EDUCATION M.D., Peking Union Medical College, Beijing, China, 1999 B.S., Beijing University, College of Life Science, Beijing, China, 1994

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1 CHAO MA, M.D. Yale University School of Medicine, Department of Anesthesiology, 333 Cedar Street, TMP3, New Haven, CT 06510, USA. Phone: (O), (C), Fax: , EXPERIENCE 2008~Present Assistant Professor, Department of Anesthesiology, Yale University School of Medicine, New Haven, CT, USA. 2003~2008 Associate Research Scientist, Department of Anesthesiology, Yale University School of Medicine, New Haven, CT, USA. 2000~2003 Postdoctoral Associate, Dr. Robert H. LaMotte s research laboratory, Department of Anesthesiology, Yale University School of Medicine, New Haven, CT, USA. 1999~2000 Resident Surgeon, Department of Surgery, Peking Union Medical College Hospital, Beijing, China. 1998~1999 Candidate for Doctorate of Medicine and Research Assistant, Prof. YiKuan Xie s research laboratory, Department of Physiology, Chinese Academy of Medical Science & Peking Union Medical College, Beijing, China. 1997~1998 Clinical intern at Peking Union Medical College Hospital, Beijing, China. EDUCATION M.D., Peking Union Medical College, Beijing, China, 1999 B.S., Beijing University, College of Life Science, Beijing, China, 1994 PROFESSIONAL AND SOCIETY MEMBERSHIPS Society for Neuroscience, member since 2000 International Association for the Society of Pain, member since 2005 American Physiological Society, member since 2006 Chinese Association for Science and Technology in Connecticut, member of Board of Directors since 2007, President from 2011 INVITED LECTURES Apr Antigen-Specific Immune Mechanisms of Pain primary afferent neurons as the immune sensor. Johns Hopkins University Blaustein Pain Conference, Baltimore, MD. Feb Antigen-Specific Immune Mechanisms of Chronic Pain. Yale Pain Symposium, Yale University School of Medicine, New Haven, CT. June 2010 Antigen-Specific Immune Mechanisms of Chronic Pain. Neuroscience Research Institute, Peking University, Beijing, China. June 2010 Animal Models of Pain Peking Union Medical College and Chinese Academy of Medical Science, Beijing, China. 1/5

2 Aug Nov Feb Jan Jan July 2002 Multiple sites for generation of ectopic spontaneous activity in neurons of the chronically compressed dorsal root ganglion. Neuroscience Research Institute, Peking University, Beijing, China. Adventure in the Primary Afferents: Peripheral Mechanisms of Neuropathic Pain. Schnurmacher Institute for Vision Research Colloquium, State University of New York - State College of Optometry, New York, NY. Peripheral Mechanisms of Neuropathic Pain. Dep. Neurology, University of Michigan, Ann Arbor, MI. Peripheral Mechanisms of Neuropathic Pain. Dep. Anesthesiology, Peking Union Medical College Hospital, and Dep. Physiology, Chinese Academy of Medical Science, Beijing, China. Peripheral Mechanisms of Neuropathic Pain. Department of Physiology, The Secondary Military Medical University, Shanghai, China. Changes of the Intact and Injured Dorsal Root Ganglion Neurons in Electrophysiological Properties after Peripheral or Central Axotomy Relationship with Neuropathic Pain. Dep. Physiology, Chinese Academy of Medical Science & Peking Union Medical College, and Dep. Anesthesiology, Peking Union Medical College Hospital, Beijing, China. FUNDINGS Ongoing Research Support: NIH/NINDS, 1-R21-NS , Antigen-specific immune mechanisms of neuronal hyperexcitability and chronic pain. P.I. Chao Ma. Percentage effort: 40%, 2/1/2009 7/31/2011. This project will reveal a novel mechanism of chronic pain driven by the antigen-specific immune response via the effects of lgg immune complex on the Fc receptors expressed in primary sensory neurons. NIH/NINDS, 2-R01-NS , Neurophysiology of Pain Adaptation and Hyperalgesia. P.I. Robert H. LaMotte. Percentage effort: 35%, 4/1/2008-3/31/2012. Study the electrophysiological properties and the mechanisms underlying hyperexcitability of primary sensory neurons in vivo after chronic compression of spinal ganglion, an animal model of chronic pain. Yale University School of Medicine, Department of Anesthesiology, Research Startup Fund. P.I. Chao Ma. Percentage effort: 15%. Completed Research Support: NIH/NINDS, 5-P01-NS , Neural Mechanisms of Itch. P.I. Robert H. LaMotte; 8/1/2004-7/30/2009. NIH/NINDS, 2-R01-NS , Neurophysiology of Pain Adaptation and Hyperalgesia. P.I. Robert H. LaMotte; 4/1/2003-3/31/2008. NIH/NINDS, 1-R01-NS44541 (Johns), Development of Gene Therapy for Chronic Pain. Johns Hopkins University Subcontract. P.I. Robert H. LaMotte; 9/30/2002-8/31/2006. NIH/NINDS, 5-R01-NS38317, Partial Rhizotomy Effects on Spinal Ganglia. P.I. Robert H. 2/5

