HUNTSMAN CANCER INSTITUTE. Report to Our Community

Transcription

1 HUNTSMAN CANCER INSTITUTE Report to Our Community 2017

2 THE PRIMARY CHILDREN S & FAMILIES CANCER RESEARCH CENTER AT HUNTSMAN CANCER INSTITUTE OPENING SUMMER 2017, this 220,000 square-foot expansion will double HCI s research capacity. Connected to the existing research facility via two skybridges, the new space is designed for the following: Study the leading causes of disease death in children: leukemia, sarcoma, and brain cancer. Advance our understanding of cancers that run in families. Accelerate the discovery of new treatments for all cancers. Improve long-term quality of life for cancer survivors. Provide world-class training opportunities for the next generation of cancer researchers. U.S. NEWS & WORLD REPORT BEST CANCER HOSPITALS NATIONAL CANCER INSTITUTE- DESIGNATED COMPREHENSIVE CANCER CENTER NATIONAL COMPREHENSIVE CANCER NETWORK MEMBER AMERICAN COLLEGE OF SURGEONS COMMISSION ON CANCER ACCREDITED WHY NOW? The past has shown a 200% increase in cancer survivorship. By the year 2026, an estimated 20 million people will be diagnosed with cancer in the United States. BECKER S HOSPITAL REVIEW 100 GREAT ONCOLOGY PROGRAMS VIZIENT QUALITY AND ACCOUNTABILITY STUDY #1 IN THE NATION FOR QUALITY Cancer moves fast. We have to move faster.

3 OUR TIME BEGAN with an empty lot and a dream full of promise, determination, and audacity. A dream to do the impossible. Achieve the unachievable. Defeat the undefeatable. AS JON M. HUNTSMAN SAYS, Cancer moves fast. And we have to move faster.

4 CONTENTS 2 FOUNDERS LEAD EDITING AND DESIGN: Ashlee Bright Meredith Vehar Courtney Colvin Lisa Anderson CONTRIBUTORS: Linda Aagard Jacqueline Brakey Charlie Ehlert Hannah Eisenberg Adam Finkle Diane Fouts Jonathan Martinez Amie Parker Jill-Ann Pearl Susan Sheehan Jill Woods PRINTING: Printer s, Inc. Thank you to all who support our mission, including donors, volunteers, researchers, clinical care professionals, administrators, and Huntsman Cancer Foundation staff. A special acknowledgment to our friends at the Moran Eye Center at the University of Utah for ideas that inspired the production of @huntsmancancer 4 EVENTS 14 RESEARCH HIGHLIGHTS 26 PATIENT CARE 34 EDUCATION AND OUTREACH 40 GIVING APPENDICES HCI Director s Cabinet 51 Internal Advisory Board 52 External Advisory Board 53 Cancer Center Program Leaders 54 Cancer Center Program Members 54 Multidisciplinary Disease Group Leaders 62 Disease Oriented Research Team Leaders 64 Donors 66 Published Research 76 Clinical Care and Research Summary 80

5 Letter from Our Founders, Jon M. and Karen Huntsman EXTERNAL ADVISORY BOARD When When I was I was a boy, a boy, people people said we said could we could never cure polio. Jonas never E. cure Salk, polio. MD, proved Jonas they E. Salk, were wrong. MD, We know that devastating proved they diseases were can wrong. be conquered. We know It that is our commitment devastating that cancer, diseases like polio, can is someday be conquered. only a haunting memory. It is our commitment that cancer, like polio, Jon is someday M. Huntsman only a haunting memory. Jon M. Huntsman Edward Benz, MD PRESIDENT AND CEO EMERITUS DANA-FARBER CANCER INSTITUTE RICHARD AND SUSAN SMITH DISTINGUISHED PROFESSOR OF PEDIATRICS, PROFESSOR OF GENETICS HARVARD MEDICAL SCHOOL Elizabeth Blackburn, PhD NOBEL LAUREATE IRWIN M. JACOBS PRESIDENTIAL CHAIR PRESIDENT OF THE SALK INSTITUTE FOR BIOLOGICAL STUDIES Michael Caligiuri, MD DIRECTOR OF THE OHIO STATE UNIVERSITY COMPREHENSIVE CANCER CENTER CEO OF THE JAMES CANCER HOSPITAL AND SOLOVE RESEARCH CENTER JL MARAKAS NATIONWIDE INSURANCE ENTERPRISE CHAIR IN CANCER RESEARCH THE OHIO STATE UNIVERSITY HUNTSMAN CANCER INSTITUTE IS PART OF THE UNIVERSITY OF UTAH AND WHOLLY OWNED BY THE STATE OF UTAH FOUNDERS EVENTS RESEARCH HIGHLIGHTS PATIENT CARE EDUCATION AND OUTREACH GIVING 2 WHEN WE FOUNDED Huntsman Cancer Institute (HCI) more than 20 years ago, we were one family hoping to ease the burden of cancer for others. To our joy and astonishment, we were soon joined by generous families, corporations, individuals, community groups, and foundations who shared our optimism and our belief that Utah and the Mountain West deserved to have the best cancer care possible. Today our family s investment, together with all the other gracious contributions, now exceeds $1.5 billion. Thank you to our dear friends and supporters. Thank you! It is extraordinary that HCI has accomplished so much in so little time. Its first research laboratory and outpatient clinics opened in From that moment, HCI has stood as a beacon of hope on the hillside of the University of Utah s medical campus. In 2004, HCI added the region s only cancer specialty hospital. It features private patient rooms, inspiring spaces that connote beauty and hope while also offering the most state-of-the art equipment and technologies available for cancer patients. From the outset, people from throughout the region and beyond have come for treatment at HCI. The hospital census grew so quickly that an addition was built and opened in 2011 to double the patient care capacity. From the beginning, researchers from all over the world have come to contribute their expertise. As we write this letter, we are close to completing construction of the Primary Children s and Families Cancer Research Center at HCI. This research expansion will allow us to focus on childhood cancers and cancers that run in families even more. We are joined in this effort by major donations from the Church of Jesus Christ of Latter-day Saints, the State of Utah, Intermountain Healthcare, and thousands of other donors who are helping to make this $125 million, 220,000-square-foot expansion financially possible. Since its founding, more than one million people have donated to help make HCI what it is today. Thanks to all of our generous supporters from the children who hold lemonade stands, to marathoners, to the individuals who can give $5, $10, or $25 we have accomplished something wondrous together. HCI s expertise now reaches into affiliate hospitals throughout the Mountain West, from Lake Tahoe, Nevada, to Grand Junction, Colorado. Moreover, in the global context, HCI has discovered more genes for inherited cancers than any other center in the world. These discoveries cross a broad spectrum of cancers such as breast, ovarian, colon, melanoma, paraganglioma, parathyroid, neurofibromatosis, and more. So whether you live in Utah or halfway around the world, our research discoveries have helped, benefitting all. Karen and I have experienced many blessings in our lifetime. We think Ralph Waldo Emerson said it best when he wrote, It is one of the most beautiful compensations of life that no man can sincerely try to help another without helping himself. Our humble and heartfelt thanks to all who have helped alleviate the suffering caused by cancer. JON WAS JUST 32 WHEN HIS MOTHER DIED OF CANCER. THE DISEASE TOOK HIS FATHER 21 YEARS LATER. WHEN JON HIMSELF WAS DIAGNOSED WITH CANCER, HE DIDN T JUST VOW TO BEAT IT, I VOWED TO ERADICATE IT FROM THE EARTH. AND I M JUST CRAZY ENOUGH TO BELIEVE I CAN DO IT, HE SAID. Brian Druker, MD DIRECTOR OF KNIGHT CANCER CENTER ASSOCIATE DEAN FOR ONCOLOGY OHSU SCHOOL OF MEDICINE JELD-WEN CHAIR OF LEUKEMIA RESEARCH INVESTIGATOR AT HOWARD HUGHES MEDICAL INSTITUTE OREGON HEALTH AND SCIENCE UNIVERSITY Rob DuWors, MPA DEPUTY DIRECTOR OF ADMINISTRATION AND PLANNING JONSSON COMPREHENSIVE CANCER CENTER UNIVERSITY OF CALIFORNIA AT LOS ANGELES Elaine Fuchs, PhD REBECCA C. LANCEFIELD PROFESSOR OF MAMMALIAN CELL BIOLOGY AND DEVELOPMENT INVESTIGATOR AT HOWARD HUGHES MEDICAL INSTITUTE THE ROCKEFELLER UNIVERSITY Ernest T. Hawk, MD, MPH VICE PRESIDENT AND DIVISION CHIEF FOR CANCER PREVENTION AND POPULATION SCIENCES BOONE PICKENS DISTINGUISHED CHAIR FOR EARLY PREVENTION OF CANCER THE UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER Timothy R. Rebbeck, PhD PROFESSOR OF EPIDEMIOLOGY HARVARD T.H. CHAN SCHOOL OF PUBLIC HEALTH PROFESSOR OF MEDICAL ONCOLOGY DANA-FARBER CANCER INSTITUTE Thomas Sellers, PhD, MPH CENTER DIRECTOR DISTINGUISHED MOFFITT SCHOLAR EXECUTIVE VICE PRESIDENT MOFFITT CANCER CENTER AND RESEARCH INSTITUTE Sandra M. Swain, MD MEDICAL DIRECTOR AT WASHINGTON CANCER INSTITUTE ASSOCIATE DEAN FOR RESEARCH DEVELOPMENT ADJUNCT F. EDWARD HEBERT SCHOOL OF MEDICINE GEORGETOWN UNIVERSITY MEDICAL CENTER FOUNDERS 3

6 The White House Looks to Utah in the Cancer Moonshot Mission During the discussion, Governor Huntsman said he hoped everyone would walk away with an understanding of three things that he views as chiefly important to the progress of cancer research: the power of community collaboration, the power of the Utah Population Database, and the importance of rural and frontier cancer care. You can go to Philadelphia, you can go to New York City, but it s rare that you go to a cancer institute with this kind of rural outreach. We have Native Americans, veterans, and other minority groups who otherwise would not be able to access cancer treatment, said Governor Huntsman. What we do here is truly unique. FOUNDERS EVENTS RESEARCH HIGHLIGHTS PATIENT CARE EDUCATION AND OUTREACH GIVING ON FEBRUARY 26, 2016, Huntsman Cancer Institute (HCI) had the honor of hosting Vice President Joe Biden as a part of President Obama s cancer moonshot initiative. During his visit, Vice President Biden toured the facility, was given an inside look at the Utah Population Database, and participated in a roundtable discussion comprising Huntsman Cancer Foundation board chair Governor Jon M. Huntsman, HCI CEO and director Mary Beckerle, PhD, University of Utah Health Care CEO and senior vice president for Health Sciences Vivian Lee, MD, PhD, MBA, and Senator Orrin Hatch. Local cancer survivors and physicians, researchers, and experts in the field also participated in the roundtable. The Vice President s visit was part of a national tour during which he traveled to select U.S. cancer institutes to learn from and collaborate with researchers and physicians. The goal is to find solutions to accelerate progress toward We are thrilled and honored that Vice President Biden and the entire White House administration has recognized Huntsman Cancer Institute as one of the best in the nation and is looking to us as a valuable resource in this fight to cure cancer, Beckerle said. If we can work together and effectively leverage and harness the information we are gathering, we can really accelerate progress. HCI holds Comprehensive Cancer Center designation by the National Cancer Institute (NCI) and is the only NCI-designated Comprehensive Cancer Center in the five-state Mountain West. HCI also manages the Utah Population Database, the largest genetic database in the world, with more than 22 million records linked to genealogies, health records, and vital statistics. Vice President Biden expressed a desire to figure out how this and other models of excellence created in Utah can be replicated throughout the country. I ve seen Democrats, Republicans, and Independents transformed in this session. Politics have been put aside, and every American is behind you in your quest to finding a cure for cancer, Governor Huntsman said to Biden. We applaud THIS IS ABOUT AGGREGATING THE INTELLECTUAL, MORAL, EMOTIONAL, SCIENTIFIC, AND CAPITAL ELEMENTS IN THIS COUNTRY TO DO WITHIN FIVE YEARS WHAT WOULD OTHERWISE TAKE US 10 TO 15 YEARS TO DO, SAID VICE PRESIDENT JOE BIDEN DURING HIS VISIT TO HCI. treating, preventing, and curing cancer. you for doing that, and we re here to help. # I THINK WE CAN DO THAT. AND THAT MEANS THOUSANDS OF LIVES SAVED AND MILLIONS OF LIVES AFFECTED. 5 EVENTS

7 Utah s Role in the National Cancer Moonshot Continues VICE PRESIDENT JOE BIDEN, MARY BECKERLE, PHD, AND JILL BIDEN, PHD, AT THE WHITE HOUSE FOUNDERS EVENTS RESEARCH HIGHLIGHTS PATIENT CARE EDUCATION AND OUTREACH GIVING IN APRIL 2016, a National Blue Ribbon Panel on the Cancer Moonshot initiative was formed. This group was tasked with making recommendations for cancer research priorities to help accelerate the progress against cancer. Huntsman Cancer Institute (HCI) CEO and director, Mary Beckerle, PhD, was invited to serve on this distinguished 26-member panel. Beckerle was chosen to co-chair a working group dedicated to strategies in precision prevention and early detection of cancer. Two other HCI investigators, Martin McMahon, PhD, professor of dermatology, and Kathleen Mooney, PhD, distinguished professor of nursing, were invited to serve as members of Blue Ribbon Panel working groups. The results of the Blue Ribbon Panel recommendations were presented in September Organized at the request of Vice President Joe Biden, more than 270 organizations hosted Cancer Moonshot summits June 29, These brought together patients and survivors, researchers, physicians, advocates, philanthropists, and technology experts to brainstorm ways of speeding up progress in cancer prevention, diagnosis, treatment, and care over the next five years and to ultimately end cancer as we know it. HCI hosted an official regional summit at the University of Utah. The Vice President hosted a group at Howard University in Washington, DC, where Susan Sheehan, president and COO of Huntsman Cancer Foundation, and Kathleen Mooney, PhD, RN, co-leader of Cancer Control and Population Sciences at HCI and distinguished professor of nursing, were in attendance. PANELISTS AT HCI S MOONSHOT SUMMIT JOHN SWEETENHAM, MD, MIKAELA LARSON, 6 SAMIR COURDY, MBA, AND RACHEL HESS, MD 7 EVENTS

8 8 HIS HOLINESS THE 14TH DALAI LAMA of Tibet met with patients and leaders of Huntsman Cancer Institute (HCI) and the University of Utah during a visit June 21, The occasion coincided with an event later that afternoon at the University s Jon M. Huntsman Center, where he spoke about compassion and universal responsibility. Mary Beckerle, PhD, HCI s CEO and director; University of Utah president David Pershing; and Vivian Lee, CEO of University of Utah Health Care, senior vice president for Health Sciences, and dean of the School of Medicine, greeted His Holiness when he arrived at HCI. After taking time to talk with patients and loved ones, His Holiness was escorted to the G. Mitchell Morris Cancer Learning Center, where he met with HCI physicians, staff, several patients, and caregivers. Emma Houston, an HCI breast cancer survivor, said, It was my pleasure to be in the presence of His Holiness and to physically feel peace and harmony as he shared his thoughts on teaching human values and inner happiness. SIDDHARTHA MUKHERJEE, MD, PHD, Pulitzerprize winning author of The Emperor of All Maladies: A Biography of Cancer, visited HCI on March 23, Mukherjee provided a public lecture on campus, participated in a panel discussion at HCI with scientists and a cancer survivor, and spent time meeting with students from a variety of backgrounds during his visit. HCI, the School of Medicine, and the University of Utah Tanner Humanities Center co-hosted the event. o be globally minded is to have a sense of unity T and oneness. Serve other human beings and promote a sense of concern for others. His Holiness the Dalai Lama SPEAKING AT THE UNIVERSITY OF UTAH JUNE 21, 2016 EVENTS FOUNDERS EVENTS RESEARCH HIGHLIGHTS PATIENT CARE EDUCATION AND OUTREACH GIVING Hosting Honored Guests 9

9 Joining the Top Cancer Centers in the World ACCESS TO MORE RESEARCH FUNDING Among the benefits of being a National Cancer Institute Comprehensive Cancer Center: HCI scientists may compete for special grants. Here are highlights of awards received: HPV IMMUNIZATION PROGRAMS WITH A FOCUS ON HPV VACCINATION IN PEDIATRIC SETTINGS Deanna Kepka, PhD, Assistant Professor of Nursing (2015) PILOT STUDY OF HPV AND HEAD AND NECK CANCER IN NEPAL Mia Hashibe, PhD, Associate Professor of Family and Preventive Medicine (2015) GEOGRAPHIC MANAGEMENT OF HEALTH DISPARITIES Ana Maria Lopez, MD, Professor of Medicine (2015) STRENGTHENING CAPACITY THROUGH COMMUNITY HEALTH EDUCATORS Ana Maria Lopez, MD, Professor of Medicine (2015) FOUNDERS EVENTS RESEARCH HIGHLIGHTS PATIENT CARE EDUCATION AND OUTREACH GIVING THE UNIVERSITY OF UTAH AND HCI HONORED THE HUNTSMAN FAMILY AND CELEBRATED NATIONAL CANCER INSTITUTE COMPREHENSIVE DESIGNATION. IT S AN HISTORIC TIME for Huntsman Cancer Institute (HCI) at the University of Utah. On July 9, 2015, HCI announced it had received the National Cancer Institute s Comprehensive Cancer Center status, the highest designation possible. This designation is the culmination of years of hard work and dedication by all members of our community, said Mary Beckerle, PhD, CEO and director of HCI. Securing this designation required excellence at every level of our organization. It is especially gratifying that such an honor comes only after rigorous scientific peer review of our programs, people, facilities, and strategic plan for the future. That rigorous peer review included a day-long, on-site visit by national cancer research experts and thought leaders in the fourth quarter of HCI is the only cancer center to be designated by the National Cancer Institute in the five-state Mountain West region, which includes Utah, Wyoming, Montana, Idaho, and Nevada more than 17% of the continental U.S. landmass. With this status, HCI joins distinguished cancer centers such as Memorial Sloan-Kettering Cancer Center, MD Anderson Cancer Center, Dana- Farber Cancer Institute of Harvard University, Johns Hopkins Kimmel Comprehensive Cancer Center, and the Mayo Clinic Cancer Center among the top cancer centers in the world. Only a small percentage of the nation s cancer programs have the excellence necessary to receive Comprehensive Cancer Center status. What a difference this will make to the cancer patients in our state, in the region, and in the world. Jon M. Huntsman HCI PATIENTS AND THEIR LOVED ONES WERE AMONG THE EVENING S HONORED GUESTS. JOHN MAACK, ULTRA MARATHON RUNNER AND HCI PATIENT, SHARED HIS STORY ABOUT BEING DIAGNOSED WITH STAGE III MANTLE CELL NON-HODGKIN LYMPHOMA. CLINICAL TRIALS REPORTING PROGRAM Theresa Werner, MD, Assistant Professor of Medicine (2015) CANCER CLINICAL INVESTIGATOR TEAM LEADERSHIP AWARD Theresa Werner, MD, Assistant Professor of Medicine (2016) NATIONAL CANCER INSTITUTE EXPERIMENTAL THERAPEUTICS CLINICAL TRIALS NETWORK Sunil Sharma, MD, Professor of Medicine (2016) PATHMAKER PROGRAM FOR UNDERREPRESENTED HIGH SCHOOL STUDENT RESEARCH EXPERIENCES Ana Maria Lopez, MD, Professor of Medicine (2016) COLLABORATIVE PRECLINICAL TRIALS UTILIZING PATIENT DERIVED XENOGRAFTS Alana Welm, PhD, Associate Professor of Oncological Sciences (2016) EVENTS

10 Furthering the Global Cancer Dialogue SELECTED HCI SEMINARS HCI hosts numerous scientific seminars and symposia each year, attracting distinguished researchers from around the world. SELECTED FACULTY HONORS AND ACHIEVEMENTS FEBRUARY 4, 2016 DAVID LARGAESPADA, PHD UNIVERSITY OF MINNESOTA Functional Genomics of Osteosarcoma Development and Progression Using Transposon Mutagenesis and Targeted Nucleases FEBRUARY 13, 2016 Sixth Annual HCI Hematology Review: Advances in Benign and Malignant Hematology Co-Sponsored by HCI, the Division of Hematology and Hematologic Malignancies, and the Department of Medicine MARCH 11, 2016 GERARD EVAN, PHD UNIVERSITY OF CAMBRIDGE Targeting Cancer s Engines, Not Its Drivers Mary Beckerle, PhD DISTINGUISHED PROFESSOR OF BIOLOGY AMERICAN ASSOCIATION FOR CANCER RESEARCH BOARD OF DIRECTORS MEMBER Jakob Jensen, PhD ASSOCIATE PROFESSOR OF COMMUNICATION NIH NEW INNOVATOR AWARD, 2015 Martin McMahon, PhD PROFESSOR OF DERMATOLOGY 2015 PRESIDENT OF THE SOCIETY FOR MELANOMA RESEARCH FOUNDERS EVENTS RESEARCH HIGHLIGHTS PATIENT CARE EDUCATION AND OUTREACH GIVING DOUG LOWY, MD, acting director of the National Cancer Institute, visited Huntsman Cancer Institute (HCI) on September 29, Lowy met with HCI faculty, staff, and trainees, and learned about HCI research in cancer genetics, rural cancer care and symptom management, and cancer models and mechanisms. He also presented on the topic HPV Vaccine: FDA Approval Was Just the Beginning. DOUG LOWY, MD MARCH 23, 2016 SIDDHARTHA MUKHERJEE, MD, PHD PULITZER-PRIZE WINNING AUTHOR OF THE EMPEROR OF ALL MALADIES Tackling Cancer in 2016: Precision Prevention and Treatment Co-Sponsored by HCI, the University of Utah Health Sciences Center, and the Tanner Humanities Center APRIL 1, 2016 DAVID GILBERT, PHD FLORIDA STATE UNIVERSITY Developmental Control of Replication Timing and Chromosome Architecture APRIL 15, 2016 PATRICIA GANZ, MD UNIVERSITY OF CALIFORNIA, LOS ANGELES Understanding the Biology of Late Effects of Cancer Treatment SEPTEMBER 29, 2016 DOUG LOWY, MD, ACTING DIRECTOR OF THE NATIONAL CANCER INSTITUTE HPV Vaccine: FDA Approval Was Just the Beginning OCTOBER 19, 2016 ANDREA MATTEVI, PHD UNIVERSITY OF PAVIA Uncovering and Drug Targeting of Complex Enzymatic Processes: From Phospholipid Biosynthesis to Chromatin Modification OCTOBER 26, 2016 MONTE WINSLOW, PHD STANFORD UNIVERSITY Molecular Drivers of Cancer Progression and Metastasis Jody Rosenblatt, PhD ASSOCIATE PROFESSOR OF ONCOLOGICAL SCIENCES HOWARD HUGHES MEDICAL INSTITUTE FACULTY SCHOLAR AWARD, 2016 John Sweetenham, MD, FRCP, FACP UTAH CANCER ACTION NETWORK CHAIR Jared Rutter, PhD PROFESSOR OF BIOCHEMISTRY HOWARD HUGHES MEDICAL INSTITUTE INVESTIGATOR, 2015 Alana Welm, PhD ASSOCIATE PROFESSOR OF ONCOLOGICAL SCIENCES SUSAN G. KOMEN SCHOLAR, 2016 Joshua Schiffman, MD PROFESSOR OF PEDIATRICS AND ONCOLOGICAL SCIENCES TOP 5 MOST POPULAR JAMA PAPERS IN 2015 Theresa Werner, MD ASSISTANT PROFESSOR OF MEDICINE NCI CANCER CLINICAL INVESTIGATOR TEAM LEADERSHIP AWARD, 2016 EVENTS 12 13

11 Team Science: Advancing HCI Lab Discoveries to a Clinical Trial RESEARCH SPOTLIGHT RESEARCHERS FOUND THE DRUG HCI2509 ALTERS THE SHAPE OF CULTURED EWING SARCOMA CANCER CELLS SO THEY ARE NO LONGER SMALL AND ROUND, BUT FLAT AND SPREAD OUT LIKE NORMAL CELLS. THE TEAM HYPOTHESIZES THIS CHANGE COULD SLOW THE METASTATIC SPREAD OF EWING SARCOMA. IMAGE OF EWING SARCOMA CELLS COURTESY BECKERLE LAB. FOUNDERS EVENTS RESEARCH HIGHLIGHTS PATIENT CARE EDUCATION AND OUTREACH GIVING EWING SARCOMA is a deadly bone cancer. Though rare, when it occurs it primarily affects children and young adults. In nearly every case, Ewing sarcoma is driven by a change in DNA that results in the production of a dysfunctional protein called EWS/FLI. This protein has been shown to turn off tumor suppressor genes the genes that help prevent cancerous cells from forming or spreading. In 2012, two Huntsman Cancer Institute (HCI) investigators reported in the journal Oncogene they had found a new drug, HCI2509, which targets this protein. In 2014 additional findings from HCI labs, published in the journal Clinical Cancer Research, showed HCI2509 led to increased activity of genes involved in stopping or killing abnormal cells. In addition, it led to decreased activity of genes involved in cell division and growth. The investigators also found that HCI2509 alters the shape of cultured Ewing sarcoma cancer cells. The researchers hypothesize this could slow the metastatic spread of Ewing sarcoma. In 2016, the drug is now being tested in a clinical trial in Ewing sarcoma, and subsequent studies are underway to determine if it may also be effective in treatment of other cancers, including endometrial and prostate (see Research Spotlight of Sunil Sharma, MD, HCI senior director of clinical research, opposite page). Clinical trials give us the data we need to advance appropriate therapies into the clinic as soon as possible, Dr. Sharma said. RESEARCH HIGHLIGHTS HCI researchers received a $1.73 million CureSearch Grand Challenges Award one of only four in the nation to test a novel targeted treatment for Ewing sarcoma that may disrupt the cancer s growth and spread. Ewing sarcoma is the second most common bone cancer in children and is challenging to treat because it has typically metastasized, or spread, by the time it is diagnosed. SUNIL SHARMA, MD SUNIL SHARMA, MD, is an expert in the development and testing of new cancer therapies. He established and directs HCI s extensive phase I clinical trials program. Dr. Sharma s interest in medicine came early on. I come from a family where both parents were physicians. My mother was an inspiration to me as she was one of only a few female doctors at that time, he said. While attending medical school, Dr. Sharma began to fuse the idea of pathology and how cancer looked under a microscope with the new wave of advances coming in oncology. In addition to his clinical research efforts, Dr. Sharma oversees a translational research laboratory focused on drug discovery and clinical trials support. CURESEARCH TEAM RESEARCH HIGHLIGHTS

12 Personalizing Lifelong Patient Care W H AT I S C A N C E R P O P U L AT I O N S C I E N C E S? Population scientists study areas across the health care continuum, from prevention, epidemiology, and screening to genomics and early detection to survivorship and end-of-life care. 16 These are the long-range goals of cancer population sciences: The program, which is borne out of HCI s membership in the Oncology Research Information Exchange Network (ORIEN), uses patient data to help match patients to clinical trials and treatment developments across the country. Reduce cancer deaths in the population, including in rural areas Patients who participate in the HCI-Total Cancer Care program partner with HCI s health care providers and researchers so they stay apprised of new treatments and information related to their cancer diagnosis. Patients donate tissue samples, share medical data for research, and may be asked to complete questionnaires about family history, health behaviors, and quality of life. The information is used to create a personal profile of the patient that will help HCI physicians provide better care. Improve quality of life, health status, and survival for patients impacted by cancer Increase cancer prevention and early detection when cancers are easiest to treat Find strategies that make the disease easier to manage for patients and their friends and relatives CORNELIA ULRICH, PHD, MS At Huntsman Cancer Institute (HCI), cancer population scientists primarily focus on three areas: Studies of cancers that run in families, ranging from the discovery of new cancer genes to meaningful communication of genetic risks By joining with leading cancer centers across the country, we have access to much more information from many more patients, allowing us to do more than any one cancer center could do alone, said John Sweetenham, MD, HCI executive medical director and senior director of clinical affairs, professor of internal medicine at the University of Utah, and co-leader of HCI-Total Cancer Care. It is becoming clear that cancers often have specific genetic defects and that patients may benefit from targeted treatments. However, since in some cases only a few HCI patients have the same defect in their tumor, it is not always possible for these patients to be included in clinical trials for specialized therapies, said Cornelia Ulrich, PhD, HCI senior director of population sciences, professor of population health sciences at the University of Utah, Jon and Karen Huntsman presidential professor in cancer research, and co-leader with Sweetenham of HCI-Total Cancer Care. By working with the ORIEN network of cancer centers and more than 150,000 participants, HCI patients have access to a broader set of clinical trials and the newest treatments. JOHN SWEETENHAM, MD, FACP, FRCP Strategies that help people manage their cancer risk such as lifestyle, behavioral choices, and appropriate screening and prevention Research on health behaviors and biologic characteristics of cancer patients and how these affect their well-being and survival HCI cancer population scientists oversee the Utah Population Database, genetic counseling, and other research resources. They collaborate with colleagues in labs and the clinic to amplify the impact of their work. They strive to identify better cancer prevention, early detection, and survivorship strategies that can be readily brought to the clinic and population. HCI joins other leading cancer centers as part of the ORIEN network. ORIEN was founded in 2014 by Moffitt Cancer Center in Tampa, Florida, and The Ohio State University Comprehensive Cancer Center Arthur G. James Cancer Hospital and Richard J. Solove Research Institute in Columbus, Ohio. RESEARCH HIGHLIGHTS FOUNDERS EVENTS RESEARCH HIGHLIGHTS PATIENT CARE EDUCATION AND OUTREACH GIVING IN 2016, HUNTSMAN CANCER INSTITUTE (HCI) launched a unique program called HCI-Total Cancer Care, which will follow patients through cancer screenings and treatments and into good health throughout their lives. 17

