the cervical pap smear cases reported to the Department of pathology at Patan Hospital. The duration of study was dated from 1 st May 2012 to 30 th April 2014 and total 1,000 cases were enrolled for the study. Results: Most of the patients were in between years (30%) followed by years (28%) in age. Predominance of inflammatory smears was noticed in 894 (89.4%) cases. In this study, there were 106 (10.6%) cases of abnormal epithelial lesions out of which 27cases i.e. 2.7% were diagnosed as Atypical squamous epithelial cells of undetermined significance (ASCUS), 43(4.3%) cases were diagnosed as Low grade SIL and 29(2.9%) cases were found to be high grade SIL on Pap smear. In the present study, 7 cases (0.70%) were diagnosed as squamous cell carcinoma which is found to be maximum between years of age. The commonest risk factors for squamous cell carcinoma in this study are early marriage, before the age of 20 years and low socioeconomic status. Conclusion: This study concludes that cervical Pap smear test is very helpful in early diagnosis of cervical cancer and it s precursor lesions.it is a simple, safe, inexpensive and painless method for diagnosis of the precancerous lesions and carcinoma of cervix. Key words: Pap smear, Intra epithelial lesion, Cervical Carcinoma, INTRODUCTION Carcinoma of the cervix is the most common cancer of women in developing [1] countries. Each year approximately 4,65,000 new cases of invasive cancer of the cervix are diagnosed and the mortality due to carcinoma of the cervix worldwide is around 2,00,000 per year. [2] Cervical carcinoma is more common in developing countries than in developed ones, particularly in parts of Asia, South [3] America and Africa. Around 3,200 women are diagnosed with cervical cancer in UK each year. [5] Carcinoma of cervix is the fourth commonest cancer in Singapore, making up 7.2% of all female cancers diagnosed between 1993 and [4] In India, the annual incidence of carcinoma of cervix is estimated to be 5,00,000 new cases per year. Carcinoma of cervix accounts for 25-50% of total cancers while for 86-90% of all genital cancers in Indian women. [5] In Nepal gynecological malignancy, particularly the cervical cancer is the most prevalent cancer. [6] International Journal of Health Sciences & Research ( 103
2 Cervical carcinoma does not develop directly from normal epithelium but is preceded by a spectrum of intra epithelial neoplastic changes. [7] Upto one third of untreated, pre-cancerous lesion could develop into carcinoma in about 10 to 15 [8] years. The Bethesda system, first introduced in 1989 is currently being followed worldwide to classify these lesions. [9] The Pap smear screening is an effective and useful screening tool for identifying pre-cancerous intra -epithelial lesions, which are often been treated on an outpatient basis. [10] The objective of this study was to determine the type and prevalence of abnormal cervical epithelial lesions in patients presenting with abnormal uterine bleeding at Patan Hospital which caters largely to women of low socioeconomic status. MATERIALS AND METHODS This is a retrospective study of all the cervical Pap smear cases reported to the Pathology department of Patan Hospital from 1 st May 2012 to 30 th April Total 1000 cases were included in this study. A detail history and clinical findings of the patients were noted from the requisition form. All of the cervical smear findings were noted and classified according to The 2001 Bethesda System reporting Pap smear cytology. Statistical Analysis The data were analyzed using Microsoft Excel 2003 for windows. OBSERVATIONS AND RESULTS Table I: Age distribution of patient Age(years) No. of patient Percentage <20yrs 0 0% 21-30yrs % 31-40yrs % 41-50yrs % 51-60yrs % 61-70yrs % Total % Table 1: All the female patients were in the age group of years. Most of the patients are in between years (30%) of age followed by years (28%). Table 1 demonstrates age distribution of all the patients. Table II: Table showing the frequency distribution of symptom complexes Symptoms No. of cases Percentage Lower abdominal pain % Abnormal vaginal bleeding % Whitish per vaginal discharge % Bleeding on coitus % Weight loss % Dysuria % Anorexia % Table2:The predominant complaints in all cases were lower abdominal pain 763 cases (76.3%) followed by abnormal vaginal bleeding in 352 cases (35.2%) and whitish discharge per vagina 391 cases (39.1%). Other symptoms were intercoital bleeding, dysuria, weight loss and anorexia. Table III: Cervical smear (Pap smear) findings in 1,000 cases Diagnosis No. of cases Percentage NIL % ASCUS % LSIL % HSIL % SCC % Total % Table IV: Age distribution pattern in different types of lesion Age (years) Inflammatory smears (IL) ASCUS LSIL HSIL SCC Total Total Percentage 89.7% 2.7% 4.3% 2.9% 0.7% 100% International Journal of Health Sciences & Research ( 104
