Diagnosis and Management of the Vomiting Patient. The Vomiting Patient: Four Important Questions. June 15 28, 2009
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1 The Vomiting Patient: Four Important Questions June 15-28, 2009 By David C. Twedt, DVM, Diplomate ACVIM AAHA gratefully acknowledges the following for their sponsorship of this Web Conference: Diagnosis and Management of the Vomiting Patient David C. Twedt, DVM, Diplomate ACVIM 1
2 Jake 10 yr C/M WWT Owner s complaint: 2 years duration of chronic vomiting Referred for a vomiting work-up The Patient Adopted 2 years ago Little history prior to adoption except a reported episode of pancreatitis On heartworm prevention Since owners obtained Jake he would vomit Jake has as been treated with a variety of medications The Four Important Questions 1. Is the animal really vomiting? 2. What is the vomiting history? 3. How should I direct my work-up? 4. When should I consider antiemetic therapy, and if so which one? 2
3 The Vomiting History The Vomiting History 1. Is the patient actually vomiting? Nausea Salivation Swallowing Retching Expulsion of gastric material The Vomiting History 1. Is the patient actually vomiting? 2. Detailed vomiting history Determine D FACTs: Duration Frequency Association with eating Character Treatments 3
4 The Vomiting History 1. Is the patient actually vomiting? 2. Detailed vomiting history 3. Diet and drug history The Vomiting History 1. Is the patient actually vomiting? 2. Detailed vomiting history 3. Diet and drug history 4. Other signs or symptoms associated with the vomiting Jake s History Vomiting: 2-3 X a week Contains predominately bile Occurs almost always during the night or early morning Occasionally has a gurgling stomach Sometimes vomits heartworm pills up to hours after given 4
5 Jake s History Additional history: Senior premium diet feed once a day Good appetite, no weight loss Past therapy: Several specialty GI diets Antibiotics Famotidine Physical Examination 9 kg bw, BCS - 5/9 Active and responsive T - 100º F, Pulse bpm GI - normal abdominal palpation Review of other systems - WNL Rectal exam - WNL and normal stool Would you consider prescribing an antiemetic as part of Jake s treatment plan? a. Yes b. No c. Need more information 5
6 Rational Use of Antiemetics First, always treat primary disease Indications would be. To prevent fluid and electrolyte loss Patient comfort from nausea and vomiting Fear of aspiration pneumonia Benefit.. Possibly an early return to nutrition Contraindications.. GI obstructions Rational Use of Antiemetics Common uses: Motion sickness Uremia Parvovirus Pancreatitis Acute gastroenteritis Cancer chemotherapy Undetermined causes and no etiology What Antiemetic? Serotonin antagonists Metoclopramide Butorphanol Phenothiazines NK 1 antagonists Antihistamines Anticholinergic drugs 6
7 Pathophysiology of Vomiting The Pathophysiology of Vomiting Remember all vomiting is a CNS initiated reflex CNS Vestibular Emetic Center CRTZ Vagal (X) Sympathetic CN IX Peripheral Sensory Receptors 2- NK1 adenergic 5-HT 1 Cat Emetic Center CRTZ Dog H 1 Histimergic Vestibular Vagal Afferents NK1 7
8 2- NK1 adenergic 5-HT 1A/3 Cat Phenothiazines Emetic Center Chlorpromazine 2 adenergic (dog?) D 2 dopaminergic H 1 histiminergic Vagal (weak) M 1 cholinergic (weak) Afferents Sedation / Hypotension Seizure threshold CRTZ Dog NK1 H 1 Histimergic Vestibular 2- NK1 adenergic 5-HT 1A/3 Emetic Antihistamines Center Diphenhydramine H 1 histiminergic M 1 cholinergic CRTZ Vagal Motion sickness Afferents Vestibular disease Sedation / dry mouth Effectiveness? NK1 H 1 Histimergic Vestibular 2- NK1 adenergic 5-HT 1A/3 Anticholinergics Emetic Isopropamide Center CRTZ M 1 cholinergic Peripheral afferent cholinergics Generally not indicated Vagal Dry mouth Afferents GI secretions GI motility NK1 H 1 Histimergic Vestibular 8
