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2 null mice. Neuron 2007; 54: Garrison SR, Dietrich A, Stucky CL. TRPC1 contributes to light-touch sensation and mechanical responses in low-threshold cutaneous sensory neurons. Journal of Neurophysiology 2012; 107: Kim DK, Kim HJ, Kim H et al. Involvement of serotonin receptors 5-HT1 and 5-HT2 in 12(S)-HPETE-induced scratching in mice. European Journal of Pharmacology 2008; 579: Kwan KY, Allchorne AJ, Vollrath MA et al. TRPA1 contributes to cold, mechanical, and chemical nociception but is not essential for hair-cell transduction. Neuron 2006; 50: Liu XY, Wan L, Huo FQ et al. B-type natriuretic peptide is neither itch-specific nor functions upstream of the GRP-GRPR signaling pathway. Mol Pain 2014; 10:4. 13 Minami T, Nakano H, Kobayashi T et al. Characterization of EP receptor subtypes responsible for prostaglandin E2-induced pain responses by use of EP1 and EP3 receptor knockout mice. Br J Pharmacol 2001; 133: Mishra SK, Hoon MA. The cells and circuitry for itch responses in mice. Science 2013; 340: Mobarakeh JI, Sakurada S, Katsuyama S et al. Role of histamine H(1) receptor in pain perception: a study of the receptor gene knockout mice. European Journal of Pharmacology 2000; 391: Mogil JS, Breese NM, Witty MF et al. Transgenic expression of a dominant-negative ASIC3 subunit leads to increased sensitivity to mechanical and

3 inflammatory stimuli. J Neurosci 2005; 25: Molliver DC, Rau KK, McIlwrath SL, Jankowski MP, Koerber HR. The ADP receptor P2Y1 is necessary for normal thermal sensitivity in cutaneous polymodal nociceptors. Mol Pain 2011; 7: Moriyama T, Higashi T, Togashi K et al. Sensitization of TRPV1 by EP1 and IP reveals peripheral nociceptive mechanism of prostaglandins. Mol Pain 2005; 1:3. 19 Noel J, Zimmermann K, Busserolles J et al. The mechano-activated K + channels TRAAK and TREK-1 control both warm and cold perception. EMBO J 2009; 28: Popp L, Haussler A, Olliges A et al. Comparison of nociceptive behavior in prostaglandin E, F, D, prostacyclin and thromboxane receptor knockout mice. Eur J Pain 2009; 13: Quick K, Zhao J, Eijkelkamp N et al. TRPC3 and TRPC6 are essential for normal mechanotransduction in subsets of sensory neurons and cochlear hair cells. Open Biology 2012; 2: Ranade SS, Woo SH, Dubin AE et al. Piezo2 is the major transducer of mechanical forces for touch sensation in mice. Nature 2014; 516: Rau KK, McIlwrath SL, Wang H et al. Mrgprd enhances excitability in specific populations of cutaneous murine polymodal nociceptors. J Neurosci 2009; 29: Reinold H, Ahmadi S, Depner UB et al. Spinal inflammatory hyperalgesia is mediated by prostaglandin E receptors of the EP2 subtype. J Clin Invest 2005;

4 115: Shimizu I, Iida T, Guan Y et al. Enhanced thermal avoidance in mice lacking the ATP receptor P2X3. Pain 2005; 116: Sluka KA, Price MP, Breese NM, Stucky CL, Wemmie JA, Welsh MJ. Chronic hyperalgesia induced by repeated acid injections in muscle is abolished by the loss of ASIC3, but not ASIC1. Pain 2003; 106: Souslova V, Cesare P, Ding Y et al. Warm-coding deficits and aberrant inflammatory pain in mice lacking P2X3 receptors. Nature 2000; 407: Suzuki M, Mizuno A, Kodaira K, Imai M. Impaired pressure sensation in mice lacking TRPV4. J Biol Chem 2003; 278: Vergnolle N, Bunnett NW, Sharkey KA et al. Proteinase-activated receptor-2 and hyperalgesia: A novel pain pathway. Nat Med 2001; 7: Vriens J, Owsianik G, Hofmann T et al. TRPM3 is a nociceptor channel involved in the detection of noxious heat. Neuron 2011; 70: Vrontou S, Wong AM, Rau KK, Koerber HR, Anderson DJ. Genetic identification of C fibres that detect massage-like stroking of hairy skin in vivo. Nature 2013; 493: Woo SH, Ranade S, Weyer AD et al. Piezo2 is required for Merkel-cell mechanotransduction. Nature 2014; 509: Wu WP, Hao JX, Halldner L et al. Increased nociceptive response in mice lacking the adenosine A1 receptor. Pain 2005; 113: Zhang FX, Liu XJ, Gong LQ et al. Inhibition of inflammatory pain by activating

5 B-type natriuretic peptide signal pathway in nociceptive sensory neurons. J Neurosci 2010; 30: