THE COMPLEMENT SYSTEM OBJECTIVES:
|
|
- Melvin Lamb
- 5 years ago
- Views:
Transcription
1
2 THE COMPLEMENT SYSTEM OBJECTIVES: When you finish this section, you should be able to: 1. Describe the effects of complement activation. 2. Outline the Classical, Mannan-Binding (MB) Lectin and Alternative pathways of complement activation, including their activators. 3. Discuss the major regulatory points in complement activation and the consequences of deficiencies in complement or complement regulators. 4. Discuss the functions of the various complement receptors. 5. Discribe the biologic activities of complement and identify the components involved.
3 Complement: History Discovered in 1894 by Bordet It represents lytic activity of fresh serum Its lytic activity destroyed when heated at 56C for 30 min
4 COMPLEMENT ƒ Complex series of plasma proteins (C1-C9). ƒ Heat labile (inactivated at 56 C for 30 min). ƒ Synthesized in vivo by liver macrophages, hepatocytes and intestinal epithelia. ƒ Can be synthesized in vitro by monocytes and macrophages. ƒ C3 is most abundant (1g/L of plasma) and important complement component. ƒ Complement system ; Plays a major role in innate and adaptive immunity.
5
6 Complement functions Host benefit: opsonization to enhance phagocytosis phagocyte attraction and activation lysis of bacteria and infected cells clearance of immune complexes clearance of apoptotic cells Host detriment: Inflammation, anaphylaxis
7
8 Proteins of the complement system (nomenclature) C1(qrs), C2, C3, C4, C5, C6, C7, C8, C9 factors B, D, H and I, properdin (P) mannose binding lectin (MBL), MBL associated serine proteases (MASP-1 MASP-2)
9 Definitions C-activation: alteration of C proteins such that they interact with the next component C-fixation: utilization of C by Ag-Ab complexes Convertase/esterase: altered C-protein which acts as a proteolytic enzyme for another C-component
10 Activation product of complement proteins (nomenclature) When enzymatically cleaved, the larger moiety, binds to the activation complex or membrane and the smaller peptide is released in the microenvironment Letter b is usually added to the larger, membrane-binding, peptide and a to the smaller peptide (e.g., C3b/C3a, C4b/C4a, C5b/C5a), EXCEPT C2 (the larger, membranebinding moiety is C2a; the smaller one is C2b)
11 Pathways of complement activation CLASSICAL PATHWAY LECTIN PATHWAY ALTERNATIVE PATHWAY antibody dependent antibody independent Activation of C3 and generation of C5 convertase activation of C5 LYTIC ATTACK PATHWAY
12 THE CLASSICAL COMPLEMENT PATHWAY ƒactivated by Ag-Ab binding (can also be activated by viruses, Mycoplasma, DNA).
13
14 ƒ One IgM molecule can stimulate C1 since it is a pentamer with 5 Fc regions. At least 2 IgG molecules are required to activate C1. ƒ IgM more efficient complement binding (fixing) antibody than IgG. ƒ IgA and IgE lack C1q receptors and cannot activate complement. ƒ Activated C1q activates C1r which activates C1s.
15
16
17
18
19 Components of the Classical Pathway C3 C4 C1 complex
20 Classical Pathway Generation of C3-convertase
21 Classical Pathway Generation of C3-convertase C4b2a is C3 convertase C4b
22 Classical Pathway Generation of C5-convertase C4b2a3b is C5 convertase; it leads into the Membrane Attack Pathway C4b C3 b
23 Biological Activities of Classical Pathway Components Component Biological Activity C2a(or b) C3a C3b C4a Prokinin; cleaved by plasmin to yield kinin, which results in edema Anaphylotoxin; can activate basophils and mast cells to degranulate resulting in increased vascular permeability and contraction of smooth muscle cells, which may lead to anaphylaxis Opsonin Activation of phagocytic cells Anaphylaotoxin C4b Opsonin 24
24 Control of Classical Pathway Components Component Regulation All C3a C3b C4a C1-inhibitor (C1-INH); dissociates C1r and C1s from C1q C3a-inactivator Factors H and I; Factor H facilitates the degradation of C3b by Factor I C3a-INH 25
25 C1-inhibitor deficiency: hereditary angioedema
26 Lytic pathway Generation of C5 convertase leads to the activation of the Lytic pathway
27 Components of the lytic pathway C6 C7 C 9
28 Lytic pathway C5-activation b C4b C3b
29 Lytic pathway: insertion of lytic complex into cell membrane C6 C C C C C 9 C 9 C 9 9 C C 9 9 C7 b
30 MANNAN-BINDING LECTIN COMPLEMENT PATHWAY ƒ Activated by binding of a serum protein -mannose-binding lectin (MBL) to mannose-containing proteins or to carbohydrates on bacteria or viruses. ƒ Activates the classical pathway in an (antibody and C1) independent manner. ƒ MBL is structurally similar to C1q. Instead of C1r and C1s, MBL associates with mannose-binding lectin-associated serum proteases (MASP-1 and MASP-2) to activate C4 and C2 ƒ Activation by MBL:MASP complex generates C3 convertase which progresses as in the classical pathway to produce the membrane attack complex.