9 2- NK1 adenergic 5-HT 1A/3 Cat Dopamine Emetic Antagonist Metoclopramide Center CRTZ D 2 dopaminergic (cats?) 5HT 3 serotonergic ( dose) Rapid metabolism - CRI CNS excitement, Vagal with phenothiazines Afferents GI motility Dog NK1 H 1 Histimergic Vestibular 2- NK1 adenergic 5-HT 1A/3 Cat Serotonin Antagonist Ondansetron Dolasetron Emetic Center CRTZ 5HT 3 antagonists Uses: Chemotherapy Severe Vagal vomiting GI motility Afferents Dog NK1 H 1 Histimergic Vestibular 2- NK1 adenergic 5-HT 1A/3 Cat Maropitant NK 1 Antagonist Emetic Vomiting/nausea Center CRTZ Chemotherapy Motion sickness ( dose) Hepatic metabolism Vagal Dose accumulates > 5 Afferents days Dog NK1 H 1 Histimergic Vestibular 9
10 No Emetic Events Peripheral Central Maropitant Mechanism of Action Blocks Substance P (a neuropeptide) at NK1 receptor P P MAROPITANT Maropitant Oral (16, 24, 60, 160 mg tabs) 2 mg/kg PO q 24 hr - vomiting 8 mg/kg PO q 24 hr - motion sickness Injectable (10 mg/ml) 1 mg/kg SQ q 24 hr Efficacy - Prevention of Vomiting Central vs. Peripherial Least Squares Mean Number of Emetic Events Ipecac Apomorphine Pfizer Study 10
11 Review of Experience At CSU May 14 to July 26, 2007 We used 19 bottles in 2 months >85 cases have been treated with Maropitant A review of first 50 clinical cases 46 dogs 3 cats 1 ferret First 50 Cases 7 Parvovirus 11 Gastroenteritis 4 Pancreatitis 2 Renal disease 2 Liver disease 17 Oncology 15 chemotherapy 2 tumor related 7 Other conditions: 2 peritonitis 2 neurological disease 1 vestibular disease 1 rattlesnake bite 1 unknown First 50 Cases Treatment response: 30/50 had treatment response recorded in record 29/30 cases showed a positive response to therapy 1 case (abdominal cancer) failed to respond with continued vomiting 11
12 First 50 Cases Adverse effects - first 50 cases 4 clinicians reported stinging at injection site Cases subsequent to first 50 Bassett hound getting chemotherapy developed gastric dilatation Pancreatitis case developed gastric atony and required gastric suction Parvovirus: 7 Cases Vomiting & nausea are a major complication Ability to begin early oral nutrition improves recovery Maropitant appears to decrease hospital time by almost one day Motion Sickness Acepromazine Maropitant Maropitant had a 84% to 93% efficacy in dogs with a history of motion sickness Give 2 hours before the trip Conder GA: Efficacy and safety of maropitant for prevention of vomiting due to motion sickness. J. Vet. Pharmacol Dec
13 QuickTime and a decompressor are needed to see this picture. Does Maropitant Effect GI Motility? SmartPill evaluation of GI motility in dogs given placebo vs Maropitant Does Maropitant Effect GI Motility? Maropitant appears to have no effect on GI motility (ACVIM Forum 2009) Antiemetics in Cats Antihistamines - poor for motion sickness Metoclopramide - a poor choice Maropitant Not yet approved for cats mg/kg q 24 h SQ or PO Motion sickness 1 mg/kg PO Hickman: Safety, pharmacokinetics of maropitant for prevention of vomiting and motion sickness in cats. J Vet Pharmacol Therap 31;220, 2008 Milton 13
14 QuickTime and a decompressor are needed to see this picture. Maropitant Off label use: IV in several cases Dogs under 16 weeks Dogs for longer than 5 days SQ Cautions: Liver disease Prolonged use When are Antiemetics Contraindicated? Not first performing diagnostics GI obstructions Antiemetic adverse side effects Chronic disease - always pursue a diagnosis Back To Jake No fluid or electrolyte loss No nausea causing anorexia No debilitation due to vomiting 14
