North West London Cancer Network
|
|
- Victor Greene
- 6 years ago
- Views:
Transcription
1 GUIDELINES FOR THE MANAGEMENT OF ADULT ACUTE LEUKAEMIA INITIAL MANAGEMENT CONSIDERATIONS N.B.: If AML is suspected definitively diagnosed, please ensure that the patient is transferred immediately f treatment to a Level 2+ Haematology unit. This can be discussed with the AML lead MDT lead in your Haematology MDT if needed. Please ensure transfer is undertaken as soon as AML is suspected such that the patient can have appropriate level 2 nursing and supptive care, and that appropriate clinical trials are considered and enrolment/treatment can occur in a timely fashion. Ideally, a bone marrow should be undertaken at the Leukaemia unit after transfer if clinically appropriate. A. Supptive Care Patients should be nursed in isolation rooms with reverse barrier nursing to prevent infections. Clean, neutropenic diets should be instituted and appropriate infection control measures should be undertaken. Prophylaxis and treatment of infection from presentation should be instituted based on local protocols with antibiotic choice largely dependent on local microbiological fla. F patients who will undergo intensive treatment schedules, a Hickman Line should be inserted as soon as is safely possible. B. Hyperleukocytosis Syndrome Definition Hyperviscosity due to an elevated leukaemic blast cell number in the peripheral blood circulation, the increased viscosity causes leukostasis within vulnerable capillary regions and ischaemia of tissues with occasional infiltration of leukaemic cells into the tissues themselves causing gan compromise. Symptoms of leukostasis occur at different blast cell count thresholds, depending on the leukaemic subtype. Patients with acute myeloid leukaemia are at highest risk and may experience symptoms with blast counts as low as 25 x 10 9 /L (especially in the monoblastic subtype), but typically the blast count is greater than 50 x 10 9 /L when symptoms occur. Leukapheresis The need f leukapheresis is determined by symptoms and risk stratification - a high leukocyte count is not in itself an indication f urgent leukapheresis. Patients with features (even very early) of leukostasis (e.g. pulmonary infiltrates, hypoxia, CNS changes, renal failure, cardiac ischaemia, priapism, severe retinopathy) should undergo leukapheresis as an emergency. C. Initial cyteduction with hydroxycarbamide F patients with high white cells counts, with symptoms ( at risk) of leukostasis, treatment with hydroxycarbamide should be started as a matter of urgency until definitive cyteductive can be administered. Treatment may be commenced with 2 Acute Leukemias Intro 2 8.docAcute_Leukaemias_Intro_2.8_Feb12.doc Page 1 of 6
2 grams every 6-8 hours daily to aim f rapid reduction of leukocyte counts together with rasburicase 0.20 mg/kg/day administered as a once daily 30 minute intravenous infusion in 50 ml of a sodium chlide 0.9% solution ( allopurinol 300mg/day ally if rasburicase contraindicated, e.g. G6PD deficiency), and adequate hydration. Saline hydration with additional bicarbonate to alkalinise urine may be instituted, with fced diuresis if necessary, to reduce the symptoms of leukostasis and to reduce the adverse effects of tumour lysis. Aggressive supptive measures (as indicated by the patient s perfmance status pri to the diagnosis of leukaemia) are advised. This may include ventilaty, and dialysis suppt until definitive cyteduction can be accomplished and thereafter as deemed appropriate. D. Blood transfusion Administer CMV negative blood products until the patient s CMV status is known. Red cell transfusions should be avoided if there is any risk of leukostasis. All platelet products should be single don collections in der to limit the risk of allo-sensitization. HLA-typing should be done pri to starting treatment in der to address don status if transplantation is appropriate f the patient and in case HLA-matched platelets become necessary during treatment (as often occurs in women who have had children especially). Irradiated blood products should be requested f patients on protocols containing Fludarabine, Cladrabine and Clofarabine E. Preservation of fertility Semen cryopreservation should be considered f all men below the age of 50. The possible need f embryo cryopreservation should be considered f women, although urgency of treatment does not usually allow f this. Contact the Andrology Department at the Hammersmith Hospital: to arrange details of collection. Acute Leukemias Intro 2 8.docAcute_Leukaemias_Intro_2.8_Feb12.doc Page 2 of 6
3 1. ACUTE MYELOID LEUKAEMIA (AML) Treatment Algithm Consider all patients f entry into clinical trials Not eligible f trials Not APML (not AML M3) APML (AML M3) see page2 Start supptive treatment, consider emergency cyteduction with and sperm cryopreservation Patient fit f aggressive Patient not fit f aggressive Induction DA, ADE FLAG +/- Ida 20-30% blasts >30% blasts Risk of relapse assessment Refracty Fit f reinduction? Supptive care + Low intensity treatment e.g. azacitidine (NICE), s.c. ara- C, ACE, EZ hydroxyurea Supptive care +/- cyteductive : hydroxycarbamide (hydroxyurea), etoposide, mitoxantrone low dose cytarabine Low Standard High Yes No ACE 2 nd induction followed by one two consolidation courses (MACE, MiDAC, Mylotarg x1 HDAC) Consider Consider allograft after 2 nd induction 1 st consolidation HLA type siblings and discuss with transplant centre Reinduction (FLAG+/-Ida, HDAC, CIA, D-Clo, CLAG) Refracty Acute Leukemias Intro 2 8.docAcute_Leukaemias_Intro_2.8_Feb12.doc Page 3 of 6 EZ
4 APML Treatment Algithm AMPL (AML M3) ATRA should be started as soon as APML is suspected. Start supptive treatment (crect coagulation, keep platelet count > 50 x10^9/l), leucopheresis is contraindicated Patient fit f Patient not fit f AIDA risk adapted PETHEMA LPA 2005 ATRA +/- low dose Arsenic +/- ATRA Acute Leukemias Intro 2 8.docAcute_Leukaemias_Intro_2.8_Feb12.doc Page 4 of 6
5 2. ACUTE LYMPHOBLASTIC LEUKAEMIA (ALL) ALL Treatment Algithm (excluding Burkitts Lymphoma (ALL FAB L3)) Consider all patients f entry into clinical trials Not eligible f trials Start supptive treatment, consider emergency cyteduction with and sperm cryopreservation Patient fit f aggressive Patient not fit f aggressive Induction (UK ALL 12, 14 UK 2003 protocols), use tyrosine kinase inhibit as per protocol if Ph+; Tissue type siblings Ph positive Ph negative Refracty Supptive care +/- Tyrosine kinase inhibit Supptive care +/- cticosteroids Continue on the protocol and consider stem cell transplantation Fit f salvage Yes No cyteductive (vincristine, hydroxycarbamide, etoposide, clofarabine) Reinduction (FLAG+/-Ida, Hyper-CVAD, CLAG+/-Ida, Clofarabine, CIA,) Refracty Acute Leukemias Intro 2 8.docAcute_Leukaemias_Intro_2.8_Feb12.doc Page 5 of 6
6 Written by: Dr N Panoskaltsis and Pauline McCalla Authised by: NWLCN Haematology TWG February 2012 Date f review by Haematology TWG: February 2014 Acute Leukemias Intro 2 8.docAcute_Leukaemias_Intro_2.8_Feb12.doc Page 6 of 6
Treatment Algorithm: Multiple Myeloma
Treatment Algithm: Multiple Myeloma This algithm applies to the majity of patients but may not be applicable to every patient. Patients should be enrolled in clinical trials if possible at all stages,
More informationClinical Management Guideline for Acute Myeloid Leukaemia
Clinical Management Guideline for Acute Myeloid Leukaemia Document Control Prepared by: Mark Drummond, Anne Parker, John Murphy Approved by: RCAG Prescribing Advisory Subgroup Issue date: December 2009
More informationHigh Intensity Chemotherapy Guidelines for Haematology Patients at ASPH
High Intensity Chemotherapy Guidelines for Haematology Patients at ASPH Contents: Page No. 1. Overview 2 2. Admission 3 3. Admission Checklist 5 4. Inpatient management during chemotherapy 6 5. Inpatient
More informationFLAG-Ida + Gemtuzumab Ozogamicin Regimen (Also known as FLAG-Ida + GO3x2) (AML19 Trial Course 1)
FLAG-Ida + Gemtuzumab Ozogamicin Regimen (Also known as FLAG-Ida + GO3x2) (AML19 Trial Course 1) AML19 Adults with Acute Myeloid Leukaemia or High-Risk Myelodysplastic Syndrome ***Refer to trial protocol
More information2.1 mmol/l or 25% increase from baseline mmol/l or 25% decrease from baseline
22.1 Hyperleukocytosis and tumour lysis syndrome The guideline is addressed for ALL patients with hyperleukocytosis (WBC 100 x109/l) only and should not be used without modifications in case of other diseases
More information1.28 Protocol Name: CODOX-M/IVAC
1.28 Protocol Name: CODOX-M/IVAC Indication Burkitt's or Burkitt's-like lymphoma - especially those with 1 of the following poor risk criteria: Lymphoblastic lymphoma - especially B subtype Acute Myeloid
More informationManaging patients with bulky cancers
SIOP PODC Supportive Care Education (ICON 2016) Presentation Date: 23 rd January 2016 Recording Link at www.cure4kids.org: https://www.cure4kids.org/ums/home/conference_rooms/enter.php?room=p2pjfjp8nha
More informationAppendix 6: Indications for adult allogeneic bone marrow transplant in New Zealand
Appendix 6: Indications for adult allogeneic bone marrow transplant in New Zealand This list provides indications for the majority of adult BMTs that are performed in New Zealand. A small number of BMTs