13 Pairing Philanthropy with Top Research to Advance Cancer Cures Cancer Care from the Comfort of Home: Telehealth ENDOWED CHAIRS show the important role philanthropy plays in advancing cancer research. Resources provided by an endowed chair can be used to attract and retain top faculty, fund lab trainees, and support innovative research. The Smith family is an example of this generosity. FOUNDERS EVENTS RESEARCH HIGHLIGHTS PATIENT CARE EDUCATION AND OUTREACH GIVING Dee Glen Smith began his career at the family grocery store in Brigham City, Utah. He parlayed that modest beginning into the successful chain of grocery stores known today as Smith s Food and Drug Centers. The brilliant entrepreneur was diagnosed with brain cancer at the age of 58 and passed away that same year. Recognizing the dire need for better treatments for brain cancer, he and his sweetheart, Ida, made a gift from the family business to pursue medical research at the University of Utah. Generosity is a trait that runs in the Smith family, and a subsequent, major gift was given by Richie and Julie Smith, continuing the legacy (see letter). One day in 1999, Jon M. Huntsman learned that Dee Smith s son Richie, wife Julie, and sons Nicholas, Ryan, and Scott, had done something remarkable. They quietly donated $1 million to support cancer research at HCI. JARED RUTTER, PHD, wears many hats at the University of Utah. He is co-leader of Huntsman Cancer Institute s Nuclear Control of Cell Growth and Differentiation Program, a group that coalesces the work of 26 laboratory investigators who study gene regulation, cancer metabolism, and genome stability. He also serves as a professor of biochemistry and in 2015 received the prestigious and highly competitive recognition as a Howard Hughes Medical Institute Investigator. Dr. Rutter s many contributions to the community from mentoring faculty, to teaching students, to advancing his productive and collaborative research program earned him the Dee Glen and Ida W. Smith KATHLEEN MOONEY, PHD, RN WHAT IS TELEHEALTH? Telehealth uses electronic information and telecommunications technologies for long-distance clinical health care, health-related education, and health administration. Technologies may include telephone, videoconferencing, the Internet, streaming media, wireless communications, and more. Source: U.S. Department of Health and Human Services, Health Resources Services Administration WHEN HUNTSMAN CANCER INSTITUTE learned about the plans for Vice President Biden s visit to Salt Lake City, out of the many areas of research strength, we showcased our work in remote symptom management. As the only National Cancer Institute-designated Cancer Center in the five-state Mountain West, an area that includes Utah, Nevada, Wyoming, Montana, and Idaho, HCI has long placed a priority on understanding how to best meet the needs of people impacted by cancer who live in rural areas. HCI researcher and distinguished professor of nursing Kathleen Mooney, PhD, RN, is a leader in this field. She and her colleagues spent years researching symptom management. Building upon past findings, they developed an algorithm based on common cancer symptoms and severity. This was used to develop a telehealth system that checks in with patients daily, asking them to report on how they feel physically and psychologically. Based on the severity of those patient responses, the system alerts care providers so they can help manage the person s needs. The strategy has shown dramatic results for people with cancer: fewer days of severe symptoms, more mild-tomoderate days reported, and more days without any symptoms at all. Caregivers also report better outcomes. Telehealth is one important strategy to improve cancer care for people who live in rural communities, enabling more JARED RUTTER, PHD 18 Endowed Chair for Cancer Research in equitable care and better outcomes for all. 19 RESEARCH HIGHLIGHTS

14 Making Cancer a Thing of the Past UTAH POPULATION DATABASE AT A GLANCE 9 database founded in 14 DATING TO THE 17 TH CENTURY ELEVEN GENERATIONS OF THIS FAMILY ARE RECORDED IN THE UPDB (BEGINNING IN 1807). THE FULL PEDIGREE ASSOCIATED WITH THE MOTHER TOTALS MORE THAN 30,000 DESCENDANTS, MORE THAN 27,000 OF WHOM ARE STILL ALIVE AND LISTED IN THE UPDB. FOUNDERS EVENTS RESEARCH HIGHLIGHTS PATIENT CARE EDUCATION AND OUTREACH GIVING THE UTAH POPULATION DATABASE (UPDB) is a unique and vast computerized research resource that contains records from many sources, including genealogies, cancer registry records, Utah birth and death certificates, hospitalization records, and driver license data. These records are linked to patient records from the University of Utah and Intermountain Healthcare. Started in 1975 with data from the Utah Family History Library, the UPDB contains genealogies for the original Utah pioneers and their modern-day descendants. Today, the UPDB has expanded its genealogical coverage by using vital records. It now includes information for more than 9 million persons some that go back 14 generations and as long ago as the late 17th century. Researchers have used the UPDB to identify and study families with an excess incidence of cancer, analyze patterns of genetic inheritance, and identify specific genetic mutations. This resource contributed to important gene discoveries, including those for colon cancer (APC), breast cancer (BRCA1), melanoma (p16), and cardiac arrhythmia (KCNH2). The UPDB is the only database of its kind in the United States and one of few such resources in the world. And it is housed right here at the University of Utah s Huntsman Cancer Institute. UTAH POPULATION DATABASE INFORMATION SOURCES Department of Health Vital Records: Birth, Death, Marriage, Divorce Inpatient Discharge, Ambulatory Surgery Driver License Division Social Security Death Records Utah Voter Registration University of Utah Health Sciences Center Intermountain Healthcare Genealogies Family History Library Utah Cancer Registry Cancer Registry of Idaho opportunities for the public to PARTICIPATE DURING A VISIT ON FEBRUARY 26, 2016, VICE PRESIDENT JOE BIDEN SPOKE WITH UTAH POPULATION DATABASE DIRECTOR KEN SMITH, PHD, 20 PICTURED HERE WITH HCI CEO AND DIRECTOR MARY BECKERLE, PHD, GOVERNOR JON M. HUNTSMAN, AND SENATOR ORRIN HATCH. # RESEARCH HIGHLIGHTS

15 Chemoprevention: A Family s Hope for a Cancer-Free Future Improving Outcomes for Myeloma Patients Who Face Grim Odds In multiple myeloma, abnormal plasma cells build up in the bone marrow and form tumors in many bones of the body. These tumors may keep the bone marrow from making enough healthy blood cells. A NEW DRUG TESTED IN A CLINICAL TRIAL BRINGS HOPE TO KATHY AND RHONDA, AUNT AND NIECE WITH A HEREDITARY COLON CANCER CONDITION. It s a sobering statistic: an average of 43% of multiple myeloma patients die within five years of diagnosis. What s more, a recent study found multiple myeloma patients with a variation in the gene FOPNL die one to three years sooner. The largest collaboration of inherited genetics and myeloma survival to date, the study included researchers from Huntsman Cancer Institute (HCI) and 17 other institutions. FOUNDERS EVENTS RESEARCH HIGHLIGHTS PATIENT CARE EDUCATION AND OUTREACH GIVING N. JEWEL SAMADDER, MD, MSC KATHY AND HER NIECE, RHONDA, regularly make the trip from their small town in Illinois to Salt Lake City. It isn t to see family and friends or to cheer for University of Utah sports teams. They travel to Huntsman Cancer Institute (HCI) to be tested for polyps in their intestines. Kathy and Rhonda have familial adenomatous polyposis (FAP), an inherited genetic disease. FAP causes hundreds of polyps to form throughout the small and large intestines. Any polyp in the intestine has the potential to become cancer. With so many polyps, people with FAP have nearly 100% risk of developing colon cancer. People with FAP often have surgery to remove the colon to prevent cancer. I remember my grandmother having surgery, Rhonda said. After that, I can remember my mom having surgery right away, and then my aunt having surgery right away, and then me having to undergo some testing. Kathy had a similar experience. As kids, she and her siblings knew their grandfather and mother had a condition, but she didn t yet understand the effect it would have on them. Family members started searching for specialists in genetic cancers. They found HCI, where the genetic cause of FAP was discovered. There, they met Jewel Samadder, MD, clinical director of HCI s high-risk cancer clinics and assistant professor of medicine. He led a clinical trial to test a new medicine that reduces the number of polyps forming in the intestine. We can target the use of a medication to people with the highest risk of cancer, Dr. Samadder said. Whether it s cancer in the colon or the small intestine, we can reduce or eliminate the chance that they develop those cancers. This preliminary trial showed very promising results, with patients who received the medication seeing a greater than 70% drop in their polyp numbers. For some, the polyps disappeared completely. The results, published in the Journal of the American Medical Association, are a step toward preventing cancers and the need for bowel surgery in patients at the highest risk. Kathy and Rhonda both took part in the trial not only for their own health, but for the health of their families. Rhonda said, HCI has given me hope for my children and my grandchildren. Now that they know the genetic marker, my children can have children without the disease. It gives my family hope. Kathy agrees, adding that she knows the researchers and doctors at HCI won t stop looking for ways to end the threat of all types of cancer. There isn t complacency, she explained. When they get through with this trial, they ll move on to something else. They ll keep working. Dr. Samadder said he s thankful to have people like Kathy and Rhonda fly across the country to be part of this important trial. Currently, HCI is working with the National Cancer Institute to open a trial for this treatment that includes several other cancer centers nationwide. We hope this treatment will spur future trials looking at chemoprevention or precision cancer prevention in high-risk disorders such as FAP, Lynch syndrome (another cause of colon cancer), and hereditary breast and ovarian cancer, said Dr. Samadder. We were able to identify the FOPNL variant because it has quite a large effect on survival. With even larger collaborative studies, we hope to add to this, said HCI investigator and professor of medicine Nicola Camp, PhD. Published in Nature Communications, the results are a step toward applying precision medicine to this aggressive cancer that affects bone marrow cells involved in coordinating the body s immune response. Future studies will focus on finding therapies to improve prospects for this newly identified group of FOPNL patients. Camp and her colleagues used data from the UPDB in this study. NICOLA CAMP, PHD 22 # RESEARCH HIGHLIGHTS

16 An Inherited Cancer Syndrome No Longer a Family Curse CANCER SCREENINGS CAN SAVE LIVES I was put in a position where I have the chance to help others. I feel very blessed and honored to get to do that. Kiera Jorgensen Kiera s mom, Eleana, had genetic testing and found she also has Li-Fraumeni Syndrome (LFS). She began regular cancer screenings, which led doctors to discover kidney cancer and, more recently, breast cancer. Both cancers were found early and Eleana underwent successful treatments. Kiera and Eleana now encourage other family members to be tested for LFS, and if they have it, to start annual screenings to spot cancer before it spreads. FOUNDERS EVENTS RESEARCH HIGHLIGHTS PATIENT CARE EDUCATION AND OUTREACH GIVING WHEN KIERA WAS DIAGNOSED with cancer at age 19, she fought not only sarcoma, but also a deadly mystery that had loomed over her family for generations. Now years out of treatment, Kiera has answers and is conducting research to help families like hers better understand a rare genetic mutation. Saying Kiera s family has a history of cancer is an understatement. Her grandfather was one of 16 children, several of whom were diagnosed with cancer. Still, when Kiera went to the emergency room in pain and a CT scan revealed a mass in her abdomen, the emergency doctors didn t suspect cancer. The mass was diagnosed as diverticulitis. She was sent home but returned two weeks later with the same pain. Her mother, Eleana, insisted on taking her to Huntsman Cancer Institute (HCI). Kiera was diagnosed with pleomorphic sarcoma, an aggressive form of cancer. After several months of treatment and surgery on her abdomen, she was pronounced cancer-free. Kiera s experience with cancer gave her a new life mission. She became a cancer researcher at HCI. I had cancer, and now I m helping others that also have cancer, Kiera said. I feel like I have this special connection that makes me more passionate and gives me a bigger drive to find answers. While working on a project in the Dr. Joshua Schiffman Lab at HCI about Li-Fraumeni Syndrome (LFS) an inherited genetic mutation that means a nearly 100% risk of cancer Kiera mentioned her family s cancer history to a colleague, who suggested Kiera be tested for LFS. Two weeks later, Kiera received a diagnosis confirming that she has LFS. It s crazy that I was working in the Schiffman Lab before I was diagnosed with LFS because it is one of the leading labs in Li-Fraumeni research, said Kiera. What are the odds? She knew her next step. I brought my paperwork home and I showed my mom. I told her she needed to be tested and that my dad needed to be tested as well, Kiera said. Knowing about her genetic mutation means Kiera can take preventive measures. She does yearly cancer screenings, gets a full-body and brain MRI, has blood work taken, and meets with several oncologists to watch out for any sign of cancer. Kiera is now in a PhD program at the University of Utah. Her goal is to finish school and continue to do the nitty-gritty research that helps move knowledge about cancer forward, so she can give hope to her family and others diagnosed with LFS. SOURCE: SCHIFFMAN LAB ELEPHANT DOG AVERAGE PERSON WITH LFS LIFETIME RISK OF CANCER <5% 25% 33-50% 90% CANCER MORTALITY RATE <5% 50% 25% Elephants rarely get cancer. The reason why has stumped scientists for decades. Research from the Dr. Joshua Schiffman Lab at HCI uncovered a possible answer. It is related to a gene called p53. The chart above shows that elephants have dozens more copies than other mammals, including dogs and humans, which is believed to protect them against cancer by heightening the response to cell damage. People with Li-Fraumeni Syndrome are nearly the opposite. They have only one copy of p53 and a 90% lifetime risk of cancer not available TP53 TUMOR SUPPRESSOR GENE LI-FRAUMENI SYNDROME RESEARCH HIGHLIGHTS

17 Oncology Nurses Providing Exceptional Patient Care WHEN CAREER AND PASSION COLLIDE I ve wanted to be a nurse since I was six years old. It was all about the cap and uniform! It has been the best career I could have chosen. I never realized the lifelong friendships I would have with colleagues. Getting to know our patients and the difficult journeys they make has been inspiring and humbling. As a group, oncology nurses are smart and kind, competent and creative, and always seem to be one step ahead of me. As I visit patients, I often hear their passionate appreciation for their physicians. And then they pause. The emotion involved in trying to tell me about how the nursing staff has impacted their cancer experience is overwhelming. I have seen stoic men get choked up and tearful as they try to tell me the impact HCI nurses have had on their lives and their families. It is a beautiful moment when a person realizes their career and passion have collided. FOUNDERS EVENTS RESEARCH HIGHLIGHTS PATIENT CARE EDUCATION AND OUTREACH GIVING HUNTSMAN CANCER INSTITUTE (HCI) is known for leading-edge cancer care, and our oncology nurses are on the leading edge of their profession. HCI s nurses and support professionals contribute to excellent patient care at every step from clinic visits to treatment to wellness and family support. HCI routinely scores in the 99th percentile in patient satisfaction based on nationwide surveys conducted by Press Ganey. Our nurses are essential to this exceptional standard of care. Some recent comments from our patients reflect the major role their nurse had in contributing to an exceptional patient experience: I had an infusion I can t say enough good things about my nurse. She is efficient and very kind. The nurses who saw me were so, so kind and so sweet and just made me feel like they wanted to help take care of my health. Each even gave me a hug at the end of my visit. I ll always remember that. Nurses play an especially important role, not only in delivery of outstanding cancer care, but also in their support of clinical research on new and better cancer treatments. The contributions of nurses are critical to our mission to advance understanding of research discoveries to better prevent, diagnose, and treat cancer patients and their families. During the visit of Vice President Biden to HCI in February 2016, a number of panelists joined the vice president in a discussion about the unique ways we in Utah are working to advance cancer research. The discussion included a conversation about the critical contributions made by nurses in delivery of cancer care. Vice President Biden conveyed to HCI what a profound impact the nurses had on him and his family while his son, Beau Biden, underwent treatments for glioblastoma. Vice President Biden said, If there are any angels in heaven, they are all nurses. This is a picture of me the day in 1979 when I got pinned by my favorite nursing instructor, Dr. Mary Bruton. She was my first mentor. Sue Childress Thanks to Jon and Karen Huntsman, HCI is an outstanding environment to care for our patients. It is also an amazing environment for our nurses to practice the art of oncology nursing. Sue Childress RN, MN, OCN DIRECTOR OF NURSING SERVICES HUNTSMAN CANCER INSTITUTE AT THE UNIVERSITY OF UTAH Best Practices Inform Unique HCI Training Program for Oncology Nurse Professionals Nursing is a demanding profession, and oncology nursing requires specialized knowledge. Training is key to help new nurses in oncology develop a strong foundation for future success. The Huntsman Oncology Nurse Residency (HONR) program is designed to help new nurses be successful in their first year in cancer care. The curriculum includes an evidence-based project to improve patient outcomes. Mentorship and professional development are also important aspects of the program. The rigorous 12-month training, which recently began its fifth cohort, prepares HONRs to become Oncology-Certified Nurses PATIENT CARE

18 Improving Quality of Life during and after Treatment Facial Prosthetics: Restoring Self-Confidence and Smiles PATIENT SPOTLIGHT JIM LINDOW PAUL TANNER FOUNDERS EVENTS RESEARCH HIGHLIGHTS PATIENT CARE EDUCATION AND OUTREACH GIVING THE WELLNESS AND INTEGRATIVE HEALTH CENTER began in 2005 through a grassroots approach, with the purpose of improving patient recovery and wellness through exercise. Many programs began with volunteer work and limited hospital space the first fitness assessments, for example, took place in a restroom. In 2007, Huntsman Cancer Institute (HCI) received a large donation to help further HCI s mission. The Linda B. and Robert B. Wiggins Wellness and Integrative Health Center was named in their honor. Linda believed these support services were important in helping people with cancer maintain their physical abilities and achieve some normalcy. The Wellness and Integrative Health Center has grown into an essential part of HCI, now offering more than 35 services and research studies, including art, creative writing, cooking classes, massage therapy, music therapy, osteopathic treatments, and much more. The center had close to 20,000 patient visits in PEOPLE WHO LOSE PART OF their face to disease or injury can have a lifelike replacement, thanks to anaplastologist Paul Tanner, who oversees Facial Prosthetics at Huntsman Cancer Institute (HCI). Started in 2004, this program restores self-image and self-confidence to people with facial disfigurements due to illness and injury, including cancer. At HCI s onsite lab, Tanner works personally with each individual to create a custom prosthesis precisely matched to skin color and translucency. Applying science to the art of making prostheses yields remarkable results, said Tanner. I tell people I am an artist who needs to think like a scientist in order to solve problems and innovate. Research at HCI focuses on the color and translucency of skin and prosthetic materials. Tanner contributes to skin color studies published in peer-reviewed scientific journals. Tanner enjoys the art and science of his work. But the most rewarding part? A sincere thank you after I ve helped someone move on with life. Jim Lindow underwent many treatments for melanoma: one surgery to amputate his ear, one surgery to remove 35 lymph nodes, dozens of radiation treatments, and a year of chemotherapy. He also faced the question of what to do about his missing ear. Should he have plastic surgery, a prosthesis, or nothing at all? Jim met another patient with a very realistic prosthesis who convinced him to see anaplastologist Paul Tanner. When asked about his experience, Jim said: Let me put it this way: unless I point it out, most people can t tell I have a prosthetic ear. And even when I tell people, some can t tell which ear it is. Today Jim is cancer-free, active, and healthy. His prosthesis fits into his active lifestyle, which includes hiking and rock climbing. I m able to do just about anything, he said. 28 # PATIENT CARE

19 Putting Better Diagnostic and Treatment Outcomes in View A DAY IN THE LIFE OF A CYCLOTRON OPERATOR The clock is nearing midnight, and the clinics have long been closed. But that s just when the Cyclotron Operations team at HCI gets started. FOUNDERS EVENTS RESEARCH HIGHLIGHTS PATIENT CARE EDUCATION AND OUTREACH GIVING IMAGING IS A CRITICAL TOOL in the fight against cancer. Imaging used in cancer treatment and research is a noninvasive way to evaluate the impact of a therapy, to see if cancerous tissues are growing or retracting, and to identify whether cancer has spread to other parts of the body. The Center for Quantitative Cancer Imaging (CQCI) at Huntsman Cancer Institute (HCI) is led by John M. Hoffman, MD, investigator and professor of radiology and imaging sciences and neurology; and Jeffrey T. Yap, PhD, investigator and research associate professor of radiology and imaging sciences. The CQCI integrates HCI s research in new cancer therapies with two dedicated human research PET/CT scanners, including a new state-of-the-art, time-offlight PET/CT. In addition, the CQCI has established a preclinical imaging laboratory with SPECT/CT and PET/MRI scanners for imaging rodent models of cancer. As HCI s focus on clinical research and clinical translation expands, the CQCI plays a key role in ensuring state-of-the-art technologies are available, along with the analytical expertise to interpret data. New imaging technologies and techniques are critical in our fight against cancer. John M. Hoffman, MD Cancer cells often use more glucose, or sugar, than healthy cells. In PET imaging, patients are injected with a special form of glucose called FDG, which accumulates in parts of the body using more glucose. Potentially cancerous lesions can be identified as areas of increased glucose consumption. Using a combined PET/CT scanner, the images produced show not only anatomy from CT, but also the actual biological function of the body using PET. IT IS EXCELLENCE YOU CAN SEE. HCI was named a Center for Quantitative Imaging Excellence by the National Cancer Institute (NCI) in A prestigious recognition, but what exactly does it mean? Being named a Center for Quantitative Imaging Excellence means that HCI has demonstrated expertise in cancer imaging technology that is, taking pictures of the inside of the body to look at healthy tissue as well as cancer tissue. This recognition means HCI is trialready to conduct rigorous NCI trials that have an imaging component. The cyclotron is a machine that manufactures very short-lived radioisotopes that can be used to manufacture PET radiopharmaceuticals. One such agent is Fluoro-2-deoxyglucose, or FDG. PET is one of the most accurate imaging techniques to detect, characterize, and stage various types of cancers. Since FDG decays rapidly within a day, time is of the essence in getting it synthesized and delivered. When the first person walks in the door at night, the initial step is to start up the cyclotron. While it produces the Fluorine-18, staff members prepare for the other manufacturing processes that will attach the Flourine-18 to FDG. After about 30 minutes of chemical synthesis, the agent is quality tested and then transferred to HCI s internal radiopharmacy for dispensing into doses. Everything is tested for safety and out the door around 6 a.m., said Brandon Buckway, PhD, senior PET radiochemist at HCI. Doses are delivered to HCI clinics, local area clinics, and neighboring state clinics throughout the Mountain West by ground or by air. Yet this is only part of the cyclotron team s day. Once the imaging agents are completed, the focus turns to research compounds needed by HCI labs and outside researchers. The compounds we develop and produce allow researchers to measure and observe exactly what is happening in a tumor or diseased tissue in real time, said Buckway. As demand from oncologists and other researchers increases, he said, there will only be more growth and diversity of the products we supply PATIENT CARE

20 From Terminal to Cancer-Free FOUNDERS EVENTS RESEARCH HIGHLIGHTS PATIENT CARE EDUCATION AND OUTREACH GIVING PHOTO BY JULIO C. VALENCIA, COURTESY NCI CENTER FOR CANCER RESEARCH METASTATIC MELANOMA CELLS TAMMY WILLIS, RN, LARRY HEGLAND, AND BRITTANY THOMAS, PA-C, MPAS LARRY HEGLAND S METASTATIC MELANOMA wasn t going away. After he finished treatment, more tumors began appearing as lesions on his arm. Enter Robert Andtbacka, MD, CM, a surgeon and investigator with Huntsman Cancer Institute (HCI). Dr. Andtbacka is principal investigator of multiple clinical trials testing talimogene laherparepvec (T-VEC), a mutated version of the cold sore virus, in late-stage melanoma. This is an example of immunotherapy: using a patient s own immune system to fight cancer. The science behind this treatment sounds more like a video game researchers hijack the virus and change its genome so it attacks only melanoma cells. Once inside the body, the virus replicates, blows up the melanoma cells, and releases a factor that trains the patient s immune system to chase down and deactivate melanomarelated proteins wherever they may be. After the lesions in Larry s arms were injected with the mutated virus, they started disappearing, Larry said. Larry s post-treatment scans showed he was cancer-free. His reaction? Wow. Just wow. Initial results of the Phase III trial, published in the Journal of Clinical Oncology in 2015, showed 64% of tumors treated with T-VEC shrank, and some tumors disappeared completely. We have a new modality for treating melanoma, and we can now look at combining this therapy with other therapies, said Dr. Andtbacka. At HCI we ve been instrumental in looking at these combination therapies. What is encouraging with many of these therapies, adds Andtbacka, is that the patients who respond tend to have very longlasting responses. Larry said he feels lucky to have been treated at HCI by Dr. Andtbacka and his team. I owe them my life. I always call Tammy and Brittany my angels, said Larry Hegland. Brittany Thomas, PA-C, MPAS, and Tammy Willis, RN, were part of Larry s care team. After his treatment was finished, Larry gave them each a necklace with an angel pendant and a card that said, You re an angel to me. Fifteen years ago, we had very few treatments that improved survival in patients with melanoma. In the past 10 years or so, the focus changed to immunotherapy. With these studies, survival continues to improve. Robert Andtbacka, MD, CM PATIENT CARE

21 Closing the Health Equity Gap for Native Americans PATIENT SPOTLIGHT KAREN BEGAII-WILSON Helping the Medically Underserved When Wayne Reaud won major lawsuits against Big Tobacco and Toshiba, he did more than celebrate a big payday for his law firm, Reaud, Morgan, and Quinn. He also founded Beaumont Foundation of America so he could continue to champion causes for working men and women and the underserved. After learning about the Native American Outreach Program at Huntsman Cancer Institute (HCI), Wayne became the single largest donor to HCI s programs for the medically underserved. In doing so, he ensured that those who need cancer services the most are able to access them. FOUNDERS EVENTS RESEARCH HIGHLIGHTS PATIENT CARE EDUCATION AND OUTREACH GIVING LYNNE HALL AND PHYLLIS PETTIT NASSI This program is more than outreach. It s about advocating for change... It s about empowering the people. Phyllis Pettit Nassi, MSW Utah is home to 7 Native American Tribes and Nations. AMERICAN INDIANS AND ALASKA NATIVES continue to have the poorest fiveyear survival rates among all racial and ethnic groups, for all cancers combined, according to the National Cancer Institute. Since Utah is home to seven Native American Tribes and Nations, Huntsman Cancer Institute (HCI) established the Native American Outreach (NAO) Program in June 2008, providing culturally competent education about cancer and forging formal agreements to support research partnerships. Phyllis Pettit Nassi, MSW, associate director of the NAO Program, is enrolled in the Otoe- Missouria Tribe and a member of the Cherokee Nation. Lynne Hall, MSW, is the NAO Program administrative coordinator and is enrolled in the Klamath Tribes and a descendant of the Confederated Tribes of Warm Springs. This program is more than outreach. It s about advocating for change, said Nassi. It s about empowering the people. The NAO Program has reached more than 920,000 people. Services have been used by 204 tribal (United States), first (Canada), and aboriginal (Australia) nations members. Medical technician, traditional dancer, cancer survivor: Karen Begaii-Wilson is all of these. Enrolled in the Navajo Nation, Karen is of The Folded Arms People, born for The Salt People (this is the Navajo way of introducing yourself and the clans you come from). Karen was treated at Huntsman Cancer Institute and worked with the Native American Outreach Program to ensure her cultural needs were met. The medical team will do anything possible to make you feel better. It doesn t matter what race or religion you are, said Karen. I had a medicine man come in and do a smudge before and after surgery. I listened to traditional music during treatments; it really helped me relax. Wayne is known throughout the legal community as a champion of working men and women. He received his law degree from Texas Tech University in 1974 and is a former member of the Lamar University Board of Regents, former director of the Texas Trial Lawyers Association, and past president of the Southeast Texas Trial Lawyers Association. He is a Life Fellow of the Texas Bar Association and a fellow of the International Society of Barristers, and he is listed in Best Lawyers in America. HCI NAMED THE CENTER FOR ADVANCED THERAPEUTICS AND THE CANCER HOSPITAL S SECOND FLOOR IN HONOR OF WAYNE REAUD EDUCATION AND OUTREACH