15 Jake s First Wave Diagnostics CBC - WNL Biochemical profile - WNL Urinalysis - WNL Fecal flotation - negative Giardia fecal ELISA - negative GI Disorders: Initial Evaluation Normal Laboratory Evaluation Classify the Case Mild Disease Significant Disease GI Disorders: Initial Evaluation Mild Disease Symptomatic Therapy Anthelmintic Therapy Dietary Trials 15
16 Parasites and Vomiting Ascarids Tricuris Giardia Physaloptera World wide prevalence Intermediate host - insects Fecal flotation - poor Treatment - febendazole Insert video physaloptera Adverse Food Reactions Food allergies Immune reaction to dietary protein Food intolerance pharmacologic to a dietary substance Chronic nonspecific GI disease ~50% responded to diet change Dogs: Gaschen; JVIM 2006 Cats: Guilford; JVIM 2001 Dietary Trials Novel protein diets Gluten free diets Hydrolyzed diets Gastrointestinal diets Other commercial diets * Diets should be fed for ~ 2 weeks to determine response 16
17 Cortisol µg/dl Jake: First Wave Treatment Trial therapies: Febendazole 50 mg/kg X 3 da Hydrolyzed protein diet X 3 weeks Day 10 days later: Vomited 3 X Owner started famotidine and bland diet Jake: Second Wave Jake was re-admitted for further diagnostics Now possible causes of chronic vomiting? Chronic pancreatitis? Atypical Addison s disease? Primary GI disease Jake s Results Spec cpl: 36 µg/l (normal < 200 µg/ L) Abdominal ultrasound : normal ACTH 18 Stimulation test : normal 15 Zero = 3.1 µg/dl 1 hr. = 13.2 µg/dl Zero A baseline cortisol > 2 µg/dl is unlikely hypoadrenocorticism 1 Hour 17
18 QuickTime and a Sorenson Video 3 decompressor are needed to see this picture. Clinical Assessment of GI Disorders Possibly Causing Vomiting Diagnostic Evaluation Radiology Endoscopy Surgical biopsy Obstructive Inflammatory Motility disorder Likely Differentials for Jake Inflammatory disease: Gastritis/IBD Helicobacter Insert video Obstructive disorders N Duodenum Mucosal hypertrophy Motility disorders Bilious vomiting disorder Jake: Second Wave Results Gastric biopsy Normal Helicobacter culture Negative Intestinal biopsy Insert video Normal Gastric reflux 18
19 Enterogastric Reflux Syndrome Bilious Vomiting Syndrome Etiology: Idiopathic Gastric motility disorder? Secondary IBD Giardia Enterogastric Reflux Syndrome Clinical syndrome Older dogs Chronic bilious vomiting Early morning Empty stomach Endoscopy Antral inflammation Enterogastric Reflux Treatment Dietary management Late evening meals Gastric protectants Antiacids Sucralfate Prokinetic agents Metoclopramide - poor Cisapride - better Erythromycin - good? Dose: mg/kg BW 19
20 Jake: Follow Up Treatment Diet 3 meals/day Last meal late in the evening Cisapride 0.25 mg/kg 30 min before last meal Outcome Resolved > 1 year Vomiting: Final Thoughts First rule out: Common conditions Non-GI disease Treat primary disease Use antiemetics with acute or severe signs or when nausea and vomiting effect nutrition or clinical status of patient 20
21 1. To complete the evaluation, please go to the following website: 1. After completing the evaluation, you will automatically be linked to the Continuing Education Certificate. The CE certificate can only be accessed after the evaluation is completed. 2. Download the CE Certificate (in pdf format) to your computer and print enough copies for those persons viewing the webcast with you. Your input is very important! We take feedback seriously in order to provide you with the highest quality experience possible. If you have any questions about completing the evaluation or accessing your CE certificate, please us at or call 800/ Questions to the Speaker Please your questions to by Sunday, July 5, Dr. Twedt will provide written responses to all of the questions and they will be posted on AAHA s website by Wednesday, July 15, AAHA gratefully acknowledges the following for their sponsorship of this Web Conference. 21
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