More informationLeukemias. Prof. Mutti Ullah Khan Head of Department Medical Unit-II Holy Family Hospital Rawalpindi Medical College
Leukemias Prof. Mutti Ullah Khan Head of Department Medical Unit-II Holy Family Hospital Rawalpindi Medical College Introduction Leukaemias are malignant disorders of the haematopoietic stem cell compartment,
More informationHull and East Yorkshire and North Lincolnshire NHS Trusts Haematology Multidisciplinary Team Guideline and Pathway. Acute Myeloid Leukaemia
Hull and East Yorkshire and North Lincolnshire NHS Trusts Haematology Multidisciplinary Team Guideline and Pathway Acute Myeloid Leukaemia 1 BACKGROUND The Hull and North Lincolnshire Haematology Multidisciplinary
More informationBC Cancer Protocol Summary for Therapy of Acute Myeloid Leukemia Using azacitidine and SORAfenib
BC Cancer Protocol Summary for Therapy of Acute Myeloid Leukemia Using azacitidine and SORAfenib Protocol Code Tumour Group Contact Physician ULKAMLAS Leukemia/BMT Dr. Donna Hogge ELIGIBILITY: Acute myeloid
More informationLD-ARA-C and Clofarabine
LD-ARA-C and Clofarabine INDICATION Induction plus consolidation chemotherapy for patients with acute myeloid leukaemia (AML). Its use is particularly for patients over 60 years of age but it can be applied
More informationWhat is a hematological malignancy? Hematology and Hematologic Malignancies. Etiology of hematological malignancies. Leukemias
Hematology and Hematologic Malignancies Cancer of the formed elements of the blood What is a hematological malignancy? A hematologic malignancy is a malignancy (or cancer) of any of the formed elements
More informationR-GDP: Rituximab, Gemcitabine, Dexamethasone &Cisplatin
: Rituximab, &Cisplatin INDICATION Relapsed or refractory Hodgkin and non-hodgkin lymphoma. Omit Rituximab for patients with Hodgkin Lymphoma. TREATMENT INTENT Palliative or curative depending on context.
More informationNCCP Chemotherapy Regimen
INDICATIONS FOR USE: Azacitidine i INDICATION ICD10 Regimen Code *Reimbursement Status Intermediate-1 and low risk myelodysplastic syndromes (MDS) according to the International Prognostic Scoring System
More informationAPPLICATION FOR SUBSIDY BY SPECIAL AUTHORITY
Page 1 Rituximab INITIAL APPLICATION - Post-transplant The patient has B-cell post-transplant lymphoproliferative disder* To be used f a maximum of 8 treatment cycles Indications marked with * are Unapproved
More informationAcute myeloid leukemia: prognosis and treatment. Dimitri A. Breems, MD, PhD Internist-Hematoloog Ziekenhuis Netwerk Antwerpen Campus Stuivenberg
Acute myeloid leukemia: prognosis and treatment Dimitri A. Breems, MD, PhD Internist-Hematoloog Ziekenhuis Netwerk Antwerpen Campus Stuivenberg Patient Female, 39 years History: hypothyroidism Present:
More informationR-GDP: Rituximab, Gemcitabine, Dexamethasone &Cisplatin
: Rituximab, Gemcitabine, Dexamethasone &Cisplatin INDICATION Relapsed or refractory Hodgkin and non-hodgkin lymphoma. Omit Rituximab for patients with Hodgkin Lymphoma or high grade T cell non-hodgkin
More informationHull and East Yorkshire and North Lincolnshire NHS Trusts Haematology Multidisciplinary Team Guideline and Pathway. Chronic Myeloid Leukaemia
Hull and East Yorkshire and North Lincolnshire NHS Trusts Haematology Multidisciplinary Team Guideline and Pathway Chronic Myeloid Leukaemia 1 BACKGROUND The Hull and North Lincolnshire Haematology Multidisciplinary
More informationAML Emerging Treatment Strategies
Welcome and Introduction Clare Karten, MS Senior Director, Mission Education The Leukemia & Lymphoma Society AML Emerging Treatment Strategies Wendy Stock, MD Professor of Medicine, Section of Hematology/Oncology
More informationBurkitt s Lymphoma or DLBCL with adverse features PATIENTS WITH GOOD PERFORMANCE STATUS
Regimen R-CODOX M Indication Burkitt s Lymphoma or DLBCL with adverse features Therapeutic Intent Radical/Curative PATIENTS WITH GOOD PERFORMANCE STATUS Day Medication Dose Route Administration Details
More information3. The Clinical Management Protocols Leukaemia s (09-7A-115)
3. The Clinical Management Protocols Leukaemia s (09-7A-115) These guidelines are for use within the SY&H CCN for treatment of haematological malignancies (excluding lymphoma) in children and young persons
More informationClinical Guidelines for Lymphoid Diseases Acute Lymphoblastic Leukaemia (ALL)
Clinical Guidelines for Lymphoid Diseases Acute Lymphoblastic Leukaemia (ALL) Reference Number Version Status Executive Lead(s) Name and Job Title Author(s) Name and Job Title 13-2H-107 8 Dr Helen Barker