31 Components of mannose-binding lectin pathway MBL MASP1
32 Mannose-binding lectin pathway MASP1 C4b2a is C3 convertase; it will lead to the generation of C5 convertase MBL
33
THE COMPLEMENT SYSTEM OBJECTIVES:
Dr Mohammed Al- ani THE COMPLEMENT SYSTEM OBJECTIVES: When you finish this section, you should be able to: 1. Describe the effects of complement activation. 2. Outline the Classical, Mannan-Binding (MB)
More informationComplement: History. Discovered in 1894 by Bordet. It represents lytic activity of fresh serum
Complement: History Discovered in 1894 by Bordet It represents lytic activity of fresh serum Its lytic activity destroyed when heated at 56C for 30 min Complement functions Host benefit: opsonization to
More informationCD B T NK NKT!! 1
CD B T NK NKT!! 1 2 !! 3 4 5 6 7 8 9 10 11 Biological effects of C5a 12 13 Opsonization and phagocytosis 14 15 http://www.med.sc.edu:85/book/wel come.htm 16 http://www.med.sc.edu:85/book/im munol-sta.htm
More informationIntroduction. A system of soluble enzymes and proteins. Complement components: C1 to C9, B, D and P
Complement Introduction A system of soluble enzymes and proteins Complement components: C1 to C9, B, D and P When activated, each component is split into small and large (major) fragments a b *A horizontal
More informationComplement. History. Chapter 7. Complement Components. Complement Pathways. Pathways of complement activation
History Chapter 7 Complement Jules Border in 1890 s discovered complement Paul Ehrlich coined the term complement The activity of blood serum that completes the action of antibody Now: Set of serum proteins
More informationHistory. Chapter 13. Complement Components. Complement Pathways
History Chapter 13 Complement Jules Border in 1890 s discovered complement Paul Ehrlich coined the term complement The activity of blood serum that completes the action of antibody Now: Set of serum proteins
More informationBasic Immunology. Lecture 16th. Complement system
Basic Immunology Lecture 16th Complement system Components: Inactive factors in the serum and body fluids which can activate each other in an enzyme cascade Cell surface receptors (CR) for binding the
More informationTopic (6): The Complement System
Topic (6): The Complement System Introduction The complement system is a complex system of many different glycoproteins. It comprises several plasma proteins that sequentially activate each other by proteolytic
More informationHistory. Chapter 13. Complement Components. Complement Pathways
History Chapter 13 Complement Jules Border in 1890 s discovered complement Paul Ehrlich coined the term complement The activity of blood serum that completes the action of antibody Now: Set of serum proteins
More informationThe term complement refers to the ability of a system of some nonspecific proteins in normal human serum to complement, i.e., augment the effects of
COMPLEMENT SYSTEM The term complement refers to the ability of a system of some nonspecific proteins in normal human serum to complement, i.e., augment the effects of other components of immune system,
More informationاالستاذ المساعد الدكتور خالد ياسين الزاملي \مناعة \المرحلة الثانية \ التحليالت المرضية \ المعهد التقني كوت
Complement System The term complement refers to the ability of a system of some nonspecific proteins in normal human serum to complement, i.e., augment the effects of other components of immune system,
More informationTarget cell lysis Opsonization Activation of the inflammatory response (e.g. degranulation, extravasation) Clearance of immune complexes
Immunology Dr. John J. Haddad Chapter 13 Complement Major roles of complement (Figure 13-1): Target cell lysis Opsonization Activation of the inflammatory response (e.g. degranulation, extravasation) Clearance
More informationComplement. Definition : series of heat-labile serum proteins. : serum and all tissue fluids except urine and CSF
Complement Complement Definition : series of heat-labile serum proteins Site : serum and all tissue fluids except urine and CSF Synthesis : in liver appear in fetal circulation during 1 st 13 W Function
More informationSuvasini Modi Complement System Activation of Membrane attacking complex (MAC) and its effect and regulation
Figure- 1 https://en.wikipedia.org/wiki/complement_system Suvasini Modi Complement System Activation of Membrane attacking complex (MAC) and its effect and regulation Content Introduction Activation of
More informationLecture 07. Complement
Lecture 07 Complement Science is a social process. It happens on a time scale longer than a human life. If I die, someone takes my place. You die; someone takes your place. What's important is to get it
More informationCellular & Molecular Immunology 2009
Cellular & Molecular Immunology 2009 Complement Nicholas M. Ponzio, Ph.D. Department of Pathology & Laboratory Medicine March 4, 2009 Innate and adaptive immunity FAMOUS BELGIANS Jules Jean Baptiste Vincent
More informationMacrophage Activation & Cytokine Release. Dendritic Cells & Antigen Presentation. Neutrophils & Innate Defense
Macrophage Activation & Cytokine Release Dendritic Cells & Antigen Presentation Neutrophils & Innate Defense Neutrophils Polymorphonuclear cells (PMNs) are recruited to the site of infection where they
More informationInflammation. (4 of 5)
Inflammation (4 of 5) What will we discuss today? Plasma protein derived mediators Anti-inflammatory mediators Morphologic patterns of acute inflammation Plasma protein derived mediators 3 systems: -Complement
More informationComplement pathways: Classical pathway Alternative pathway Lectin pathway
Complement Complement pathways: Classical pathway Alternative pathway Lectin pathway Complement proteins Classical pathway C1q C1r C1s C4 C2 Alternative pathway D C3 B Lectin pathway MBL MASP-1 MASP-2
More informationM1 - Immunology, Winter 2008
University of Michigan Deep Blue deepblue.lib.umich.edu 2008-09 M1 - Immunology, Winter 2008 Fantone, J.; Pietropaolo, M. T. Fantone, J., Pietropaolo, M. T. (2008, August 13). Immunology. Retrieved from
More informationAttribution: University of Michigan Medical School, Department of Microbiology and Immunology
Attribution: University of Michigan Medical School, Department of Microbiology and Immunology License: Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution
More informationClinical Basis of the Immune Response and the Complement Cascade
Clinical Basis of the Immune Response and the Complement Cascade Bryan L. Martin, DO, MMAS, FACAAI, FAAAAI, FACOI, FACP Emeritus Professor of Medicine and Pediatrics President, American College of Allergy,
More informationComplement Elizabeth Repasky, PhD Fall, 2015
Complement Elizabeth Repasky, PhD Fall, 2015 Complement pathways: Classical pathway Alternative pathway Lectin pathway White Board Schematic C3 plays a central role in complement activation Complement
More informationIntroduction to the immune system Innate humoral immunity
Introduction to the immune system Innate humoral immunity Bartosz Wojciuk Immunology course for the 2nd year Medical Faculty students Pomeranian Medical University Academic year 2017/2018, winter semester
More informationImmunology Part II. Innate Immunity. 18. April 2018, Ruhr-Universität Bochum Marcus Peters,
Immunology Part II Innate Immunity 18. April 2018, Ruhr-Universität Bochum Marcus Peters, marcus.peters@rub.de Conserved structures of pathogens PAMPs are detected by Pattern Recognition Receptors PRRs
More informationبسم هللا الرحمن الرحيم. Immunology lecture 7
بسم هللا الرحمن الرحيم Immunology lecture 7 Last time we studied the B cell receptor which is IgM & IgD. Today we will talk about the T Cell Receptor which is the TCR #TCR: it is the receptor that belongs
More informationANTIBODIES Jiri Mestecky, M.D., Ph.D. - Lecturer
ANTIBODIES Jiri Mestecky, M.D., Ph.D. - Lecturer Distribution in body fluids: secretions plasma (serum), tears, saliva, milk, genitourinary, and intestinal Cells producing antibodies and their tissue distribution:
More informationThird line of Defense
Chapter 15 Specific Immunity and Immunization Topics -3 rd of Defense - B cells - T cells - Specific Immunities Third line of Defense Specific immunity is a complex interaction of immune cells (leukocytes)
More informationLECTURE: 21. Title IMMUNOGLOBULINS FUNCTIONS & THEIR RECEPTORS LEARNING OBJECTIVES:
LECTURE: 21 Title IMMUNOGLOBULINS FUNCTIONS & THEIR RECEPTORS LEARNING OBJECTIVES: The student should be able to: Determine predominant immunoglobulin isotypes in serum. Determine the predominant immunoglobulin
