Case Report Selection

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1 Granulox Case Report Selection Dr. Peter Engels Case reports Granulox

2 Starting point:wound exudat is a - Oxygen barrier Wound exudat is a efficient barrier for oxygen exchange, an prohibits an external oxygen supply from the air. Dr. Peter Engels Case reports Granulox

3 Please take Haemoglobin Substance: Status: haemoglobin purified, aqueous solution Function: Binding and Release of oxygen Question: Can haemoglobin bind and release oxygen outside of erythrocyts? Yes it can!!! Dr. Peter Engels Case reports Granulox

4 Bypass of oxygen barrier Principle: Haemoglobin as O 2 shuttle High oxygen partial pressure Low oxygen partial pressure Equably distributed haemoglobin in the wound exudat, binds the oxygen at the surface and release it at the wound ground Dr. Peter Engels Case reports Granulox

5 Clinical study results Dr. Peter Engels Case reports Granulox

6 Case Reports Various successful treatments of different wound types are reported by several users Venous leg ulcers Diabetic foot ulcers Arterial leg ulcers Secundary healing wounds Burns Dr. Peter Engels Case reports Granulox

7 Case 1 43 year old male patient Venous leg ulcer Wound existed for 8 years, several relapses Start of treatment February 2012 Start of Granulox application: March 2012 Successful end of therapy: June 2012 Chronic wound management of a venous leg ulcer patient with complication of Budd Chiari Syndrome (paper submitted) Dr. Peter Engels Case reports Granulox

8 Start of treatment Dr. Peter Engels Case reports Granulox

9 Compression therapy Dr. Peter Engels Case reports Granulox

10 End of therapy after 115 days Dr. Peter Engels Case reports Granulox

11 Case 2 85 year old male patient Diabetic foot ulcer Interdigital DI-II left. Diabetes mellitus paod Arterial Hypertension Wound maintained for 7 months Treatment with: Iruxol paste, Alginate, Hydrocoloid, Polyurethan foam Dr. Peter Engels Case reports Granulox

12 Start of Granulox application & Silicone foam Dr. Peter Engels Case reports Granulox

13 Case 2 Dr. Peter Engels Case reports Granulox

14 End of treatment after 73 days & 24 changes of bandages Dr. Peter Engels Case reports Granulox

15 Case 3 (a&b) 62 year old patient Arterial leg ulcer (right leg) paod IV, right lower leg amputation 05/11 Diabetes mellitus Chronic nictotine abuse Wound persists for 7 months Treatment with : Hydrocolloid, Alginate, Alginate-Ag, Polyurethane Foam Dr. Peter Engels Case reports Granulox

16 Start of treatment with Granulox & non-adhesive foam Dr. Peter Engels Case reports Granulox

17 Case 3 Dr. Peter Engels Case reports Granulox

18 End of treatment after 89 days & 27 changes of bandages Dr. Peter Engels Case reports Granulox

19 Lower leg prothesis pressure mark (3b) Wound persisted for 6 Wochen Treatment with : Hydrocolloid, Alginate, Alginate-Ag, Polyurethane Foam Dr. Peter Engels Case reports Granulox

20 Start of treatment Dr. Peter Engels Case reports Granulox

21 End of treatment after 53 days & 17 changes of bandages Dr. Peter Engels Case reports Granulox

22 Case 4 a&b 72 year old female patient Venous leg ulcer, left Persists since 6,5 years Varikose left leg Multiple allergies Dr. Peter Engels Case reports Granulox

23 Lower leg (Left outer, 4a) Dr. Peter Engels Case reports Granulox

24 Case 4a Dr. Peter Engels Case reports Granulox

25 Treatment successful after 58 days Dr. Peter Engels Case reports Granulox

26 Lower leg (inner left, 4b) Successful closure within 114 days Dr. Peter Engels Case reports Granulox

27 Case 5 62 year old patient Venous leg ulcer (right) CVI Diabetes mellitus Arterial hypertension Wound maintained for 6 months Treatment with: Iruxol, Repithel gel, Hydrocolloid, Alginate, Dr. Peter Engels Case reports Granulox