More informationStandard Regimens for Haematology
Regimens for Haematology ChlVPP Chlorambucil 6mg/m 2 PO D1 to 14 Vinblastine 6mg/m 2 (max 10mg) IV on D1 & 8 Procarbazine 100mg/m 2 PO on D1 to 14 Prednisolone 40mg PO D1 to 14 ABVD Doxorubicin 25mg/m
More informationSystemic Treatment of Acute Myeloid Leukemia (AML)
Guideline 12-9 REQUIRES UPDATING A Quality Initiative of the Program in Evidence-Based Care (PEBC), Cancer Care Ontario (CCO) Systemic Treatment of Acute Myeloid Leukemia (AML) Members of the Acute Leukemia
More informationEmetogenicity level 1. Emetogenicity level 2
Emetogenicity level 1 15 mins Pre-Chemo Maxalon 10mg po During chemo and Post Chemo 3 days Maxalon10mg po 8 hourly Increase Maxalon 20mg po 8 hourly Change to Cyclizine 50mg po 8 hourly 3 days If nausea
More informationPAEDIATRIC FEBRILE NEUTROPENIA CARE PATHWAY
PAEDIATRIC FEBRILE NEUTROPENIA CARE PATHWAY Purpose: This document is intended as a guide to the investigation and management of children presenting in Salisbury District Hospital with suspected neutropenic
More informationGuideline for the Management of Patients with Chronic Myeloid Leukaemia (CML)
Guideline for the Management of Patients with Chronic Myeloid Leukaemia (CML) Version History Version Summary of change Date Issued 3.0 Approved by Doug Wulff on behalf of the Governance 14.11.08 Committee
More informationReference: NHS England 1602
Clinical Commissioning Policy Proposition: Clofarabine for refractory or relapsed acute myeloid leukaemia (AML) as a bridge to stem cell transplantation Reference: NHS England 1602 First published: TBC
More informationPDF of Trial CTRI Website URL -
Clinical Trial Details (PDF Generation Date :- Wed, 19 Dec 2018 02:45:15 GMT) CTRI Number Last Modified On 25/12/2017 Post Graduate Thesis Type of Trial Type of Study Study Design Public Title of Study
More informationDERBY-BURTON LOCAL CANCER NETWORK FILENAME R-CODOX-M.DOC CONTROLLED DOC NO: HCCPG B115 CSIS Regimen Name: R-CODOXM. Rituximab + CODOX-M
Rituximab + CODOX-M Available for Routine Use in Burton in-patient Derby in-patient Burton day-case Derby day-case Burton community Derby community Burton out-patient Derby out-patient Indication Burkitt
More informationNational Institute for Health and Care Excellence. Single Technology Appraisal (STA)
Single Technology Appraisal (STA) Gemtuzumab ozogamacin for untreated de novo acute myeloid leukaemia Response to consultee and commentator comments re-scope Please note: Comments received in the course
More informationJC Hofmann, MD 1,2 ; KM Grant, MD 3 ; DD Kiprov, MD 1,2. Apheresis Care Group, 2. Division of Immunotherapy, 3
Greater Than Ninety Percent of Patients with Acute Leukemia and Hyperleukocytosis Who Receive Leukocytapheresis Treatment Successfully Undergo Induction Chemotherapy: Follow-up Analysis of Data from 2006-2013
More informationAcute Lymphoblastic Leukaemia Guidelines
Acute Lymphoblastic Leukaemia Guidelines Approved by Pathway Board for Haematological Malignancies Coordinating author: Adele Fielding, Royal Free London NHS Trust Date of issue: 12.03.2015 Version number:
More informationCharles Mxxx DCEM2 Toulouse Purpan Medical School 01/26/2012 ECN Item 162
Charles Mxxx DCEM2 Toulouse Purpan Medical School 01/26/2012 ECN Item 162 Definition Pathophysiology Clinical signs and symptoms Biology and Diagnosis Different types of AL Prognosis and Treatment Malignant
More informationDr Kavita Raj Consultant Haematologist Guys and St Thomas Hospital
Dr Kavita Raj Consultant Haematologist Guys and St Thomas Hospital IPSS scoring system Blood counts Bone marrow blast percentage Cytogenetics Age as a modulator of median survival IPSS Group Median Survival
More informationAdult Acute leukemia. Matthew Seftel. August
Adult Acute leukemia Matthew Seftel August 21 2007 mseftel@cancercare.mb.ca Principles 3 cases Diagnosis and classification of acute leukemia (AL) Therapy Emergencies Remission induction BMT Complications
More informationAML 17 Protocol Amendments: Version 7.2 June 2012 to version 8.0 October 2012
AML 17 Protocol Amendments: Version 7.2 June 2012 to version 8.0 October 2012 Section Original Change Page 1 The trial is open to all patients aged less than 60 years, whether adults or children, and also
More informationAcute Promyelocytic Leukemia
Acute Promyelocytic Leukemia Outline of Management Suleimman AlSweedan,MD,MS,FAAP Consultant Pediatric Hematology/oncology TABLE OF CONTENTS Background 3 Pediatric APL Trials 4 Adult APL Trials 4 Diagnostic
More information1 Acute Lymphoblastic Leukaemia