More informationComplement disorders and hereditary angioedema
Complement disorders and hereditary angioedema Michael M. Frank, MD Durham, NC The term complement was introduced more than 100 years ago to refer to a group of plasma factors important in host defense
More informationComplement System. Jil Schrader 16 th of May 2018 Immunology Lecture
Source: https://bestprac.dk/2017/05/30/diagnosticering-af-almindelig-variabel-immundefekt-cvid-2/, letzter Zugriff: 14.05.2018 Complement System Jil Schrader 16 th of May 2018 Immunology Lecture Contents
More informationInnate vs Adaptive Response
General Immunology Innate vs Adaptive Response Innate- non-specific (4 types of barriers) anatomic- ato mechanical ca (skin), ph, mucous, normal flora Physiologic- temperature, ph, chemicals (lysozyme,
More informationTopics. Humoral Immune Response Part II Accessory cells Fc Receptors Opsonization and killing mechanisms of phagocytes NK, mast, eosynophils
Topics Humoral Immune Response Part II Accessory cells Fc Receptors Opsonization and killing mechanisms of phagocytes NK, mast, eosynophils Immune regulation Idiotypic network 2/15/2005 MICR 415 / 515
More informationTime course of immune response
Time course of immune response Route of entry Route of entry (cont.) Steps in infection Barriers to infection Mf receptors Facilitate engulfment Glucan, mannose Scavenger CD11b/CD18 Allows immediate response
More informationAnastasios E. Germenis
Anastasios E. Germenis Professor and Chairman Department of Immunology & Histocompatibility School of Medicine University of Thessaly University Hospital of Larissa Greece agermen@med.uth.gr The Complement
More informationFor questions 1-5, match the following with their correct descriptions. (24-39) A. Class I B. Class II C. Class III D. TH1 E. TH2
Questions Made by SI ATTENDEES!! :) Page 1 of 6 Student-Made Practice Exam Activity All questions, answers, and slide numbers are based off of Monday s SI activity, where students/attendees created possible
More informationNatural Defense Mechanisms
Color code: Important in red Extra in blue For team error adjustments, click here Natural Defense Mechanisms Objectives To know First (non-specific immunity) and second (adaptive immunity) lines of defense
More informationUnderstanding the Complement Cascade and Its Role in Cold Agglutinin Disease. 1 M-CAgD-US-3006 February 2018
Understanding the Complement Cascade and Its Role in Cold Agglutinin Disease 1 February 2018 Instructions This information is provided as an educational resource for healthcare providers. It is not intended
More informationSecretory antibodies in the upper respiratory tract
Secretory antibodies in the upper respiratory tract B lymphocytes IgM (pneumococcus) Dimeric IgA J chain Polymeric immunoglobulin receptor (PigR) Polysaccharide capsule Epithelial cell Basolateral Secretory
More informationThe Biology of Fc γ Receptors and Complement
Discovery consists of seeing what everybody has seen, and thinking what nobody has thought --Albert Szent-György Nobel prize in Physiology or Medicine, 1937 The Biology of Fc γ Receptors and Complement
More informationLecture 17: Attack by Complement and Counterattack by Microbes
Lecture 17: Attack by Complement and Counterattack by Microbes 2 Review Concepts of Complement Complement was addressed in Lecture 3 Major first line of defense (innate immunity) Major functions: Opsonization
More informationBiology of Fc γ Receptors. Selected Functions of Ig Isotypes
Biology of Fc γ Receptors Selected Functions of Ig Isotypes Biology of Fc γ Receptors 1 Functional Sites on the IgG Molecule V H V L C1q binding site FcγR binding site Glycosylation site Selected Functions
More informationThe Biology of Fc γ Receptors and Complement. Biology of Fc γ Receptors. Discovery consists of seeing what everybody
Discovery consists of seeing what everybody has seen, and thinking what nobody has thought The Biology of Fc γ Receptors and Complement --Albert Szent-György Nobel prize in Physiology or Medicine, 1937
More informationThe Innate Immune Response
The Innate Immune Response FUNCTIONS OF THE IMMUNE SYSTEM: Recognize, destroy and clear a diversity of pathogens. Initiate tissue and wound healing processes. Recognize and clear damaged self components.
More informationINFLAMMATION & REPAIR
INFLAMMATION & REPAIR Lecture 7 Chemical Mediators of Inflammation Winter 2013 Chelsea Martin Special thanks to Drs. Hanna and Forzan Course Outline i. Inflammation: Introduction and generalities (lecture
More informationOverview of the immune system
Overview of the immune system Immune system Innate (nonspecific) 1 st line of defense Adaptive (specific) 2 nd line of defense Cellular components Humoral components Cellular components Humoral components
More informationChapter 17B: Adaptive Immunity Part II
Chapter 17B: Adaptive Immunity Part II 1. Cell-Mediated Immune Response 2. Humoral Immune Response 3. Antibodies 1. The Cell-Mediated Immune Response Basic Steps of Cell-Mediated IR 1 2a CD4 + MHC cl.
More information1.Nature of the Immune System
1.Nature of the Immune System I. Historical Concepts A. Age of Serology 1. Time period from 1900 to 1950 called era of international serology. 2. Immunology is a relatively new science. 3. Tests were developed
More informationCatalog Number: A114 Sizes Available: 250 µg/vial Concentration: 1.0 mg/ml (see Certificate of Analysis for actual concentration)
Name: C3b Catalog Number: A114 Sizes Available: 250 µg/vial Concentration: 1.0 mg/ml (see Certificate of Analysis for actual concentration) Form: Liquid Purity: >90% by SDS-PAGE Buffer: 10 mm sodium phosphate,
More informationAdaptive Immunity. PowerPoint Lecture Presentations prepared by Mindy Miller-Kittrell, North Carolina State University C H A P T E R
PowerPoint Lecture Presentations prepared by Mindy Miller-Kittrell, North Carolina State University C H A P T E R 16 Adaptive Immunity The Body s Third Line of Defense Adaptive Immunity Adaptive immunity
More informationCapítulo 32. Defensas Inespecíficas 21/11/2014. Mecanismos de Defensa del Huésped. Mecanismos Específicos. Mecanismos no Específicos
Capítulo 32 Defensas Inespecíficas Mecanismos de Defensa del Huésped Mecanismos no Específicos Mecanismos Específicos Primera Línea de Defensa Segunda Línea de Defensa Tercera Línea de Defensa 1 Vistazo
More informationThe Complement System
Calbiochem The Complement System Complement Reagents of the Highest Quality The complement system provides innate defense against microbial infection and is a complement to antibody mediated immunity.
More information16 Innate Immunity: M I C R O B I O L O G Y. Nonspecific Defenses of the Host. a n i n t r o d u c t i o n
ninth edition TORTORA FUNKE CASE M I C R O B I O L O G Y a n i n t r o d u c t i o n 16 Innate Immunity: Nonspecific Defenses of the Host PowerPoint Lecture Slide Presentation prepared by Christine L.
More informationMICROBIO320 EXAM 1-Spring 2011 Name True/False (1 point each) T 2. T cell receptors are composed of constant and variable regions.
True/False (1 point each) T 1. Mature T cells (lymphocytes) bind only to processed antigen. T 2. T cell receptors are composed of constant and variable regions. F 3. Natural Killer cells do not proliferate
More informationLymphatic System. Where s your immunity idol?