28 Start of treament Dr. Peter Engels Case reports Granulox

29 End of treatment after 78 days & 25 changes of bandages Dr. Peter Engels Case reports Granulox

30 Case 6 68 year old patient Diabetic foot ulcer (right) IDDM CVI Nicotine abuse Wound exists for 7 months Treatment - Hydrocolloid, Hydrogel, Alginate, Alginate-Ag, Foam Surgical debridement Dr. Peter Engels Case reports Granulox

31 Start of treatment with Granulox, Alginate & Polyurethane foam Dr. Peter Engels Case reports Granulox

32 End of treatment after 50 days & 15 changes of bandages Dr. Peter Engels Case reports Granulox

33 Case 7 85 year old female patient Arterial leg ulcer (right leg) paod grade II III Stenosis of A carotis interna (right) Multiple allergies Wound since 7 years Dr. Peter Engels Case reports Granulox

34 Start of Granulox treatment & non adhesive foam Dr. Peter Engels Case reports Granulox

35 End of treatment after 169 Tagen & 50 chang. o. band. Dr. Peter Engels Case reports Granulox

36 Case 8 69 year old female patient Arterial leg ulcer (lateral right leg) paod Stadium IV (right) Diabetes mellitus Two closures of By-passes since 2010 Hodgin Lymphoma, Polychemotherapy COPD C2 associated liver chirrosis Wound exists for 28 months Treatment: everything!! Dr. Peter Engels Case reports Granulox

37 Treatment result after 67 days Dr. Peter Engels Case reports Granulox

38 Case 9 65 year old female patient Diabetic gangrene at the left big toe Diabetes mellitus paod Stadium IV Obesity 07/12 Amputation of the left big toe, trans-metatarsal Resection Split-skin graft Wound since 8 weeks Krankenhaus Nordwest 24. Juli Dr. Peter Engels Case reports Granulox

39 Treatment with Granulox & silicone foam for 59 days Dr. Peter Engels Case reports Granulox

40 Case year old male patient Arterial leg ulcer & diabetic gangrene Diabetic gangrene ( Dig right foot with necrosis of filament) foot phlegmone Diabetic polyneuropathy Lower leg amputation (left) Diabetes Mellitus Type II Obesity Dr. Peter Engels Case reports Granulox

41 Treatment success within Dr. Peter Engels Case reports Granulox

42 42 days (outer wound) & 66 days (inner wound) Dr. Peter Engels Case reports Granulox

43 Case year old female patient Diabetic foot gangrene Diabetes mellitus Colon Ca./ Chemo therapy MRSA in wound Amputation D I + II Negative pressure therapy without success Dr. Peter Engels Case reports Granulox

44 Therapy result after 98 days Dr. Peter Engels Case reports Granulox

45 53 year old male patient Case 12 Post surgical wound healing dysfunction Pre-peritoneal Lipoma Lipoma-resection 02/12 partial mucosectomy Nicotine abuse Depression Psoriasis Allergic asthma Wound exists for 8 months Therapy before hospital visit: repeated daily shower of the wound Dr. Peter Engels Case reports Granulox

46 Successful wound closure after 41 days Dr. Peter Engels Case reports Granulox

47 Case year old male patient Neck carbuncle Surgery 02/12 Wound since 9 weeks Therapy before hospital visit: repeated daily shower of the wound Dr. Peter Engels Case reports Granulox

48 Start of treatment with Granulox & silicone foam Dr. Peter Engels Case reports Granulox

49 Case 13 Dr. Peter Engels Case reports Granulox

50 End of therapy after 29 days & 9 c. o. b. Dr. Peter Engels Case reports Granulox

51 Case year old male patient Post surgical impairment of wound healing (after OP) Abdominal wall phlegmons Multiple wound revisions after incisional hernia reparation MRSA Wound for 13 months Therapy: Negative pressure therapy, Alginate, Foam dressings Dr. Peter Engels Case reports Granulox