1 Acute Lymphoblastic Leukaemia 1.05 Intensification - Philadelphia Negative Patients Indication ALL Philadelphia negative patients Pre-treatment Evaluation The intensification module begins two weeks
More informationMANAGEMENT OF ACUTE LYMPHOBLASTIC LEUKEMIA. BY Dr SUBHASHINI 1 st yr PG DEPARTMENT OF PEDIATRICS
MANAGEMENT OF ACUTE LYMPHOBLASTIC LEUKEMIA BY Dr SUBHASHINI 1 st yr PG DEPARTMENT OF PEDIATRICS Introduction The management of ALL, the most common childhood malignancy (1/3 rd of all malignancy), has
More informationBelgium recommendations for the management of acute promyelocytic leukaemia
6 Belgium recommendations for the management of acute promyelocytic leukaemia S. Wittnebel, MD, PhD 1 The management of acute promyelocytic leukaemia has evolved considerably. The standard front-line approach
More information2.07 Protocol Name: CHOP & Rituximab
2.07 Protocol Name: CHOP & Rituximab Indication Intermediate and high grade, B-cell non-hodgkins lymphoma expressing CD20. Second or third line therapy for low grade, B cell non- Hodgkins lymphoma expressing
More informationCommissioning policies agreed by PCTs in Yorkshire and the Humber at Board meeting of YH SCG on December
Commissioning policies agreed by PCTs in Yorkshire and the Humber at Board meeting of YH SCG on December 17 2010. 32/10 Imatinib for gastrointestinal stromal tumours (unresectable/metastatic) (update on
More informationNCCP Chemotherapy Regimen. LEAM Autologous Transplant Conditioning Protocol
INDICATIONS FOR USE: LEAM Autologous Transplant Conditioning Protocol Regimen *Reimbursement INDICATION ICD10 Code Status Autologous conditioning in non-hodgkins Lymphoma (NHL) C85 00468a Hospital Autologous
More informationTRANSPARENCY COMMITTEE OPINION. 14 February 2007
The legally binding text is the original French version TRANSPARENCY COMMITTEE OPINION 14 February 2007 GLIVEC 100 mg, capsule B/120 capsules (CIP: 358 493-5) GLIVEC 100 mg, capsule B/180 capsules (CIP:
More informationHaematological Emergencies (Part 1) Ray Mun Koo Haematology Advanced Trainee Canberra Hospital
Haematological Emergencies (Part 1) Ray Mun Koo Haematology Advanced Trainee Canberra Hospital Case Number 1 43 year old male presenting with fevers, abdominal distension and weight gain over 2 weeks.
More informationNational Horizon Scanning Centre. Azacitidine (Vidaza) for myelodysplastic syndrome. September 2007
Azacitidine (Vidaza) for myelodysplastic syndrome September 2007 This technology summary is based on information available at the time of research and a limited literature search. It is not intended to
More informationTreatment options for acute myeloid leukaemia
122 Clinical Pharmacist April 2010 Vol 2 Acute myeloid leukaemia is treated with chemotherapy and, if appropriate, stem cell transplantation. For those with chronic myeloid leukaemia, therapy has been
More informationBCCA Protocol Summary for Treatment of Burkitt Lymphoma and Leukemia (ALL-L3) with Ifosfamide, Mesna, Etoposide, Cytarabine (IVAC) and rituximab
BCCA Protocol Summary for Treatment of Burkitt Lymphoma and Leukemia (ALL-L3) with Ifosfamide, Mesna, Etoposide, Cytarabine (IVAC) and rituximab Protocol Code Tumour Group Contact Physician LYIVACR Leukemia/BMT
More informationMACE. Etoposide via an infusion (drip) over 1 hour, once a day for 5 days
MACE MACE This leaflet is offered as a guide to you and your family. The possible benefits of treatment vary; for some people chemotherapy may reduce the risk of the cancer coming back, for others it may
More informationSingle-Dose Rasburicase 6 mg in the Management of Tumor Lysis Syndrome in Adults
Single-Dose Rasburicase 6 mg in the Management of Tumor Lysis Syndrome in Adults Anne M. McDonnell, Pharm.D., Kristi L. Lenz, Pharm.D., Debra A. Frei-Lahr, M.D., John Hayslip, M.D., and Philip D. Hall,
More informationMS.4/ Acute Leukemia: AML. Abdallah Al Abbadi.MD.FRCP.FRCPath Feras Fararjeh MD
MS.4/ 27.02.2019 Acute Leukemia: AML Abdallah Al Abbadi.MD.FRCP.FRCPath Feras Fararjeh MD Case 9: Acute Leukemia 29 yr old lady complains of fever and painful gums for 1 week. She developed easy bruising
More informationGUIDELINE FOR ACUTE MYELOID LEUKAEMIA IN CHILDREN AND YOUNG ADULTS
GUIDELINE FOR ACUTE MYELOID LEUKAEMIA IN CHILDREN AND YOUNG ADULTS February 2016 Childhood Leukaemia Clinicians Network (CLCN) CCLG and CLCN do not sponsor or indemnify the treatment detailed herein. These
More informationMatthew Ulrickson, MD Banner MD Anderson Cancer Center September 12, 2017
