Dr Rock LEUNG Transfusion Safety Officer Queen Mary Hospital, Hong Kong West Cluster
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1 Dr Rock LEUNG Transfusion Safety Officer Queen Mary Hospital, Hong Kong West Cluster
2 HOSPITAL TRANSFUSION SERVICE IN HK Single supplier for the territory: HK Red Cross Blood Transfusion Service Public hospitals run by Hospital Authority, subsided by government, segregated into seven Clusters according to geographical location. Red cells transfusion: 33/1000 population. Governance structures established in 90s. Well-established Quality & Safety framework. All Hospitals ACHS-accredited (transfusion safety criterion 1.5.5).
3 QUEEN MARY HOSPITAL 1700 Beds Quaternary service Liver transplant, heart lung transplant, haemopoietic stem cell transplant Annual use of ~80000 blood components
4 TRANSFUSION SERVICE: OUR HISTORY 1992: Hospital Blood Bank taken over by Division of Haematology 1993: QMH Blood Transfusion Committee 1993: T & S 1994: Electronic X-match 2006: Appointment of TSO 2008: HKWC haemovigilance programme : OTBTS / RBRS Before Beyond 2017 ABO Incompatible Blood Transfusion Incident in QMH 2001: Blood Transfusion Manual 2002: Blood Bank accredited by College of American Pathologists Laboratory Accreditation Program (CAP-LAP)
5 HAEMOVIGILANCE (HV) PROGRAMME Reporting of Adverse Transfusion Reaction (ATR) & Transfusion Incidents (TI) Corporate web-based system ABO incompatible transfusion as sentinel event. Filtered by designated persons Transfusion Safety Officer Haematopathologist Coordination of HV programme. HV data analysis & reporting. Investigation of ATR & TI Expert panel for ATR every three months Investigation panel for Blood Bank-related TI. Communication Half-yearly Transfusion Seminar. Transfusion Tips.
6 AIRS
7
8 Figure 2: Transfusion Seminar reporting on haemovigilance data
9 TRANSFUSION INCIDENTS IN HKWC ( ) Incident categories Related to transfusion request Requisition of blood components for the wrong patient Related to blood bank procedure Related to collection & transportation of blood/component Related to storage of blood/component Related to blood administration Blood clot in blood bags/abnormal appearance of Blood bag Notification of positive results from bacterial surveillance programme Others Total (No. of TI / No. of T&S & components requests x 100%) 121 (0.252%) 97 (0.203%) 117 (0.211%) 134 (0.245%) 131 (0.216%) 146 (0.268%) Others = Mi typing result discrepant from label from HKBTS/blood fridge alarm activation
10 BLOOD BANK PROCESS 1 Testing T&S 2 Blood Issue 3 Blood Return
11 BLOOD BANK PROCESS 1 2 Testing T&S Blood Issue Process involved in BB incidents 1. Wrong number issued 2. Wrong type issued 3. ABO matching in BMT setting 4. ABO in Neonates 5. Mixing up of issue report 3 Blood Return 1. Re-issue of unit deemed unfit
12 BLOOD BANK PROCESS Testing T&S Blood Issue Blood Return Improvements 1. Request downloaded to Lab IT system. 2. Standard T&S remark format to facilitate checking of transfusion rules in BMT. 3. IT-assisted ABO decision for neonatal transfusion. 4. Blood Bank Renovation (like pharmacy). 1. New format of return form to facilitate decision making.
13 ATR IN HKWC *HTR: Haemolytic transfusion reaction, #FNHTR: Febrile non-haemolytic transfusion reaction, TRALI: Transfusion-related acute lung injury, TACO: Transfusion-associated circulatory overload 2007: unexplained hyperbilirubinaemia after transfusion in neonates; 2011: unexplained acute intravascular haemolysis after red cells & platelets transfusion; 2016: probable transfusion-associated hyperkalaemia.
14 HOW SAFE ARE WE? Ten-year cumulative incidence of ATR is 1 in blood components issued for major ATR, and 1 in 4034 for minor ATR. Anaphylaxis is the most common major ATR
15 IMPROVEMENT First local reported case of TRALI in 2007 Use of male-derived plasma containing components since BB-related TI Improvement of Blood Bank Laboratory Information System to mitigate risk of wrong blood issues. Classification of ATR Reporting system aligned with ISBT, with severity & imputability grading has to be ente
16 ALERT Figure 3: Alert signals generated from Blood Bank Laboratory Information System (LIS) to safeguard the correct number & type of blood components issued
17 ADVERSE TRANSFUSION REACTION CATEGORIES MAPPING BY ISBT DEFINITION Current AIR3 group Previous AIR3 type Revised ATR categories n AIR3 (ISBT classification) Adverse Transfusion Reaction- Major Acute haemolysis - ABO mismatch Acute haemolytic transfusion reaction (AHTR) Acute haemolysis - other cause Anaplylactic reaction Circulatory overload Transfusion related acute lung injuiry Septic reaction Others Anaplylactic reaction Transfusion associated circulatory overload (TACO) Transfusion related acute lung injuiry (TRALI) Septic reaction due to bacterial contamination of component Transfusion associated dyspnea (TAD) Hypotensive transfusion reaction Adverse Transfusion Reaction- Minor Febrile non-haemolytic transfusion reaction Febrile non-haemolytic transfusion reaction (FNHTR) Minor allergic reaction Non-severe allergic reaction Others Adverse Transfusion Reaction- Delayed Delayed haemolysis Delayed haemolytic transfusion reaction (DHTR) Post-transfusion hepatitis/ infection Transfusion- transmitted infections: Virus or other agents Post-transfusion purpura Post-transfusion purpura (PTP) Transfusion associated graft-versus-host disease Transfusion associated graft-versus-host disease (TA-GVHD) Others Delayed serologic reaction (DSTR) Transfusion associated haemosiderosis Adverse Transfusion Reaction- Others Unclassifiable Complication of Transfusion (UCT) Transfusion associated hyperkalemia Unrelated to transfusion Others 3rd July,
18 18
19 FUTURE Hospital-based to territory-wide More systematic More sharing More expertise More TSO Transfusion nurse More local & international networking
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