Brand Name(s)/ Manufacturer(s) Labeled Uses Vincristine sulfate Oncovin/Eli Lilly;

Transcription

1 Medical Alert Charcot-Marie-Tooth The medications listed below are potentially toxic to CMT patients. Vincristine has been proven hazardous and should be avoided by all CMT patients, including those with no symptoms. The remainder of the medications listed below present varying degrees of potential risk for worsening CMT neuropathy. Before taking any medication or changing medication, all CMT patients should make sure the treating physician is fully aware of their medical condition. (Note: This table is not a complete list of brand names, manufacturers, or labeled uses. There may be others, and patients should be aware that many drugs have off-label uses. Always check the ingredients before taking any medication.) Definite High Risk Vincristine sulfate Oncovin/Eli Lilly; Acute leukemia; Vincasar PFS/Pfizer; malignant lymphomas Vincristine Sulfate and carcinomas Injection/Abbott, Mayne Cabazitaxel Jevtana/Sanofi-Aventis Advanced prostate cancer Docetaxel Taxotere/Sanofi-Aventis Breast and prostate carcinomas; lung cancer Paclitaxel Onxol/IVAX; Breast, lung, ovarian Paclitaxel Injection/UDL, and esophageal Bedford carcinomas Taxol/Bristol-Myers Squibb Taxols (see specific drug names) Moderate to Significant Risk Amiodarone HCL Cordarone/Wyeth-Ayerst Ventricular arrhythmias (fibrillation and tachycardia Auranofin Ridaura/Prometheus Rheumatoid arthritis, Aurothioglucose Solganal/Schering Rheumatoid arthritis Intramuscular Bortezomib Velcade/Millenium Multiple myeloma (bone cancer) Cisplatin Cisplatin Injection/Abbot, Bladder, ovarian, and American Pharmaceutical testicular carcinomas Partners, Baxter; Platinol-AQ/Bristol-Myers Squibb Colchicine* *risk with extended use Colchicine Tablets/Abbot; Colchicine Injection/Bedford; Probenecid and ColchicineTablets/IVAX, Truxton Gout prevention; gouty arthritis; (unlabeled use: hepatic cirrhosis due to alcohol) Dapsone Dapsone Tablets/Jacobus Bullous herpetiformis dermatitis; leprosy Didanosine; Videx/Bristol-Myers Squibb HIV infection Dideoxyinosine (ddi) Dichloroacetate (DCA) Not FDA approved; in clinical trials Chronic lactic acidosis Disulfiram Antabuse/Odyssey Alcoholism, Eribulin Mesylate Halaven/Eisai Metastatic breast cancer (patients who have received two prior chemotherapy regimens) CMTA Medical Alert - Revised 01/23/2015 Page 1 of 6

2 Gold Salts (see specific drug names) Gold Sodium Thiomalate Moderate to Significant Risk, cont. Aurolate/Taylor Rheumatoid arthritis Intramuscular Ixabepilone Ixempra/Bristol-Myers Squibb Metastatic or locally advanced breast cancer Leflunomide Arava/Aventis Rheumatoid arthritis Metronidazole* *risk with extended use Misonidazole* *risk with extended use Nitrofurantoin; Macrodantin Nitrous Oxide* Flagyl/Pfizer Nitrofurantoin Capsules/Sandoz; Macrobid/Proctor & Gamble; Furadantin/Elan Intestinal, vaginal and other bacterial infections; septicemia; peritonitis; endocarditis Cancer treatment; radiotherapy Urinary tract infections General anesthesia, * *also a topical application in some formulations Inhalation *risk with inhalation abuse or vitamin B12 deficiency Oxaliplatin Eloxatin/Sanofi-Synthelabo Colorectal carcinoma Perhexiline* *not used in US Pyridoxine* Pexsig/Sigma (Australia and New Zealand) Angina pectoris Vitelle Nestrex/Fielding Vitamin B 6 deficiency; antidote to druginduced *risk with megadoses neuropathy Stavudine (d4t) Zerit/Bristol-Myers Squibb HIV infection Suramin Awaiting FDA approval African sleeping sickness; river blindness; experimental cancer treatment (prostate) Thalidomide Thalomid/Celgene Erythema (reddening of the skin); nosodum leprosum (a rash associated with treatment of leprosy); many other off-label uses (mainly autoimmune disease Zalcitabine; Dideoxycytidine (ddc) 5-Fluorouracil; (5-FU) Adriamycin (Doxorubicin HCL) and chemotherapy) Hivid/Roche HIV infection Uncertain or Minor Risk Adrucil/Pfizer; Fluorouracil injection/baxter, Valeant, SoloPak, APP Adriamycin/Bedford; Adriamycin RDF/Pfizer Breast, colorectal, gastric and pancreatic carcinomas Leukemia; lymphomas; carcinomas Acute respiratory Almitrine Vectarion/Not manufactured in US failure Atorvastatin Lipitor/Pfizer Elevated LDL,, CMTA Medical Alert - Revised 01/23/2015 Page 2 of 6