Matthew Ulrickson, MD Banner MD Anderson Cancer Center September 12, 2017 Discuss the clinical presentation and diagnosis of acute leukemia * Discuss the impact of molecular features on prognosis and management
More informationAcute leukemia. Ibrahim Aldoss, MD Assistant Professor, City of Hope Hematology and Hematopoietic Cell Transplantation
Acute leukemia Ibrahim Aldoss, MD Assistant Professor, City of Hope Hematology and Hematopoietic Cell Transplantation Helocyte- Advisory board Acute myeloid leukemia (AML) Heterogeneous clonal malignancy
More informationBlood Cancers. Blood Cells. Blood Cancers: Progress and Promise. Bone Marrow and Blood. Lymph Nodes and Spleen
Blood Cancers: Progress and Promise Mike Barnett & Khaled Ramadan Division of Hematology Department of Medicine Providence Health Care & UBC Blood Cancers Significant health problem Arise from normal cells
More information5/21/2018. Disclosures. Objectives. Normal blood cells production. Bone marrow failure syndromes. Story of DNA
AML: Understanding your diagnosis and current and emerging treatments Nothing to disclose. Disclosures Mohammad Abu Zaid, MD Assistant Professor of Medicine Indiana University School of Medicine Indiana
More informationHematologic Emergency. Le Wang, MD, PhD Hematology & Oncology
Hematologic Emergency Le Wang, MD, PhD Hematology & Oncology Severe Thrombocytopenia (ITP) Clinical: bleeding risk 0 no bleeding; 1 minimal bleeding after trauma; 2 spontaneous but selflimited bleeding;
More informationTRANSPARENCY COMMITTE OPINION. 19 December 2007
The legally binding text is the original French version TRANSPARENCY COMMITTE OPINION 19 December 2007 ATRIANCE 5 mg/ml, Solution for Infusion Pack of 6 vials (571 348-9) Applicant: GlaxoSmithKline nelarabine
More informationStRs and CT doctors in haematology. September Folinic acid dose modified.
High dose Methotrexate and folinic acid rescue Full Title of Guideline: Author (include email and role): Division & Speciality: Clinical Guideline Review Date September 2018 GUIDELINE FOR THE USE OF HIGH
More informationThis is a controlled document and therefore must not be changed or photocopied L.80 - R-CHOP-21 / CHOP-21
R- / INDICATION Lymphoma Histiocytosis Omit rituximab if CD20-negative. TREATMENT INTENT Disease modification or curative depending on clinical circumstances PRE-ASSESSMENT 1. Ensure histology is confirmed
More informationScottish Medicines Consortium
Scottish Medicines Consortium azacitidine 100mg powder for suspension for injection (Vidaza ) No. (589/09) Celgene Ltd 05 March 2010 The Scottish Medicines Consortium (SMC) has completed its assessment
More informationGuidelines for diagnosis and management of Adult Myelodysplastic Syndromes (MDS)
Guidelines for diagnosis and management of Adult Myelodysplastic Syndromes (MDS) Author: Dr A Pillai, Consultant Haematologist On behalf of the Haematology CNG Re- Written: February 2011, Version 2 Revised:
More informationTiming and complications of allogeneic stem cell transplant in Ph + ALL
Timing and complications of allogeneic stem cell transplant in Ph + ALL Dr Ashlea Campbell Haematology Advanced Trainee Concord Repatriation and General Hospital Royal Prince Alfred Hospital 24 th Feb
More informationTumour Lysis Syndrome (TLS)
(TLS) Overview: Tumour lysis syndrome refers to a number of metabolic disturbances (hyperuricaemia, hyperphosphataemia, hyperkalaemia and hypocalcaemia) that occur as the result of rapid cell lysis. This
More informationThis is a controlled document and therefore must not be changed
AZACITIDINE NICE TA218 Treatment of adults not eligible for haematopoietic stem cell transplantation who have: Intermediate-2 and high-risk MDS according to the International Prognostic Scoring System
More informationN Engl J Med Volume 373(12): September 17, 2015
Review Article Acute Myeloid Leukemia Hartmut Döhner, M.D., Daniel J. Weisdorf, M.D., and Clara D. Bloomfield, M.D. N Engl J Med Volume 373(12):1136-1152 September 17, 2015 Acute Myeloid Leukemia Most
More informationSummary. Table 1 Blinatumomab administration, as per European marketing authorisation
Cost-effectiveness of blinatumomab (Blincyto ) for the treatment of relapsed or refractory B precursor Philadelphia chromosome negative acute lymphoblastic leukaemia in adults. The NCPE assessment of blinatumomab
More informationStem cell transplantation. Dr Mohammed Karodia NHLS & UP
Stem cell transplantation Dr Mohammed Karodia NHLS & UP The use of haemopoeitic stem cells from a donor harvested from peripheral blood or bone marrow, to repopulate recipient bone marrow. Allogeneic From
More informationNational Horizon Scanning Centre. Decitabine (Dacogen) for myelodysplastic syndrome. April 2008