3 LaMotte; 8/15/1999-7/31/2004. NIH/NINDS, 5-R01-NS14624, Neurophysiology of Pain Adaptation and Hyperalgesia. P.I. Robert H. LaMotte; 4/1/1998 3/31/2003. PUBLICATIONS [Research Articles] 1. Qu L, Zhang P, LaMotte RH, and Ma C*. Neuronal Fc-gamma Receptor I Mediated Excitatory Effects of IgG Immune Complex on Rat Dorsal Root Ganglion Neurons. Brain Behav Immun 2011; In Press, Accepted April 12, 2011; DOI: /j.bbi (*: corresponding author) 2. Fan N, Sikand P, Donnelly DF, Ma C, and LaMotte RH. Increased sodium and potassium currents in small mouse dorsal root ganglion neurons after ganglion compression. J Neurophysiol 2011; In Press, Accepted April 21, Ma C, Rosenzweig J, Zhang P, Johns DC, and LaMotte RH. Expression of inwardly rectifying potassium channels by an inducible adenoviral vector reduced the neuronal hyperexcitability and hyperalgesia produced by chronic compression of the spinal ganglion. Mol Pain 6:65, PMCID: PMC Ma C, Donnelly DF, and LaMotte RH. In-vivo visualization and functional characterization of primary somatic neurons. J Neurosci Methods 191(1):60-5, PMCID: PMC Zhang H, Mei X, Zhang P, Ma C, White FA, Donnelly DF, and LaMotte RH. Altered Functional Properties of Satellite Glial Cells in Compressed Spinal Ganglia. Glia 57: , PMCID: PMC Ma C, and LaMotte RH. Multiple sites for generation of ectopic spontaneous activity in neurons of the chronically compressed dorsal root ganglion. J Neurosci 27: , PMCID: PMC Sun J, Yang B, Donnelly DF, Ma C, and LaMotte RH. MCP-1 enhances excitability of nociceptive neurons in chronically compressed dorsal root ganglia. J Neurophysiol 96: , Ma C, Greenquist KW, and LaMotte RH. Inflammatory Mediators Enhance the Excitability of Chronically Compressed Dorsal Root Ganglion Neurons. J Neurophysiol 95: , White FA, Sun J, Waters SM, Ma C, Ren D, Ripsch M, Steflik J, Cortright DN, Lamotte RH, and Miller RJ. Excitatory monocyte chemoattractant protein-1 signaling is up-regulated in sensory neurons after chronic compression of the dorsal root ganglion. Proc Natl Acad Sci USA 102: , PMCID: PMC Ma C, and LaMotte RH. Enhanced excitability of dissociated primary sensory neurons after chronic compression of the dorsal root ganglion in the rat. Pain 113: Yao H, Donnelly D, Ma C, and LaMotte RH. Up-regulation of I H current after chronic compression of the dorsal root ganglion. J Neuroscience 23: , Ma C, Shu Y, Zheng Z, Chen Y, Yao H, Greenquist KW, White FA, and LaMotte RH. Similar Electrophysiological Changes in Axotomized and Neighboring Intact Dorsal Root Ganglion Neurons. J Neurophysiol 89: , /5

4 13. Ma C, Zheng Z, and Xie YK. Meridian-like character of reflex electromyogram activity in longissimus dorsi muscles. Chinese Science Bulletin 46: 57-62, [Book Chapters and Reviews] 14. Qu L and Ma C*. Animal models of pain after peripheral nerve injury. In: Chao Ma and Jun-Ming Zhang (eds.), Animal Models of Pain, Neuromethods, vol. 49: 69-80, Springer Science+Business Media, LLC Ma C*, and Zhang P. Application of digital imaging technology in basic and experimental medical research. [Chinese] In: Hui Pan and Shenqian Dai (eds.), Digital Imaging Technology and Application in Medicine. pp , Peking Union Medical College Press, LaMotte RH and Ma C. Hyperexcitable neurons and altered non-neuronal cells in the compressed spinal ganglion. In: Joint Sino-US Workshop on Pain, edited by J. Chen and R. LaMotte, Sheng Li Xue Bao 60(5): , PMCID: PMC Ma C*. Animal Models of Pain. In: International Anesthesiology Clinics, 45: , Lippincott Williams & Wilkins, Baltimore, MD [Selected Abstracts and Conference Presentations] 18. Qu L, Zhang P, and Ma C*. Mechanisms of neuronal Fc-gamma receptor I-mediated activation of the rat dorsal root ganglion neurons. Program No San Diego, CA: Society for Neuroscience, Ma C, Shimada SG, and LaMotte RH. In-vivo responses of cutaneous C-mechanosensitive neurons, and behavior, evoked in the mouse by punctuate chemical stimuli that elicit itch and nociceptive sensations in humans. Program No San Diego, CA: Society for Neuroscience, Qu L, Zhang P, LaMotte RH and Ma C*. A Novel Antigen-Specific Immune Mechanism of Pain. Presentation No. PM170. Montreal, Quebec, Canada: 13 th World Congress on Pain, Ma C, Zhang P, Sikand P, LaMotte RH and Gu Q. Antigen-Specific Immune Mechanisms of Chronic Pain. Program No Chicago, IL: Society for Neuroscience, Ma C, Johns DC and LaMotte RH. Role of neuronal hyperexcitability and ectopic spontaneous activity in hyperalgesia after chronic compression of spinal ganglion. Nociceptor-New Biology Symposium of the 12 th World Congress on Pain, Edinburgh, UK: International Association for the Study of Pain, Ma C and LaMotte RH. Multiple sites for generation of ectopic spontaneous activity in neurons of the chronically compressed dorsal root ganglion. Program No San Diego, CA: Society for Neuroscience, Ma C, Rosenzweig J, Zhang P, Johns DC and LaMotte RH. Expression of inwardly rectifying potassium channels by an inducible adenoviral vector reduced the neuronal hyperexcitability and hyperalgesia produced by chronic compression of the spinal ganglion. Program No Atlanta, GA: Society for Neuroscience, Ma C, LaMotte RH, Rosenzweig J, Gehlbach PL and Johns DC. Modulation of 4/5

5 voltage-gated potassium channels in dorsal root ganglion neurons by an inducible adenoviral vector in vivo. Abstract No Baltimore, MD: American Society of Gene Therapy 9 th Annual Meeting, Ma C, LaMotte RH, and Johns DC. Inhibition of voltage-gated potassium channels by an inducible adenoviral vector produced mechanical hyperalgesia and neuronal hyperexcitability in dorsal root ganglion neurons. Program No Washington, DC: Society for Neuroscience, Ma C, Sun J, Tan Z, and LaMotte RH. Two Types of Spontaneous Activity in Neurons of the Chronically Compressed Dorsal Root Ganglion. Program No San Diego, CA: Society for Neuroscience, Ma C, Greenquist KW, Yao H, and LaMotte RH. Inflammatory Mediators Enhance the Excitability of Chronically Compressed Dorsal Root Ganglia Neurons. Program No New Orleans, LA: Society for Neuroscience, Ma C, Yao H, and LaMotte RH. Enhanced excitability of dissociated primary sensory neurons in rats after chronic compression of the dorsal root ganglion. Program No Orlando, FL: Society for Neuroscience, Ma C, Zheng Z, Shu YS, and LaMotte RH. Electrophysiological changes in axotomized and intact dorsal root ganglia neurons outlast hyperalgesia after partial. Soc Neurosci Abstr 27: 736. San Diego, CA: Society for Neuroscience, /5