3 Uncertain or Minor Risk, cont. Ciprofloxacin Cipro; Cipro IV/Bayer Bacterial infections, including skin, bone, blood, urinary, respiratory, and gastrointestinal tract infections; pneumonia; sinusitis; typhoid fever Chloroquine Aralen Phosphate/Sanofi- Amebiasis; malaria Synthelabo; Aralen Hydrochloride/Sanofi- Synthelabo Cytarabine;* (Ara-C; Cytarabine Injection/Mayne, Leukemias Cytosine arabinoside) Bedford; Cytosar-U/Pfizer, Cytarabine liposomal* DepoCyt/Enzon Lymphomatous meningitis *risk with high doses Enoxacin Penetrex/Aventis Urinary tract infections; gonorrhea Ethambutol Ethambutol Tablets/Versa; Tuberculosis Myambutol/Elan Etoposide (VP-16) Etoposide Capsules/Mylan; Small cell lung VePescid/Bristol-Myers carcinoma Squibb Etoposide for Small cell lung Injection/Abbot, Bedford, carcinoma; Gensia Sicor, SuperGen; refractory testicular Toposar/Pfizer; neoplasm VePescid, Etopophos/Bristol-Myers Squibb Fluoroquinolones (see specific drug names) Fluvastatin Lescol/Reliant Elevated LDL Gatifloxacin Tequin/Bristol-Myers Squibb; Tequin Injection/Bristol- Myers Squibb Pneumonia and bronchitis; sinus, respiratory tract, and urinary tract infections; sexually transmitted diseases Gemcitabine Gemzar/Lilly Non-small cell lung cancer; pancreatic carcinoma Griseofulvin Hexamethylmelamine (Altretamine) Hydralazine Grifulvin V/Ortho- Neutrogena; Fulvicin U/F/Schering; Gris-PEG/Pedinol Tineas (ringworm infections) of the skin, hair, and nails Intrathecal (Spinal infusion), Hexalen/MGI Pharma Ovarian cancer Apresoline/IVAX; Hydra-zide/Par; Apresazide/Novartis; Marpres/Marnel Hypertension Ifosfamide Ifex/Bristol-Myers Squibb Testicular germ cell carcinoma; bone and soft tissue sarcomas Infliximab Remicade/Centocor Rheumatoid arthritis; Crohn s disease Isoniazid (INH) Nydrazid/Sandoz; Tuberculosis Laniazid/Lannett,, CMTA Medical Alert - Revised 01/23/2015 Page 3 of 6

4 Lansoprazole Uncertain or Minor Risk, cont Prevacid/TAP Phramaceuticals Ulcers; gastroesophageal reflux disease (GERD); Zolliger- Ellison Syndrome Levofloxacin Levaquin/Ortho-McNeil Infections, including skin, respiratory, and urinary tract infections; venereal diseases Lomefloxacin Maxaquin/Pfizer Bronchitis and urinary tract infections Lovastatin Lovastatin/Mylan, Par, Elevated LDL Sandoz, Teva; Mevacor/Merck; Altocor/Andrx Mefloquine Lariam/Roche Prevention and treatment of malaria Moxifloxacin Avelox/Bayer Skin and respiratory tract infections Norfloxacin Noroxin/Merck Urinary tract infections; prostatitis; gonorrhea Ofloxacin Floxin/Ortho-McNeil Urinary tract, skin, bone, and heart infections Omeprazole Penicillamine Phenytoin Prilosec/Proctor and Gamble; Zegerid/ Santarus Cuprimine/Merck; Depen/Wallace Dilantin/Pfizer; Phenytoin Sodium Injection/Baxter, Hospira, Sanofi Ulcers; gastroesophageal reflux disease (GERD); Zolliger- Ellison Syndrome Rheumatoid arthritis; Wilson s Disease (accumulation of copper in liver and other organs); cystinuria (kidney stones) Epilepsy; convulsions; seizures,,,, Sparfloxacin Zagam/Bertek Lower respiratory tract infections Trovafloxacin Trovan/Pfizer Pneumonia; (Alatrofloxain) abdominal, pelvic, and Podophyllin resin* *high risk with excessive time exposure or unintended route (oral; deep injection) Podocon-25/Paddock skin infections Removal of benign growths and warts, esp. external genital and perianal exophytic warts caused by human papillomavirus (HPV) Pravastatin Pravachol; Pravigard/Bristol- Myers Squibb Elevated LDL Rosuvastatin Crestor/AstraZeneca Elevated LDL Sertraline Zoloft/Pfizer Depression; panic attacks; obsessivecompulsive disorder; PTSD; social disorder, CMTA Medical Alert - Revised 01/23/2015 Page 4 of 6