Lymphatic System Where s your immunity idol? Functions of the Lymphatic System Fluid Balance Drains excess fluid from tissues Lymph contains solutes from plasma Fat Absorption Lymphatic system absorbs
More informationInflammation Inflammation is the response of living tissue to damage. The acute inflammatory response has 3 main functions. The affected area is occup
Inflammation VLA October 4, 2011 Inflammation Inflammation is the response of living tissue to damage. The acute inflammatory response has 3 main functions. The affected area is occupied by a transient
More informationInnate Immunity. Hathairat Thananchai, DPhil Department of Microbiology Faculty of Medicine Chiang Mai University 2 August 2016
Innate Immunity Hathairat Thananchai, DPhil Department of Microbiology Faculty of Medicine Chiang Mai University 2 August 2016 Objectives: Explain how innate immune system recognizes foreign substances
More informationBlood and Immune system Acquired Immunity
Blood and Immune system Acquired Immunity Immunity Acquired (Adaptive) Immunity Defensive mechanisms include : 1) Innate immunity (Natural or Non specific) 2) Acquired immunity (Adaptive or Specific) Cell-mediated
More informationImmune system. Self/non-self recognition. Memory. The state of protection from infectious disease. Acceptance vs rejection
Immune system The state of protection from infectious disease Self/non-self recognition 自我 非我 Acceptance vs rejection Memory 疫苗 2 Microbes Commensal Microbes 共生菌 Normal flora: usually confined to certain
More informationChapter 23 Immunity Exam Study Questions
Chapter 23 Immunity Exam Study Questions 1. Define 1) Immunity 2) Neutrophils 3) Macrophage 4) Epitopes 5) Interferon 6) Complement system 7) Histamine 8) Mast cells 9) Antigen 10) Antigens receptors 11)
More information1. Overview of Innate Immunity
Chapter 15: Innate Immunity 1. Overview of Innate Immunity 2. Inflammation & Phagocytosis 3. Antimicrobial Substances 1. Overview of Innate Immunity Chapter Reading pp. 449-456 The Body s Defenses The
More informationIMMUNITY AND ANTIBODIES
IMMUNITY AND ANTIBODIES Stem cells in bone marrow differentiate into various blood cells Phagocytes attack alien cells A non-specific reaction Mast cells release histamine Histamine dilates capillaries,
More informationChapter 21: Innate and Adaptive Body Defenses
Chapter 21: Innate and Adaptive Body Defenses I. 2 main types of body defenses A. Innate (nonspecific) defense: not to a specific microorganism or substance B. Adaptive (specific) defense: immunity to
More informationAdaptive Immunity. PowerPoint Lecture Presentations prepared by Mindy Miller-Kittrell, North Carolina State University C H A P T E R
CSLO7. Describe functions of host defenses and the immune system in combating infectious diseases and explain how immunizations protect against specific diseases. PowerPoint Lecture Presentations prepared
More informationGeneral Biology. A summary of innate and acquired immunity. 11. The Immune System. Repetition. The Lymphatic System. Course No: BNG2003 Credits: 3.
A summary of innate and acquired immunity General iology INNATE IMMUNITY Rapid responses to a broad range of microbes Course No: NG00 Credits:.00 External defenses Invading microbes (pathogens). The Immune
More informationAn update on the the lectin pathway of complement
An update on the the lectin pathway of complement Laboratory of Molecular Medicine Department of Clinical Immunology, Section 7631 Rigshospitalet Copenhagen Denmark E-mail: garred@post5.tele.dk Malmø,
More informationSummary for mid material immunology. THIS APPLIES FOR ALL SECTIONS Heyam Awad
Summary for mid material immunology THIS APPLIES FOR ALL SECTIONS Heyam Awad Innate immune system Innate immunity is composed of: 1. Epithelial barriers: skin, respiratory and gastrointestinal epithelium..
More informationCELL BIOLOGY - CLUTCH CH THE IMMUNE SYSTEM.
!! www.clutchprep.com CONCEPT: OVERVIEW OF HOST DEFENSES The human body contains three lines of against infectious agents (pathogens) 1. Mechanical and chemical boundaries (part of the innate immune system)
More informationThird line of Defense. Topic 8 Specific Immunity (adaptive) (18) 3 rd Line = Prophylaxis via Immunization!
