Partnering Activity Update
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- Henry Barker
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1 Partnering Activity Update February 2, 2018
2 Recent Partnering Date Product name / code number Indication / MOA Phase (JP / Overseas) Partner 2010 KYPROLIS / Carfilzomib Multiple Myeloma / Proteasome inhibitor Amgen, USA (Onyx, USA) 2011 Ivabradine / Chronic Heart Failure / If channel blocker III / L Servier, France 2011 PARSABIV / Etelcalcetide Secondary Hyperparathyroidism / Calcium sensing receptor agonist Amgen, USA (KAI, USA) 2011 ORENCIA / Abatacept Rheumatoid Arthritis / T cell activation Inhibitor IV: SC: BMS, USA (co-development & co-marketing) Apr 2013 Opicapone / Symptom Reemergence in Parkinson s disease / COMT inhibitor II / L Bial, Portugal Oct 2013 Metyrosine / Pheochromocytoma / Tyrosine hydroxylase inhibitor I/II / L Valeant, USA Dec 2013 FORXIGA / Dapagliflozin Type 2 Diabetes / SGLT-2 inhibitor AstraZeneca, UK (co-promotion)
3 Recent Partnering Date Product name / code number Indication / MOA Phase (JP / Overseas) Partner May 2016 IT1208 Solid Tumors / Anti-CD4 mab I / - IDAC Theranostics, Japan (Exclusive evaluation and license negotiation right) Jul 2016 NKR-2 Solid Tumors and Hematological Malignancies / Allogeneic CAR T-cell therapy PC / PC Celyad, Belgium May 2017 Binimetinib / Encorafenib / Binimetinib / Encorafenib / BRAF-mutant melanoma / MEK inhibitor Combination BRAF inhibitor therapy BRAF-mutant melanoma / MEK inhibitor Combination BRAF inhibitor therapy III / Filed - / III Array, USA Aug 2017 SI-613 / Osteoarthritis / Combined drug of hyaluronic acid and NSAID III / - Seikagaku, Japan (co-development & marketing collaboration ) Oct 2017 Selinexor KPT-8602 Solid Tumors and Hematological Malignancies / XPO1 (Exportin 1) inhibitor Solid Tumors and Hematological Malignancies / second generationxpo1 (Exportin 1) inhibitor -/ Ⅲ - / PC Karyopharm, USA
4 Recent Partnering Date Product name / code number Indication / MOA Phase (JP / Overseas) Partner 2011 OPDIVO / Nivolumab Melanoma, NSCLC, RCC, Hodgkin Lymphoma, H&N Cancer, Gastric Cancer, etc. / Anti-PD-1 mab BMS, USA (out-license except JP, KR & TW) Jul 2014 OPALMON / Limaprost α-cd Lumber Spinal Canal Stenosis / oral PGE1 analogue L / Filed Meiji Seika Pharma, Japan (out-license in Thailand & Indonesia) Dec 2014 Tirabrutinib / B Cell Lymphoma / Btk inhibitor I/II / II Gilead Sciences, USA (out-license except JP, KR, TW, CN & ASEAN) Mar 2015 OPALMON / Limaprost α-cd Lumber Spinal Canal Stenosis / oral PGE1 analogue L / - China Chemical & Pharmaceutical, Taiwan (out-license in Taiwan) Mar 2016 etaprost / Glaucoma and Ocular Hypertension / FP/EP3 dual receptor agonist II / II Santen Pharmaceutical, Japan (out-license globally as ophthalmologic topical formulation) Dec Solid Tumors / Prostaglandin Receptor (EP 4 ) Antagonist I / - BMS, USA (out-license except JP, KR, TW, CN & ASEAN) OPDIVO / Nivolumab Melanoma, NSCLC, RCC, Hodgkin Lymphoma, H&N Cancer, Gastric Cancer, etc. / Anti-PD-1 mab Jul YERVOY / Ipilimumab Lirilumab / Urelumab / Relatlimab / BMS / Cabiralizumab / BMS / Solid Tumors / Prostaglandin Receptor (EP 4 ) Antagonist Melanoma, etc. / Anti-CTLA-4 mab Solid Cancer / Anti-KIR mab Solid Tumors / Anti-CD137 mab Melanoma / Anti-LAG3 mab Solid Tumors / Anti-TIGIT mab Solid /Blood cancer / Anti-CSF1R mab Melanoma/ IDO1 inhibitor I / - I / I/II I / I/II I/II / - I/II / I/II I / I III / III BMS, USA co-development & co-promotion in JP, KR & TW Launched in Japan
5 Collaboration with BMS for OPDIVO Innovative Immuno-oncology Therapy Start collaboration in May 2005 Expand collaboration in 2011 IP on PD-1 UltiMab Human Antibody Development System Worldwide except N America Medarex BMS Acquisition of Medarex in July 2009 North America JP, KR & TW BMS Worldwide except N America, JP, KR & TW North America
6 Strategic Alliance with BMS in JP, KR & TW To Strengthen Immuno-oncology Portfolio To Accelerate Combination Therapies Co-development Co-promotion Asset OPDIVO MEK inhibitor EP 4 Antagonist Development cost share Profit/loss allocation Mainly BMS BMS Asset Distribution Promotion BMS Subsidiary Medical sites BMS BMS BMS Asset Partly Asset Asset + Asset Equally Partly BMS Asset BMS Asset + BMS Asset BMS Asset BMS Subsidiary BMS BMS BMS Mainly Mainly Partly Equally Partly Mainly
7 Collaboration with BMS for ORENCIA Novel Biologic Inhibiting Upstream Inflammation in RA BMS Distribution SC SC IV BMSKK IV Promotion Medical sites SC IV BMSKK BMKK: Bristol-Myers Squibb K. K.