5 Uncertain or Minor Risk, cont Simvastatin Zocor/Merck Elevated LDL Statins (see specific drug names) Note: Statins are generally prescribed to control and triglyceride levels and to prevent coronary events. Tacrolimus (FK506) Prograf/Fujisawa Prevention of liver,, kidney, and other organ transplant rejection Zimeldine (not in US) (Withdrawn from market) Depression α-interferon Allopurinol Roferon/Roche; Intron; Rebetron/Schering; Infergen/InterMune; Alferon/Hemispherx Hepatitis B and C; warts caused by human papillomavirus (HPV); Kaposi s sarcoma; renal cell carcinoma; multiple myeloma (bone cancer); malignant melanoma (skin cancer); Non-Hodgkin s lymphoma Negligible or Doubtful Risk Zyloprim/Prometheus; Aloprim/Nabi Gout; gouty arthritis; kidney and urinary tract stones Amitriptyline Elavil/Zeneca Depression Intramuscular, intralesional, or subcutaneous injection, Chloramphenicol Cloramphenicol Sodium Succinate/American Pharmaceutical Partners; Chloromycetin/Monarch Meningitis; typhoid fever Chlorprothixene Taractan/Roche Psychosis, Intramuscular Cimetidine Tagamet/GlaxoSmithKline; Cimetadine Hydrocloride Injection/American Regent, Hospira, Endo Gastric and duodenal ulcers; gastroesophageal reflux, Clioquinol Clioquinol is an ingredient in numerous formulations (often in combination with hydrocortisone) used to treat bacterial and fungal infections of the skin Dermatitis; folliculitis; eczema; athlete s foot; jock itch; ringworm Clofibrate Atromid/Wyeth-Ayerst Hyperlipidaemias (high and triglyceride levels) Cyclosporin A Enalapril Gluthethimide Lithium Sandimmune; Neoral/Novartis Vasotec/Biovail; Enalaprilat Injection/Abbott, Baxter, Bedford, Faulding Superceded by other drugs; not currently in use Lithium Carbonate/Rugby, Roxane; Lithobid/Solvay; Eskalith/GlaxoSmithKline Prevention of rejection of organ transplants; severe cases of psoriasis and rheumatoid arthritis Hypertension; congestive heart failure Insomnia Bipolar disorder (manic/depressive disorder) Phenelzine Nardil/Pfizer Depression (powders, creams, ointments),, CMTA Medical Alert - Revised 01/23/2015 Page 5 of 6

6 Propafenone Sulfacetamide Negligible or Doubtful Risk, cont. Propafenone HCL/Watson; Rythmol/Abbott Numerous brand names and manufacturers Atrial fibrillation; ventricular arrhythmias Acne; seborrheic dermatitis; eye and vaginal infections Vaginitis Sulfabenzamide Numerous brand names and manufacturers Sulfadiazine Sulfadiazine Tablets/Eon, Toxoplasmosis Raway, UDL Sulphasalazine Azulfidine/Pfizer Rheumatoid arthritis; ulcerative colitis Sulfathiazole Sulphamethoxazole Sulfisoxazole (sulfafurazole) Sulfonamides (see specific drug names) Numerous brand names and manufacturers Proloprim; Septra/Monarch; Trimpex/Roche Gantrisin/Roche Vaginitis Urinary tract infections; otitis media (middle ear infection) Urinary tract infections; otitis media, (middle ear infection) Note: Although listed here, the use of sulfonamides to treat infections has decreased due to the increase in drug-resistant bacteria. CMTA Medical Alert - Revised 01/23/2015 Page 6 of 6