Topic 8 Specific Immunity (adaptive) (18) Topics - 3 rd Line of Defense - B cells - T cells - Specific Immunities 1 3 rd Line = Prophylaxis via Immunization! (a) A painting of Edward Jenner depicts a cow
More informationThe Immune System. These are classified as the Innate and Adaptive Immune Responses. Innate Immunity
The Immune System Biological mechanisms that defend an organism must be 1. triggered by a stimulus upon injury or pathogen attack 2. able to counteract the injury or invasion 3. able to recognise foreign
More information1. The barriers of the innate immune system to infection
Section 3.qxd 16/06/05 2:11 PM Page 12 12 SECTION THREE: Fleshed out 1. The barriers of the innate immune system to infection Questions What are the three characteristics of the innate immune system? What
More informationANATOMY OF THE IMMUNE SYSTEM
Immunity Learning objectives Explain what triggers an immune response and where in the body the immune response occurs. Understand how the immune system handles exogenous and endogenous antigen differently.
More informationJ07 Titer dynamics, complement fixation test and neutralization tests
avllm0421c (spring 2017) J07 Titer dynamics, complement fixation test and neutralization tests Outline titer, antibody titer dynamics complement, complement fixation reaction neutralization tests 2/35
More informationUnit 5 The Human Immune Response to Infection
Unit 5 The Human Immune Response to Infection Unit 5-page 1 FOM Chapter 21 Resistance and the Immune System: Innate Immunity Preview: In Chapter 21, we will learn about the branch of the immune system
More informationAdaptive Immunity: Humoral Immune Responses
MICR2209 Adaptive Immunity: Humoral Immune Responses Dr Allison Imrie 1 Synopsis: In this lecture we will review the different mechanisms which constitute the humoral immune response, and examine the antibody
More informationHypersensitivity is the term used when an immune response results in exaggerated or inappropriate reactions harmful to the host.
Hypersensitivity is the term used when an immune response results in exaggerated or inappropriate reactions harmful to the host. Hypersensitivity vs. allergy Hypersensitivity reactions require a pre-sensitized
More informationComplement deficiencies, diagnosis and management. Contents
Complement deficiencies, diagnosis and management Classification: Protocol Lead Author: Dr Hana Alachkar Additional author(s): Victoria Blakeley Authors Division: Tertiary Medicine Unique ID: D5 Issue
More informationSINGLE CHOICE. 5. The gamma invariant chain binds to this molecule during its intracytoplasmic transport. A TCR B BCR C MHC II D MHC I E FcγR
A Name: Group: SINGLE CHOICE 1. Which is the most important ligand of TLR5? A endospore B flagellin C polysaccharide capsule D DNA E pilus 2. The antibody-binding site is formed primarily by... A the constant
More informationAdaptive Immunity. PowerPoint Lecture Presentations prepared by Mindy Miller-Kittrell, North Carolina State University C H A P T E R
PowerPoint Lecture Presentations prepared by Mindy Miller-Kittrell, North Carolina State University C H A P T E R 16 Adaptive Immunity The Body s First Line of Defense Innate Immunity The Role of Skin
More informationPhysiology Unit 3. ADAPTIVE IMMUNITY The Specific Immune Response
Physiology Unit 3 ADAPTIVE IMMUNITY The Specific Immune Response In Physiology Today The Adaptive Arm of the Immune System Specific Immune Response Internal defense against a specific pathogen Acquired
More informationImmunology. Lecture- 8
Immunology Lecture- 8 Immunological Disorders Immunodeficiency Autoimmune Disease Hypersensitivities Immunodeficiency 1. Immunodeficiency --> abnormal production or function of immune cells, phagocytes,
More informationT cell-mediated immunity
T cell-mediated immunity Overview For microbes within phagosomes in phagocytes.cd4+ T lymphocytes (TH1) Activate phagocyte by cytokines studies on Listeria monocytogenes For microbes infecting and replicating
More informationMedical Virology Immunology. Dr. Sameer Naji, MB, BCh, PhD (UK) Head of Basic Medical Sciences Dept. Faculty of Medicine The Hashemite University
Medical Virology Immunology Dr. Sameer Naji, MB, BCh, PhD (UK) Head of Basic Medical Sciences Dept. Faculty of Medicine The Hashemite University Human blood cells Phases of immune responses Microbe Naïve
More informationCellular Pathology of immunological disorders
Cellular Pathology of immunological disorders SCBM344 Cellular and Molecular Pathology Witchuda Payuhakrit, Ph.D (Pathobiology) witchuda.pay@mahidol.ac.th Objectives Describe the etiology of immunological
More informationThe Immune System is the Third Line of Defense Against Infection. Components of Human Immune System
Chapter 17: Specific Host Defenses: The Immune Response The Immune Response Immunity: Free from burden. Ability of an organism to recognize and defend itself against specific pathogens or antigens. Immune
More informationPrinciples of Adaptive Immunity
Principles of Adaptive Immunity Chapter 3 Parham Hans de Haard 17 th of May 2010 Agenda Recognition molecules of adaptive immune system Features adaptive immune system Immunoglobulins and T-cell receptors
More informationThe Immune System: Innate and Adaptive Body Defenses Outline PART 1: INNATE DEFENSES 21.1 Surface barriers act as the first line of defense to keep
The Immune System: Innate and Adaptive Body Defenses Outline PART 1: INNATE DEFENSES 21.1 Surface barriers act as the first line of defense to keep invaders out of the body (pp. 772 773; Fig. 21.1; Table
More informationCHAPTER-VII IMMUNOLOGY R.KAVITHA, M.PHARM, LECTURER, DEPARTMENT OF PHARMACEUTICS, SRM COLLEGE OF PHARMACY, SRM UNIVERSITY, KATTANKULATHUR.