3 Table III depicts the different patterns of Pap smear findings. Predominance of inflammatory smears was noticed in 89.4 (89.4%) cases. Abnormal findings were noted in 106 (10.6%) cases. Out of 106 abnormal findings, the prevalence of low grade SIL was 4.3% followed by high grade SIL 2.9% with ASCUS 2.7% and squamous cell carcinoma of cervix 0.7%. Table IV shows the age distribution of the patients in relation to different types of Pap smear findings. This data shows that inflammatory smear was commonest finding in females of age group of years. ASCUS was commonest in the age group years. Similarly, squamous intraepithelial lesions (SIL) are more common in years and peak incidence of both LSIL and HSIL is and years age group. Squamous cell carcinoma was found to be maximum between years of age. Among 7 diagnosed of carcinoma, all women were in peri and postmenopausal age group. Table V: Relation of Inflammatory smears (IS), ASCUS, LSIL, HSIL, SCC with age at marriage. Type of Age at marriage < 20 Age at marriage > 20 lesion yrs yrs IS 278 (27.8%) 616 (61.6%) ASCUS 11 (1.1%) 16(1.6%) LSIL 13 (1.3%) 30(3.0%) HSIL 18 (1.8%) 11(1.1%) SCC 05 (0.5%) 02(0.2%) Total 325 (32.5%) 675(67.5%) In this present study, 7 cases were diagnosed as squamous cell carcinoma in Pap smear and we found out that 5 patient were married before 20 years of age. Similarly all the 7 cases of SCC were from poor socioeconomic status. However, among 894 cases of inflammatory smears, only 278 (31.09%) cases were married before the age of 20 years. DISCUSSION Carcinoma of cervix is the most common malignant tumor of female genital tract in most countries. On a global scale, cancer of cervix is one of the major causes of death, especially in third world countries, where such screening is often not routinely performed. Invasive cancer of the uterine cervix is preventable when its precursor lesions are detected and treated early. Cervical cytology has been in use now for more than 50 years, and has proven itself to be the main weapon of defence against this disease. As prevention is always better than cure, in Nepal s context also Pap smear screening should be designed to detect the precursor lesions in cervical epithelium which may antedate the development of invasive cancer by several years. A total 1000 patients were included in this study from 1 st May 2012 to 30 th April Predominance of inflammatory smears was noticed in 894 (89.4%) cases. Cronje et al (2001) reported similar preponderance of inflammatory smears in their study. [11] In another study conducted by Sharma S. (2000) higher frequency of inflammatory smears of 302 cases (45.3) was noted out of 667 cases. [12] In this study, there were 106(10.6%) cases of abnormal epithelial lesions. The percentage of epithelial abnormalities is 2.3%to 6.6% in USA, from 1.6% to 7.9% in the Middle East and 1.87% to 5.9% in India. [13] In this study 43(4.3%) cases were diagnosed as Low grade SIL and 29 (2.9%) cases were found to be high grade SIL on Pap smear. Shrivastav et al (1998) reported the incidence of low grade SIL to be 15% in 100 cases of Pap smear. [14] The HSIL was reported as high as 3.75 % in Zimbabwe. [15] In the present study, 7 cases (0.7%) were diagnosed as squamous cell carcinoma in Pap smear. Other types of malignancy (adenocarcinoma or sarcomas) were not detected. In a similar study done by Alasio et al (2000), 8 cases (2.87%) out of 278 cases were diagnosed as squamous cell carcinoma on Pap smears. [16] Mostafa et al (2000) reported the incidence of squamous cell carcinoma to be 5.93 %. [17] On correlation with age with inflammatory smears and Atypical Squamous cell of Undetermined Significance (ASCUS), the maximum International Journal of Health Sciences & Research ( 105
4 numbers of inflammatory smear were presented between the age group of years. Similar, correlation with age in inflammatory smears have found in other studies. Among 27 cases of ASCUS of our study 23 cases presented between the age group years. However, Bogaertt et al (2001) in their study of 22,160 cases showed the age group with maximum number of cases to be in between years. [18] In this study SIL is more common in years and peak incidence of both LSIL and HSIL is years. In a similar study done by Bogaertt et al (2001) the common age group of SIL years and the peak incidence of HSIL occurred between the ages of years. [18] Misra et al found that 51.5% of SIL cases were in above 40 years of age. [19] On correlation of age with Squamous cell carcinoma, age group for cervical cancer in this study is comparable to that reported in literature and is found to be maximum between years of age. Among 7 diagnosed cases 6 women were postmenopausal. All of them had never been screened by the Pap smear test before. Patten et al (1996) studied the common age group for carcinoma cervix and it was found to be 53.4 years. [20] Similarly, Reagin and Hick et al (1953) in their study found the common age of carcinoma cervix to be 48years. [21] Bogaertt et al (2001) reported the common age group of squamous cell carcinoma as the 6 th decades. [18] Kobilkova et al (2001) studied that the incidence of cervical cancer had two peaks, one at age group of years and another at age group of years. [22] The commonest risk factors for Squamous cell carcinoma in this study are early marriage (before the age of 20 years) and low socioeconomic status. In this study out of 7 cases of SCC 5 patient were married before 20 years of age. However among 894 cases of IS only 278(31.09%) cases were married before the age of 20 years and 616 (68.90%) cases were married after the age of 20 years. Similarly all the 7 cases of SCC were from poor socioeconomic status. Ryan et al considered early marriage as the primi cause. [23] Similarly, in a study done by Ia Vecchia et al (1986) and Herrero R. et al (1989) the single most important risk factor is early age