22 Forging New Paths to Careers in Cancer Research 2016 PATHMAKER PROGRAM STUDENTS I love math and science and solving problems by coming up with creative solutions. I want to work in pharmaceutical research and development when I grow up. Elizabeth Morrill DAVID WETTER, PHD New Huntsman Center for HOPE FOUNDERS EVENTS RESEARCH HIGHLIGHTS PATIENT CARE EDUCATION AND OUTREACH GIVING FORGING NEW PATHS IS NO EASY FEAT. With economic and educational obstacles, some routes may feel permanently closed and some goals impossible to conquer. A partnership between Huntsman Cancer Institute (HCI), the Office of Health Equity and Inclusion, and the University of Utah biology department increases inclusivity and clears the path to health professions for students who face some of the biggest hurdles. The PathMaker Summer Research Program was piloted in 2016 to engage diverse students in biomedical cancer research. Ana Maria Lopez, MD, MPH, director of Cancer Health Equity at HCI and associate vice president for Health Equity and Inclusion at the University of Utah, partnered with Rosemary Gray, PhD, associate professor in the Department of Biology, to encourage students underrepresented in the health professions to learn more about their professional possibilities while experiencing the university setting. For eight weeks during the summer, students learned laboratory techniques, worked in HCI research labs, and learned about careers in cancer research, medicine, and health professions. PathMaker has since been awarded funding, under Lopez s direction, from the National Cancer Institute s Center to Reduce Cancer Health Disparities Continuing Umbrella of Research Experiences (CURE) program. PathMaker can now offer NCI CURE Scholar research opportunities year-round to underrepresented high school and undergraduate students. The impact of PathMaker, Lopez said, is that students feel they are one step closer to their goal as they begin to experience the possibility of being a health professional. In September 2016, Huntsman Cancer Institute (HCI) announced a new initiative: the HCI Center for Health Outcomes and Population Equity (HOPE). This will focus on discovering new ways to prevent and treat cancer among underserved populations, including people living in poverty and residents of rural and frontier areas. HCI and the Department of Population Health Sciences at the University of Utah recruited David W. Wetter, PhD, an international leader in the study of health-related behavior in high-risk and underserved populations, minorities, and women. He previously led groundbreaking studies focused on tobacco use and cessation, alcohol, diet, and physical activity at the University of Texas MD Anderson Cancer Center. At the HCI Center for HOPE, Wetter will lead a team of scientists dedicated to improving cancer prevention and cancer outcomes for underserved populations. EDUCATION AND OUTREACH 36 37

23 HCI Leads Regional Cancer Health Disparities Project HCI s GMaP REGION MT ND ID WY SD NV UT HEALTH EDUCATORS AND PATIENT NAVIGATORS LILIANA MULATO, GUADALUPE TOVAR, AND ANNA MARTINEZ Navigating the Way through Cancer Treatment FOUNDERS EVENTS RESEARCH HIGHLIGHTS PATIENT CARE EDUCATION AND OUTREACH GIVING ANA MARIA LOPEZ, MD, MPH GMAP IS DESIGNED TO ENHANCE and expand cancer health equity research while simultaneously promoting workforce diversity. GMaP stands for the Geographical Management of Cancer Health Disparities Program (GMaP). Supported through a National Cancer Institute (NCI) grant, GMaP brings together researchers, trainees and students, new and early-stage investigators, and community members from specific regions throughout the United States. Groups, which include 152 partners, collectively identify and prioritize the cancer research, training, education, and outreach topics that matter most in their areas. It s a national program with an appreciation for geographically unique issues, but with an overarching goal: to end cancer health inequities and make quality cancer care accessible for everyone nationwide. Ana Maria Lopez, MD, MPH, director of Cancer Health Equity at Huntsman Cancer Institute (HCI) and project director for GMaP Region 6, said the GMaP grant is one of the first efforts at HCI to cultivate cancer researchers focused specifically on cancer health disparities. HCI was eligible to apply for the grant after earning Comprehensive Cancer Center status from the NCI in July Region 6 serves Idaho, Montana, Nevada, North Dakota, South Dakota, Utah, and Wyoming. This grant enables us to contribute in the field of developing researchers who are focused on addressing these inequities, Lopez said. By sharing information, resources, and tools, GMaP regions set out to do the following: Advance cancer health equity research Encourage the next generation of competitive underrepresented cancer and cancer health equity researchers Contribute to measurable reductions in cancer health disparities in our region Increase sharing of cancer information and best practices among researchers and trainees To date, GMaP Region 6 has awarded seven travel stipends of $800 each for career development opportunities and two $20,000 pilot awards for new or early-stage investigators. An inaugural conference will kick off in spring 2017, bringing regional partners together to share research and lessons learned. Being diagnosed with cancer is difficult enough, but what comes next can be just as overwhelming making appointments with multiple doctors, planning how to get to those appointments, filling out insurance forms. Things can be complicated and hard to understand. There s a whole new language of cancer to learn. Spanish-speaking patient navigators at Huntsman Cancer Institute (HCI) work with Spanish-speaking patients and their families to guide them through the complex health care system. The patient navigator serves as a single, consistent point of contact between patients and their health care team throughout treatment. Launched in 2009, the Patient Navigator Program has a primary goal to eliminate barriers to quality care. This includes assessing patient and family needs, setting or changing appointments, getting or refilling prescriptions, and accompanying patients to critical appointments where diagnosis and treatment options are discussed. Patient navigators also help patients understand instructions or changes to treatments and communicate needs and concerns to care providers. When patients are diagnosed with cancer, they don t know what to do. The emotional impact is really hard for them, said patient navigator Guadalupe Tovar. Misunderstanding can lead patients to drop treatment or be non-compliant. We navigators are linguistically and culturally able to address their concerns. As of 2016, HCI s patient navigator program has served more than 800 Hispanic patients and their families. Every patient is unique, said Guadalupe. Maybe a patient doesn t have as many needs at the beginning, but along the way they may need much more. Utah s Hispanic/Latino population is the 2nd largest and fastest growing, according to the 2013 U.S. census EDUCATION AND OUTREACH

24 Embraced by Beauty People who come here are sick, or they wouldn t be here. You want to embrace them with all the beauty you can, so they can take their minds off their troubles. Karen Huntsman FOUNDERS EVENTS RESEARCH HIGHLIGHTS PATIENT CARE EDUCATION AND OUTREACH GIVING WHEN DEVELOPING PLANS for Huntsman Cancer Institute (HCI), Jon M. and Karen Huntsman envisioned an inspirational environment and believed art was an important part of that vision. Patients, families, staff, and care providers enjoy hundreds of works of art throughout the buildings. Curated by volunteer experts, the collection was donated by patients, doctors, and artists. It warms up the space and gives it life, said Karen. Mark Peterson noticed the beautiful art when he spent time as an inpatient. He and his family have shown their gratitude to HCI in myriad ways. He and his wife, Nancy, made generous financial contributions, named the hospital family room in honor of HCI oncologist John Ward, MD, and introduced their adult children to the importance of giving back. Their children also became major donors to HCI. Throughout their relationship with HCI, which continues to this day, the Peterson family asked, What more can we do to improve the experience for other patients and families who will walk in our shoes as cancer patients and caregivers? Imagine the collective surprise and gratitude when the family donated its entire collection of early Utah art to Huntsman Cancer Foundation, to be displayed at HCI for all to enjoy. Thanks to the generosity of the V. Mark and Nancy Peterson family and the P.I. Foundation, HCI exhibits a significant selection of extraordinary Utah art. These works feature artists such as C.C.A. Christensen, Henry Culmer, John Hafen, James Harwood, Frank Huff, Alfred Lambourne, B.F. Larsen, William Major, George Martin Ottinger, LeConte Stewart, and Mahonri Young. A number of these works are featured in the first floor pharmacy area, on the sixth floor adjacent to the Cancer Learning Center (where a collection of the work of landscape artist LeConte Stewart is housed), in the hallway leading from the cancer hospital to the research building, and in the fourth floor waiting area. Visitors to HCI are invited to view the collection and celebrate Utah s artistic heritage while enjoying the beautiful art and architecture throughout the cancer hospital and research buildings. MARK AND NANCY PETERSON This 16-foot-long LeConte Stewart painting, Mt. Ben Lomond and Foothills, was too massive to fit in the HCI elevators. During a major expansion of the cancer hospital, the painting was lifted by crane and carried through the windows. The painting is on display on the sixth floor of the cancer hospital near the Cancer Learning Center GIVING

25 Generosity Leads by Example, Inspires Others to Join the Fight FOUNDERS EVENTS RESEARCH HIGHLIGHTS PATIENT CARE EDUCATION AND OUTREACH GIVING 42 RON AND JODIE SMART are pleased to work with many important charities in our local and national community. But Huntsman Cancer Institute (HCI) is a standout in their minds. Having already lost his father to cancer, in 2004 Ron watched his dear friend, business partner, and brother-in-law slip away to the disease. Ron and Jodie were devastated by this loss and decided to help support cancer research in honor of Ronald Lee Richardson. Ronald Lee Richardson loved life, and he loved Utah Utes football. His last season cheering for the Utes was one of the most winning seasons in University of Utah history. The Runnin Utes gave him much to celebrate, and their winning ways were a welcome distraction from cancer. It was only fitting that upon his passing, Ron and Jodie would choose a private patient room at HCI affording a perfect view of Rice-Eccles Stadium to honor Richardson s memory. The patient room the one Ronald actually stayed in is dedicated to the memory of Ronald Lee Richardson and in honor of his wife Ruth Ann and their children. The first to name a patient room at HCI, Ron and Jodie knew if they modeled philanthropy, others would follow their example. They are proud to witness every private patient room 100 in all has since been named by other generous donors, each representing a gift between $50,000 and $150,000 for cancer research. The Smart family and their company, Won-Door, have steadfastly supported HCI each year since that first gift. Not only do they lead as philanthropists, they encourage friends and associates to do so as well. Thanks to their generosity, millions of dollars have been raised through the gala and golf events Ron chairs annually. JODIE AND RON SMART RUTH ANN AND THE LATE RONALD LEE RICHARDSON The next phase of Huntsman Cancer Institute (HCI) is now underway a project that will double our research capacity and accelerate discoveries leading to better treatments and prevention strategies for cancer. Thank you to our generous supporters who have joined with us to advance cancer research that saves lives through the Primary Children s and Families Cancer Research Center at HCI, opening summer 2017: The Church of Jesus Christ of Latter-Day Saints The State of Utah Intermountain Healthcare Salt Lake County The University of Utah The Jon M. Huntsman family and more than 100,000 donors to the Huntsman Cancer Foundation GIVING 43

26 Giving $10 Million to Be the Generation to End Cancer I know from personal experience that cancer can be relentless and discouraging. But I believe together we can do what might seem impossible: end cancer. Brandon Plewe ON APRIL 12, 2013, SIGMA CHI MEMBERS PRESENTED THE ONE-MILLIONTH DOLLAR RAISED FOR CANCER RESEARCH AT HUNTSMAN CANCER INSTITUTE TO SIGNIFICANT SIG AND ORDER OF CONSTANTINE SIG JON M. HUNTSMAN. PATIENT SPOTLIGHT BRANDON PLEWE BRANDON, GRAY, KATIE, AND SIMON PLEWE When I go up to HCI for my routine visits I honestly feel like I m visiting family, said Brandon Plewe. FOUNDERS EVENTS RESEARCH HIGHLIGHTS PATIENT CARE EDUCATION AND OUTREACH GIVING WE BELIEVE THIS IS THE GENERATION TO END CANCER, AND WE BELIEVE HUNTSMAN CANCER INSTITUTE IS THE PLACE TO MAKE THIS HAPPEN. These words from the 68th Grand Consul of Sigma Chi Fraternity, Michael Greenberg, echo the thoughts of Sigma Chi members throughout North America. The fraternity named Huntsman Cancer Institute (HCI) a preferred charity in 2005 in honor of Significant Sig and Order of Constantine Sig Jon M. Huntsman. In 2013, Huntsman Cancer Foundation was named the sole philanthropic partner of Sigma Chi. To date, Sigma Chi has raised more than $4.5 million for cancer research at HCI. On June 15, 2015, Sigma Chi announced a sevenyear, $10 million fundraising commitment in support of HCI. In honor of this commitment, HCI named the sixth floor of the cancer hospital The Sigma Chi International Fraternity Sixth Floor. Everyone who walks through our doors and onto this floor will know that an entire generation is working on their behalf to beat this horrible disease, said Huntsman. To our researchers, patients, and caregivers, this will be a reminder that young people all around the United States and Canada are pulling for them. The Sigma Chi International Fraternity Sixth Floor is a healing space for patients and their families, reinforcing our values of friendship, justice, and learning, said Greenberg. This gift represents huge efforts across campuses in North America, said Brandon Plewe, a Sigma Chi member and former HCI patient. I am proud that our fraternity has dedicated its efforts to people like me and this place that gave me a fighting chance. FUNDS RAISED FOR HCI BY SIGMA CHI $39, $156, $1,160, YTD...$1,138, In 2009, Brandon was diagnosed with multiple myeloma. When he was admitted at HCI, he was in such bad shape that his diagnosing physicians were sure he didn t have long to live. But Brandon s team felt he was curable. They put him on an aggressive treatment, and it worked. Brandon has been in full remission since To be part of Sigma Chi and a former patient at HCI is something very special, said Brandon, a member of the University of Utah Sigma Chi chapter. To witness my fellow Sigma Chis working to be the generation to end cancer is amazing and makes me incredibly proud. In order to give back to the place that gave him so much, Brandon now works at Huntsman Cancer Foundation. This is a great cause I believe in, he said. I am confident as more and more of us pitch in together, we can beat this disease GIVING

27 Loss of a Beloved Son Inspires Generous Philanthropy PATIENT SPOTLIGHT DAN HEDLUND THE HEDLUND FAMILY THE LATE GAYE MARRASH PHILIP ALFORD Just three weeks after their wedding in 2007, newlyweds Dan and Melanie Hedlund were in for some startling news Dan had osteosarcoma, a rare form of bone cancer. FOUNDERS EVENTS RESEARCH HIGHLIGHTS PATIENT CARE EDUCATION AND OUTREACH GIVING GAYE MARRASH began giving generously to Huntsman Cancer Institute (HCI) in Her gifts were directed to advancing sarcoma research, specifically Ewing sarcoma a lethal cancer that takes the lives of children and young adults. HCI s most generous donor to sarcoma research, Marrash was also a private woman. For years, she preferred that her philanthropy and her motivation for doing so be kept quiet. Likewise, she was reticent to share much about herself. Each year, she closely followed research and accomplishments at HCI and cheered on discoveries. As Gaye s relationship with HCI deepened, she began to share more about her extraordinary life. Born on a humble farm in rural Arkansas, Gaye went on to obtain four university degrees, travel the world, and live in many exotic and exciting places in her career with the State Department. And while she had entrusted her hard-earned financial resources to HCI, she gave her most generous gift when she confided she was ready to share and honor her most cherished, most heartfelt treasure, the memory of her son Philip. Diagnosed with Ewing sarcoma, Philip passed away at the age of seven. The loss was so painful and private that Gaye could not openly discuss it for decades. In 2008, with Gaye s blessing, HCI dedicated the Philip Alford Stairway at the hospital. It will honor Philip s memory in perpetuity. Because of generous support from Gaye and so many others, HCI s sarcoma research is some of the strongest in the country, and its team of researchers and clinicians is making great strides in improving outcomes for this deadly cancer. Gaye passed away in 2016, but her impact will be felt by patients at HCI for many years to come. Because of his age and strong overall health, Dan s physician, R. Lor Randall, MD, director of Sarcoma Services at HCI, chose an aggressive treatment regimen. Dan said it was rough, but he accepted the challenge and it worked. Dan had his last surgery in 2012 and has been cancer-free since. In 2013, Dan and Melanie welcomed a baby boy into their lives. His name is Noah Randall in honor of Dr. Randall. In 2016, Noah became a big brother when Dan and Melanie welcomed twin boys to the family. The lessons I ve learned, the strength I ve been given, the support I ve received, and the faith I ve developed have all shaped me into who I am today. Dan Hedlund DAN HEDLUND AND R. LOR RANDALL, MD GIVING

28 Design Informed by Experience, Inspired by Love A BEACON OF HOPE THE POINTED TIP OF THE JON M. HUNTSMAN CANCER RESEARCH CENTER WAS DESIGNED TO SYMBOLIZE A BEACON OF HOPE RISING UP IN OUR COMMUNITY. DON FINLAYSON, PRINCIPAL ARCHITECT, ARCHITECTURAL NEXUS FOUNDERS EVENTS RESEARCH HIGHLIGHTS PATIENT CARE EDUCATION AND OUTREACH GIVING WHEN VISITORS COME TO HUNTSMAN CANCER INSTITUTE (HCI), they consistently remark that it does not look like a hospital. It does not feel like a hospital. That is exactly the intended impression. And it is thanks to the vision of Jon M. and Karen Huntsman that the cancer campus resembles a beautiful five-star hotel. Jon is a four-time cancer survivor. During his treatment for prostate cancer, he felt the clinics and hospitals he went to were cold and clinical, inspiring anxiety but not hope. When Jon and Karen decided to seed the Mountain West s only cancer specialty hospital, they insisted on hope. At that same time, a talented architect s teenage daughter was battling cancer. And as that father watched his child slip away, he too felt the need to create a cancer treatment space that inspired beauty, serenity, inspiration, and above all, hope. He envisioned beautiful vistas and soothing spaces that brought the stunning Utah landscapes into the patient s room. Together, principal architect Don Finlayson, the firm Architectural Nexus, and Jon and Karen dreamed, then designed, and then put the first shovel in the ground to create the stunning cancer campus we have today. They never lost sight of the vision to create the very best spaces possible to marry exceptional research and exceptional care. As we celebrate the 20th year of its founding, and just 16 years since its first building opened, the fourth phase is underway to create the Primary Children s and Families Cancer Research Center at HCI. The Center will advance cures for childhood cancers and for families at higher DURING DESIGN PHASES OF THE CANCER HOSPITAL, DON S DAUGHTER UNDERWENT VARIOUS COURSES OF CANCER TREATMENTS. WE WOULD DISCUSS OUR EXPERIENCES AND HOW THE NEW CANCER HOSPITAL COULD BE BETTER FROM THE PATIENT S POINT OF VIEW AND FROM A FAMILY MEMBER S POINT OF VIEW. MANY OF THOSE DISCUSSIONS LED TO DETAILS THAT ARE PRESENT IN THE DESIGN. risk for cancers throughout their lifetimes. The pace of investment in science and researchers, the rate of building facilities, the unprecedented discoveries of cancer predisposition genes, and the uncompromising insistence for the very best have all been breathtaking. They have made HCI the fastest growing cancer institute in the world. After retiring in 2016, Don reflected on a career as an architect and a lifetime of accolades and awards earned by his firm. He said he is proudest of his 20-year engagement as HCI s principal architect. He continues to contribute to HCI as a volunteer in its chemotherapy infusion center. A philanthropist with a life-threatening disease and an architect grieving the loss of a daughter. Together, they changed the very nature of the cancer treatment experience in Utah and the Mountain West. THE LATE ERIN ELIZABETH FINLAYSON LOVED ANIMALS, ESPECIALLY HORSES. GIVING 48 49

29 Huntsman Cancer Institute Director s Cabinet 2016 GALA and NIGHT OFF FROM CANCER THE ANNUAL HUNTSMAN CANCER Gala was held September 29, 2016, at the Grand America Hotel. More than 1,000 supporters, doctors, researchers, and patients attended the event, presented by Corbin and Kara Church. The gala was hosted by Jon M. and Karen Huntsman, founders of Huntsman Cancer Institute, Gov. Jon M. Huntsman, Jr., Peter R. Huntsman, and Susan Sheehan. Mary Beckerle, PhD CEO AND DIRECTOR The evening kicked off with a silent auction followed by dinner and a program. Afterward, attendees were invited to the Take a Night Off from Cancer celebration. RALPH E. AND WILLIA T. MAIN PRESIDENTIAL ENDOWED CHAIR IN CANCER RESEARCH DISTINGUISHED PROFESSOR OF BIOLOGY Bradley Cairns, PhD Michael Deininger, MD, PhD JON AND KAREN HUNTSMAN PRESIDENTIAL PROFESSOR IN CANCER RESEARCH M.M. WINTROBE SENIOR DIRECTOR OF BASIC SCIENCE PROFESSOR AND CHAIR OF ONCOLOGICAL SCIENCES 50 Scott Lloyd, MBA, CPA SENIOR DIRECTOR OF FINANCE AND ADMINISTRATION Martin McMahon, PhD SENIOR DIRECTOR OF PRECLINICAL TRANSLATION CUMMING ENDOWED CHAIR PROFESSOR OF DERMATOLOGY PROFESSOR AND DIVISION CHIEF OF HEMATOLOGY AND HEMATOLOGIC MALIGNANCIES HUNTSMAN CANCER BOARD OF DIRECTORS CHAIRMAN EMERITUS Jon M. Huntsman, Sr. CHAIRMAN Gov. Jon M. Huntsman, Jr. CHIEF EXECUTIVE OFFICER Peter R. Huntsman PRESIDENT AND CHIEF OPERATING OFFICER Susan Sheehan Sunil Sharma, MD John Sweetenham, MD JON AND KAREN HUNTSMAN PRESIDENTIAL PROFESSOR IN CANCER RESEARCH SENIOR DIRECTOR OF CLINICAL RESEARCH SENIOR DIRECTOR OF CLINICAL AFFAIRS AND EXECUTIVE MEDICAL DIRECTOR Ben Tanner, MHA CANCER HOSPITAL EXECUTIVE DIRECTOR Cornelia Ulrich, PhD SENIOR DIRECTOR OF POPULATION SCIENCES JON AND KAREN HUNTSMAN PRESIDENTIAL PROFESSOR IN CANCER RESEARCH DIVISION CHIEF OF MEDICAL ONCOLOGY DIVISION CHIEF OF CANCER POPULATION SCIENCES PROFESSOR OF POPULATION HEALTH SCIENCES CHIEF FINANCIAL OFFICER Thomas E. Muir SECRETARY Ronald Moffitt BOARD OF DIRECTORS David W. Pershing A. Scott Anderson FOUNDERS EVENTS RESEARCH HIGHLIGHTS PATIENT CARE EDUCATION AND OUTREACH GIVING INVESTIGATOR, HOWARD HUGHES MEDICAL INSTITUTE SENIOR DIRECTOR OF TRANSDISCIPLINARY RESEARCH 51

30 Internal Advisory Board External Advisory Board Mary Beckerle, PhD INTERNAL ADVISORY BOARD CHAIR CEO AND DIRECTOR, HUNTSMAN CANCER INSTITUTE RALPH E. AND WILLIA T. MAIN PRESIDENTIAL ENDOWED CHAIR IN CANCER RESEARCH DISTINGUISHED PROFESSOR OF BIOLOGY Angie Fagerlin, PhD PROFESSOR AND CHAIR OF POPULATION HEALTH SCIENCES John Zone, MD PROFESSOR AND CHAIR OF DERMATOLOGY Ex Officio Member Edward Benz, MD PRESIDENT AND CEO EMERITUS DANA-FARBER CANCER INSTITUTE RICHARD AND SUSAN SMITH DISTINGUISHED PROFESSOR OF PEDIATRICS PROFESSOR OF GENETICS HARVARD MEDICAL SCHOOL Brian Druker, MD DIRECTOR OF KNIGHT CANCER CENTER ASSOCIATE DEAN FOR ONCOLOGY OHSU SCHOOL OF MEDICINE JELD-WEN CHAIR OF LEUKEMIA RESEARCH INVESTIGATOR AT HOWARD HUGHES MEDICAL INSTITUTE OREGON HEALTH AND SCIENCE UNIVERSITY Ernest T. Hawk, MD, MPH VICE PRESIDENT AND DIVISION CHIEF FOR CANCER PREVENTION AND POPULATION SCIENCES BOONE PICKENS DISTINGUISHED CHAIR FOR EARLY PREVENTION OF CANCER THE UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER Vivian Lee, MD, PhD, MBA SENIOR VICE PRESIDENT FOR HEALTH SCIENCES DEAN OF THE SCHOOL OF MEDICINE CEO OF UNIVERSITY OF UTAH HEALTH CARE Samuel Finlayson, MD, MPH CLAUDIUS Y. GATES, MD, AND CATHERINE B. GATES PRESIDENTIAL ENDOWED CHAIR IN SURGERY PROFESSOR AND CHAIR OF SURGERY Dean Li, MD, PhD VICE DEAN OF RESEARCH, UNIVERSITY OF UTAH SCHOOL OF MEDICINE ASSOCIATE VICE PRESIDENT FOR RESEARCH AND CHIEF SCIENTIFIC OFFICER, UNIVERSITY OF UTAH HEALTH CARE AND CARDIOLOGY Elizabeth Blackburn, PhD NOBEL LAUREATE IRWIN M. JACOBS PRESIDENTIAL CHAIR PRESIDENT OF THE SALK INSTITUTE FOR BIOLOGICAL STUDIES Rob DuWors, MPA DEPUTY DIRECTOR OF ADMINISTRATION AND PLANNING JONSSON COMPREHENSIVE CANCER CENTER, UNIVERSITY OF CALIFORNIA AT LOS ANGELES Timothy R. Rebbeck, PhD PROFESSOR OF EPIDEMIOLOGY HARVARD T. H. CHAN SCHOOL OF PUBLIC HEALTH PROFESSOR OF MEDICAL ONCOLOGY DANA-FARBER CANCER INSTITUTE Peter Jensen, MD ARUP PRESIDENTIAL PROFESSOR AND CHAIR OF PATHOLOGY Edward Clark, MD PROFESSOR AND CHAIR OF PEDIATRICS WILMA T. GIBSON PRESIDENTIAL PROFESSOR PRESIDENT, UNIVERSITY OF UTAH MEDICAL GROUP CHAIRMAN OF THE ARUP LABORATORIES BOARD OF DIRECTORS Michael Caligiuri, MD DIRECTOR OF THE OHIO STATE UNIVERSITY COMPREHENSIVE CANCER CENTER CEO OF THE JAMES CANCER HOSPITAL AND SOLOVE RESEARCH CENTER JL MARAKAS NATIONWIDE INSURANCE ENTERPRISE CHAIR OF CANCER RESEARCH, THE OHIO STATE UNIVERSITY Elaine Fuchs, PhD REBECCA C. LANCEFIELD PROFESSOR OF MAMMALIAN CELL BIOLOGY AND DEVELOPMENT INVESTIGATOR AT HOWARD HUGHES MEDICAL INSTITUTE THE ROCEKELLER UNIVERSITY Thomas Sellers, PhD, MPH CENTER DIRECTOR DISTINGUISHED MOFFIT SCHOLAR EXECUTIVE VICE PRESIDENT MOFFITT CANCER CENTER AND RESEARCH INSTITUTE Kathleen Cooney, MD H.A. AND EDNA BENNING PRESIDENTIAL ENDOWED CHAIR Dennis Shrieve, MD, PhD HUNTSMAN CANCER INSTITUTE ENDOWED CHAIR IN CANCER RESEARCH PROFESSOR AND CHAIR OF RADIATION ONCOLOGY Sandra M. Swain, MD MEDICAL DIRECTOR, WASHINGTON CANCER INSTITUTE ASSOCIATE DEAN FOR RESEARCH DEVELOPMENT PROFESSOR AND CHAIR OF MEDICINE ADJUNCT 52 F. EDWARD HEBERT SCHOOL OF MEDICINE 53 GEORGETOWN UNIVERSITY MEDICAL CENTER