8 Collaboration with AstraZeneca for FORXIGA The First SGLT-2 Inhibitor in the World for Type 2 Diabetes Distribution Promotion Medical sites AZKK AZKK: AstraZeneca K.K.
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June 5, Attached from the following page is the press release made by BMS for your information.
June 5, 2017 First Presentation of Efficacy Data from CheckMate -204 Evaluating the Combination of Opdivo (nivolumab) and Yervoy (ipilimumab) Demonstrates Anti-tumor Activity in Advanced Melanoma Patients
Challenges in Distinguishing Clinical Signals to Support Development Decisions: Case Studies
Challenges in Distinguishing Clinical Signals to Support Development Decisions: Case Studies David Feltquate MD, PhD Head of Early Clinical Development, Oncology Bristol-Myers Squibb, Princeton, NJ Challenges
Cancer Progress. The State of Play in Immuno-Oncology
Cancer Progress The State of Play in Immuno-Oncology Axel Hoos, MD, PhD VP, Oncology R&D, Glaxo Smith Kline Co-Director, Cancer Immunotherapy Consortium Key Drivers in Immuno-Oncology Science Methods Combinations
Role of the Pathologist in Guiding Immuno-oncological Therapies. Scott Rodig MD, PhD
Role of the Pathologist in Guiding Immuno-oncological Therapies Scott Rodig MD, PhD Department of Pathology, Brigham & Women s Hospital Center for Immuno-Oncology, Dana-Farber Cancer Institute Associate
Bristol-Myers Squibb Independent Medical Education
Bristol-Myers Squibb Independent Medical Education Request for Educational Support (RFE) Date 6/15/18 RFE Requestor Information RFE Code Name: Pavit Singh, PharmD Title: Post-Doctoral Fellow, Independent
Immuno-Oncology Clinical Trials Update: Therapeutic Anti-Cancer Vaccines Issue 7 April 2017
Delivering a Competitive Intelligence Advantage Immuno-Oncology Clinical Trials Update: Therapeutic Anti-Cancer Vaccines Issue 7 April 2017 Immuno-Oncology CLINICAL TRIALS UPDATE The goal of this MONTHLY
Using the Mozambique National Quality Policy to Encourage Biomedical Research, Innovation, & Infrastructure Investment
Using the Mozambique National Quality Policy to Encourage Biomedical Research, Innovation, & Infrastructure Investment Rachael Eckles, JD/MA Director, Regulatory Policy Bristol-Myers Squibb August 10,
A WEALTH OF COMPOUNDS IN DEVELOPMENT IN ONCO-IMMUNOLOGY: HOPE FOR PATIENTS BUT A CHALLENGE FOR COMMERCIAL SUCCESS
A WEALTH OF COMPOUNDS IN DEVELOPMENT IN ONCO-IMMUNOLOGY: HOPE FOR PATIENTS BUT A CHALLENGE FOR COMMERCIAL SUCCESS PROF DR WALTER VAN DYCK VLERICK HEALTHCARE MANAGEMENT CENTRE FACULTY OF PHARMACEUTICAL
Bristol-Myers Squibb Receives FDA Approval for Opdivo
February 3, 2017 Bristol-Myers Squibb Receives FDA Approval for Opdivo (nivolumab) in Previously Treated Locally Advanced or Metastatic Urothelial Carcinoma, a Type of Bladder Cancer (PRINCETON, N.J.,
Opdivo (nivolumab) Shows Durable Response in Longest Follow-up for a PD-1 Inhibitor in Previously Treated Advanced Non-Small Cell Lung Cancer
October 11, 2016 Opdivo (nivolumab) Shows Durable Response in Longest Follow-up for a PD-1 Inhibitor in Previously Treated Advanced Non-Small Cell Lung Cancer (PRINCETON, NJ, October 9, 2016) Bristol-Myers