Decitabine (Dacogen) for myelodysplastic syndrome April 2008 This technology summary is based on information available at the time of research and a limited literature search. It is not intended to be
More informationHematologic Emergencies. Udomsak Bunworasate Chulalongkorn University
Hematologic Emergencies Udomsak Bunworasate Chulalongkorn University Hematologic Emergencies Hyperleukocytosis Tumor lysis syndrome SVC syndrome Spinal cord compression Hypercalcemia 1. Hyperleukocytosis
More information(R) CODOX M / (R) IVAC
(R) CODOX M / (R) IVAC Indication Burkitt's or Burkitt's-like lymphoma, especially those with 1 or more of the following poor risk criteria: - Raised LDH level - WHO performance status 2-4 - Ann Arbor
More informationClinical commissioning policy statement: Arsenic trioxide for the treatment of high risk acute promyelocytic leukaemia (all ages)
Clinical commissioning policy statement: Arsenic trioxide for the treatment of high risk acute promyelocytic leukaemia (all ages) NHS England Reference: 170072P 1 Contents 1 Plain language summary... 3
More informationGUIDELINE FOR THE MANAGEMENT AND PREVENTION OF ACUTE TUMOUR LYSIS SYNDROME IN HAEMATOLOGICAL MALIGNANCIES
GUIDELINE FOR THE MANAGEMENT AND PREVENTION OF ACUTE TUMOUR LYSIS SYNDROME IN HAEMATOLOGICAL MALIGNANCIES Full Title of Guideline: Author (include email and role): Division & Speciality: Scope (Target
More informationAcute Leukemia. Maureen Carr, MN, RN, AGPCNP-BC, AOCNP Hematology and Hematopoietic Cell Transplantation
Acute Leukemia Maureen Carr, MN, RN, AGPCNP-BC, AOCNP Hematology and Hematopoietic Cell Transplantation Disclosures Jazz Pharmaceuticals Speaker Bureau Acute myeloid leukemia (AML) Heterogeneous clonal
More informationPETHEMA; 2 HOVON; 3 PLAG and 4 GATLA Groups.
Clinical significance of complex karyotype at diagnosis in Pa7ents with Acute Promyelocy7c Leukemia Treated with ATRA and chemotherapy based PETHEMA trials Labrador J 1, Montesinos P 1, Bernal T 1, Vellenga
More informationLondon Cancer ALL guidelines
London Cancer ALL guidelines Page 1 of 7 CONTENTS OVERVIEW - main points in ALL management... 3 AGE-SPECIFIC THERAPEUTIC APPROACHES... 4 SPECIFIC THERAPEUTIC PROBLEMS... 5 SUPPORTIVE CARE... 6 PATIENTS
More informationMUD SCT for Paediatric AML?
7 th South African Symposium on Haematopoietic Stem Cell Transplantation MUD SCT for Paediatric AML? Alan Davidson Haematology / Oncology Service Red Cross Children s Hospital THE SCENARIO A 10 year old
More informationNECN CHEMOTHERAPY HANDBOOK PROTOCOL
DRUG ADMINISTRATION SCHEDULE Day Drug Dose Route Diluent Rate 1* to 5 Prednisolone 40mg/m 2 Oral Once Daily For 5 days 1 Paracetamol 1gram Oral Once Only Chlorphenamine 10mg IV bolus Ondansetron 8mg IV
More informationInternational Trial Relapsed AML 2001/01: Registration
Please fax or mail to the appropriate trial office! Appendix I International Trial Relapsed AML 2001/01: Registration Identification number : Surname / Initials: Date of Birth Gender male female dd/mm/yr
More informationDisclosure. Study was sponsored by Karyopharm Therapeutics No financial relationships to disclose Other disclosures:
Combination of Selinexor with High-Dose Cytarabine and Mitoxantrone for Remission Induction in Acute Myeloid Leukemia is Feasible and Tolerable A Phase I Study (NCT02573363) Amy Y. Wang, Howie Weiner,
More informationAcute Lymphoblastic and Myeloid Leukemia
Acute Lymphoblastic and Myeloid Leukemia Pre- and Post-Disease Form Acute Lympoblastic Leukemia Mary Eapen MD, MS Acute Lymphoblastic Leukemia SEER Age-adjusted incidence rate 1.6 per 100,000 men and women
More informationSingle Technology Appraisal (STA) Midostaurin for untreated acute myeloid leukaemia
Single Technology Appraisal (STA) Midostaurin for untreated acute myeloid leukaemia Response to consultee and commentator comments on the draft remit and draft scope (pre-referral) Please note: Comments
More informationClinical Guidelines for Leukaemia and other Myeloid Disorders MDS
Clinical Guidelines for Leukaemia and other Myeloid Disorders MDS Reference Number Version Status Executive Lead(s) Name and Job Title Author(s) Name and Job Title 13-2H-106 2 Dr Helen Barker MDT Lead
More informationAcute myeloid leukemia. M. Kaźmierczak 2016
Acute myeloid leukemia M. Kaźmierczak 2016 Acute myeloid leukemia Malignant clonal disorder of immature hematopoietic cells characterized by clonal proliferation of abnormal blast cells and impaired production
More informationNote: There are other bendamustine protocols, ensure this is the correct one for a given patient.