31 Cancer Center Research Programs and Members Cancer Center Research Program Leaders and Members The National Cancer Institute Cancer Center Support Grant (CCSG) provides funding for programs that promote scientific excellence through coordinated, broad-based transdisciplinary research. HCI s four Cancer Center programs include almost 170 members from across the University of Utah campus. NUCLEAR CONTROL OF CELL GROWTH AND DIFFERENTIATION (NC) PROGRAM Bradley Cairns, PhD PROFESSOR OF ONCOLOGICAL SCIENCES Jared Rutter, PhD PROFESSOR OF BIOCHEMISTRY CELL RESPONSE AND REGULATION (CRR) PROGRAM Jody Rosenblatt, PhD ASSOCIATE PROFESSOR OF ONCOLOGICAL SCIENCES EXPERIMENTAL THERAPEUTICS (ET) PROGRAM Sunil Sharma, MD Alana Welm, PhD ASSOCIATE PROFESSOR OF ONCOLOGICAL SCIENCES CLINICAL TRIALS OFFICE Theresa Werner, MD MEDICAL DIRECTOR ASSISTANT CANCER CONTROL AND POPULATION SCIENCES (CCPS) PROGRAM Kathleen Mooney, PhD, RN DISTINGUISHED PROFESSOR OF NURSING Sean Tavtigian, PhD PROFESSOR OF CANCER CENTER PROGRAM MEMBERS Jayant Agarwal, MD (ET) ASSOCIATE PROFESSOR OF SURGERY/PLASTIC SURGERY Research Focus: Plastic surgery and reconstructive microsurgery Neeraj Agarwal, MD (ET) ASSOCIATE /ONCOLOGY Research Focus: Prostate and kidney cancers Wallace Akerley, MD (ET) /ONCOLOGY Research Focus: Experimental therapeutics; cancer clinical trials Orly Alter, PhD (CCPS) ADJUNCT ASSISTANT PROFESSOR OF HUMAN GENETICS ASSOCIATE PROFESSOR OF BIOENGINEERING Research Focus: Matrix and tensor modeling of large-scale molecular biological data that can be used to correctly predict previously unknown physical, cellular, and evolutionary mechanisms that govern the activity of DNA and RNA Blake Anderson, BS (NPA) Research Focus: Director of the Histology Section of the Biorespository and Molecular Pathology Shared Resource Robert Andtbacka, MD, CM (ET) ASSOCIATE PROFESSOR OF SURGERY/GENERAL SURGERY Research Focus: New modalities for the detection of sentinel lymph nodes in patients with melanoma and breast cancer Melinda Angus-Hill, PhD (NC) ASSOCIATE / GASTROENTEROLOGY Research Focus: Colon development; colon cancer initiation and progression using mouse models Lisa Aspinwall, PhD (CCPS) PROFESSOR OF PSYCHOLOGY Research Focus: Psychological and behavioral response to genetic testing for mutations that increase cancer risk Djordje Atanackovic, MD (ET) ASSOCIATE /HEMATOLOGY/BMT Research Focus: Novel immunotherapeutic approaches such as tumor vaccinations, immunomodulatory antibodies, and the adoptive transfer of receptor-modified T cell Donald Ayer, PhD (NC) PROFESSOR OF ONCOLOGICAL SCIENCES You Han Bae, MD (ET) PROFESSOR OF PHARMACEUTICS AND PHARMACEUTICAL CHEMISTRY Research Focus: Anticancer drug carrier design targeting MDR Phillip Barnette, MD (ET) ASSOCIATE PROFESSOR OF PEDIATRICS/ PEDIATRIC HEMATOLOGY/ONCOLOGY Research Focus: Cancer clinical trials in pediatric patients Brenda Bass, PhD (NC) DISTINGUISHED PROFESSOR OF BIOCHEMISTRY H.A. AND EDNA BENNING PRESIDENTIAL ENDOWED CHAIR IN BIOCHEMISTRY Research Focus: Double-stranded RNA (dsrna); RNA editing by adenosine deaminases that act on RNA (ADARs); RNA interference (RNAi) Susan Beck, PhD, RN (CCPS) PROFESSOR OF NURSING/ACUTE AND CHRONIC CARE ROBERT S. AND BETH M. CARTER ENDOWED CHAIR IN THE COLLEGE OF NURSING Research Focus: Pain and symptom management; quality of life; cancer survivorship Mary Beckerle, PhD (CRR) DISTINGUISHED PROFESSOR OF BIOLOGY RALPH E. AND WILLIA T. MAIN PRESIDENTIAL PROFESSOR IN CANCER RESEARCH Research Focus: Cell adhesion; cell migration; Ewing sarcoma Cindy Berg, PhD (NPA) PROFESSOR OF PSYCHOLOGY Research Focus: How individuals across the life span cope with chronic health conditions such as cancer and their close relationships Philip Bernard, MD (ET) ASSOCIATE PROFESSOR OF PATHOLOGY/ ANATOMIC PATHOLOGY Research Focus: Molecular diagnostics of solid and non-solid tumors Srividya Bhaskara, PhD (NC) ASSISTANT PROFESSOR OF RADIATION ONCOLOGY Research Focus: Mammalian histone deacetylases and their inhibition as a therapeutic strategy for cancers Andrea Bild, PhD (NC) ASSOCIATE PROFESSOR OF PHARMACOLOGY AND TOXICOLOGY Juergen Boehm, MD (CCPS) RESEARCH ASSISTANT PROFESSOR OF POPULATION HEALTH SCIENCES/CANCER POPULATION HEALTH SCIENCES Research Focus: Diabetes, obesity, and body composition in colorectal cancer Kenneth Boucher, PhD (CCPS) RESEARCH ASSOCIATE PROFESSOR OF MEDICINE/EPIDEMIOLOGY Research Focus: Cancer biostatistics Diana Brixner, PhD (NPA) PROFESSOR OF PHARMACOTHERAPY Research Focus: Retrospective database studies and prospective patient assessment; patient care guidelines in epilepsy; pain management outcomes; drug delivery systems Mary Bronner, MD (ET) PROFESSOR OF PATHOLOGY/ ANATOMIC PATHOLOGY CARL R. KJELDSBERG PRESIDENTIAL CHAIR OF PATHOLOGY Research Focus: Cancerous cell growth in the gastrointestinal tract Barbara Brown, PhD (CCPS) PROFESSOR OF FAMILY AND CONSUMER STUDIES Research Focus: Healthy levels of physical acitivy that might reduce trends toward overweight and risk of cancer Cynthia Burrows, MD (NC) DISTINGUISHED PROFESSOR OF CHEMISTRY THATCHER PRESIDENTIAL ENDOWED CHAIR OF BIOLOGICAL CHEMISTRY Research Focus: Chemistry and biochemistry of DNA damage Saundra Buys, MD (CCPS) /ONCOLOGY Research Focus: Breast cancer genetics; cancer screening Bradley Cairns, PhD (NC) PROFESSOR OF ONCOLOGICAL SCIENCES JON AND KAREN HUNTSMAN PRESIDENTIAL PROFESSOR IN CANCER RESEARCH Research Focus: Chromatrin remodeling transcription; DNA methylation Nicola Camp, PhD (CCPS) /HEMATOLOGY AND HEMATOLOGIC MALIGNANCIES Research Focus: Localizing genes for complex traits, including increased cancer risks; evaluating genotype/phenotype relationship; developing statistical genetic methods Lisa Cannon-Albright, PhD (CCPS) / GENETIC EPIDEMIOLOGY Research Focus: Breast cancer susceptibility genes; disease predisposition genes with an emphasis on melanoma and prostate cancer Mario Capecchi, PhD (NC) DISTINGUISHED PROFESSOR OF HUMAN GENETICS HELEN LOWE BAMBERGER COLBY AND JOHN E. BAMBERGER PRESIDENTIAL ENDOWED CHAIR IN THE HEALTH SCIENCES CENTER Research Focus: Mammalian development; genetic recombination Dana Carroll, PhD (NC) PROFESSOR OF BIOCHEMISTRY Research Focus: Gene targeting Michael Caserta, PhD (CCPS) PROFESSOR OF NURSING IN THE HEALTH SYSTEMS AND COMMUNITY-BASED CARE DIVISION ROBERT L. AND JOYCE T. RICE PRESIDENTIAL ENDOWED CHAIR IN HEALTHY AGING Research Focus: How aspects of cancer caregiving influence health and well-being outcomes; intervening relationship with self-care practices Demian Cazalla, PhD, MS (NC) ASSISTANT PROFESSOR OF BIOCHEMISTRY Research Focus: Functions of non-coding RNAs of viral or cellular orgin that regulate gene expression Mahesh Chandrasekharan, PhD (NC) RESEARCH ASSISTANT PROFESSOR OF RADIATION ONCOLOGY Research Focus: Regulation and function of histone modifications in gene transcription and genome stability maintenance pathways Mingnan Chen, PhD (ET) ASSISTANT PROFESSOR OF PHARMACEUTICS AND PHARMACEUTICAL CHEMISTRY Research Focus: Polypeptide-based nanoparticles to deliver cancer-stem cell-specific drugs to halt drug resistance or/and metastasis Danny Chou, PhD (ET) ASSISTANT PROFESSOR OF BIOCHEMISTRY Research Focus: New chemical and biochemical methods in engineering peptides and proteins to achieve therapeutic benefits Jan Christian, PhD (CRR) PROFESSOR OF NEUROBIOLOGY AND ANATOMY Research Focus: Signal transduction in tumor initiation Research Focus: Celluar mechanisms that regulate the ONCOLOGICAL SCIENCES Research Focus: Transcription regulation; nuclear oncogenes and metastasis; molecular diagnostics activity of Wnts and bone morphgenetic proteins 54 55

32 Cancer Center Research Program Leaders and Members Cancer Center Research Program Leaders and Members Margaret Clayton, PhD, APRN (CCPS) ASSOCIATE PROFESSOR OF NURSING/ACUTE AND CHRONIC CARE Research Focus: Cancer communications with breast cancer survivors Adam Cohen, MD (ET) ASSISTANT /ONCOLOGY Research Focus: Personalizing treatment decisions for brain and breast cancer Michael Cohen, MD (CRR) PROFESSOR OF PATHOLOGY/ ANATOMIC PATHOLOGY Research Focus: Signaling pathways in prostate cancer as a prelude to the development of better therapeutic strategies and approaches Howard Colman, MD, PhD (ET) ASSOCIATE PROFESSOR OF NEUROSURGERY/ ADULT NEUROSURGERY Research Focus: Treatment of primary and metastatic brain tumors Jorge Contreras, JD (CCPS) ASSOCIATE PROFESSOR OF LAW Research Focus: Gene patenting, particularly the Myriad Genetics case involving the patenting of the BRCA1/2 breast/ovarian cancer genes and alleles Kathleen Cooney, MD (CCPS) H. A. AND EDNA BENNING PRESIDENTIAL ENDOWED CHAIR Research Focus: Furthering the ability to identify genetic defects in sporadic and hereditary prostate cancer Samir Courdy, MBA (NPA) Research Focus: Director of Research Informatics Shared Resource Daniel Couriel, MD (ET) /HEMATOLOGY AND HEMATOLOGIC MALIGNANCIES HUNTSMAN CANCER INSTITUTE ENDOWED PROFESSORSHIP IN ADULT LEUKEMIA RESEARCH Research Focus: Bone marrow transplantation; acute and chronic graft-versus-host disease Karen Curtin, PhD, M.Stat (CCPS) RESEARCH ASSISTANT PROFESSOR OF MEDICINE/GENETIC EPIDEMIOLOGY Research Focus: Genetic and epigenetic risk factors for cancer and their relationship to environmental influences Brian Dalley, PhD (NPA) Research Focus: Director of High-Throughput Genomics and Bioinformatic Analysis Shared Resource Michael Deininger, MD, PhD (ET) /HEMATOLOGY AND HEMATOLOGIC MALIGNANCIES M.M. WINTROBE Research Focus: Molecular therapy of hematologic malignancies: target and drug discovery; biomarkers to predict clinical response Gary Donaldson, PhD (CCPS) PROFESSOR OF ANESTHESIOLOGY Research Focus: Substantive and methodological integration in the fields of acute and chronic pain, cancer, and quality of life in progressive disease Lee Ellington, PhD (CCPS) ASSOCIATE PROFESSOR OF NURSING/ACUTE AND CHRONIC CARE Research Focus: Patient-provider communication psycho-oncology Michael Engel, MD, PhD, FAAP (NC) ASSISTANT PROFESSOR OF PEDIATRICS/ PEDIATRIC HEMATOLOGY/ONCOLOGY Research Focus: Molecular pathogenesis of acute leukemias and the perturbations of regulatory relationships that govern normal hematopoiesis Kimberley Evason, MD, PhD (CRR) ASSISTANT PROFESSOR OF PATHOLOGY/ ANATOMIC PATHOLOGY Research Focus: Mechanism of HCC initiation and progression and identifying potential treatments for HCC using a combination of approaches, including human tissue, cultured human cells, and zebrafish models Rachel Factor, MD, MHS (CRR) ASSISTANT PROFESSOR OF PATHOLOGY/ ANATOMIC PATHOLOGY Research Focus: Breast cancer pathology Angela Fagerlin, PhD (CCPS) PROFESSOR OF POPULATION HEALTH SCIENCES Research Focus: Methods to improve shared decision making regarding cancer screening and cancer treatment between patients and their physicians Bingjian Feng, PhD (NPA) RESEARCH ASSISTANT PROFESSOR OF DERMATOLOGY Research Focus: Epidemiology and genetic epidemiology of complex diseases; development of bioinformatic and statistical tools for analysis of largescale genomic data Chris Fillmore, PhD (NPA) Research Focus: Managing the Biorepository and Molecular Pathology Shared Resource to obtain biospecimens related to cancer research and provide these materials to support research at HCI Mark Fluchel, MD (CCPS) ASSOCIATE PROFESSOR OF PEDIATRICS/ PEDIATRIC HEMATOLOGY/ONCOLOGY Research Focus: Cancer clinical trials in pediatric patients Timothy Formosa, PhD (NC) PROFESSOR OF BIOCHEMISTRY Research Focus: DNA replication in yeast Raphael Franzini, PhD (ET) ASSISTANT PROFESSOR OF MEDICINAL CHEMISTRY Research Focus: Development of DNA-encoded libraries as an advanced tool for drug discovery and the pursuit of ligand-targeted therapeutics as anticancer drugs Adam Frost, MD, PhD (CRR) ADJUNCT ASSISTANT PROFESSOR OF BIOCHEMISTRY Research Focus: Mechanisms of cellular physiology; how malignancy changes these mechanisms Daniel Fults, MD (CRR) PROFESSOR OF NEUROSURGERY/ ADULT NEUROSURGERY Research Focus: Defective signaling in medulloblastoma David Gaffney, MD, PhD (ET) PROFESSOR OF RADIATION ONCOLOGY Research Focus: Radiotherapy for gynecology, breast, and lymphoma Ignacio Garrido-Laguna, MD, PhD (ET) ASSISTANT /ONCOLOGY Research Focus: Pancreatic ductal adenocarcinoma (PDA) Jason Gertz, PhD (NC) ASSISTANT PROFESSOR OF ONCOLOGICAL SCIENCES Research Focus: How gene regulation is impacted during cancer progression Hamidreza Ghandehari, PhD (ET) PROFESSOR OF PHARMACEUTICS AND PHARMACEUTICAL CHEMISTRY Research Focus: Design of new polymers for gene therapy of head and neck cancer David Goldgar, PhD (CCPS) RESEARCH PROFESSOR OF DERMATOLOGY Research Focus: Genetic studies of breast cancer and melanoma; clinical classification of BRCA1 and BRCA2 Kent Golic, PhD (NC) PROFESSOR OF BIOLOGY Research Focus: Drosophila genetics; chromosome structure and function Barbara Graves, PhD (NC) PROFESSOR OF ONCOLOGICAL SCIENCES Research Focus: DNA-protein interactions; eukaryotic transcriptional regulation Tom Greene, PhD (NPA) PROFESSOR OF POPULATION HEALTH SCIENCES, DIVISION OF BIOSTATISTICS H. A. AND EDNA BENNING PRESIDENTIAL ENDOWED CHAIR Research Focus: Director of Cancer Biostatistics Shared Resource Douglas Grossman, MD, PhD (CRR) PROFESSOR OF DERMATOLOGY Research Focus: Apoptotic mechanisms underlying skin cancer development, with focus on apoptosis and cell cycle regulator Survivin; oxidative stress in melanoma Allie Grossmann, MD, PhD (CRR) ASSISTANT PROFESSOR OF PATHOLOGY/ ANATOMIC PATHOLOGY Research Focus: Mechanisms of cancer disease progression; Identification and development of therapeutic interventions Kenneth Grossmann, MD, PhD (ET) ASSISTANT /ONCOLOGY Research Focus: Demethylase enzyme complex and other signaling pathways in melanoma tumors David Grunwald, PhD (NC) PROFESSOR OF HUMAN GENETICS HELEN LOWE BAMBERGER COLBY PRESIDENTIAL ENDOWED CHAIR IN HUMAN GENETICS Research Focus: Cell differentiation in the zebrafish Sumati Gupta, MD (ET) INSTRUCTOR OF MEDICINE/ONCOLOGY Research Focus: Bladder cancer Ahmad Halwani, MD (ET) ASSISTANT / HEMATOLOGY/BMT Research Focus: Immunotherapy/immunomodulation as a therapeutic modality for cancer treatment Chris Hanrahan, MD, PhD (NPA) ASSISTANT PROFESSOR OF RADIOLOGY Research Focus: Molecular imaging for musculoskeletal disease Heidi Hanson, PhD, MS (CCPS) RESEARCH ASSISTANT PROFESSOR OF FAMILY AND PREVENTIVE MEDICINE/PUBLIC HEALTH Research Focus: Healthy aging and longevity by understanding genetic and environmental determinants of health throughout the life course Mia Hashibe, PhD (CCPS) ASSOCIATE PROFESSOR OF FAMILY AND PREVENTIVE MEDICINE/PUBLIC HEALTH Research Focus: Global and molecular epidemiology of cancer Christopher Hill, PhD (NC) DISTINGUISHED PROFESSOR OF BIOCHEMISTRY DR. LEO T. SAMUELS AND BARBARA K. SAMUELS PRESIDENTIAL ENDOWED CHAIR IN BIOCHEMISTRY Research Focus: Structure and mechanisms of proteins that function in proteasome activation; nucleosome remodeling and reorganization John Hoffman, MD (ET) PROFESSOR OF RADIOLOGY/ CLINICAL RADIOLOGY WILLARD SNOW HANSEN PRESIDENTIAL ENDOWED CHAIR IN CANCER RESEARCH ESTABLISHED IN LOVING MEMORY BY HIS DAUGHTER, MARY BOESCHE Research Focus: Molecular imaging; PET imaging; imaging of cancer-associated physiologic changes and complications John Hoidal, MD (NPA) CLARENCE M. AND RUTH N. BIRRER PRESIDENTIAL ENDOWED CHAIR IN THE SCHOOL OF MEDICINE IN MEMORY OF DR. AND MRS. A.J. NIELSON, DR. KARL O. NIELSON, DR. KENNETH A. NIELSON, DR. PAUL E. NIELSON, AND MR. DOUGLAS W. NIELSON Research Focus: Genetic and molecular basis for nicotine addiction and the consequences of cigarette smoking Sheri Holmen, PhD (CRR) ASSOCIATE PROFESSOR OF SURGERY/ GENERAL SURGERY Research Focus: To identify and validate novel molecular targets for cancer therapy Nan Hu, PhD, MS (CCPS) RESEARCH ASSISTANT / EPIDEMIOLOGY Research Focus: Statistical methodology in diagnostic/ prognostic study in clinical trials in survival analysis and their application to cancer diagnosis and screening L. Eric Huang, MD, PhD (NC) ASSOCIATE PROFESSOR OF NEUROSURGERY/ ADULT NEUROSURGERY Research Focus: Tumor hypoxia and molecular mechanisms underlying tumorigenesis and progression Chris Ireland, PhD (ET) PROFESSOR OF MEDICINAL CHEMISTRY Research Focus: Cancer genetics; marine natural products Margit Janat-Amsbury, MD, PhD (ET) RESEARCH ASSISTANT PROFESSOR OF OBSTETRICS AND GYNECOLOGY/ GYNECOLOGIC ONCOLOGY Research Focus: Novel, mainly nanotechnology-based systems for clinical cancer therapy Jakob Jensen, PhD (CCPS) ASSISTANT PROFESSOR OF COMMUNICATIONS Research Focus: Cancer communication; psychometrics of key cancer constructs; design and behavioral interventions Randy Jensen, PhD (ET) PROFESSOR OF NEUROSURGERY/ ADULT NEUROSURGERY Research Focus: Brain tumor angiogenesis and hypxoxia Kevin Jones, MD (NC) ASSISTANT PROFESSOR OF ORTHOPAEDICS Research Focus: Mesenchymal transformation; sarcoma progression Dan Kadrmas, PhD (ET) PROFESSOR OF RADIOLOGY Research Focus: Biomaterials and drug delivery; positron emission tomography (PET) imaging Julie Kadrmas, PhD (CRR) RESEARCH ASSISTANT PROFESSOR OF ONCOLOGICAL SCIENCES Research Focus: Cell adhesion and migration in cancer Kimberly Kaphingst, ScD (CCPS) PROFESSOR OF COMMUNICATIONS Research Focus: Communicating genetic and genomic information related to cancer risk Deanna Kepka, PhD, MPH, MA (CCPS) ASSISTANT PROFESSOR OF NURSING/ACUTE AND CHRONIC CARE Research Focus: Cervical cancer prevention and control, specifically HPV vaccination; prevention of cancerrelated disparities among vulnerable populations Hung Khong, MD (ET) ASSOCIATE /ONCOLOGY Research Focus: Cancer immunotherapy; epigenetic modulation 56 57

33 Cancer Center Research Program Leaders and Members Cancer Center Research Program Leaders and Members Sung Wan Kim, PhD (ET) DISTINGUISHED PROFESSOR OF PHARMACEUTICS AND PHARMACEUTICAL CHEMISTRY Research Focus: Medical polymers and drug delivery; angiogenesis targeting Anne Kirchhoff, PhD, MPH (CCPS) ASSISTANT PROFESSOR OF PEDIATRICS/ PEDIATRIC HEMATOLOGY/ONCOLOGY Research Focus: How cancer affects social and economic outcomes for childhood cancer survivors Wendy Kohlmann, MA (NPA) Research Focus: Director of Genetic Counseling Shared Resource Jindrich Kopecek, MD (ET) DISTINGUISHED PROFESSOR OF PHARMACEUTICS AND PHARMACEUTICAL CHEMISTRY Research Focus: Biomaterials and drug delivery Tibor Kovacsovics, MD (ET) /HEMATOLOGY/BMT Research Focus: Prevention and treatment of acute lymphoblastic leukemia (ALL), acute myeloid leukemia (AML), and multiple myeloma Lori Kowaleski-Jones, PhD (NPA) ASSOCIATE PROFESSOR OF FAMILY AND CONSUMER STUDIES Research Focus: Cancer-related associations between the social environment and energy balance, physical activity, and obesity Paul LaStayo, PhD (CCPS) PROFESSOR OF PHYSICAL THERAPY Research Focus: Aging cancer patients and survivors Sancy Leachman, MD, PhD (CCPS) ADJUNCT PROFESSOR OF DERMATOLOGY Research Focus: Melanoma genetics translation Amy Lee, PhD (CCPS) VISITING INSTRUCTOR OF FAMILY AND PREVENTIVE MEDICINE Research Focus: Utilize etiological information, identify interventions, perform controlled trials, and establish sustainable interventions in the population to improve cancer prevention measures and quality of life for cancer patients Catherine Lee, MD (CCPS) ASSISTANT / HEMATOLOGY AND HEMATOLOGIC MALIGNANCIES Research Focus: Expression and function of T-cell immunoglobulin and mucin domain-3 (TIM-3), a candidate biomarker of acute myeloid leukemia stem cells Elizabeth Leibold, PhD (NC) /HEMATOLOGY/BMT Research Focus: Gene regulation by stress Mark Leppert, PhD (CCPS) DISTINGUISHED PROFESSOR OF HUMAN GENETICS Research Focus: Melanoma genetics translation; human genetics Alexander Lex, PhD (NPA) ASSISTANT PROFESSOR OF COMPUTER SCIENCE Research Focus: Visual analysis of biological data, bioinformatics, and human computer interaction Dean Li, MD, PhD (CRR) / CARDIOVASCULAR MEDICINE Research Focus: Signaling in angiogenesis; targeting angiogenesis in cancer Carol Lim, PhD (CRR) ASSOCIATE PROFESSOR OF PHARMACEUTICS AND PHARMACEUTICAL CHEMISTRY Research Focus: Targeting apoptotic mechanisms in cancer cells Lauri Linder, PhD (CCPS) ASSISTANT PROFESSOR OF NURSING/ACUTE AND CHRONIC CARE Research Focus: Symptom management for children and adolescents with an emphasis on the use of technology to support symptom assessment and interventions Shane Lloyd, MD (NPA) ASSISTANT PROFESSOR OF RADIATION ONCOLOGY Research Focus: Comparative effectiveness research to determine the best ways to combine treatment modalities in cancer care; bibliometric analysis of clinical trial research questions, enrollment, and funding; guideline creation and use Ryan Looper, PhD (ET) ASSOCIATE PROFESSOR OF CHEMISTRY Research Focus: Synthesis of new compounds with under-utilized or under-appreciated mechanisms of action, with a particular interest in natural productinspired compounds that cause zinc-dyshomeostasis in cancer cells Ana Maria Lopez, MD, MPH (CCPS) /ONCOLOGY Research Focus: Collaborative research to inform access to care with a focus on integrative oncology William Lowrance, MD, MPH (CCPS) ASSISTANT PROFESSOR OF SURGERY/UROLOGY Research Focus: Surgical treatment of urologic malignancies Gabor Marth, DSc (CCPS) PROFESSOR OF HUMAN GENETICS Research Focus: Computational biology; genomic variant identification and interpretation Cindy Matsen, MD (NPA) ASSISTANT PROFESSOR OF SURGERY/ GENERAL SURGERY Research Focus: How patients perceive and understand their disease and management and how we can influence these perceptions through better communication and education Martin McMahon, PhD (CRR) PROFESSOR OF DERMATOLOGY Research Focus: Signal transduction, oncogenes, tumor suppressors, experimental therapeutics, and mouse models of cancer Michelle Mendoza, PhD (CRR) ASSISTANT PROFESSOR OF ONCOLOGICAL SCIENCES Research Focus: Biochemical signaling mechanisms that control the cytoskeletal changes of cell motility Rodney Miles, MD, PhD (NC) ASSISTANT PROFESSOR OF PATHOLOGY/ CLINICAL PATHOLOGY Research Focus: Role of gene copy number changes in the biology; prognosis of pediatric lymphoblastic leukemia and Burkitt lymphoma Geraldine Mineau, PhD, MPH (CCPS) RESEARCH PROFESSOR OF ONCOLOGICAL SCIENCES Research Focus: Epidemiology of cancer Marcus Monroe, MD (CCPS) ASSISTANT PROFESSOR OF SURGERY/ OTOLARYNGOLOGY Research Focus: Survivorship in head and neck and thyroid cancer; thyroid cancer risk stratification; HPV head and neck cancers Kathleen Mooney, PhD, RN (CCPS) DISTINGUISHED PROFESSOR OF NURSING/ACUTE AND CHRONIC CARE LOUIS S. PEERY, MD, AND JANET B. PEERY PRESIDENTIAL ENDOWED CHAIR IN NURSING RESEARCH Research Focus: Quality of life; prevention adherance behaviors; cancer symptom experience Philip Moos, MD, MPH (CRR) ASSOCIATE PROFESSOR OF PHARMACOLOGY AND TOXICOLOGY Research Focus: Redox dysregulation in cancer; selenoprotein function in cancer Glen Morrell, MD, PhD (ET) ASSOCIATE PROFESSOR OF RADIOLOGY/ CLINICAL RADIOLOGY Research Focus: Breast MRI and MRI characterization of breast cancer Kathryn Morton, MD (ET) PROFESSOR OF RADIOLOGY/ CLINICAL RADIOLOGY Research Focus: Molecular imaging; PET imaging; imaging of cancer-associated physiologic changes and complications Sean Mulvihill, MD (ET) PROFESSOR OF SURGERY/GENERAL SURGERY ROSS R. ANDERSON, MD, PRESIDENTIAL ENDOWED CHAIR IN SURGERY ESTABLISHED BY ELLIOTT V. ANDERSON IN HONOR OF HIS FATHER Research Focus: Biology of pancreatic cancer L. Charles Murtaugh, PhD (CRR) ASSOCIATE PROFESSOR OF HUMAN GENETICS Research Focus: Pancreatic development and cancer Maureen Murtaugh, PhD (NPA) ASSOCIATE / EPIDEMIOLOGY Research Focus: Nutrition epidemiology in cancer Deborah Neklason, PhD (CCPS) RESEARCH ASSOCIATE PROFESSOR OF MEDICINE/GENETIC EPIDEMIOLOGY Research Focus: Genetic etiology of colon cancer Ryan O Connell, PhD (NC) ASSISTANT PROFESSOR OF PATHOLOGY/ MICROBIOLOGY AND IMMUNOLOGY Research Focus: Roles of noncoding RNAs in leukemia and tumor immunity Thomas O Hare, PhD (CRR) RESEARCH ASSOCIATE PROFESSOR OF MEDICINE/HEMATOLOGY/BMT Research Focus: Target discovery and inhibitor development for chronic and acute leukemias; mechanism-based targeting of leukemic cells, including leukemia stem cells; design, validation, and coordination of function-first profiling for new therapeutic target in leukemia John O Shea, PhD (NPA) Research Focus: Quickly obtaining patient specimens to enable researchers to integrate real-time molecular testing into clinical trial protocols and providing basic researchers with a vast repository of clinically relevant samples Trudy Oliver, PhD (CRR) ASSISTANT PROFESSOR OF ONCOLOGICAL SCIENCES Research Focus: Mouse models of lung cancer; chemotherapeutic resistance; p53 regulation Shawn Owen, PhD (ET) ASSISTANT PROFESSOR OF PHARMACEUTICS AND PHARMACEUTICAL CHEMISTRY Research Focus: Creating biopharmaceuticals (e.g., antibodies, growth factors) that can be used for cancer diagnosis and treatment Dennis Parker, PhD (ET) PROFESSOR OF RADIOLOGY MARK H. HUNTSMAN ENDOWED CHAIR IN ADVANCED MEDICAL TECHNOLOGIES Research Focus: MR angiography; MRI scanner design; MRI guided thermal ablation of tumors Marc Porter, PhD (ET) PROFESSOR OF CHEMISTRY Research Focus: Innovations in nanotechnology for creating ultrasensitive and real-time assays to detect cancer markers, including PSA and pancreatic cancer Josef Prchal, MD (ET, NC) /HEMATOLOGY/BMT CHARLES A. NUGENT, JR, MD, AND MARGARET NUGENT CHAIR IN MEDICINE Research Focus: Germ line and somatic mutations leading to myeloproliferative disorders Elizabeth Raetz, MD (ET) PROFESSOR (CLINICAL) OF PEDIATRICS/ PEDIATRIC HEMATOLOGY/ONCOLOGY Research Focus: Treatment of all pediatric cancers and hematologic disorders, with an emphasis on acute lymphoblastic leukemia (ALL) and lymphoma R. Lor Randall, MD, FACS (ET) PROFESSOR OF ORTHOPAEDICS L.B. AND OLIVE S. YOUNG ENDOWED CHAIR FOR CANCER RESEARCH Research Focus: Genetics of sarcoma Jody Rosenblatt, PhD (CRR) ASSOCIATE PROFESSOR OF ONCOLOGICAL SCIENCES H.A. AND EDNA BENNING PRESIDENTIAL ENDOWED CHAIR Research Focus: Mechanisms and regulation of cell death and division; novel mechanisms for initiating tumor cell metastasis Erin Rothwell, PhD (CCPS) RESEARCH ASSISTANT PROFESSOR OF NURSING, HEALTH SYSTEMS AND COMMUNITY-BASED CARE DIVISION Research Focus: Cancer support groups and biobehavioral models for improving quality of life for individuals with cancer June Round, PhD (CRR) ASSISTANT PROFESSOR OF PATHOLOGY/ MICROBIOLOGY AND IMMUNOLOGY Research Focus: How the microbiota influences the immune response Randall Rupper, MD, MPH (CCPS) ASSOCIATE PROFESSOR OF MEDICINE/GERIATRICS Research Focus: Cancer screening, diagnosis, and treatment decisions of older adults Jared Rutter, PhD (NC) PROFESSOR OF BIOCHEMISTRY DEE GLEN AND IDA W. SMITH ENDOWED CHAIR IN CANCER RESEARCH Research Focus: Metabolic signaling N. Jewel Samadder, MD, MSc (CCPS) ASSISTANT / GASTROENTEROLOGY Research Focus: Gastrointestinal cancer syndromes; endoscopic oncology Wade Samowitz, MD (CCPS) PROFESSOR OF PATHOLOGY/ ANATOMIC PATHOLOGY Research Focus: Colorectal cancer genetics Courtney Scaife, MD (ET) ASSOCIATE PROFESSOR OF SURGERY/ GENERAL SURGERY Research Focus: Pancreas cancer modeling; mechanisms of metastases Joshua Schiffman, MD (NC) ASSOCIATE PROFESSOR OF PEDIATRICS/ PEDIATRIC HEMATOLOGY/ONCOLOGY Research Focus: Pediatric hereditary cancer syndromes with a special interest in genetic susceptibility to childhood cancers Paul Shami, MD (ET) /HEMATOLOGY/BMT Research Focus: Nitric oxide and hematopoietic cell biology; acute leukemia; myelodysplastic syndromes 58 59

34 Cancer Center Research Program Leaders and Members Wesley Sundquist, PhD (CRR) JON AND KAREN HUNTSMAN PRESIDENTIAL PROFESSOR IN CANCER RESEARCH Research Focus: Membrane trafficking; cytokinesis Research Focus: Phase I clinical trials; development and testing of new cancer therapies; treatment of patients with gastrointestinal cancers and rare tumors Sankar Swaminathan, MD (NC) /ONCOLOGY Jill Shea, PhD (NPA) RESEARCH ASSISTANT PROFESSOR OF SURGERY/GENERAL SURGERY Research Focus: Better understanding of the importance of tumor-stroma interactions in the progression of pancreas cancer; improve patient care by developing new imaging and treatments Dennis Shrieve, MD, PhD (ET) PROFESSOR OF RADIATION ONCOLOGY DR. DON MERRILL REES ENDOWED CHAIR IN THE DIVISION OF INFECTIOUS DISEASES FOR THE INVESTIGATION OF VECTOR BORNE DISEASES Mark Yandell, PhD (CCPS) /HEMATOLOGY/BMT Dean Tantin, PhD (NC) Research Focus: Mammalian gene regulation in cancer Sean Tavtigian, PhD (CCPS) PROFESSOR OF ONCOLOGICAL SCIENCES JON AND KAREN HUNTSMAN PRESIDENTIAL PROFESSOR IN CANCER RESEARCH ASSISTANT PROFESSOR OF PATHOLOGY/ ANATOMIC PATHOLOGY Research Focus: How changes in cellular identity affect cancer progression and response to therapy Carl Thummel, PhD (NC) ASSISTANT PROFESSOR OF HUMAN GENETICS Research Focus: Cell polarity; cell migration and the role of proteases in cancer PROFESSOR OF PEDIATRICS RESEARCH ASSISTANT PROFESSOR OF RADIOLOGY Research Focus: Targeted therapeutics for advanced cancers; design of theranostics for cancer imaging and therapy John Ward, MD (ET) /ONCOLOGY Research Focus: Breast cancer prevention trials; breast cancer treatment guidelines Sharon Weinstein, MD, FAAHPM (NPA) PROFESSOR OF ANESTHESIOLOGY Yelena Wu, PhD, MA (CCPS) PROFESSOR OF HUMAN GENETICS H.A. AND EDNA BENNING PRESIDENTIAL ENDOWED CHAIR Research Focus: Computational genomics tools for personalized medicine, cancer, infectious disease, population biology, agriculture, and forensics Jiyuan Yang, PhD (NPA) RESEARCH PROFESSOR OF PHARMACEUTICS AND PHARMACEUTICAL CHEMISTRY Research Focus: New combination on several animal models, including transgenic mouse model for pancreatic cancer treatment and acute myeloid leukemia treatment Research Focus: Pain, neuropathic pain, palliative care, and end-of-life care Jeffrey Yap, PhD (ET) Alana Welm, PhD (CRR) Research Focus: Evaluation and characterization of therapeutic response using imaging biomarkers ASSOCIATE PROFESSOR OF ONCOLOGICAL SCIENCES RESEARCH ASSOCIATE PROFESSOR OF RADIOLOGY/ CLINICAL RADIOLOGY 0000C CHANGING THE DNA OF CANCER CARE Help drive research even faster. Show our community you help fund cutting-edge science with a Huntsman Cancer Institute specialty license plate. HERE S HOW Research Focus: Tumor inflammation and cancer, particularly breast cancer Jaehee Yi, PhD (NPA) Research Focus: Gene expression; steroid hormone action Bryan Welm, PhD (CRR) Research Focus: Young adult survivors of childhood cancer; Photovoice methodology; post-traumatic stress and growth 1. Go to dmv.utah.gov. Guy Zimmerman, MD (CRR) 2. Click Special Group Plates. Research Focus: Cell adhesion and inflammation; thrombosis in cancer 3. Select Cancer Research, then follow the instructions. Katharine Ullman, PhD (CRR) PROFESSOR OF ONCOLOGICAL SCIENCES Research Focus: Cell division, biomarkers, and tumor suppressors in breast cancer Cornelia Ulrich, PhD, MS (CCPS) ASSOCIATE PROFESSOR OF SURGERY/ GENERAL SURGERY Research Focus: Breast cancer stem cells; cancer drug screening Ming Wen, PhD (CCPS) ASSISTANT PROFESSOR OF SOCIAL WORK /PULMONARY ASSISTANT PROFESSOR OF SOCIOLOGY Research Focus: Socio-environmental influences on health, including cancer ASSISTANT PROFESSOR OF ONCOLOGICAL SCIENCES JON AND KAREN HUNTSMAN PRESIDENTIAL PROFESSOR IN CANCER RESEARCH Theresa Werner, MD (ET) Research Focus: Cell survival and migration during embryogenesis and cancer Research Focus: Colorectal cancer; exercise and cancer ASSISTANT PROFESSOR OF MEDICINE/ONCOLOGY Research Focus: High risk breast/ovarian cancer NC: NUCLEAR CONTROL OF CELL GROWTH AND DIFFERENTIATION PROGRAM CRR: CELL RESPONSE AND REGULATION PROGRAM ET: EXPERIMENTAL THERAPEUTICS PROGRAM CCPS: CANCER CONTROL AND POPULATION SCIENCES PROGRAM 100% of fun ds canc raised go er res t earch o PROFESSOR OF HUMAN GENETICS PROFESSOR OF POPULATION HEALTH SCIENCES DIVISION OF CANCER CONTROL AND POPULATION HEALTH SCIENCES Rodney Stewart, PhD, MPhil (CRR) Research Focus: Molecular pathway for the biogenesis and regulaton of succinate dehydrogenase Xuli Wang, PhD (ET) Research Focus: Molecular epidemiology of cancer Research Focus: Identification and characterization of intermediate-risk and high-risk cancer susceptibility genes, primarily breast, ovarian, and prostate Gillian Stanfield, PhD (CRR) /HEMATOLOGY/BMT Research Focus: Psychological and behavioral factors impacting health self-management within pediatric onology populations, and designing interventions to improve self-management and health outcomes C. SCOTT AND DOROTHY E. WATKINS CHAIR IN PATHOLOGY IN HONOR OF ERNST J. EICHWALD, MD Research Focus: Phase I developmental therapeutics; quality of life assessment; decision making in adolescent and young adult cancer patients Dennis Winge, PhD (NC) ASSISTANT PROFESSOR OF ONCOLOGICAL SCIENCES Research Focus: Neurofibromatosis type 1; malignant peripheral nerve sheath tumor; genetics of familial cancer syndromes ASSOCIATE PROFESSOR OF MEDICINE/EPIDEMIOLOGY Research Focus: Epidemiological methods, environmental and genetic factors affecting cancer development ASSISTANT PROFESSOR OF PEDIATRICS/ PEDIATRIC HEMATOLOGY/ONCOLOGY Katherine Varley, PhD (NC) ASSISTANT PROFESSOR OF FAMILY AND PREVENTIVE MEDICINE/PUBLIC HEALTH ASSOCIATE PROFESSOR OF PATHOLOGY/ MICROBIOLOGY AND IMMUNOLOGY Holly Spraker-Perlman, MD, MS (NPA) Research Focus: Cellular and molecular signals that regulate the differentiation and cell fate decisions of activated T cells in vivo David Viskochil, MD, PhD (NPA) /EPIDEMIOLOGY Eric Snyder, MD, PhD (NC) Research Focus: Novel molecular targets that can be developed for therapeutic intervention strategies ASSISTANT PROFESSOR OF PATHOLOGY/ MICROBIOLOGY AND IMMUNOLOGY Carol Sweeney, PhD (CCPS) Research Focus: New treatment strategies for malignant lymphomas Research Focus: Psychosocial consequences of genetic testing Matthew Williams, PhD (CRR) ASSISTANT PROFESSOR OF SURGERY/ GENERAL SURGERY Research Focus: Post-transcriptional gene regulation in herpes viruses; RNA export Research Focus: Intrinsic radiosensitivity of human tumors; mechanisms of intrinsic cellular resistance to radiation and chemotherapy and combined chemotherapy/radiotherapy PROFESSOR OF FAMILY AND CONSUMER STUDIES Matthew VanBrocklin, PhD (CRR) Research Focus: Characterizing the transcriptional defects in breast cancer that are associated with treatment response and disease progression John Sweetenham, MD, FRCP, FACP (ET) Ken Smith, PhD, MS (CCPS) HUNTSMAN CANCER INSTITUTE ENDOWED CHAIR IN CANCER RESEARCH Martha Slattery, PhD (CCPS) 60 PROFESSOR OF BIOCHEMISTRY 4. Invite your family and friends to help drive cancer research. Sunil Sharma, MD, MBA, FACP (ET) NPA: NON-PROGRAM ALIGNED 61

35 Multidisciplinary Disease Group (MDG) Leaders Multidisciplinary Disease Group (MDG) Leaders Multidisciplinary Disease Groups (MDGs) include specialists such as physicians, surgeons, researchers, genetic counselors, and social workers who meet for weekly patient treatment planning conferences. EXECUTIVE MEDICAL DIRECTOR BREAST MDG GASTROINTESTINAL/ PANCREATIC MDG INVESTIGATIONAL THERAPEUTICS MDG SKIN MDG NEURO-ONCOLOGY MDG John Sweetenham, MD Saundra Buys, MD Edward Nelson, MD PROFESSOR OF SURGERY Courtney Scaife, MD PROFESSOR OF SURGERY Sunil Sharma, MD Robert Andtbacka, MD ASSOCIATE PROFESSOR OF SURGERY Glen Bowen, MD ASSOCIATE PROFESSOR OF DERMATOLOGY Howard Colman, MD, PhD PROFESSOR OF NEUROSURGERY GENITOURINARY MDG GYNECOLOGICAL MDG NEURO-ONCOLOGY MDG (CONT.) THORACIC MDG Neeraj Agarwal, MD ASSOCIATE PROFESSOR OF MEDICINE Christopher Dechet, MD ASSOCIATE PROFESSOR OF SURGERY David Gaffney, MD, PhD PROFESSOR OF RADIATION ONCOLOGY Andrew Soisson, MD PROFESSOR OF OBSTETRICS AND GYNECOLOGY William Couldwell, MD, PhD PROFESSOR OF NEUROSURGERY Randy Jensen, MD, PhD PROFESSOR OF NEUROSURGERY Wallace Akerley, MD Thomas Varghese, MD ASSOCIATE PROFESSOR OF SURGERY HEAD AND NECK MDG HEMATOLOGY/BMT MDG SARCOMA MDG SUPPORTIVE ONCOLOGY AND SURVIVORSHIP MDG Jason Hunt, MD ASSOCIATE PROFESSOR OF SURGERY Daniel Couriel, MD Michael Deininger, MD, PhD Martha Glenn, MD R. Lor Randall, MD PROFESSOR OF SURGERY Anna Beck, MD 62 63

36 Disease-Oriented Research Team (DOT) Leaders Disease-Oriented Research Team (DOT) Leaders Disease-Oriented Research Teams (DOTs) support collaboration and advancements by bringing together laboratory, clinical, and population scientists with expertise in specific disease areas. SENIOR DIRECTOR TRANSDISCIPLINARY RESEARCH COLON CANCER DOT GENITOURINARY MALIGNANCIES DOT NEURO-ONCOLOGY DOT PANCREATIC CANCER DOT Michael Deininger, MD, PhD Ignacio Garrido-Laguna, MD, PhD ASSOCIATE PROFESSOR OF MEDICINE Cornelia Ulrich, PhD PROFESSOR OF POPULATION HEALTH SCIENCES Jonathan Tward, MD, PhD ASSOCIATE PROFESSOR OF RADIATION ONCOLOGY Howard Colman, MD, PhD PROFESSOR OF NEUROSURGERY Randy Jensen, MD, PhD PROFESSOR OF NEUROSURGERY Matthew Firpo, PhD RESEARCH ASSOCIATE PROFESSOR OF SURGERY Charles Murtaugh, PhD ASSOCIATE PROFESSOR OF HUMAN GENETICS GENITOURINARY MALIGNANCIES DOT (CONT.) HEMATOLOGIC MALIGNANCIES DOT PANCREATIC CANCER DOT (CONT.) SARCOMA DOT UPPER AERODIGESTIVE TRACT DOT Will Lowrance, MD, MPH ASSOCIATE PROFESSOR OF SURGERY Thomas O Hare, PhD ASSOCIATE PROFESSOR OF MEDICINE Elizabeth Raetz, MD PROFESSOR OF PEDIATRICS Paul Shami, MD Courtney Scaife, MD PROFESSOR OF SURGERY R. Lor Randall, MD PROFESSOR OF SURGERY Jeffrey Yap, PhD RESEARCH ASSOCIATE PROFESSOR OF RADIOLOGY Wallace Akerley, MD HEPATOBILIARY CANCERS WORKING GROUP MELANOMA DOT UPPER AERODIGESTIVE TRACT DOT (CONT.) WOMEN S CANCERS DOT Robin Kim, MD PROFESSOR OF SURGERY Robert Andtbacka, MD ASSOCIATE PROFESSOR OF SURGERY Doug Grossman, MD, PhD PROFESSOR OF DERMATOLOGY Sheri Holmen, PhD ASSOCIATE PROFESSOR OF SURGERY Mia Hashibe, PhD ASSOCIATE PROFESSOR OF FAMILY AND PREVENTIVE MEDICINE Marcus Monroe, MD ASSISTANT PROFESSOR OF SURGERY Nicola Camp, PhD David Gaffney, MD, PhD PROFESSOR OF RADIATION ONCOLOGY 64 65

37 Donors DONORS AS OF 9/29/2016 FOUNDING MEMBER *DECEASED Donors FOUNDING MEMBERS 3COM AIR PRODUCTS & CHEMICAL, INC. APPLIED TECHNOLOGY, INC. ARLEN B. CROUCH FAMILY ASHTON FAMILY *F. LEE AND *FRED FOX AUERBACH ELDER AND SISTER M. RUSSELL BALLARD BANKERS TRUST COMPANY MR. AND *MRS. HAVEN J. BARLOW THE JOHN T. BAUMSTARK FAMILY DENISE E. AND JACK BERNHISEL BERTIN FAMILY *MARY HANSEN BOESCHE H. ROGER AND SARA S. BOYER C. SCOTT AND DOROTHY E. WATKINS CHARITABLE BOYD AND JEAN CHRISTENSEN THE CHURCH OF JESUS CHRIST OF LATTER-DAY SAINTS CIBA SPECIALTY CHEMICALS HOWARD AND BETTY CLARK MR. THOMAS W. COLE MICHAEL COLEMAN COMPLETE HEALTHCARE COMMUNICATIONS, INC. MARY ANNE AND FLOYD COOPER CRAIG AND PAMELA CORRY FINKELSTEIN, THOMPSON & LOUGHRAN FLUOR ENTERPRISES, INC. FRANKLIN COVEY CO. *BLANCHE AND *DAVID FREED DR. AND MRS. DAVID P. GARDNER SENATOR AND MRS. JAKE GARN THE GEORGE S. AND DOLORES DORÉ ECCLES THOMAS AND ANNA GERRITY GLAXO WELLCOME, INC. ESTATE OF EVELYN GOOTEE PERRY AND MARTIN GRANOFF PAUL R. AND *ANN C. GREEN SHARON AND RANDY HARMSEN HARRY S. SLOANE L. RUSSELL AND EILEEN HEALY MR. AND MRS. JOHN B. HENKELS HEVERT INDUSTRIES, INC. MR. THORNTON L. HILL JOHN L. HINDS JEFF, STACY, RYAN, TYLER, AND ABIGAIL HORNACEK MARY AND FREDERICK HUBER *RAMONA AND *ALEX HURTADO ICI AMERICAN HOLDINGS INC. THE IMPART GROUP, INC. INTERMOUNTAIN HEALTHCARE *JEFFREY L. S. KOO GERALD G. KRUEGER, MD AND MELISSA WEIDNER BARBARA AND FRANK LAYDEN *MERLINE CLARK LEAMING DIANA W. AND *RICHARD E. LEE, MD ANN-MARIE AND ROBERT LENCE ESTATE OF JAMES B. LENDALL H. WILLIAM LICHTENBERGER MS. NANCY LIEBERMAN MR. AND MRS. STEVEN J. LUND M. HOLLAND COMPANY *COACH RICK MAJERUS KARL AND KAY MALONE MARSH USA, INC. *SUSAN A. MARTIN IN MEMORY OF THOMAS KEARNS MCCARTHEY, GIVEN BY HIS FAMILY MARIE AND MURRAY MCCOMAS CONSTANCE AND FRANCIS MADSEN NANCEE AND WILLIAM MADSEN MR. LOUIS J. MARSCHAK MR. AND MRS. JOHN D. MELLOTT THE MITCHELL AND JUNE MORRIS IN HONOR OF BENJAMIN EDWARD MORAN, GIVEN BY JOHN A. MORAN MR. AND MRS. JOHN MORGAN FRED AND LUCY MORETON IN LOVING MEMORY OF BEN E. RAWLINGS GIVEN BY HIS FAMILY MARILEE RAWLINGS ANDERSON JULIE RAWLINGS BAGLEY MICHELLE RAWLINGS HUNTSMAN DAVID B. RAWLINGS R. SCOTT RAWLINGS MARY LOUISE RAWLINGS RANDALL M. RAWLINGS STEPHEN M. RAWLINGS DR. J. CHARLES AND *JASMINE FREED RICH AND FAMILY MR. AND MRS. BRIAN RIDD JOY W. AND ODELL F. RIGBY, MD ROSALIE AND MICHAEL RINGWOOD THE ROBERT I. WISHNICK HAZEL M. ROBERTSON ROCKY MOUNTAIN POWER CHERE AND JOHN ROMNEY *JO AND J. MARK ROSE *EVELYN ROSENBLATT RUBICON, INC. SALOMON SMITH BARNEY THE SAN FRANCISCO BERTRAM H. AND JANET M. SCHAAP SAMUEL D. SCRUGGS DR. HOWARD C. AND MRS. MARJORIE T. SHARP HARRIS H. AND AMANDA P. SIMMONS DAN C. SIMONS FAMILY SANDY AND DON STANUTZ MARGO AND BRENT STEVENSON SUN MICROSYSTEMS TERRY AND JAMES TAYLOR HARU AND *ARTHUR TOIMOTO *MARY LOU UNICE AND FAMILY VAN COTT, BAGLEY, CORNWALL & MCCARTHY VANGUARD MEDIA KAREN AND STEVEN WEST STEVEN AND MARGARET WHEELWRIGHT KENNETH L. WILLIAMS GAIL AND CURTIS WINTERFELD ROBERT WHYTE - AUDANT PROPERTY LIMITED ESTATE OF OLIVE S. YOUNG BENEFACTORS $1,000,000 + THE KERRY PACKER FAMILY JAMES PACKER KHALID AND SALLY ALTURKI AMERICAN CANCER SOCIETY, INC. ARMY MEDICAL RESEARCH ELDER AND SISTER M. RUSSELL BALLARD BEAUMONT OF AMERICA RON AND *JACKIE BOONE THE CHURCH OF JESUS CHRIST OF LATTER-DAY SAINTS CURESEARCH FOR CHILDREN S CANCER INTERMOUNTAIN HEALTHCARE THE J. WILLARD AND ALICE S. MARRIOTT LEUKEMIA AND LYMPHOMA SOCIETY THE LINCY MAJERUS FAMILY IN LOVING MEMORY OF SAMIR E. MARRASH, MD, CARDIOVASCULAR SURGEON, GIVEN BY *GAYE MARRASH IN LOVING MEMORY OF PHILIP ALFORD, GIVEN BY *GAYE MARRASH THE MATHEW B. WORTON AND LADEAN R. WORTON MEMORIAL FUND MICHE BAG, LLC *LARRY AND GAIL MILLER THE MITCHELL AND JUNE MORRIS NIH NATIONAL CANCER INSTITUTE NIH NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES NIH NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT NIH NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES NIH NATIONAL INSTITUTE ON AGING NIH NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH NIH NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES *IDA AND *DEE SMITH JULIE AND RICHIE SMITH RYAN, SCOTT, AND NICHOLAS SMITH SOUTHWEST ONCOLOGY GROUP SPENCER F. KIRK FAMILY STATE OF UTAH *HAROLD AND *ELEANORE STEELE SUSAN G. KOMEN BREAST CANCER THOMAS C. MATHEWS JR. TRUST WITH SPECIAL THANKS TO *LARRY AND DOROTHY MOSS THE VAN HORN FAMILY KEITH, AMY, SABRINA, NICHOLS, AND NOELLE WILLARD L. ECCLES CHARITABLE ZIONS BANK ANONYMOUS PATRONS $500,000 - $999,999 ALEX S LEMONADE STAND *JIM S. BATEMAN BERTIN FAMILY *MARY HANSEN BOESCHE *C. SCOTT AND DOROTHY E. WATKINS CHARITABLE CANCER PREVENTION INSTITUTE OF CALIFORNIA PATRICIA AND WILLIAM CHILD JOHN WAYNE CANCER INSTITUTE AT ST. JOHN S HEALTH CENTER KJZZ 14 SKIP AND KIMBERLY KLINTWORTH DAVID AND JULIE LAYTON THE LAYTON COMPANIES MILLER BUCKFIRE LEWIS & COMPANY, LLC NIH NATIONAL HUMAN GENOME RESEARCH INSTITUTE PAREXEL INTERNATIONAL PINNACLE ENTERTAINMENT R. HAROLD BURTON R.C. WILLEY HOME FURNISHINGS MARY LOUISE AND *BEN E. RAWLINGS MARSHA AND BLAKE ROBINSON SALOMON SMITH BARNEY SARCOMA ALLIANCE FOR RESEARCH THROUGH COLLABORATION THE SDA RON AND JODIE SMART ESTATE OF *HELEN SWALLOW TEE IT UP U.S. DEPARTMENT OF DEFENSE VLCM THE WIGGINS FAMILY WON-DOOR CORPORATION NIKOLAY YANKOVSKY- STYROL CONCERN (UKRAINE) ANONYMOUS ELLIS R. AND KATHRYN MR. AND MRS. THOMAS MUIR *LEE S. SKIDMORE NIH NATIONAL INSTITUTE JOE AND ALEXANDRA DWEK DAMON RUNYON CANCER OF NEUROLOGICAL CIBA SPECIALTY S. IVORY RESEARCH DISORDERS AND STROKE CHEMICALS GUARANTORS NATIONAL BASKETBALL AND CHRISTINE C. HOPE ECCLES AND THE J. PAUL GETTY TRUST ASSOCIATION PUGMIRE-SKIDMORE DESERET POWER $250,000 - $499,999 RANDAL QUARLES ANDY NOORDA COLUMBIA UNIVERSITY JACOBSEN CONSTRUCTION NIKOLAY YANKOVSKY- MR. AND MRS. KATIE ECCLES AND FLUOR ENTERPRISES, INC. SUSAN NOORDA COMMUNITY HEALTH COMPANY, INC. STYROL CONCERN GERALD SLOAN JAMES CARL ALLEN DAVID BURNETT THE FOSTER CHARITABLE CHARITIES OF UTAH ESTATE OF EDITH (UKRAINE) SMITHKLINE BEECHAM OREGON HEALTH AND KAREN AND BRENT KRISTINE AND M. JENNINGS O. C. TANNER COMPANY THE HYRUM AND GAIL SCIENCE UNIVERSITY CUMULUS BARTHOLOMEW SPENCER ECCLES IRA A. AND *MARY THE CAROL M. AND WESLEY OKLAND CONSTRUCTION SMITH FAMILY IN MEMORY OF TERRI CTBC BANK LOU FULTON DIANN BENDER LISA ECCLES A. JOHNSON FAMILY COMPANY *IDA AND *DEE SMITH ANNA PERINE THE *GEORGE AND *SHAREE DEUTSCHE BANK DORIS M. BOMGARDNER SPENCER F. AND MS. BARBARA F. KAMPEN *MS. LARUE OLSEN JULIE AND RICHIE SMITH PI *CLEONE P. ECCLES PAULSON 1997 UNITRUST FIDELITY INVESTMENTS LYNDA AND GARY BRIDGE LINDA AND ILAN KAUFTHAL SUSAN AND STEVE RYAN, SCOTT, AND PRA INTERNATIONAL THE GEORGE S. CHARITABLE FUND EDWARD L. BURTON PAUL E. BROWN DIANE AND MICHAEL KERN PRESCOTT, MD NICHOLAS SMITH AND DOLORES DORÉ QUALTRICS, INC. DR. AND MRS. DAVID CLISE FAMILY ECCLES RALPH E. AND WILLIA P. GARDNER ERIE PLASTICS SKIP AND KIMBERLY *BARBARA B. PRINCE MS. JANNIE SPADER VIRGINIA AND GLAXO WELLCOME, INC. T. MAIN TRUST LYNETTE AND FAIRCHILD-MARTINDALE KLINTWORTH MR. AND MRS. F. *R. STERLING AND GORDON D. COOK HUNTSMAN CORPORATION THE RAY & TYE NOORDA ROBERT GAY, PHD, HARRY KOKI AND CHARLES AMIN, SEATON PRINCE, JR. MARILYN SPAFFORD ETHEL AND CARL DEFOSSE, T. AND ELIZABETH R. AMERICAN PLASTICS THE R. ANTHONY SPENCER F. KIRK HUNTSMAN CORPORATION HRSA RURAL IN LOVING MEMORY MARTINDALE, FOUNDERS INDUSTRIES, LTD. SWEET FAMILY FAMILY EMPLOYEES SIGMA CHI CHAPTERS HEALTH POLICY OF *JAMES WILCOX 66 67

38 Donors DONORS AS OF 9/29/2016 FOUNDING MEMBER *DECEASED Donors RICHARD AND PAMELA DROPEK RICHARD A. AND CAROL M. FAY FREDERIKA HARLIN CHARITABLE REMAINDER UNITRUST STEVE FREDRICKSON DR. WILLIAM M. GASSERT MR. AND MRS. JAMES CRAIG GILBERT LOWELL AND JERRY GLASS PAUL R. AND *ANN C. GREEN CHRISTINA AND MICHAEL GREENBERG SUSAN GREENDORFER MRS. JUDY GRUENBERG, IN LOVING MEMORY OF HER HUSBAND KEITH DOUGLAS AND MARY HADLEY *HAROLD P. HARGREAVES, MD GEOFFREY HASSAN AND SUSAN BOESCH CINDY AND WYATT HAWS NANCY AND ROBERT HAYDEN MARTHA AND CRAIG HEATH RICK JANY JOEL R. AND LISA DIMICK CHARITABLE REMAINDER UNITRUST THE JUDY KELLY AND RICHARD WHITLOCK ENDOWED FUND MR. DONALD KALMAN MRS. RUTH KURZBAUER MILTON AND KAY LARSEN SARAH AND GEORGE LEWIS JULIE LOCKEY SIR ROB AND LADY MARGETTS *GAYE H. MARRASH SIDNEY MCDONALD GREG L. MCEWAN EDITH MCGOVERN DAVID MCGUIRE TAYLOR MILLER MICHAEL MITCHELL AND JEAN MARIE EAGLETON-MITCHELL CHARLOTTE A. PHILLIPS, IN HONOR OF LOTTIE A. PHILLIPS JOHN A. REED *CAROLYN REINBOLD *RICHARD E. ELLISON LIFETIME TRUST JOYCE AND *ROBERT L. RICE NORMA ROHDE ANTOINETTE M. RUTH *BERTRAM H. AND JANET M. SCHAAP JOAN AND ROBERT SELL *JAY A. AND *RUTH R. SMART LAURA AND ALBERT SPICER JANCE STUESSI, IN LOVING MEMORY OF LOUIS RAYMOND WRIGHT KATHY AND TOM TANGNEY HARU AND *ARTHUR TOIMOTO *NORRIS WEIMER WESTERN BOYS BASEBALL ASSOCIATION J. AND JOANNE WILLIAMS JAMES B. WOOD ANONYMOUS PLATINUM $250,000 - $499,999 ALAN B. SLIFKA AMERICAN DIABETES ASSOCIATION ANNE STIRBA CANCER ARMY MEDICAL RESEARCH AND MATERIAL COMMAND BANK OF AMERICA, INC. GLENN AND TANIA BECK BONNEVILLE CYCLING CLUB THE BOSTON CENTURYLINK CISCO SYSTEMS DELOITTE DELTA AIR LINES, INC. DESERET NEWS ALEXANDRA AND JOSEPH DWEK ICON CLINICAL RESEARCH THE J. PAUL GETTY TRUST KAHLERT *MERLINE CLARK LEAMING *SHEILA A. LEE LIDDY SHRIVER SARCOMA INITIATIVE FUND MR. AND MRS. STEVEN J. LUND MAYO CLINIC ROCHESTER SANDRA AND PHILIP MCCARTHEY JOY AND DON NELSON NIH NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES OKLAND CONSTRUCTION COMPANY THE OKLAND FAMILY *CHARLES A. OLIVERIO PLAYING FOR LIFE PEARSON EDUCATION *V. MARK AND *NANCY PETERSON REAUD FAMILY *FRANK W. RENALD SIEMENS MEDICAL SOLUTIONS USA, INC. ST. BALDRICK S SWING FOR LIFE, INC. SYSCO INTERMOUNTAIN FOOD SERVICES, INC. THE TOM AND WILMA PANOS UNIVERSITY OF CALIFORNIA SAN DIEGO UNIVERSITY OF TEXAS AT HOUSTON V FOR CANCER RESEARCH VALUEMOMENTUM VINSON & ELKINS, LLP ESTATE OF OLIVE S. YOUNG ZIONS MANAGEMENT SERVICES COMPANY ANONYMOUS ALLIANCE HEALTH AMERICAN COLLEGE OF GASTROENTEROLOGY AMERICAN SOCIETY OF HEMATOLOGY AMGEN, INC. ANDERS H. BERGVIND ANITA W. BETZ REVOCABLE TRUST ASGAARD ENTERTAINMENT ASHTON FAMILY DELOITTE AUTOLIV CYCLING CLUB BANKERS TRUST COMPANY BARKER FAMILY, INC. BENEFICIAL FINANCIAL GROUP BOBETTE AND VAN BOHNE THE BOYER FAMILY TRUST H. ROGER AND SARA S. BOYER BRISTOL-MYERS SQUIBB JENNIFER AND FRASER BULLOCK C.R. ENGLAND, INC. OSCAR CANTU CHIMERIX, INC. CORBIN AND KARA CHURCH ESTATE OF *JOSEPH C. CLARK JR. CLOVIS ONCOLOGY CODALE ELECTRIC SUPPLY COMCAST COMMUNITY HEALTH CHARITIES OF AMERICA MARY ANNE AND FLOYD COOPER CREDIT SUISSE WILL CRENSHAW CROHN S AND COLITIS OF AMERICA DEVINE RACING, LLC DR. EZEKIEL R. & EDNA WATTIS DUMKE *KATHERINE W. AND EZEKIEL R. DUMKE JR. EDWARD L. BURTON ELYSE PANTKE WHITE FIDELITY FRANCES W. BURTON FRANKLIN COVEY COMPANY FRATERNAL ORDER OF EAGLES *DAVID L. AND BLANCHE FREED ANNA AND THOMAS GERRITY, PHD PERRY AND MARTIN GRANOFF MR. AND MRS. DELL LOY HANSEN HARRY J. LLOYD CHARITABLE TRUST HARRY S. SLOANE HARVARD SCHOOL OF PUBLIC HEALTH HELEN HAY WHITNEY JEFF, STACY, RYAN, TYLER, AND ABIGAIL HORNACEK HUNTSMAN WORLD SENIOR GAMES, INC. DAVID AND MICHELLE HUNTSMAN GOVERNOR AND MRS. JON M. HUNTSMAN JR. PETER AND BRYNN HUNTSMAN ICI AMERICAN HOLDINGS, INC. THE RIGHT REVEREND CAROLYN TANNER IRISH, RET. AND REVEREND FREDERICK QUINN ELLIS R. AND KATHRYN S. IVORY JEANNE & JOEL LEFF, INC. JOHNS HOPKINS UNIVERSITY ROBERT AND ANITA KELEZ FAMILY LISA AND JEFFREY KELLOGG SUSAN AND ROBERT KIMSEY *GLADYS MADSEN KAY AND KARL MALONE JANET AND VINCENT MANCINI MARRIOTT DAUGHTERS LISA AND DAVID MATLIN MELANOMA RESEARCH ALLIANCE MCCARTHEY FAMILY IN MEMORY OF THOMAS KEARNS MCCARTHEY, GIVEN BY HIS FAMILY THE MELANIE LARSEN FAMILY TRUST MERRILL LYNCH & COMPANY, INC. MOFFITT CANCER CENTER IN HONOR OF BENJAMIN EDWARD MORAN, GIVEN BY JOHN A. MORAN *JOHN AND MARGARET MORRIS MOUNTAIN AMERICA CREDIT UNION MPN RESEARCH NATIONAL BASKETBALL ASSOCIATION NOREEN FRASER O. C. TANNER COMPANY GORDON AND *MARCIA OLCH O. DON AND BARBARA B. OSTLER PACIFICORP MARY AND JEFF PETERSON JONIQUE AND *TIG PETERSON THE PHILANTHROPY ROUNDTABLE PROGERIA RESEARCH PROSTATE CANCER QUINTILES TRANSNATIONAL CORPORATION REGENCE BLUECROSS BLUESHIELD OF UTAH THE REGENCE FUND OF THE OREGON COMMUNITY DR. J. CHARLES AND MRS. *JASMINE B. RICH AND FAMILY HAZEL M. ROBERTSON ROCKY MOUNTAIN POWER MAX T. SABOUR SALT LAKE ORGANIZING COMMITTEE WINTER 2002 OLYMPICS SAMUEL WAXMAN CANCER RESEARCH SIGMA CHI BETA EPSILON CHAPTER - UNIVERSITY OF UTAH SIGMA CHI EPSILON - GEORGE WASHINGTON UNIVERSITY SINCLAIR OIL CORPORATION STEIN ERIKSEN LODGE THRASHER RESEARCH FUND ANITA M. TROTTER-COX UNIVERSITÉ LAVAL UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER UNIVERSITY OF CINCINNATI UNIVERSITY OF MICHIGAN UNIVERSITY OF UTAH RESEARCH SANDRA AND SHELDON URLIK UTAH SPORTS COMMISSION UTAH STATE UNIVERSITY VIVINT SMART HOME ARENA THE WALBRIDGE FUND, LTD. WASHINGTON UNIVERSITY IN ST. LOUIS ROBERT WHYTE - AUDANT PROPERTY LIMITED THE WILLIAM AND FLORA HEWLETT THE WILLIAM LAWRENCE AND BLANCHE HUGHES YM BIOSCIENCES, INC. ANONYMOUS SILVER $50,000 - $99,999 AMERICAN SOCIETY FOR GASTROINTESTINAL ENDOSCOPY AMES CONSTRUCTION, INC. MARILEE AND BOYD ANDERSON APPLIED TECHNOLOGY, INC. BEN BARNES *ELAINE AND SCOTT BERGESON BIOMET BOART LONGYEAR COMPANY BONNEVILLE INTERNATIONAL CORPORATION BREAST CANCER RESEARCH OF ALABAMA BRITISH COLUMBIA CANCER AGENCY DALE AND JANEEL BURNINGHAM CAMBIA HEALTH HOWARD AND BETTY CLARK CLISE FAMILY BARBARA AND BILL CHRISMAN DINESH & KALPANA PATEL DIXIE POWER ROSS E. DOAN EAGLE EYE PRODUCE, INC. *MARY B. ELICH MAZILE ENGLAND FAIRCHILD-MARTINDALE, HARRY T. AND ELIZABETH R. MARTINDALE, FOUNDERS FAIRWAYS MEDIA FASSIO EGG FARMS, INC. TAMMY AND JAMES FELT CAROLYN AND KEM GARDNER GIBBS & BRUNS, LLP JOHN A. GODFREY GOLF TO ERADICATE CANCER SUSAN AND EVAN GOODWIN PAUL R. AND *ANN C. GREEN PAM AND SCOTT HALE ELAINE AND BARRY HARMAN SHARON AND RANDY HARMSEN HGGC JOHN L. HINDS ANTHONY AND JULIA EPIC EVENTS GOLD HOPE STREET KIDS RICHARD AND CHRISTENA CARMEN AND ARNOLD MACHINERY MONTAGUE *ELDER AND *SISTER $100,000 - $249,999 DURHAM AND FAMILY RICHARD ROGERS COMPANY *BLAINE AND NANCY DAVID AND TERRIE MOSS DAVID B. HAIGHT MARCH OF DIMES BIRTH HUNTSMAN JAMES L. EASTON DEFECTS *JO AND J. MARK ROSE DARLA AND MIKE ASSMAN CAROL A. NANTKES RAE ANN HAMILTON 3COM INFILISE HOLDINGS, INC. SPENCER F. AND MARRINER S. ECCLES IN MEMORY OF NELL MR. AND *MRS. *BETH NIELSON IBM CORPORATION ACTION DONATIONS *CLEONE P ECCLES LORENE RUSSELL, FN, MS HAVEN J. BARLOW INTERFORM GRAPHICS 68 69

39 Donors DONORS AS OF 9/29/2016 FOUNDING MEMBER *DECEASED Donors JACOBSEN CONSTRUCTION COMPANY, INC. ESTATE OF EDITH M. JENNINGS *CONRAD J. KNOWLES, MD AJAY AND SHAILAJA KRISHNAN LARRY AND JANEENE KRYSTKOWIAK BRENT AND CHRISTIE LAMBERT LEUCADIA NATIONAL CORPORATION H. WILLIAM LICHTENBERGER LOW BOOK SALES MACY S MAGGIE SOTTERO DESIGN *COACH RICK MAJERUS MAKE SOME NOISE: CURE KIDS CANCER MARSH USA, INC. NEAL H. MAYERSON MARIE AND MURRAY MCCOMAS KATHY AND TONY MCCORD DAN W. MCKNIGHT MEGADYNE MEDICAL PRODUCTS, INC. MELANOMA RESEARCH MR. AND MRS. JOHN D. MELLOTT MERIT MEDICAL SYSTEMS METAVIVOR RESEARCH AND SUPPORT, INC. FRED AND LUCY MORETON MUSSELLA FOR BRAIN TUMOR RESEARCH AND INFORMATION MYRIAD GENETICS, INC. N & B FAMILY LTD. PARTNERSHIP NIKE GOLF NORA ECCLES TREADWELL JEANNE OKI *NANCY AND ANTHONY OLIVERIO BONNIE AND JAMES L. PARKIN, MD JENNIFER AND DAVID PARKIN THE PEERY PHARMACEUTICAL PRODUCT DEVELOPMENT, INC. POPP HUTCHESON, PLLC PRIMARY CHILDREN S MEDICAL CENTER SUSAN AND STEPHEN PRESCOTT, MD *MR. AND MRS. F. SEATON PRINCE JR. QUESTAR THE R. ANTHONY SWEET FAMILY IN LOVING MEMORY OF BEN E. RAWLINGS GIVEN BY HIS FAMILY MARILEE RAWLINGS ANDERSON JULIE RAWLINGS BAGLEY MICHELLE RAWLINGS HUNTSMAN DAVID B. RAWLINGS R. SCOTT RAWLINGS MARY LOUISE RAWLINGS RANDALL M. RAWLINGS STEPHEN M. RAWLINGS JOYCE AND *ROBERT L. RICE HELENE AND *ALVIN RICHER RUBICON, INC. CARLOS RUISANCHEZ SHRIDEVI AND PURNA SAGGURTI SALT LAKE CITY MARRIOTT DOWNTOWN ANGELA AND ANTHONY SANFILIPPO *BERTRAM H. AND JANET M. SCHAAP SAMUEL D. SCRUGGS SARCOMA OF AMERICA VIRGINIA E. SHANKS SIGMA CHI ALPHA CHI - PENNSYLVANIA STATE UNIVERSITY SIGMA CHI ALPHA NU - UNIVERSITY OF TEXAS SIGMA CHI DELTA IOTA CHAPTER - UNIVERSITY OF DENVER SIGMA CHI DELTA OMEGA - UNIVERSITY OF TULSA SIGMA CHI ETA ZETA CHAPTER - GEORGIA SOUTHERN UNIVERSITY SIGMA CHI KAPPA BETA - UNIVERSITY OF NORTHERN FLORIDA SIGMA CHI ZETA MU CHAPTER - WESTERN KENTUCKY UNIVERSITY SIGMA CHI ZETA OMICROM - NORTHERN ARIZONA UNIVERSITY HARRIS H. AND AMANDA P. SIMMONS SINCLAIR BROADCAST GROUP, INC. SKADDEN, ARPS, SLATE, MEAGHER & FLOM, LLP MR. AND MRS. GERALD SLOAN DOROTHA SMART SMILES FOR LIFE BOYD C. AND JILL J. SMITH KAREN AND SCOTT SMITH SOCCER FOR HOPE SORENSON DEVELOPMENT MARY S. SOUVALL STAMPIN UP! STERLING AND SHELLI GARDNER STORM PRODUCTS, INC. SUN MICROSYSTEMS COMPUTER CORPORATION MAJOR GENERAL DAVID TANZI, USAF, RET. IN HONOR OF MARIA A. TORRES, GIVEN BY THE SKOLNICK SHARON K. THOMPSON JUDY AND LARRY TILLERY HARU AND *ARTHUR TOIMOTO UNITED WAY OF SALT LAKE UNIVERSITY OF ALABAMA AT BIRMINGHAM UNIVERSITY OF BRITISH COLUMBIA UNIVERSITY OF CALIFORNIA SAN FRANCISCO UNIVERSITY OF ULSTER BONNIE AND NATE WADE *JANE WAGNER NANCY AND NICHOLAS WARD THE WATTLES FAMILY SUSAN AND RONALD WHITE ROMNEY AND ROSS WHITE GAIL AND CURTIS WINTERFELD WOLLAM CONSTRUCTION CO., INC. WREN AND FIDA INTERNATIONAL ANONYMOUS FRIENDS $10,000 - $49,999 4NATHALIE ESTATE OF MARTHA FRIEDA ADAMSDOTTER A-CORE CONCRETE CUTTING, INC. ADMIRAL BEVERAGE CORPORATION RAVI ADUSUMALLI AGEL CARES AGILENT TECHNOLOGIES AIR & SEA INTERNATIONAL, INC. AIR PRODUCTS & CHEMICALS, INC. DRS. WALLACE AKERLEY AND ROBERTA WANG ALBERT G. CLAY FAMILY TRUST ALBERTSON S, INC. CARL AND GAIL ALBRECHT IN MEMORY OF *GORDON AND *JUNE ALDOUS CLAIRE H. ALLEN PATRICIA HODGES AND JOHN ALLEN ALLEN SALES & SERVICE, INC. DAWN ALLRED KEITH ALLRED ALTUS ONE FUND, INC. AMERICA FIRST CREDIT UNION AMERICAN ACADEMY OF DERMATOLOGY AMERICAN EXPRESS PHILANTHROPIC PROGRAM AMERICAN FAMILY INSURANCE KOKI AND CHARLES AMIN, AMERICAN PLASTICS INDUSTRIES, LTD. JESSELIE AND A. SCOTT ANDERSON ARCHER FAMILY CHARITABLE CORPORATION ARCHITECTURAL NEXUS, INC. THE ARNOLD F. BAGGINS, INC. ESTATE OF *BILLIE JO ASHLEY ASSOCIATED BRIGHAM CONTRACTORS, INC. ASSOCIATED FOOD STORES, INC. ATHENA PARTNERS ANGELA ATKIN *F. LEE AND *FRED FOX AUERBACH ISAAC AND DENISE AUSTIN AVENTIS PHARMACEUTICALS, INC. AZTECA SYSTEMS INC - CITYWORKS JEANETTE AND MARK BABBITT JUDITH AND RUSSELL BABCOCK THE BAD ASS COFFEE COMPANY OF HAWAII, INC. PAM AND JEFF BAILEY CHRISTOPHER J. BALFE BARRICK BONNIE BARRY BASTIAN FAMILY THE JOHN T. BAUMSTARK FAMILY BAYLOR COLLEGE OF MEDICINE MARY BECKERLE, PHD AND DAVID G. MURRELL IV *VERNON R. BEELER BEIJER ELECTRONICS DANIEL L. BERMAN DENISE AND JACK BERNHISEL BESSEMER TRUST ANN AND A. LORRIS BETZ, MD BIKE2BIKE BIODISCOVERY, INC. KIM AND JASON BLEAK SHARI AND KEITH BLOOM BLUE AND GOLD EDUCATIONAL BMW OF MURRAY BONNEVILLE COMMUNICATIONS BORDEN, INC. JUDY BRADY AND DREW BROWNING BRIDGER VALLEY ELECTRIC ASSOCIATION, INC. BRIGHTON RETAIL CATHY AND STEPHEN BRUNKEN JEFF BULLOCK STEVEN B. BURNS MARJORIE AND RANDALL BURT, MD SUSAN AND RICHARD BURTON SCOTT BURTON *ANNA M. AND ELIOT BUTLER CHARLES C. BUTT BYU ATHLETIC DEPARTMENT C. R. BARD, INC. CACHE VALLEY ELECTRIC CALIFORNIA COMMUNITY CAMPBELL SCIENTIFIC, INC. CANCER RESEARCH INSTITUTE CANYON FINANCIAL, INC. YVONNE J. CARDWELL PETE CARMODY CAROL T. CARLSON CARSON TAHOE REGIONAL HEALTH, DBA, CARSON TAHOE REGIONAL MEDICAL CENTER CASE WESTERN RESERVE UNIVERSITY KAY AND R. DON CASH THE CASTLE CECIL C. WALL FAMILY TRUST CENTURYLINK BETH AND SAM CHAPIN CHARITABLE ADULT RIDES & SERVICES, INC. CHILDREN S ONCOLOGY GROUP *CAROL CHRISTENSEN LOUIS R. CHRISTENSEN BOYD AND JEAN CHRISTENSEN DR. WILLIAM R. CHRISTENSEN SHAUNNA AND RICK CLARK CLARKSTON CONSULTING GROUP GEORGIANA AND DOUGLAS CLAUSEN RHONDA AND SCOTT CLAYTON CLEANING SERVICES GROUP, INC. CLEARFIELD HIGH SCHOOL CMIC MR. THOMAS W. COLE JACKIE AND MICHAEL COLEMAN COLONIAL MFG. INSULATION THE COLUMBUS COMMUNITY OF JACKSON HOLE COMMUNITY OF UTAH COMMUNITY VOLUNTEERS OF UTAH COMPLETE HEALTHCARE COMMUNICATIONS, INC. CONSONUS, INC. CONTINENTAL GRAIN COLLEEN MALOUF DESIGNS, LTD. MARY AND RICHARD COOK RAE B. COOMBS PAMELA AND CRAIG CORRY JOHN COSTA COURTESY CAR COMPANY COWBOY LEGENDS TAMARA AND DAVID CRABTREE JAE AND JERRY CRAMER MARTHA CROCKER AND TOM LEONARD JOSEPH CRONLEY ARLEN B. CROUCH FAMILY FLORA AND JOHN D ARCY MARY AND *WELDEN DAINES MARC S. DALLA COSTA KARYN AND MIKE DAMBACH LISA AND DAVID DAME LISA AND ANDREW DANIELS ALEXANDER DANOYAN DAVID N. ROSE REVOCABLE TRUST DAVID S. DOLOWITZ LIVING TRUST DAVIS SCHOOL DISTRICT DAYBREAK COMMUNITY CENTER DAYBREAK COMMUNITY COUNCIL DAYNES MUSIC THE DAYS OF 47, INC. DE LAGE LANDEN FINANCIAL SERVICES ESTATE OF *LAWRENCE H. DELAND ANN AND NEIL DECKER DEE S INCORPORATED NICEA AND SCOTT DEGERING NANCY AND MAX DELGADO THE STEPHEN G. AND SUSAN E. DENKERS FAMILY THE DENNIS AND JOAN NORTON FAMILY, IN LOVING MEMORY OF MARY NORRIS DEPARTMENT OF ORTHOPEDICS DESERET TRUST COMPANY DESERT OASIS ENTERPRISES DJB GAS SERVICES, INC. DJL ENTERPRISES EVELYN K. DOBROSKI MEMORIAL TRUST DON KAY CLAY CASH CHRISTINA J. DONELSON TERRELL AND PAUL DOUGAN DOUGLAS C. SHONKWILER TRUST DOUGLAS N. THOMPSON ANN AND SEAN DOUGLAS LESLEY AND WAYNE AMERICAN FAMILY MUTUAL CHARITY FOLKS, INC. BLAINE N. AND BARBARA ANNETTE AND IAN THE DOW CHEMICAL PAUL NABIL BUSTANY FUND WEBSTER INSURANCE COMPANY W. HARMON CHARITABLE LYNETTE AND J. M. CUMMING COMPANY SIGMA CHI GAMMA ELIZABETH AND DELTA - OKLAHOMA WHEELER FAMILY AMERICOM REED CHIDESTER KARAN AND L. DEE CURTIS SHERYL AND CHRIS CHRIS PECHOCK STATE UNIVERSITY TECHNOLOGY, INC. SUSAN AND JAMES BLAIR AUSTIN CHILDERS D & B METALS, INC. DOWLING 70 71

40 Donors DONORS AS OF 9/29/2016 FOUNDING MEMBER *DECEASED Donors LANETT AND ROCKLAND DRAPER DURBANO METALS DYKE S ELECTRIC, INC. ELAINE AND IVAN DYRENG E. FARLEY ESKELSON FAMILY TRUST E TRADE FINANCIAL EAST MILLARD LIONS EBAY C. HOPE ECCLES AND RANDAL QUARLES KATIE ECCLES AND DAVID BURNETT LISA ECCLES KRISTINE AND SPENCER ECCLES ED VICTOR LIMITED DONNA E. AND *M.G. EDWARDS ELECTRICAL WHOLESALE SUPPLY ELLIOTT WOLFE MARITAL DEDUCTION TRUST SUE J. ELLIS ENTHEOS ACADEMY M. CATHAY ERICSON *RUSSELL E. ERICSON ERIE PLASTICS KAYE AND J. KIMO ESPLIN EUREKA CASINO HOTEL FREDRICK H. BARTH FREEDOM BLAST, LLC FRENCH RIVIERA HEALTH SPA, INC. NEW ORLEANS FRIENDS OF MIKE LEE, INC. LYNN AND FOSTER FRIESS *DONALD B. AND *BONNIE FRONCE FROSTEE TREE FARM FUEL FOR THE FIGHT SHIRLEEN AND ERNESTO GAMONAL GARFF ENTERPRISES, INC. ROBERT AND KATHARINE GARFF GARKANE ENERGY, INC. SENATOR AND MRS. JAKE GARN GE GENESEE & WYOMING, INC. JANIE AND DEAN GESTAL GETTYSBURG COLLEGE OPERATING FUND BARBARA GICQUEL KATHY AND NEWMAN GILES J. KELLY GODDARD JOHN AND *GERALDINE GODDARD CONSTANCE AND DAVID GOLDGAR HARRY W. MORRISON, INC. SHARON HARVEY *DAVID AND BARBARA HATCH NANCY AND ROBERT HAYDEN HD SMITH L. RUSSELL AND EILEEN HEALY HECTOR C. HAIGHT EDWARD A. HEIDT JR. AND ALYCE Z. HEIDT MR. AND MRS. JOHN HENKELS HERAEUS ELECTRO- NITE, CO. HERRICK INDUSTRIAL SUPPLY COMPANY C. CHARLES HETZEL HEVERT INDUSTRIES, INC. JUNE AND CLAUDE HICKEN PEGGY HICKS M. JUNE AND EDWARD HIGBEE RICK AND JULIE ANN HIGGINS TED AND *KATHLEEN HIGGINS HILL BROTHERS CHEMICAL COMPANY MR. THORNTON L. HILL THE HYRUM AND GAIL SMITH FAMILY IKE AUSTIN ILYANG CENTRAL INSTITUTE THE IMPART GROUP, INC. INC RESEARCH, INC. INDUSTRIAL PIPING PRODUCTS, INC. INDUSTRIAL SUPPLY COMPANY, INC. INTERIOR SOLUTIONS INTERSTATE CHEMICAL COMPANY, INC. THE IPOP J.P. MORGAN SECURITIES, INC. J.T. INDUSTRIAL CONTRACTOR JACKSON HOLE SNOW DEVILS *JAMES R. HALVERSON IRREVOCABLE TRUST JANELL L. JAMES LORRAINE AND LEON JAMES JANECEK HOLDINGS, LLC RICK JANY JASMAT ENTERPRISES, LLC JCO BASS CLUB JENSEN HASLEM ARCHITECTS JEREMY GOLF AND COUNTRY CLUB *CONNIE AND *DAVID KATZ LINDA AND ILAN KAUFTHAL KEN GARFF MERCEDES BENZ OF SALT LAKE ROBERT D. KENNEDY DIANE AND MICHAEL KERN KEYSTONE AVIATION KAMRON KEYVANI TERRY AND RANDALL KILIAN ALICYN AND MICHAEL KING KING FAMILY ANDREI AND MASHA KIRILENKO KIRILENKO S KIDS, INC. KIRTON & MCCONKIE BETTY AND JIM KNIGHT ELIZABETH A. KNOCH KATSUO KOH *JEFFREY L. S. KOO MELISSA WEIDNER AND GERALD G. KRUEGER, MD JANE AND CHARLES KUSEK MARKUS KYTOMAA MAUREEN AND C. STEVEN LA PRAY LADIES AUXILIARY, VFW LANCE ARMSTRONG J. CRAIG AND *TONI LARSON SUSAN AND DOUGLAS LARSON JANET AND STEPHEN LEWIS LHOIST NORTH AMERICA LI-FRAUMENI SYNDROME ASSOCIATION THE LICHTENBERGER MS. NANCY LIEBERMAN VICKI AND RICHARD LINTON BIANCA AND DAVID LISONBEE THE LITIGATION DOCUMENT GROUP, LLC LIVESTRONG COLLEEN LIVSEY SUSAN AND CHRISTOPHER LOCKWOOD THE LOUIS S. PEERY CHARITABLE LOVE COMMUNICATIONS LOW BOOK SALES JUSTIN LUO LYMPHOMA RESEARCH *MADELINE AND RAYMOND LYNCH JR. THE LYNN AND FOSTER FRIESS FAMILY M. HOLLAND COMPANY MABEL W. RENZETTI FAMILY TRUST JOYCE AND VAN MACCABE MACY S LINDA AND MICHAEL MCCURDY THE MCELROY FAMILY TRUST SALLY AND JOE MCKEE MD ANDERSON CANCER CENTER MEDICAL COLLEGE OF WISCONSIN MELBA MCKENZIE CHARITABLE TRUST KATHERINE AND JAMES MCQUEEN STEPHANIE AND KRIS MECHAM LOWELL J. MECHAM RABIAB MEKADENAONPORN MEMORIAL HOSPITAL OF SWEETWATER COUNTY MEMORIAL SLOAN- KETTERING CANCER CENTER METROPOLIS INTEGRATED MEDIA THE MGIVE, INC. *FRANCIS J. MICEK MILE HIGH UNITED WAY MILES2GIVE MILLENNIAL CHARITIES AND PHILANTHROPY, INC. *CAROLYN L. MILLER KATHIE AND MARK MILLER SHANNA AND MATTHEW NELSON DRS. LEIGH NEUMAYER AND DAVID BULL NEVER BETTER THE NEW YORK COMMUNITY TRUST MEGHAN AND JEFF NEWMAN THUY NGUYEN-ALLEN AND JOHN ALLEN ROBERT A. NICKELL DUANE NICOLAYSEN CRICKIE AND BROOK NIEMI RICARDO W. NOLASCO HAROLD L. NORDICK NORTH CAROLINA STATE UNIVERSITY NOVA CHEMICALS, INC. NU SKIN FORCE FOR GOOD NUCOR BAR MILL - PLYMOUTH NUCOR STEEL - VULCRAFT GROUP NUCOR STEEL SEATTLE, INC. NYU LANGONE MEDICAL CENTER ROBERT P. O BLOCK KIMBERLY AND MICHAEL O DONNELL CONNOR O HANLON MINHAVIDA, LLC EVOLUTION SKI & GOLDMAN, SACHS JERRY S PLUMBING *JUDITH AND W. CONSTANCE AND ESTATE OF *EDITH SNOWBOARD COMPANY & COMPANY *JANICE AND *ROBERT SPECIALTIES HINCKLEY MACK LAWRENCE FRANK MADSEN MONARCH COIN C. O ROURKE CORPORATION EXLI CORP ESTATE OF EVELYN JEWEL KADE GOOTEE HK SYSTEMS EMPLOYEE BARBARA AND NANCEE AND PATRICIA AND MARK OBERG JEWISH COMMUNAL FUND FRANK LAYDEN WILLIAM MADSEN JANICE AND STEWART DAVID AND, INC. MONTEITH DANIEL S. OCH STEPHANIE FARIS GRAND CHAPTER JOHN D. TRAUT OES OF UTAH SUSAN AND THOMAS CHARITABLE LEAD TRUST MARSHA AND MAKE LIFE BETTER MOON LAKE ELECTRIC OLD BONES RIDERS JOY AND RICHARD FASSIO HODGSON SCOTT LAYDEN BARBARA GRAVES, PHD AND JOHNSON POWER, LTD. ASSOCIATION, INC. JULIE AND ALAN OLSEN CYNTHIA F. FAYARD ROBERT SCHACKMAN, PHD LIZ HOLZEMER LAYTON HIGH SCHOOL MANCINI MARKETING THE CAROL M. AND MR. AND MRS. SPECIALISTS - UTAH MS. *LARUE OLSEN CARRI AND DAN SUSAN L. GREENDORFER TAMIJI HOMMA WESLEY A. JOHNSON FAMILY LAZARD FRERES & JOHN MORGAN FERGUSSON COMPANY, LLC LOUISE AND W. ONEO, LLC THE H. R. WING FAMILY HORIZON MANUFACTURING JACK B. JOHNSON KAREN AND NATHAN JEFFERIES MANN FINKELSTEIN, THOMPSON TED R. LEBEAU SR. MORGAN CATHY ANN AND BENEVOLENT CORPORATION & REPAIR, INC. RUTH E. JOHNSON & LOUGHRAN MARCONI COMMUNICATIONS *RICHARD E. LEE, MD MT. WHEELER POWER, INC. DONALD ORMOND THE HACKETT GROUP, INC. CATHY R. HOWARD PAMELA AND G. AND DIANA W. LEE MARK MILLER SUBARU, INC. JOAN AND JOHN FIRMAGE HEIDI AND THOMAS MUIR *GEORGE AND ASHLEY AND NEIL HAFER CLAUDIA AND JERRY FRANK JOKLIK DIANE AND JOHN LEES EMILY MARKHAM *MARIAN OVERY AMELIA AND FRANK HOWELLS DRS. SEAN AND FITZPATRICK, PHD PRAMOT JON M. HUNTSMAN SCHOOL LEHI CITY MR. LOUISE J. MARSCHAK KIMBERLEY MULVIHILL EMILY AND MICHAEL HANWATANANUGOOL MARY LYNNE AND OF BUSINESS AT UTAH PAASCHE FLOWELL ELECTRIC FREDERICK HUBER STATE UNIVERSITY LEHI LEGACY CENTER THE MARSHA L. HASSEY DARCY AND TONY MURILLO ASSOCIATION, INC. HOLLY AND AARON HARDY REVOCABLE TRUST PACIFICORP BRIAN HUGGARD CALLIE JONES *ANN-MARIE AND ARLENE AND KEVIN MURPHY FOR LEARNING 4 LIFE DARLENE AND TOM HARE DRUE AND ALAN HUISH K O H MECHANICAL ROBERT LENCE *SUSAN A. MARTIN NAMMO COMPOSITE DR. BARLOW L. PACKER FOX CHASE CANCER HARKER DESIGN HULLINGER FAMILY CONTRACTORS, INC. ESTATE OF *JAMES GLORIA J. MARTINEAU SOLUTIONS, LLC CENTER HARLAND CLARKE *FRANCIS C. PADDOCK, JR. BARBARA F. KAMPEN B. LENDALL MATCH & FARNSWORTH, PC NATE WADE SUBARU FOXLEY & PIGNANELLI CORPORATION JAMI L. PALMER HUNTSMAN LLC KARL M. JOHNSON LES OLSON COMPANY AMY AND BRADLEY MAYEDA NATIONAL CHILDHOOD GALE R. FRANDSEN ANN AND DEL HARRIS MARY AND BARRY DONNA AND DONALD CANCER VIVIAN AND SAMUEL PATON *RAMONA AND THE FRANKLIN AND JOE W. HARRIS *ALEX HURTADO TOM KARTSOTIS LESMEISTER MCARTHUR NATIONAL CHRISTIAN BARBARA AND MARVIN ELIZABETH ALEX HARRIS REBAR LESMEISTER MARY AND THOMAS PATTERSON DEANNE AND THOMAS NICKIE AND CHRIS CHARITABLE SALT LAKE, INC. HUTCHISON KATSANEVAS TRANSPORTATION, INC. MCCARTHEY JO NEBEKER ANDI AND TODD PEDERSEN 72 73

41 Donors DONORS AS OF 9/29/2016 FOUNDING MEMBER *DECEASED Donors GAYLE AND G. REED PETERSEN ANNE AND PETER PETERSON *MARGIE PETTIGREW LUDI E. PHILLIPS THE PI FUND KIM AND RICK PLAUTZ PLAZA CYCLE POINT OF HOPE CHARLES POTEMPA AND JANE PAPE KATIE AND SIONE POUHA PRAXAIR, INC. PRICE WATERHOUSE COOPERS, LLP *BARBARA B. PRINCE PWC CHARITABLE, INC. QUADRA CHEMICAL, LTD. QWEST R & S BOYER FAMILY, LC R. STERLING SPAFFORD FAMILY TRUST JOHN A. RAEMER SHARON AND JOHN RAGSDALE ROBERT RALSTON JAN J. RASMUSSEN SHELLEY AND KIMBALL RASMUSSEN GERTRUDE G. RAYMOND, IN HONOR OF HELEN ANDERSON RBC CAPITAL MARKETS, LLC RBC WEALTH MANAGEMENT CAROLYN AND RONALD REAVELEY STACEY AND MICHAEL REICHERT *CAROLYN REINBOLD MABEL W. RENZETTI MICHELLE AND ROBERT REYNOLDS RHINEHART OIL COMPANY, INC. SANDRA AND REYNOLD RICE RICHARD E. AND NANCY P. MARRIOTT, INC. MELODY SAWYER RICHARDSON RAYE AND JOSEPH RINGHOLZ ROSALIE AND MICHAEL RINGWOOD THE ROBERT I. WISHNICK ROBERT S. CARTER, INC. CANDICE AND DOUGLAS ROBERTS ROCK THE U NORMA ROHDE CHERE AND JOHN ROMNEY ROMNEY REAL ESTATE COLLEEN AND LYNN ROSE *JO AND J. MARK ROSE PENNY AND NICK ROSE *EVELYN ROSENBLATT MRS. ROBERTA B. ROSSETTER ELIZABETH THOMAS- ROSSWOG AND JOHN ROSSWOG ROTARY CLUB OF PARK CITY RUN13 LLC DAN AND MANON CAINE RUSSELL S. J. AND JESSIE E. QUINNEY JARUNEE AND SAMARD SAENGFAH PARI AND MOHAMMAD SALARI MUHAMMAD SALEEM SALES ENGINEERING COMPANY, INC. SALT LAKE BEES SALT LAKE CITY BIOSCIENCE, INC. SALT LAKE JETCENTER, INC. SALT LAKE MAGAZINE THE SAM AND DIANE STEWART FAMILY THE SAN FRANCISCO INDRANEEL SARKAR MILDRED AND NEAL SAUER SANDI AND JAMES SCHOUDEL SCHWAB CHARITABLE FUND SEVIER SCHOOL DISTRICT SHEARMAN & STERLING, LLP SUSAN SHEEHAN AND RICHARD SCHWERMER SALLY AND ALVIN SHOEMAKER SIEGFRIED & JENSEN SIGMA CHI ALPHA - UNIVERSITY OF MINNESOTA SIGMA CHI ALPHA - PENNSYLVANIA STATE UNIVERSITY SIGMA CHI ALPHA BETA CHAPTER - UNIVERSITY OF CALIFORNIA BERKELEY SIGMA CHI ALPHA OMICRON - TULANE UNIVERSITY SIGMA CHI BETA KAPPA - UNIVERSITY OF OKLAHOMA SIGMA CHI BETA PHI - UNIVERSITY OF ARIZONA SIGMA CHI BETA RHO - MONTANA STATE UNIVERSITY SIGMA CHI BETA TAU CHAPTER - COLORADO STATE UNIVERSITY SIGMA CHI BETA THETA - UNIVERSITY OF PITTSBURGH SIGMA CHI DELTA DELTA CHAPTER - PURDUE UNIVERSITY SIGMA CHI DELTA ZETA - WILLAMETTE UNIVERSITY SIGMA CHI EPSILON MU CHAPTER - TEXAS CHRISTIAN UNIVERSITY SIGMA CHI EPSILON RHO - UNIVERSITY OF RICHMOND SIGMA CHI EPSILON UPSILON CHAPTER - ARIZONA STATE UNIVERSITY SIGMA CHI ETA CHAPTER - UNIVERSITY OF CALIFORNIA IRVINE SIGMA CHI ETA DELTA - TENNESSEE TECH UNIVERSITY SIGMA CHI ETA LAMBDA CHAPTER - VIRGINIA TECH SIGMA CHI ETA MU CHAPTER - EASTERN ILLINOIS UNIVERSITY SIGMA CHI ETA UPSILON - TEXAS A&M UNIVERSITY SIGMA CHI FRATERNITY NATIONAL HEADQUARTERS SIGMA CHI IOTA GAMMA CHAPTER - JACKSONVILLE UNIVERSITY SIGMA CHI IOTA PHI CHAPTER - UNIVERSITY OF NORTH TEXAS SIGMA CHI IOTA PSI CHAPTER - RUTGERS UNIVERSITY SIGMA CHI IOTA TAU CHAPTER - UNIVERSITY OF ST. THOMAS SIGMA CHI KAPPA - VILLANOVA UNIVERSITY SIGMA CHI KAPPA PHI - EMBRY-RIDDLE AERONAUTICAL UNIVERSITY SIGMA CHI KAPPA RHO CHAPTER - AMERICAN UNIVERSITY SIGMA CHI KAPPA THETA - CALIFORNIA STATE UNIVERSITY SIGMA CHI KAPPA ZETA CHAPTER - RADFORD UNIVERSITY SIGMA CHI LAMBDA CHAPTER - INDIANA UNIVERSITY SIGMA CHI LAMBDA ETA - BRYANT UNIVERSITY SIGMA CHI LAMBDA GAMMA - SANTA CLARA UNIVERSITY SIGMA CHI LAMBDA LAMBDA CHAPTER - UNIVERSITY OF KENTUCKY SIGMA CHI LAMBDA NU - LOYOLA UNIVERSITY SIGMA CHI LAMBDA XI - BOISE STATE UNIVERSITY SIGMA CHI LAMBDA ZETA - FLORIDA GULF COAST UNIVERSITY SIGMA CHI OMEGA OMEGA CHAPTER - UNIVERSITY OF ARKANSAS SIGMA CHI PHI PHI - UNIVERSITY OF PENNSYLVANIA SIGMA CHI RHO CHAPTER - BUTLER UNIVERSITY SIGMA CHI TAU TAU CHAPTER AT WASHINGTON UNIVERSITY IN ST. LOUIS SIGMA CHI THETA CHAPTER GETTYSBURG COLLEGE SIGMA CHI THETA CHAPTER - ARKANSAS STATE UNIVERSITY SIGMA CHI THETA OMICRON - UNIVERSITY OF CALIFORNIA - DAVIS SIGMA CHI XI XI CHAPTER - UNIVERSITY OF MISSOURI SIGMA CHI ZETA PSI - UNIVERSITY OF CINCINNATI SIGMA CHI ZETA RHO - CENTRAL MICHIGAN UNIVERSITY SILVERLEAF FINANCIAL DAVID AND MELINDA SIMMONS DAN C. SIMONS FAMILY JOAN AND GORDON SIMPSON SIXTEENTH HOLDING GROUP, LLC LEE S. SKIDMORE AND CHRISTINE PUGMIRE-SKIDMORE SKIDMORE FAMILY TRUST SKYLINE HIGH SCHOOL JOAN A. SLACK *EUGENE O. SMITH JANAE AND SEAN SMITH JUDITH A. SMITH SMITHKLINE BEECHAM JONE AND CALVIN SMOOT SMOOT ENTERPRISES, INC. SNELL & WILMER, LLP SNOW CANYON HIGH SCHOOL NEREIDA AND RODOLFO SOTOLONGO GORDON T. SOUTTER AND ANITA M. HARDING JANNIE SPADER *R. STERLING AND MARILYN SPAFFORD SPALDING/HOGAN SPARE THE TA TA S LIZ AND DAVE SPARKS JOY AND CHARLES STANLEY SANDY AND DON STANUTZ STEEL ENCOUNTERS, INC. MARGO AND BRENT STEVENSON PAUL STIFFLER STIFFLER SERVICE CENTER, INC. STRATEGIC IMPORT SUPPLY, LLC MELISSA STRICKLAND MARJORIE AND WILLIAM STRINGHAM MARK STULL AND ELODIE CADENCE STUTMAN, TREISTER & GLATT CHARITABLE PARTNERSHIP SUE AND RICHARD SUGDEN M. FRANK SULLIVAN SUNBEAM SUNDOWNER STATION, INC. SUPER 1 FOODS THE SUPPORT GROUP, LLC THE SUSAN ILEENE WIRTHLIN PATRICE AND H. LEWIS SWAIN SWEET CANDY FUND FOR HEALTH AND WELLNESS SYMANTEC GIVING STATION THE T.R. PAUL FAMILY PAM AND BENJAMIN TANNER TERRY AND JAMES TAYLOR TAYLORSVILLE HIGH SCHOOL EDWIN TAZOI TEAMIRONDEAN 5K FRANCES AND ALLAN TESSLER TEVA PHARMACEUTICALS MARSHA AND J. EDWARD THATCHER TJ AND GOLDIE HAUER TRUST ELIZABETH THOMAS- ROSSWOG AND JOHN ROSSWOG TOYS R US CHILDREN S FUND, INC. TRUCK SHIELDS, LLC TUBE CITY IMS BARB AND BEN TUCKER TURN-TEX MACHINE & TOOL, INC. *MARJORIE TURNER HEIDI AND JONATHAN TWARD, MD UINTAH MACHINE AND MANUFACTURING COMPANY UNIVERSITY HOSPITAL UNIVERSITY OF TENNESSEE UNIVERSITY OF UTAH UNIVERSITY OF UTAH ATHLETICS DEPARTMENT UNIVERSITY OF UTAH HEALTH CARE PAULA UNRATH AND KEITH TAYLOR UOP, LLC UPS U.S. SYNTHETIC CORPORATION UTAH DEPARTMENT OF HEALTH UTAH BLAZE UTAH CANCER ACTION NETWORK UTAH GRIZZLIES CHILDREN S CHARITIES UTAH JAZZ UTAH ONIONS, INC. UTAH STATE FRATERNAL ORDER OF EAGLES UTAH VALLEY UNIVERSITY VAN COTT, BAGLEY, CORNWALL & MCCARTHY JOAN AND NEIL VAN LEEUWEN VANGUARD MEDIA VERN AND MARVA WOLCOTT CHARITABLE VICKERS TRUCKING, INC. VOICES AGAINST BRAIN CANCER TAMMY AND BLAKE WADE MR. RODNEY WADE JOSEPH AND CYNTHIA WALKOWSKI EDWARD AND MERRILL WALL THE WALMART WILLIAM E. WARD WASATCH AREA RACE PRODUCTIONS WASATCH CHEVY S, LTD. WASATCH TOOL & DIE, INC. DR. W. C. SWANSON FAMILY, INC. WELLS FARGO WELLS FARGO ADVISORS, LLC WEST JORDAN HIGH SCHOOL KAREN AND STEVEN WEST WESTECH ENGINEERING, INC. WESTERN METALS RECYCLING, LLC WHEELER MACHINERY COMPANY STEVEN AND MARGARET WHEELWRIGHT MARLENE WHICKER LINDA WHITAKER THE WHITE REVOCABLE LIVING TRUST DARLENE AND JON WHITE WHITEHEAD WHOLESALE ELECTRIC TIMOTHY AND BARBARA WILDING WILLA S WORKSHOP ANN M. WILLIAMS DEBBIE AND *ANDY WILLIAMS KENNETH L. WILLIAMS WILSON SONSINI GOODRICH & ROSATI LINDA AND JAMES WILSON JERALYNN AND DAVID WINDER MARIO WINTER *BETTY JO AND *W. MEEKS WIRTHLIN ELIZABETH AND ROBERT WISE WITZ FAMILY MARVA AND VERN WOLCOTT JUDITH AND MICHAEL WOLFE THOMAS E. WOLTERS KATHRYN AND J. BRENT WOOD LYNDA WYCHERLEY WYMAN LIVING TRUST MARGARET P. WYMAN X OUT BREAST CANCER DBA STRIKING AGAINST BREAST CANCER BARBARA AND W. RORY YOUNGBERG BUDDY AND JULIE ZARBOCK ZIDEK FAMILY ZIONS BANCORPORATION KATHY AND HUGH ZUMBRO ZUMBRO FAMILY ANONYMOUS DR. HOWARD C. AND MRS. SIGMA CHI GAMMA ETA - STILLWATER RUTH ANN S. RICHARDSON MARJORIE T. SHARP UNIVERSITY OF IDAHO, INC. SIGMA CHI THETA EPSILON - *MARY LOU UNICE WELLS FARGO BANK NA MR. AND MRS. BRIAN RIDD GLORIA AND EDWARD SIGMA CHI IOTA CHAPTER NORTH GEORGIA COLLEGE KRISTIN A. AND THOMAS AND FAMILY WELLS FARGO COMMUNITY G. STOCKHAM JOY W. AND ODELL SHAUGHNESSY - UNIVERSITY OF SIGMA CHI THETA CHAPTER UNITED JEWISH COMMUNITY SUPPORT CAMPAIGN F. RIGBY, MD KARINA AND DANIEL SHAVER CALIFORNIA SAN DIEGO - CALIFORNIA POLYTECHNIC STOEL RIVES LLP ENDOWMENT TRUST WELLS FARGO 74 75

