CURE. Translation of Genomics into Improvements in Cancer Prevention and Treatment. SUMR Scholar: Tyler Chavez Mentor: Angela Bradbury, MD
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1 CURE Translation of Genomics into Improvements in Cancer Prevention and Treatment SUMR Scholar: Tyler Chavez Mentor: Angela Bradbury, MD
2 Agenda I. How We Got Started II. III. IV. Goal/Hypothesis Experimental Methods Subject Eligibility V. My Role VI. VII. Progress/Moving Forward Implications VIII. Involvement with METEOR IX. Acknowledgements
3 How We Got Started u Program project grant u Partnership with Fox Chase Cancer Center (to address recruiting challenges) u Began recruiting in July 2013
4 Background u Family history has been used in primary care for decades and has been shown to be an independent risk factor for most common diseases. u Incorporates shared environmental, social and behavioral risk. u Can increase an individual s risk two- to six-fold. u There are also BRCAPRO programs that produce a numerical value for a person s risk.
5 Goal u To evaluate two alternative strategies for conveying the genetic risk information from family history on risk reducing behaviors among 1st and 2nd degree relatives of newly diagnosed breast or colorectal cancer patients.
6 Hypothesis u Enhanced risk communication will provide improved short-term outcomes (knowledge and intention to adhere to risk reduction recommendations) and 12 month outcomes (knowledge and compliance with recommended health behaviors) as compared to the family history education alone.
7 Methods u Recruit subjects through patients u Baseline survey/family History u Pedigree u visual representation of the family structure and facilitates the identification of patterns of cancer transmission
8
9 Methods (cont.) u Subjects are randomized to one of two different types of education sessions u Strictly family history (low/moderate/high risk) u Family history plus a numerical BRCAPRO value u 3 day follow-up survey u 12 month follow-up survey to assess behavioral outcomes during the past 12 months u Starting screening at an earlier age/more frequent screening u Chemoprevention options u Prophylactic surgeries u Lifestyle modifications
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11 Subject Eligibility u Patient must have been diagnosed in the past 18 months u Subjects more likely to take action during this period u Subject must be a first-degree relative u Mother/Father, Sister/Brother, Aunt/Uncle, Daughter/Son u Subject must be over the age of 40 u Age of eligibility for screening options u Subject cannot have a personal history of cancer or genetic counseling u Family history wouldn t be the only risk factor for cancer u Previous influence of genetic counseling
12 My Role u Subject recruitment through patients u Screen patients for 18 month eligibility u Approach patients in clinic u Follow up phone calls u Send mailings u Distribute surveys u Build pedigrees based on family history and calculate risk
13 Progress u 100 total subjects u 11 consented this summer u Challenges u Addressing them
14 Moving Forward u Continuation of recruitment until we reach 200 subjects u Projected to be July 2015
15 Implications u We expect results to be definitive as to which method of risk communication better educates subjects u We expect that the results will be translated into a generalized method of risk communication that may not require a genetic counselor u Will increase preventative measures taken by family members of cancer patients u We expect this research to inform evidence based practice guidelines and potentially change the paradigm of delivery of genetic services for disease susceptibility.
16 u Multiplex panel testing u Tiered-Binned Approach u Patient driven counseling
17 My Role u Literature Review of genomic literacy in cancer genetic counseling u Genetic counseling tape review to assess fidelity
18 Lessons Learned u How to properly approach patients and discuss sensitive information u Appreciation of clinical research difficulties u Research process u Translation of genetics into the clinical world
19 Special Thanks u Angela Bradbury, MD u Linda Crossette u Matthew Astolfi u Michael Leff u Urooj and Abha u Joanne Levy u Safa Browne
20 CURE Translation of Genomics into Improvements in Cancer Prevention and Treatment SUMR Scholar: Tyler Chavez Mentor: Angela Bradbury, MD
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