Astrid Pujari, MD

Transcription

1 Astrid Pujari, MD

2 Not just germs: tumor cells too!

3 White blood cells Natural killer cells T cells Organs Spleen, thymus, tonsils Bone marrow Lymph nodes Lymphatic system Roads that your white blood cells use to travel

4 Thymus Tonsils Lymph nodes/channels Spleen Intestine (Peyer s patches) Bone marrow

5 Colon cancer and sugar JNCI Feb ,451 women followed for 8 years Most high glycemic foods = 3x risk of colon cancer =

6 Pancreatic cancer Nurses Health Study with 88,802 women followed for 18 yrs Overweight, Sedentary: Increase risk 2x with high glycemic index foods 3x with fructose JNCI J Natl Cancer Inst (2002) 94 (17): Fructose: Soda, punch, fruit juices

7 J Clin Oncol 2002 Goodwin 512 women with early stage breast cancer Highest quartile of fasting insulin levels 3x risk of dying 2x as likely to have tumor metastasize

8 Insulin = growth factors = tumor growth =

9 Increases insulin = Decreases ability of your WBC to use vitamin C Makes the WBC less able to adhere to your blood vessels to get into tissues (adhesion) Make the WBC less able to eat foreigners (phagocytosis)

10 g sugar solution drops ability of WBC to overpower and destroy bacteria Effects last for at least a few hours =

11 White flour White sugar, brown sugar etc. High fructose corn syrup Sugary cereals Pastries, cookies, cakes etc.

12

13 Weight loss decreases insulin resistance = Overweight mice: lower immune system When given vaccine, make fewer antibodies

14 Moderate, consistent exercise Immune cells circulate more quickly Kill bacteria and viruses more quickly Reduce number of days sick by ½ over 15 weeks Brisk walk for 30 minutes on most days Gradual increase to this level

15 Marathon etc. >90 minutes Suppresses immunity for up to 72 hours

16 Increase risk colds for 1-2 weeks afterwards Lower WBC counts Increased inflammation May be related to increase in cortisol

17 Sleep boosts immune system Germany Gave 19 people Hepatitis A vaccine Slept that night: 2x the antibodies 4 weeks later vs. those who stayed awake Have seen effects up to one year later J Immunol 2012

18 University of Chicago students 4 hours of sleep for 6 nights Flu shot: ½ the number of antibodies Increase in insulin resistance (pre-diabetes) Decrease leptin: increases appetite

19 In1960: 9 hours/night Current: about 6.8 hours/night Ideally around 8 hours/night If you miss one night, you recover in 3 nights

20 Weight gain, glucose, memory loss/concentration Tumors grow 2x faster in animals with severe sleep issues

21 Consistent bed time and wake time Dark bedroom No TV or reading in bed If can t sleep, get out of bed after 20 minutes No alcohol

22 Live microorganisms, usually bacteria Similar to those in human intestines Friendly bacteria or good bacteria WHO: Live microorganisms that when given in sufficient amounts confer a health benefit on host

23 Boost IgA Increase immune cells ability to eat foreigners Decrease inflammation intestine Drops allergic reactions

24 ?Cancer prevention Bind to carcinogens in food Eat a hamburger with lactobacillus and mutagens in urine drop by 50% Ann Rev Nutr 2002 Decrease generation of colon tumors in animals after carcinogen challenge

25 May help shorten frequency, severity colds - BMJ kids age 1-6 in daycare - Probiotic milk vs. plain milk - 16% less absence for GI or upper respiratory illness -19% less had severe infections needing ABX

26 Taking probiotics may help allergic issues in kids Mom took probiotic for 2 wks before delivery, & for first 3-6 mo breastfeeding Prevents allergies, asthma, eczema in infants Effects last to 4 yrs Probiotic: 43% less likely develop allergic issues Lancet 2003

27 Use higher numbers More variety of bacteria Alive Many do not have what they say they do: Yogurt, kefir

28 Europe: Fairies and elves would appear if sat under bush at night

29 Boosts immune system from anthocyanidins Half life of two hours Used for flu epidemic in Panama

30 Study of 60 people with the flu Improved symptoms 4 days earlier Needed less rescue medications J Int Med Res 2004

31 40 people with flu took elderberry or placebo People who took elderberry; 93% improved fever Symptoms improved in 2 days (vs. 6 days) Better antibody response J Alter Comp Med 1995

32 Black berries: been used as food, cooked Can find in store as syrup Take regularly and soon if cold DO NOT Use red berries, stems, leaves

33 Indiana State University 33 healthy women in two groups Funny video vs. tourism video Funny video: Much less stress Natural killer cells significantly higher Alternative Therapies in Health and Medicine. 2003;9:38-45.

34 Japanese study 19 people Day 1: boring 40 minute lecture Day 2: comedy show Ate the same meal: Blood sugar after meal about 33% lower with comedy

35 Improves circulation Blood vessels function better after laughing Decreases stress Burns calories

36 Relaxing Visualization Uses your imagination

37 American Cancer Society reviewed 48 studies between Decrease stress Drop anxiety, depression Decrease pain Drop side effects chemotherapy

38 Increases white blood cell counts With visualization, can affect each type individually Stronger effect with medical issue Int J Neuroscience 2008 Jun =

39 Gratitude cultivates optimism Healthy law students with greater optimism scores maintained higher number of white blood cells under stress than pessimistic classmates Aspinwall, 2010

40 Less heart attacks More likely to do positive self-care: exercise and eat well Less stress and better able to cope with stress

41 Improves Cancer Outcomes Breast cancer patients who explored their feelings around cancer = less doctor s visits for cancer related problems

42 Improves cancer outcomes Avoiding or hidden emotions = increases cancer progression and decreases survival Lancet Soc Sci Med. 1989

43 Boosts immune system HIV patients who wrote about their worries 4 days in a row had a drop in viral load and rise in t cells

44 Improves immune system Improves lung and liver function Drops blood pressure Improved pain, physical function in cancer patients Improves sports performance and grade point average Advances in Psychiatric Treatment (2005)

45

46 Covers: Guided imagery Expressive writing Gratitude tools Techniques for positive self transformation Ebook available at Print copies also available

47