Drug Discovery. Drug Target Analysis. Drug Delivery. College of Pharmacy Genome to Drug Discovery Group

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1 College of Pharmacy Genome to Drug Discovery Group Drug Discovery Drug Delivery Drug Target Analysis Chemistry + Biology + Genetics = Advancing Human Health

2 College of Pharmacy Genome To Drug Discovery

3 The Bacterial Extracellular Proteome as Potential Therapeutic Target Intensity CFUs/mouse m/z wt T2S mutant Aleksandra Sikora

4 What makes Chlamydia Chlamydia? Chlamydia trachomatisinfected cells Vacuole bacteria Host nucleus Dan Rockey

5 Skin Wound Healing Healing of Chronic, diabetic, burn wounds is a major health concern Head and neck cancer Gitali Ganguli-Indra indrag@onid.orst.edu Cancer is a wound that does not heal Identify gene targets Identify factors to mobilize stem cells Validating targets Patient s biopsies & cancer cell lines C U R E Collaborators : A.Indra & M.Leid) New Drug Targets Identify pathways Diagnosis & Prevention 1. Patented Biomarker (Collaborator: A.Indra & M.Leid) 2.New anticancer drugs (Collaborator: T. Mahmud) C U R E

6 Taifo Mahmud Laboratory Department of Pharmaceutical Sciences Natural product discovery Drug Discovery and Development Biosynthetic engineering Chemical synthesis Infectious diseases and cancers Genome mining and metabolomics

7 OSU Natural Products as Probes to study Autophagy and Cell Death in cancer cells Jane Ishmael Pharmacology Mandelalide A discovered by Kerry McPhail in South Africa Coibamide A discovered by Kerry McPhail in Panama Coibamide A induces autophagy "self eating" in glioblastoma cells as a survival response but the cell still dies

8 Molecular CancerTherapeutics Siva Kolluri Molecular Therapeutics A new generation of drugs designed to interfere with a specific molecular target Our Focus: I. Dioxin Receptor from a mediator of toxic responses to an Anti-Cancer Target II. Conversion of Bcl-2 from a Protector to a Killer Protein New Molecular Targets For Breast Cancer

9 Novel inhibitors of the Receptor-tyrosine-kinase-like Orphan Receptor 2 (ROR2) enzyme for cancer treatment GENERAL RESEARCH FUND AWARD - URISC UNDERGRAD AWARD Wright et al. Oncogene 2009 Rasmussen et al. JBC 2013 CADD Artim et al. Biochem J 2012 A375 HCT116 RCC4 U2OS-3 tissue skin colon kidney bone Significance Innovation Interdisciplinarity Successful data drive publications and NHI grant submissions

10 Trans-kingdom network Andrey Morgun Assistant Professor College of Pharmacy (541) microbiome Host transcriptome Drivers of cervical cancer GERM FREE animals Usp

11 Cell Signaling in Organ Development and Disease Theresa Filtz, Ph.D. Pharmaceutical Sciences, College of Pharmacy 323 Pharmacy; ; To identify the cell signals that regulate cell differentiation through gene activation. To understand how enzymatic modifications of transcription factors change gene activation in development and disease. To reveal new drug targets that regulate gene activation in disease.

12 Pharmacy Practice Research What is pharmacy practice research? Examines how and why people access pharmacy services, the associated costs, and resulting patient outcomes My areas of interest include: Impact of clinical pharmacy services on quality metrics and patient outcomes Primary care Dynamics of federally qualified health centers (FQHC) Adriane Irwin

13 Nano-therapy for cancer treatment Drug solubilization Controlled release Drug targeting Combinatorial drug therapy Ease of administration Synergy/additive drug effects Imaging Radiotherapy Adam Alani

14 Multifunctional Nanomedicine Platforms for Cancer Treatment Chemotherapy Hyperthermia Photodynamic Therapy Gene Therapy Theranostic : Photodynamic Therapy and Image-Guided Drug Delivery Phthalocyanine Photodynamic Therapy Light Image-Guided Drug Delivery No light Tumor rs Oleh Taratula

15 Skin - Dr. Jekyll and Mr. Hyde NIAMS (R01) Leid and Indras Arup Indra eczema NIEHS (R01) Leung et. al, Journal of Clinical Investigation, Arup.indra@oregonstate.edu Melanoma :beast Eczema : itch Cause Cause Chambon and Indra Alani and Indra Cure Ctip2 ep-/- Ctip2 -/- Vehicle Drug Cure + +vehicle +Ack2 Ctip2 -/- Stevens and Indra XN TK inhibitor controls melanocyte survival Reduced Lymph Node invasion after targeted drug delivery

16 College of Pharmacy Genome To Drug Discovery