CHAPTER-VII IMMUNOLOGY R.KAVITHA, M.PHARM, LECTURER, DEPARTMENT OF PHARMACEUTICS, SRM COLLEGE OF PHARMACY, SRM UNIVERSITY, KATTANKULATHUR. The Immune Response Immunity: Free from burden. Ability of an
More informationImmune system. Aims. Immune system. Lymphatic organs. Inflammation. Natural immune system. Adaptive immune system
Aims Immune system Lymphatic organs Inflammation Natural immune system Adaptive immune system Major histocompatibility complex (MHC) Disorders of the immune system 1 2 Immune system Lymphoid organs Immune
More informationComponents of the innate immune system
Components of the innate immune system Before our discussion about innate immunity Differences between innate and adaptive systems: Innate immune system = natural = native -Germline: prepared before exposure
More informationCell-Derived Inflammatory Mediators
Cell-Derived Inflammatory Mediators Introduction about chemical mediators in inflammation Mediators may be Cellular mediators cell-produced or cell-secreted derived from circulating inactive precursors,
More informationInternal Defense Notes
Internal environment of animals provides attractive area for growth of bacteria, viruses, fungi Harm via: 1. destruction of cells 2. production of toxic chemicals To protect against foreign invaders, humans
More informationchapter 17: specific/adaptable defenses of the host: the immune response
chapter 17: specific/adaptable defenses of the host: the immune response defense against infection & illness body defenses innate/ non-specific adaptable/ specific epithelium, fever, inflammation, complement,
More informationChapter 6 Diseases of Immunity:
Chapter 6 Diseases of Immunity: 1. The innate immune system includes the following components EXCEPT lung surfactant complement Natural killer (NK) cells dendritic cells B lymphocytes 2. Regarding the
More informationHYPERSENSITIVITY REACTIONS D R S H O AI B R AZ A
HYPERSENSITIVITY REACTIONS D R S H O AI B R AZ A HYPERSENSITIVITY REACTIONS Are exaggerated immune response upon antigenic stimulation Individuals who have been previously exposed to an antigen are said
More informationLecture on Innate Immunity and Inflammation
Lecture on Innate Immunity and Inflammation Evolutionary View Epithelial barriers to infection Four main types of innate recognition molecules:tlrs, CLRs, NLRs, RLRs NF-κB, the master transcriptional regulator
More information10. Which of the following immune cell is unable to phagocytose (a) neutrophils (b) eosinophils (c) macrophages (d) T-cells (e) monocytes
Chapter 2. Acute and chronic inflammation(6): 1. In acute inflammation, which events occur in the correct chronological order? (Remembered from 2000, 2004 exam.) p50 (a) transient vasoconstriction, stasis
More informationDisease causing organisms Resistance Immunity
Part 1 Disease causing organisms Resistance Immunity Bacteria Most common pathogens Anthrax Cholera Staphylococcus epidermidis bacteria Bacterial diseases Tuberculosis Cholera Bubonic Plague Tetanus Effects
More informationIntroduction to Immune System
Introduction to Immune System Learning outcome You will be able to understand, at a fundamental level, the STRUCTURES and FUNCTIONS of cell surface and soluble molecules involved in recognition of foreign
More information