INDICATIONS 1 st line treatment for follicular lymphoma with FLIPI score 2 or higher: (NICE TA513- BLUETEQ required) Rituximab refractory follicular lymphoma (progression on R-chemo, R-maintenance or within
More informationOutcome of patients with hematologic malignancy admitted to the ICU
Outcome of patients with hematologic malignancy admitted to the ICU Geeta Mehta MD, FRCPC Mount Sinai Hospital Toronto, Canada CCCF November 2, 2016 Disclosures Hematologic Malignancy Advances in diagnostics,
More informationManchester Cancer Haematological-Oncology Pathway Board. Guidelines for the Diagnosis and treatment of Adult Acute Lymphoblastic Leukaemia
Manchester Cancer Haematological-Oncology Pathway Board Guidelines for the Diagnosis and treatment of Adult Acute Lymphoblastic Leukaemia Coordinating author: Dr Anna Castleton Date of issue: June 2016
More informationScottish Medicines Consortium
Scottish Medicines Consortium clofarabine, 1mg/ml concentrate for solution for infusion (Evoltra ) (No. 327/06) Bioenvision Limited 8 December 2006 The Scottish Medicines Consortium (SMC) has completed
More informationLEUKAEMIA and LYMPHOMA. Dr Mubarak Abdelrahman Assistant Professor Jazan University
LEUKAEMIA and LYMPHOMA Dr Mubarak Abdelrahman Assistant Professor Jazan University OBJECTIVES Identify etiology and epidemiology for leukemia and lymphoma. Discuss common types of leukemia. Distinguish
More informationBlood Cancers in the Community
Over to you, mate Blood Cancers in the Community National Rural Health Conference NZ Rural General Practice Network April 7, 2018 Brian Grainger Haematology Registrar Auckland Acknowledgements Dr James
More informationUPDATE Autologous Stem Cell Transplantation for Lymphoma and Myeloma
UPDATE Autologous Stem Cell Transplantation for Lymphoma and Myeloma Supported by a grant from Supported by a grant from UPDATE Autologous Stem Cell Transplantation for Lymphoma and Myeloma Jonathan W.
More informationMedical Policy. MP Hematopoietic Cell Transplantation for Acute Myeloid Leukemia
Medical Policy MP 8.01.26 BCBSA Ref. Policy: 8.01.26 Last Review: 01/30/2018 Effective Date: 01/30/2018 Section: Therapy Related Policies 2.04.124 Genetic Testing for FLT3, NPM1, and CEBPA Variants in
More informationAcute Myeloid Leukemia
NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines ) Acute Myeloid Leukemia Version 2.2016 NCCN.g Continue Version 2.2016, 06/29/16 National Comprehensive Cancer Netwk, Inc. 2016, All rights
More informationDERBY-BURTON LOCAL CANCER NETWORK FILENAME ESHAP.DOC CONTROLLED DOC NO: HCCPG B44. ESHAP Regimen
ESHAP Regimen Available for Routine Use in Burton in-patient Derby in-patient Burton day-case Derby day-case Burton community Derby community Burton out-patient Derby out-patient Indication Relapsed/ refractory
More informationAdult T-cell lymphoblastic leukemia/lymphoma. Lymphoma Tumor Board. September 8, 2017
Adult T-cell lymphoblastic leukemia/lymphoma Lymphoma Tumor Board September 8, 2017 Diagnosis of T-cell lymphoblastic leukemia/lymphoma Lymphoblastic lymphoma (LBL) is rare Sub-type of lymphoma that is
More informationGreater Manchester and Cheshire Cancer Network Chronic Myeloid Leukaemia v3 2012
Greater Manchester and Cheshire Cancer Network Chronic Myeloid Leukaemia v3 2012 Dr Simon Watt Dr Shiva Natarajan 1.0 Introduction The landscape in chronic myeloid leukaemia (CML) has changed dramatically
More informationObjectives. I do not have anything to disclose.
Treatment of APL Objectives I do not have anything to disclose. Objectives 1. Urgency of early recognition and treatment 2. Treatment based on risk stratification 3. Monitoring for relapse 4. Treatment
More information