42 Published Research A sample of more than 460 publications by HCI investigators from January 1, 2015 to December 31, 2015 Published Research 76 A Coiled-Coil Mimetic Intercepts BCRABL1 Dimerization in Native and Kinase-Mutant Chronic Myeloid Leukemia LEUKEMIA:29: (2015) PMCID: PMC Woessner DW, Eiring AM, Bruno BJ, Zabriskie MS, Reynolds KR, Miller GD, O Hare T (CRR), Deininger MW (ET), Lim CS (CRR) A Two-Step Pretargeted Nanotherapy for CD20 Crosslinking May Achieve Superior Anti-Lymphoma Efficacy to Rituximab THERANOSTICS:5: (2015) PMCID: PMC Chu TW, Zhang R, Yang J, Chao MP, Shami PJ (ET), Kopechek J (ET) Addressing Methodological Challenges in Large Communication Data Sets: Collecting and Coding Longitudinal Interactions in Home Hospice Cancer Care HEALTH COMMUN:1-9 (2015) Reblin M, Clayton MF (CCPS), John KK, Ellington L (CCPS) AKT1 Activation Promotes Development of Melanoma Metastases CELL REP:13: (2015) PMCID: PMC Cho JH, Robinson JP, Arave RA, Burnett WJ, Kircher DA, Chen G, Davies MA, Grossmann AH, VanBrocklin MW (CRR), McMahon M (CRR), Holmen SL (CRR) An Epidemiologic Review of Marijuana and Cancer: An Update CANCER EPIDEMIOL BIOMARKERS PREV:24:15-31 (2015) PMCID: PMC Huang YH, Zhang ZF, Tashkin DP, Feng B, Straif K, Hashibe M (CCPS) Association of Aspirin and NSAID Use with Risk of Colorectal Cancer According to Genetic Variants JAMA:313: (2015) PMCID: PMC Nan H, Hutter CM, Lin Y, Jacobs EJ, Ulrich CM, White E, Baron JA, Berndt SI, Brenner H, Butterbach K, Caan BJ, Campbell PT, Carlson CS, Casey G, Chang-Claude J, Chanock SJ, Cotterchio M, Duggan D, Figueiredo JC, Fuchs CS, Giovannucci EL, Gong J, Haile RW, Harrison TA, Hayes RB, Hoffmeister M, Hopper JL, Hudson TJ, Jenkins MA, Jiao S, Lindor NM, Lemire M, Le Marchand L, Newcomb PA, Ogino S, Pflugeisen BM, Potter JD, Qu C, Rosse SA, Rudolph A, Schoen RE, Schumacher FR, Seminara D, Slattery ML (CCPS), Thibodeau SN, Thomas F, Thornquist M, Warnick GS, Zanke BW, Gauderman WJ, Peters U, Hsu L, Chan AT Breastfeeding, PAM50 Tumor Subtype, and Breast Cancer Prognosis and Survival J NATL CANCER INST:107:DJV087 (2015) PMCID: PMC Kwan ML, Bernard PS (ET), Kroenke CH, Factor RE (CRR), Habel LA, Weltzien EK, Castillo A, Gunderson EP, Maxfield KS, Stijleman IJ, Langholz BM, Quesenberry CP, Kushi LH, Sweeney C (CCPS), Caan BJ Cervical Cancer, Version J NATL COMPR CANC NETW:13: ; QUIZ 404 (2015) Koh WJ, Greer BE, Abu-Rustum NR, Apte SM, Campos SM, Cho KR, Chu C, Cohn D, Crispens MA, Dorigo O, Eifel PJ, Fisher CM, Frederick P, Gaffney DK (ET), Han E, Huh WK, Lurain JR, Mutch D, Fader AN, Remmenga SW, Reynolds RK, Teng N, Tillmanns T, Valea FA, Yashar CM, McMillian NR, Scavone JL Coffee, Tea, Caffeine Intake, and the Risk of Cancer in the PLCO Cohort BR J CANCER:113: (2015) PMCID: PMC Hashibe M (CCPS), Galeone C, Buys SS (CCPS), Gren L, Boffetta P, Zhang ZF, La Vecchia C Cohort Profile: The Breast Cancer Prospective Family Study Cohort (ProF-SC) INT J EPIDEMIOL: (2015) Terry MB, Phillips KA, Daly MB, John EM, Andrulis IL, Buys SS (CCPS), Goldgar DE (CCPS), Knight JA, Whittemore AS, Chung WK, Apicella C, Hopper JL Combined Nivolumab and Ipilimumab or Monotherapy in Untreated Melanoma N ENGL J MED:373:23-34 (2015) Larkin J, Chiarion-Sileni V, Gonzalez R, Grob JJ, Cowey CL, Lao CD, Schadendorf D, Dummer R, Smylie M, Rutkowski P, Ferrucci PF, Hill A, Wagstaff J, Carlino MS, Haanen JB, Maio M, Marquez-Rodas I, McArthur GA, Ascierto PA, Long GV, Callahan MK, Postow MA, Grossmann K (ET), Sznol M, Dreno B, Bastholt L, Yang A, Rollin LM, Horak C, Hodi FS, Wolchok JD Combined STAT3 and BCRABL1 Inhibition Induces Synthetic Lethality in Therapy-Resistant Chronic Myeloid Leukemia LEUKEMIA:29: (2015) PMCID: PMC Eiring AM, Page BD, Kraft IL, Mason CC, Vellore NA, Resetca D, Zabriskie MS, Zhang TY, Khorashad JS, Engar AJ, Reynolds KR, Anderson DJ, Senina A, Pomicter AD, Arpin CC, Ahmad S, Heaton WL, Tantravahi SK, Todic A, Colaguori R, Moriggl R, Wilson DJ, Baron R, O Hare T (CRR), Gunning PT, Deininger MW (ET) Corp Regulates P53 in Drosophila melanogaster via a Negative Feedback Loop PLOS GENET:11:E (2015) PMCID: PMC Chakraborty R, Li Y, Zhou L, Golic KG (NC) Cross Cancer Genomic Investigation of Inflammation Pathway for Five Common Cancers: Lung, Ovary, Prostate, Breast, and Colorectal Cancer J NATL CANCER INST:107:DJV246 (2015) PMCID: PMC Hung RJ, Ulrich CM (CCPS), Goode EL, Brhane Y, Muir K, Chan AT, Marchand LL, Schildkraut J, Witte JS, Eeles R, Boffetta P, Spitz MR, Poirier JG, Rider DN, Fridley BL, Chen Z, Haiman C, Schumacher F, Easton DF, Landi MT, Brennan P, Houlston R, Christiani DC, Field JK, Bickebˆller H, Risch A, Kote-Jarai Z, Wiklund F, Grˆnberg H, Chanock S, Berndt SI, Kraft P, Lindstrˆm S, Al Olama AA, Song H, Phelan C, Wentzensen N, Peters U, Slattery ML (CCPS), Sellers TA, Casey G, Gruber SB, Hunter DJ, Amos CI, Henderson B Defective Apical Extrusion Signaling Contributes to Aggressive Tumor Hallmarks ELIFE:4:E04069 (2015) PMCID: PMC Gu Y, Shea J, Slattum G, Firpo MA, Alexander M, Mulvihill SJ (ET), Golubovskaya VM, Rosenblatt J (CRR) Defining Breast Cancer Intrinsic Subtypes by Quantitative Receptor Expression ONCOLOGIST:20: (2015) PMCID: PMC Cheang MC, Martin M, Nielsen TO, Prat A, Voduc D, Rodriguez-Lescure A, Ruiz A, Chia S, Shepherd L, Ruiz- Borrego M, Calvo L, Alba E, Carrasco E, Caballero R, Tu D, Pritchard KI, Levine MN, Bramwell VH, Parker J, Bernard PS (ET), Ellis MJ, Perou CM, Di Leo A, Carey LA Design and Characterization of Bioengineered Cancer-Like Stem Cells PLOS ONE:10:E (2015) PMCID: PMC Cho S, Park H, Jarboe EA, Peterson CM, Bae YH (ET), Jan t-amsbury M (ET) Design, Synthesis, and Biological Evaluation of Sulfonyl Acrylonitriles as Novel Inhibitors of Cancer Metastasis and Spread J MED CHEM:58: (2015) Shen Y, Zificsak CA, Shea JE, Lao X, Bollt O, Li X, Lisko JG, Theroff JP, Scaife CL (ET), Ator MA, Ruggeri BA, Dorsey BD, Kuwada SK Discussion of Photoprotection, Screening, and Risk Behaviors with Children and Grandchildren after Melanoma Genetic Testing J COMMUNITY GENET:7:21-31 (2015) PMCID: PMC Wu YP (CCPS), Aspinwall LG (CCPS), Michaelis TC, Stump T, Kohlmann WG, Leachman SA (CCPS) Drosophila Dicer-2 Cleavage Is Mediated by Helicase- and dsrna Termini-Dependent States that Are Modulated by Loquacious-PD MOL CELL:58: (2015) PMCID: PMC Sinha NK, Trettin KD, Aruscavage PJ, Bass BL (NC) Elevated Cancer-Specific Mortality Among HIV-Infected Patients in the United States J CLIN ONCOL:33: (2015) PMCID: PMC Coghill AE, Shiels MS, Suneja G (CCPS), Engels EA0 Evidence for a Heritable Contribution to Neuroendocrine Tumors of the Small Intestine ENDOCR RELAT CANCER:23: (2015) PMCID: PMC Neklason DW (CCPS), VanDerslice J, Curtin K (CCPS), Cannon-Albright LA (CCPS) Folate-Mediated One-Carbon Metabolism Genes and Interactions with Nutritional Factors on Colorectal Cancer Risk: Women s Health Initiative Observational Study CANCER:121: (2015) PMCID: PMC Cheng TY, Makar KW, Neuhouser ML, Miller JW, Song X, Brown EC, Beresford SA, Zheng Y, Poole EM, Galbraith RL, Duggan DJ, Habermann N, Bailey LB, Maneval DR, Caudill MA, Toriola AT, Green R, Ulrich CM (CCPS) Genepanel Sequencing and the Prediction of Breast Cancer Risk N ENGL J MED:372: (2015) PMCID: PMC Easton DF, Pharoah PD, Antoniou AC, Tischkowitz M, Tavtigian SV (CCPS), Nathanson KL, Devilee P, Meindl A, Couch FJ, Southey M, Goldgar DE (CCPS), Evans DG, Chenevix-Trench G, Rahman N, Robson M, Domchek SM, Foulkes WD Genome-Wide Association Study Identifies Variants at 16p13 Associated with Survival in Multiple Myeloma Patients NAT COMMUN:6:7539 (2015) Ziv E, Dean E, Hu D, Martino A, Serie D, Curtin K (CCPS), Campa D, Aftab B, Bracci P, Buda G, Zhao Y, Caswell-Jin J, Diasio R, Dumontet C, Dudzi_ski M, Fejerman L, Greenberg A, Huntsman S, Jamroziak K, Jurczyszyn A, Kumar S, Atanackovic D (ET), Glenn M, Cannon-Albright LA (CCPS), Jones B, Lee A (CCPS), Marques H, Martin T, Martinez-Lopez J, Rajkumar V, Sainz J, Vangsted AJ, W_tek M, Wolf J, Slager S, Camp NJ (CCPS), Canzian F, Vachon C HDAC1,2 Inhibition Impairs EZH2- and BBAP-Mediated DNA Repair to Overcome Chemoresistance in EZH2 Gain-of-Function Mutant Diffuse Large B-Cell Lymphoma ONCOTARGET:6: (2015) PMCID: PMC Johnson DP, Spitz GS, Tharkar S, Quayle SN, Shearstone JR, Jones S, McDowell ME, Wellman H, Tyler JK, Cairns BR (NC), Chandrasekharan MB (NC), Bhaskara S (NC) Identification of DNA Lesions Using a Third Base Pair for Amplification and Nanopore Sequencing NAT COMMUN:6:8807 (2015) PMCID: PMC Riedl J, Ding Y, Fleming AM, Burrows CJ (NC) Identification of Six New Susceptibility Loci for Invasive Epithelial Ovarian Cancer NAT GENET:47: (2015) PMCID: PMC Kuchenbaecker KB, Ramus SJ, Tyrer J, Lee A (CCPS), Shen HC, Beesley J, Lawrenson K, McGuffog L, Healey S, Lee JM, Spindler TJ, Lin YG, Pejovic T, Bean Y, Li Q, Coetzee S, Hazelett D, Miron A, Southey M, Terry MB, Goldgar DE (CCPS), Buys SS (CCPS), Janavicius R, Dorfling CM, van Rensburg EJ, Neuhausen SL, Ding YC, Hansen TV, J nson L, Gerdes AM, Ejlertsen B, Barrowdale D, Dennis J, Benitez J, Osorio A, Garcia MJ, Komenaka I, Weitzel JN, Ganschow P, Peterlongo P, Bernard L, Viel A, Bonanni B, Peissel B, Manoukian S, Radice P, Papi L, Ottini L, Fostira F, Konstantopoulou I, Garber J, Frost D, Perkins J, Platte R, Ellis S, Godwin AK, Schmutzler RK, Meindl A, Engel C, Sutter C, Sinilnikova OM, Damiola F, Mazoyer S, Stoppa-Lyonnet D, Claes K, De Leeneer K, Kirk J, Rodriguez GC, Piedmonte M, O Malley DM, de la Hoya M, Caldes T, Aittom ki K, Nevanlinna H, CollÈe JM, Rookus MA, Oosterwijk JC, Tihomirova L, Tung N, Hamann U, Isaccs C, Tischkowitz M, Imyanitov EN, Caligo MA, Campbell IG, Hogervorst FB, Olah E, Diez O, Blanco I, Brunet J, Lazaro C, Pujana MA, Jakubowska A, Gronwald J, Lubinski J, Sukiennicki G, Barkardottir RB, Plante M, Simard J, Soucy P, Montagna M, Tognazzo S, Teixeira MR, Pankratz VS, Wang X, Lindor N, Szabo CI, Kauff N, Vijai J, Aghajanian CA, Pfeiler G, Berger A, Singer CF, Tea MK, Phelan CM, Greene MH, Mai PL, Rennert G, Mulligan AM, Tchatchou S, Andrulis IL, Glendon G, Toland AE, Jensen UB, Kruse TA, Thomassen M, Bojesen A, Zidan J, Friedman E, Laitman Y, Soller M, Liljegren A, Arver B, Einbeigi Z, Stenmark- Askmalm M, Olopade OI, Nussbaum RL, Rebbeck TR, Nathanson KL, Domchek SM, Lu KH, Karlan BY, Walsh C, Lester J, Hein A, Ekici AB, Beckmann MW, Fasching PA, Lambrechts D, Van Nieuwenhuysen E, Vergote I, Lambrechts S, Dicks E, Doherty JA, Wicklund KG, Rossing MA, Rudolph A, Chang-Claude J, Wang-Gohrke S, Eilber U, Moysich KB, Odunsi K, Sucheston L, Lele S, Wilkens LR, Goodman MT, Thompson PJ, Shvetsov YB, Runnebaum IB, D rst M, Hillemanns P, Dˆrk T, Antonenkova N, Bogdanova N, Leminen A, Pelttari LM, Butzow R, Modugno F, Kelley JL, Edwards RP, Ness RB, du Bois A, Heitz F, Schwaab I, Harter P, Matsuo K, Hosono S, Orsulic S, Jensen A, Kjaer SK, Hogdall E, Hasmad HN, Azmi MA, Teo SH, Woo YL, Fridley BL, Goode EL, Cunningham JM, Vierkant RA, Bruinsma F, Giles GG, Liang D, Hildebrandt MA, Wu X, Levine DA, Bisogna M, Berchuck A, Iversen ES, Schildkraut JM, Concannon P, Weber RP, Cramer DW, Terry KL, Poole EM, Tworoger SS, Bandera EV, Orlow I, Olson SH, Krakstad C, Salvesen HB, Tangen IL, Bjorge L, van Altena AM, Aben KK, Kiemeney LA, Massuger LF, Kellar M, Brooks-Wilson A, Kelemen LE, Cook LS, Le ND, Cybulski C, Yang H, Lissowska J, Brinton LA, Wentzensen N, Hogdall C, Lundvall L, Nedergaard L, Baker H, Song H, Eccles D, McNeish I, Paul J, Carty K, Siddiqui N, Glasspool R, Whittemore AS, Rothstein JH, McGuire V, Sieh W, Ji BT, Zheng W, Shu XO, Gao YT, Rosen B, Risch HA, McLaughlin JR, Narod SA, Monteiro AN, Chen A, Lin HY, Permuth-Wey J, Sellers TA, Tsai YY, Chen Z, Ziogas A, Anton-Culver H, Gentry-Maharaj A, Menon U, Harrington P, Lee A (CCPS)W, Wu AH, Pearce CL, Coetzee G, Pike MC, Dansonka-Mieszkowska A, Timorek A, Rzepecka IK, Kupryjanczyk J, Freedman M, Noushmehr H, Easton DF, Offit K, Couch FJ, Gayther S, Pharoah PP, Antoniou AC, Chenevix-Trench G In vivo Evaluation of Matrix Metalloproteinase Responsive Silk- Elastinlike Protein Polymers for Cancer Gene Therapy J CONTROL RELEASE:213: (2015) PMCID: PMC Price R, Poursaid A, Cappello J, Ghandehari H (ET) Intermittent Induction of HIF-1 Produces Lasting Effects on Malignant Progression Independent of Its Continued Expression PLOS ONE:10:E (2015) PMCID: PMC Choi H, Gillespie DL, Berg S, Rice C, Couldwell S, Gu J, Colman H (ET), Jensen RL (ET/NC), Huang LE (NC) Latino Parents Awareness and Receipt of the HPV Vaccine for Sons and Daughters in a State with Low Three-Dose Completion J CANCER EDUC:30: (2015) Kepka D (CCPS), Ding Q, Bodson J, Warner EL, Mooney K (CCPS) 77

43 Published Research A sample of more than 460 publications by HCI investigators from January 1, 2015 to December 31, 2015 Published Research Low Human Papillomavirus (HPV) Vaccine Knowledge among Latino Parents in Utah J IMMIGR MINOR HEALTH:17: (2015) Kepka D (CCPS), Warner EL, Kinney AY, Spigarelli MG, Mooney K (CCPS) Metabolic Reprogramming in Triple-Negative Breast Cancer through Myc Suppression of TXNIP PROC NATL ACAD SCI U.S.A:112: (2015) PMCID: PMC Shen L, O Shea JM, Kaadige MR, Cunha S, Wilde BR, Cohen AL (ET), Welm AL (CRR), Ayer DE (NC) Mutations in G Protein β Subunits Promote Transformation and Kinase Inhibitor Resistance NAT MED:21:71-5 (2015) PMCID: PMC Yoda A, Adelmant G, Tamburini J, Chapuy B, Shindoh N, Yoda Y, Weigert O, Kopp N, Wu SC, Kim SS, Liu H, Tivey T, Christie AL, Elpek KG, Card J, Gritsman K, Gotlib J, Deininger MW (ET), Makishima H, Turley SJ, Javidi-Sharifi N, Maciejewski JP, Jaiswal S, Ebert BL, Rodig SJ, Tyner JW, Marto JA, Weinstock DM, Lane AA NCCN Oncology Research Program s Investigator Steering Committee and NCCN Best Practices Committee Molecular Profiling Surveys J NATL COMPR CANC NETW:13: (2015) Kurzrock R, Colevas AD, Olszanski A, Akerley W (ET), Arteaga CL, Carson WE, Clark JW, DiPersio JF, Ettinger DS, Morgan RJ, Schwartzberg LS, Venook AP, Gocke CD, Tait J, Stewart FM NIH s Genomic Data Sharing Policy: Timing and Tradeoffs TRENDS GENET:31:55-7 (2015) Contreras JL (CCPS) Non-Small Cell Lung Cancer, Version J NATL COMPR CANC NETW:13: (2015) Ettinger DS, Wood DE, Akerley W (ET), Bazhenova LA, Borghaei H, Camidge DR, Cheney RT, Chirieac LR, D Amico TA, Demmy TL, Dilling TJ, Dobelbower MC, Govindan R, Grannis FW, Horn L, Jahan TM, Komaki R, Krug LM, Lackner RP, Lanuti M, Lilenbaum R, Lin J, Loo BW, Martins R, Otterson GA, Patel JD, Pisters KM, Reckamp K, Riely GJ, Rohren E, Schild SE, Shapiro TA, Swanson SJ, Tauer K, Yang SC, Gregory K, Hughes M Oct1 and OCA-B Are Selectively Required for CD4 Memory T-Cell Function J EXP MED:212: (2015) PMCID: PMC Shakya A, Goren A, Shalek A, German CN, Snook J, Kuchroo VK, Yosef N, Chan RC, Regev A, Williams MA (CRR), Tantin D (NC) Orally Administered Colony Stimulating Factor 1 Receptor Inhibitor PLX3397 in Recurrent Glioblastoma: An Ivy Foundation Early Phase Clinical Trials Consortium Phase II Study NEURO ONCOL:18: (2015) Butowski N, Colman H (ET), De Groot JF, Omuro AM, Nayak L, Wen PY, Cloughesy TF, Marimuthu A, Haidar S, Perry A, Huse J, Phillips J, West BL, Nolop KB, Hsu HH, Ligon KL, Molinaro AM, Prados M Pancreatic Cancer: From State-of-the-Art Treatments to Promising Novel Therapies NAT REV CLIN ONCOL:12: (2015) Garrido-Laguna I (ET), Hidalgo M PD-1 Blockade with Nivolumab in Relapsed or Refractory Hodgkin s Lymphoma N ENGL J MED:372:311-9 (2015) PMCID: PMC Ansell SM, Lesokhin AM, Borrello I, Halwani A (ET), Scott EC, Gutierrez M, Schuster SJ, Millenson MM, Cattry D, Freeman GJ, Rodig SJ, Chapuy B, Ligon AH, Zhu L, Grosso JF, Kim SY, Timmerman JM, Shipp MA, Armand P Phase III Multinational, Randomized, Double-Blind, Placebo- Controlled Study of Tivantinib (ARQ 197) plus Erlotinib versus Erlotinib Alone in Previously Treated Patients With Locally Advanced or Metastatic Nonsquamous Non-Small- Cell Lung Cancer J CLIN ONCOL:33: (2015) Scagliotti G, von Pawel J, Novello S, Ramlau R, Favaretto A, Barlesi F, Akerley W (ET), Orlov S, Santoro A, Spigel D, Hirsh V, Shepherd FA, Sequist LV, Sandler A, Ross JS, Wang Q, von Roemeling R, Shuster D, Schwartz B Polymeric Oncolytic Adenovirus for Cancer Gene Therapy J CONTROL RELEASE:219: (2015) PMCID: PMC Choi JW, Lee YS, Yun CO, Kim SW (ET) Potential Mechanisms for Cancer Resistance in Elephants and Comparative Cellular Response to DNA Damage in Humans JAMA:314: (2015) Abegglen LM, Caulin AF, Chan A, Lee K, Robinson R, Campbell MS, Kiso WK, Schmitt DL, Waddell PJ, Bhaskara S (NC), Jensen ST, Maley CC, Schiffman JD (NC) Preclinical Efficacy of Ron Kinase Inhibitors Alone and in Combination with PI3K Inhibitors for Treatment of sfron- Expressing Breast Cancer Patient-Derived Xenografts CLIN CANCER RES:21: (2015) PMCID: PMC Bieniasz M, Radhakrishnan P, Faham N, De La O JP, Welm AL (CRR) Preferences for Return of Incidental Findings from Genome Sequencing among Women Diagnosed with Breast Cancer at a Young Age CLIN GENET:89: (2015) Kaphingst KA (CCPS), Ivanovich J, Biesecker BB, Dresser R, Seo J, Dressler LG, Goodfellow PJ, Goodman MS Prostate Cancer Risk Prediction Based on Complete Prostate Cancer Family History PROSTATE:75:390-8 (2015) PMCID: PMC Albright F, Stephenson RA, Agarwal N (ET), Teerlink CC, Lowrance WT (CCPS), Farnham JM, Albright LA (CCPS) Public Attitudes Regarding the Use of Electronic Health Information and Residual Clinical Tissues for Research J COMMUNITY GENET:6:183 (2015) PMCID: PMC Botkin JR, Rothwell E (CCPS), Anderson R, Stark LA, Mitchell J Radotinib Is an Effective Inhibitor of Native and Kinase Domain-Mutant BCR-ABL1 LEUKEMIA:29: (2015) PMCID: PMC Zabriskie MS, Vellore NA, Gantz KC, Deininger MW (ET), O Hare T (CRR) Reproductive History and Later-Life Comorbidity Trajectories: A Medicare-Linked Cohort Study From the Utah Population Database DEMOGRAPHY:52: (2015) PMCID: PMC Hanson HA (CCPS), Smith KR (CCPS), Zimmer Z Risk Analysis of Prostate Cancer in PRACTICAL, a Multinational Consortium, Using 25 Known Prostate Cancer Susceptibility Loci CANCER EPIDEMIOL BIOMARKERS PREV:24: (2015) PMCID: PMC Amin Al Olama A, Benlloch S, Antoniou AC, Giles GG, Severi G, Neal DE, Hamdy FC, Donovan JL, Muir K, Schleutker J, Henderson BE, Haiman CA, Schumacher FR, Pashayan N, Pharoah PD, Ostrander EA, Stanford JL, Batra J, Clements JA, Chambers SK, Weischer M, Nordestgaard BG, Ingles SA, Sorensen KD, Orntoft TF, Park JY, Cybulski C, Maier C, Doerk T, Dickinson JL, Cannon-Albright L (CCPS), Brenner H, Rebbeck TR, Zeigler-Johnson C, Habuchi T, Thibodeau SN, Cooney KA, Chappuis PO, Hutter P, Kaneva RP, Foulkes WD, Zeegers MP, Lu YJ, Zhang HW, Stephenson R, Cox A, Southey MC, Spurdle AB, FitzGerald L, Leongamornlert D, Saunders E, Tymrakiewicz M, Guy M, Dadaev T, Little SJ, Govindasami K, Sawyer E, Wilkinson R, Herkommer K, Hopper JL, Lophatonanon A, Rinckleb AE, Kote-Jarai Z, Eeles RA, Easton DF Risk of Incident Colorectal Cancer and Death After Colonoscopy: A Population-Based Study in Utah CLIN GASTROENTEROL HEPATOL:14: E2 (2015) Samadder NJ (CCPS), Curtin K (CCPS), Pappas L, Boucher K (CCPS), Mineau GP (CCPS), Smith K (CCPS), Fraser A, Wan Y, Provenzale D, Kinney AY, Ulrich C (CCPS), Burt RW (CCPS) shrna Library Screening Identifies Nucleocytoplasmic Transport as a Mediator of BCR-ABL1 Kinase- Independent Resistance BLOOD:125: (2015) PMCID: PMC Khorashad JS, Eiring AM, Mason CC, Gantz KC, Bowler AD, Redwine HM, Yu F, Kraft IL, Pomicter AD, Reynolds KR, Iovino AJ, Zabriskie MS, Heaton WL, Tantravahi SK, Kauffman M, Shacham S, Chenchik A, Bonneau K, Ullman KS (CRR), O Hare T (CRR), Deininger MW (ET) Social Support Needs: Discordance between Home Hospice Nurses and Former Family Caregivers PALLIAT SUPPORT CARE:13: (2015) Reblin M, Clayton MF (CCPS), John KK, Ellington L (CCPS) Structural Basis for the Activation and Inhibition of the UCH37 Deubiquitylase MOL CELL:57: (2015) PMCID: PMC VanderLinden RT, Hemmis CW, Schmitt B, Ndoja A, Whitby FG, Robinson H, Cohen RE, Yao T, Hill CP (NC) Structural Insight into Selectivity and Resistance Profiles of ROS1 Tyrosine Kinase Inhibitors PROC NATL ACAD SCI U.S.A:112:E (2015) PMCID: PMC Davare MA, Vellore NA, Wagner JP, Eide CA, Goodman JR, Drilon A, Deininger MW (ET), O Hare T (CRR), Druker BJ Structure and Membrane Remodeling Activity of ESCRT-III Helical Polymers SCIENCE:350: (2015) PMCID: PMC McCullough J, Clippinger AK, Talledge N, Skowyra ML, Saunders MG, Naismith TV, Colf LA, Afonine P, Arthur C, Sundquist WI (CRR), Hanson PI, Frost A (CRR) Summary of the UPICT Protocol for 18F-FDG PET/CT Imaging in Oncology Clinical Trials J NUCL MED:56: (2015) PMCID: PMC Graham MM, Wahl RL, Hoffman JM (ET), Yap JT (ET), Sunderland JJ, Boellaard R, Perlman ES, Kinahan PE, Christian PE, Hoekstra OS, Dorfman GS Supplemental Security Income and Social Security Disability Insurance Coverage among Long-Term Childhood Cancer Survivors J NATL CANCER INST:107:DJV057 (2015) PMCID: PMC Kirchhoff AC (CCPS), Parsons HM, Kuhlthau KA, Leisenring W, Donelan K, Warner EL, Armstrong GT, Robison LL, Oeffinger KC, Park ER Talimogene Laherparepvec Improves Durable Response Rate in Patients with Advanced Melanoma J CLIN ONCOL:33: (2015) Andtbacka RH (ET), Kaufman HL, Collichio F, Amatruda T, Senzer N, Chesney J, Delman KA, Spitler LE, Puzanov I, Agarwala SS, Milhem M, Cranmer L, Curti B, Lewis K, Ross M, Guthrie T, Linette GP, Daniels GA, Harrington K, Middleton MR, Miller WH, Zager JS, Ye Y, Yao B, Li A, Doleman S, VanderWalde A, Gansert J, Coffin RS The Acinar Differentiation Determinant PTF1A Inhibits Initiation of Pancreatic Ductal Adenocarcinoma ELIFE:4:E07125 (2015) PMCID: PMC Krah NM, De La O JP, Swift GH, Hoang CQ, Willet SG, Chen Pan F, Cash GM, Bronner MP (ET), Wright CV, MacDonald RJ, Murtaugh LC (CRR) The BRAF Kinase Domain Promotes the Development of Gliomas In Vivo GENES CANCER:6:9-18 (2015) PMCID: PMC Shin CH, Grossmann AH, Holmen SL (CRR), Robinson JP The Chromatin Remodelers RSC and ISW1 Display Functional and Chromatin-Based Promoter Antagonism ELIFE:4:E06073 (2015) PMCID: PMC Parnell TJ, Schlichter A, Wilson BG, Cairns BR (NC) Transcription and Imprinting Dynamics in Developing Postnatal Male Germline Stem Cells GENES DEV:29: (2015) PMCID: PMC Hammoud SS, Low DH, Yi C, Lee CL, Oatley JM, Payne CJ, Carrell DT, Guccione E, Cairns BR (NC) Tyrosine Kinase Inhibitor-Associated Cardiovascular Toxicity in Chronic Myeloid Leukemia J CLIN ONCOL:33: (2015) PMCID: PMC Moslehi JJ, Deininger M (ET) Uterine Sarcoma, Version : Featured Updates to the NCCN Guidelines J NATL COMPR CANC NETW:13: (2015) Koh WJ, Greer BE, Abu-Rustum NR, Apte SM, Campos SM, Cho KR, Chu C, Cohn D, Crispens MA, Dizon DS, Dorigo O, Eifel PJ, Fisher CM, Frederick P, Gaffney DK (ET), George S, Han E, Higgins S, Huh WK, Lurain JR, Mariani A, Mutch D, Fader AN, Remmenga SW, Reynolds RK, Tillmanns T, Valea FA, Yashar CM, McMillian NR, Scavone JL β-catenin Stabilization Enhances SS18-SSX2-Driven Synovial Sarcomagenesis and Blocks the Mesenchymal to Epithelial Transition ONCOTARGET:6: (2015) PMCID: PMC Barrott JJ, Illum BE, Jin H, Zhu JF, Mosbruger T, Monument MJ, Smith-Fry K, Cable MG, Wang Y, Grossmann AH, Capecchi MR (NC), Jones KB (NC) (2015) 78 79

44 Cancer Care and Outreach Highlights CLINICAL RESEARCH 200 CLINICAL TRIALS open at any given time 18% of new trials opened in 2015 are immunotherapy trials HCI participates in major national trials such as NCI-MATCH and NCI Exceptional Responder >$93 million invested in research ACROSS THE CANCER CENTER 170 cancer center members representing >25 academic departments or colleges at the University of Utah 450 CANCER RESEARCH PROJECTS supported by scientific funding agencies LOCATIONS A DAY AT HCI 15 surgeries 70 inpatients 83 infusion treatments 110 radiation therapy treatments 245 radiology procedures 354 outpatient visits PATIENT CARE ANNUAL STATISTICS 4,000 new cancers diagnosed 1,200 genetic counseling consultations 125,000 outpatient visits EDUCATION AND OUTREACH ANNUAL STATISTICS 14,000 individuals served through visits, calls, and s 73,000 people reached through community health events >500 visitors to HCI at inaugural Be Well Utah Open House Educational events held in 15 Utah counties and four U.S. States: UT, WY, ID, NV FREE SKIN CANCER SCREENINGS IN 2016: 436 screened for skin cancer 69 screened for oral cancer 80 Carson City HCI at Farmington Health Center Salt Lake City Murray HCI at South Jordan Health Center Cedar City St. George Rexburg Logan Ogden Rock Springs HCI at the University of Utah American Fork Provo Jackson Hole Grand Junction Huntsman-Intermountain Cancer Care Program Facilities Clinical Affiliations Huntsman Cancer Institute Locations WELLNESS AND SUPPORTIVE CARE The Linda B. and Robert B. Wiggins Wellness and Integrative Health Center offers 36 programs to support people impacted by cancer. Offerings include acupuncture, group fitness, massage, mindfulness groups, and many others. The Wellness and Integrative Health Center hosted nearly 18,000 patient visits in 2016.