at first intercourse. [24,25] One explanation is that spermatozoa are considered to act as carcinogen to the cervical epithelium. It attacks the immature metaplastic cells in the transforming zone (TZ) causing these cells to transform into cervical intraepithelial neoplasm (CIN). Thus, the longer duration of marriage, the greater is the risk of exposure to spermatozoa and hence higher risk of carcinoma cervix. The most common clinical presentation in all cases were lower abdominal pain 763(76.3%) followed by abnormal vaginal bleeding 352(35.2%) and whitish discharge per vagina 391(39.1%). Moghal in his study observed menorrhagia (41%) as the most common symptoms. [26] In this study all the 7 cases of SCC never had cervical screening before. It is appropriate to continue to perform annual Pap tests in women considered to be at high risk for cervical cancer on the basis of the risk factors. Cervical smear can detect the presence of a premalignant lesion allowing for the prevention of cancer. Most of the time, patients present in advanced stage of the disease when treatment is less effective.the widespread use of Pap smear in developed countries has proven that if measures are taken for early detection of these types of cancer mortality and morbidity can be significantly minimized. In Iceland, 100% of the eligible population is screened every 2-3 years and the incidence of carcinoma of the cervix in 1980 had fallen to less than one third of that in [27] In Denmark, about 40% of the population is screened every 3-5 years and the incidence of carcinoma of the cervix over the 15 years of period fell by about two thirds. [28] It is appropriate to continue to perform annual Pap tests in women considered to be at high risk for cervical International Journal of Health Sciences & Research ( 106
5 cancer on the basis of the risk. A large scale study encompassing women from different strata and age groups is required to determine the actual incidence of abnormal cervical epithelium lesions in Nepal. Cancer of Cervix should get priority in terms of control programs through mass screening in Nepal. CONCLUSION Carcinoma of the cervix is the most common cancer of women in developing countries including in Nepal. The Bethesda system classifies these lesions as squamous intraepithelial lesions (SIL). These precancerous lesions, if untreated would lead to the development of cervical carcinoma in a period of about years. From this present study, it is concluded that cervical smear test is very helpful in early diagnosis of cervical cancer and its precursor lesions.it is a simple, safe, inexpensive and painless method for diagnosis of the precancerous lesions and carcinoma of cervix. So, it is very appropriate in a country like ours to continue regular PAP tests in women consider being at high risk for cervical cancer. ACKNOWLEDGEMENT We would like to thank all team and colleagues of Department of Pathology and Department of gynecology at Patan hospital for their invaluable help. REFERENCES 1. Landis SH, Murray T, Bolden S, Wingo PA. Cancer statistics. 1998, CA 1998:48: Parkin DM, Pisani P, Ferlay J. Estimates of worldwide incidence of eighteen major cancers in Int J cancer 1993; 54: Malcolm Coppleson, John M. Monagham, C. Paul Morrow: Gynecologic Oncology Epidemiology of cancer, 2 nd vol.i, 1992; T.P. Thamboo, M Salto-Tellez, KB Tan, B Nilson, A Rajwanshi.Cervical cytology: An audit in a Singapore Teaching Hospital. Singapore Med J (5): Mishra S, Srivastava S, Singh U, Srivastava AN. Risk factors and strategies for control of carcinoma cervix in India: Hospital based cytological screening experience of 35 years. Indian J Cancer 2009; 46: Shrestha M.M, Pradhan S., Shrestha B. Evaluation of the comparative efficiency of single and double freeze technique of cryotherapy in controlling CIN lesions in Bharatpur Municipality, Chitwan, Nepal a randomized clinical trial. 1 st National oncology conference souvenir, organized by B.P. Koirala Memorial Cancer Hospital. Chitwan, Bharatpur.3-5Dec 2004; page Dawn CS: Cervical intraepithelial neoplasia in text book of Gynecology and contraception.11 th Ed published by Arati Dawn 1992; Larry J. Copeland, John F Jarrell. Premalignant lesions of the cervix.text book of Gynecology2 nd Ed.1993, Bethesda workshop. The Bethesda system for reporting cervical/vaginal diagnosis. Acta.Cytol. 1993:37: J Monsonego et al.liquid-based cytology for primary cervical cancer screening: a multi-centre study.british Journal of Cancer (2001) 84(3), Hendriks Cronje, Groesbeck P.,Parham Bruno F. Cooreman. A comparison of four screening methods for cervical neoplasia in a developing country. American Journal of obstetrics and Gynecology vol188. No.2: Sharma Sudha. Down staging of carcinoma cervix: A suitable of approach for low resource settings. J.NP. Med. Assoc. 2000, 39: Mulay K, Swain M, Patra S,Gowrishankar S. Comparative study of cervical smears in an Urban Hospital in India and population-based screening program in Mauritus. Indian J Pathol Microbol. 2009; 52: Shrivastav Veena, Bhanot UK. Prospective study of 100 cases of Pap smears. J. NP Med. Assoc : International Journal of Health Sciences & Research ( 107
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Department of Pathology, Kathmandu Medical College & Teaching Hospital, Sinamangal, Kathmandu, Nepal
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