52 Start of treatment with Granulox & non-adhesive PU foam End of therapy after 111 Tagen & 37 c.o.bs. Dr. Peter Engels Case reports Granulox

53 Case year old female patient Decollement pretibial left lower leg Maligne Melanoma right foot toe DII Liver metastases Radiation Situation after fall at home Previous treatment: not known Dr. Peter Engels Case reports Granulox

54 Successful treatment after 40 days and 12 c.o.bs. Dr. Peter Engels Case reports Granulox

55 Case year old female patient Abscess left forearm Spaltung 01/12 Revision 02/12 Allergic asthma Wound exists for 2 months Previous Treatment: surgical & dry dressings Dr. Peter Engels Case reports Granulox

56 Treatment with Granulox, (absorbent dressing pads) silicone foam Dr. Peter Engels Case reports Granulox

57 End of treatment after 78 days (23 c.o.b) Dr. Peter Engels Case reports Granulox

58 Case year old male patient Circular saw injury Laceration and detachment of skin, left hand D1 Dr. Peter Engels Case reports Granulox

59 Treatment period of two weeks Dr. Peter Engels Case reports Granulox

60 Case year old patient Incised wound, right hand, finger D II Skin necrosis Dr. Peter Engels Case reports Granulox

61 Two weeks treatment Dr. Peter Engels Case reports Granulox

62 Case year old female patient Woundinfekt after: Radial head implant Platten dislocation und Radial head pseudo arthrose nach Monteggia # re. Mit Osteosynthesseund Cerklage am Wundrevision und VAC-Verband Dr. Peter Engels Case reports Granulox

63 Dr. Peter Engels Case reports Granulox

64 Case year old male patient Venous leg ulcer, left lower leg CVI Diabetes Mellitus Nesat Mustafi 64 Dr. Peter Engels Case reports Granulox

65 Dr. Peter Engels Case reports Granulox

66 Case J. Patient Erysipel Re. US (Rezidiv) Diabetes mellitus Typ 2 insulinpflichtig Adipositas Nesat Mustafi 66 Dr. Peter Engels Case reports Granulox

67 Dr. Peter Engels Case reports Granulox

68 Case J. Patient: Finger DIII Re. Verbrennung 2A D III Re. Nesat Mustafi 68 Dr. Peter Engels Case reports Granulox

69 Finger DIII Re. Dr. Peter Engels Case reports Granulox

70 Case 23 a & b: Verbrennung am Oberschenkel rechts 85 J. Patient Diabetes mellitus pavk Arterielle Hypertonie Z.n. Plaqueruptur thorakale Aorta Pers descendes mit Hämatothorax li. Z.n. endovaskulärer Implantation einer Stentprothese am Postoperativ Verdacht auf Myelonischemie mit Beinparese re. Wunde seit 4 Wochen bestehend Behandlung mit : Flamazine salbe Dr. Peter Engels Case reports Granulox

71 Beginn der Behandlung mit Granulox Wundspray und nichtklebenden Polyurethanschaum Dr. Peter Engels Case reports Granulox

72 Ende der Behandlung nach 53 Tagen und 17 VW Dr. Peter Engels Case reports Granulox

73 Beispiel 4: Verbrennung am Oberschenkel links 85 J. Patient Diabetes mellitus pavk Arterielle Hypertonie Z.n. Plaqueruptur thorakale Aorta Pers descendes mit Hämatothorax li. Z.n. endovaskulärer Implantation einer Stentprothese am Postoperativ Verdacht auf Myelonischemie mit Beinparese re. Wunde seit 4 Wochen bestehend Behandlung mit : Flamazine Salbe, Dr. Peter Engels Case reports Granulox

74 Start of treatment Granulox & non-adhesive PU foam dressing Dr. Peter Engels Case reports Granulox

75 Dr. Peter Engels Case reports Granulox

76 End of successful treatment after 53 days (17 c.o.bs) Dr. Peter Engels Case reports Granulox

77 Thank you for your attention Dr. Peter Engels Case reports Granulox

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