MISMS Latin America Influenza Meeting and Training Workshop June 25-28, 2012 Estelar Hotel Miraflores Lima, Peru

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MISMS Latin America Influenza Meeting and Training Workshop June 25-28, 2012 Estelar Hotel Miraflores Lima, Peru Day 1 - Monday, June 25: Scientific presentations 8:30-9:00 am Registration 9:00-10:15

9:25 9:50 am Eric Halsey, NAMRU-6, Peru: An overview of NAMRU-6's international respiratory surveillance network.

10:15-10:45 am Coffee Break 10:45 am - 12:15 pm Session II: 2009 Pandemic influenza in the Americas: Lessons learned 10:45-11:00am Jorge Gomez, Epidemiology General Directorate (DGE) of the Peruvian

1 MISMS Latin America Influenza Meeting and Training Workshop June 25-28, 2012 Estelar Hotel Miraflores Lima, Peru Day 1 - Monday, June 25: Scientific presentations 8:30-9:00 am Registration 9:00-10:15 am Session I: Welcome and MISMS overview 9:00 9:25 am Mark Miller, Fogarty International Center (FIC), NIH, USA: Welcome and MISMS overview. 9:25 9:50 am Eric Halsey, NAMRU-6, Peru: An overview of NAMRU-6's international respiratory surveillance network. 9:50 10:15 am Wladimir Alonso, FIC, NIH, USA: Epidemiology of influenza in the tropics: The case of Brazil. 10:15-10:45 am Coffee Break 10:45 am - 12:15 pm Session II: 2009 Pandemic influenza in the Americas: Lessons learned 10:45-11:00am Jorge Gomez, Epidemiology General Directorate (DGE) of the Peruvian Ministry of Health, Peru: Lessons learned from the 2009 pandemic in Peru. 11:00 11:15 am Gerardo Chowell, Arizona State University and FIC, NIH, USA: Transmission dynamics of the 2009 A/H1N1 influenza pandemic using high resolution surveillance data. 11:15 11:30 am Fernanda Moura, Universidade Federal do Ceará, Brazil: Influenza in an equatorial city: Something else about the more recent influenza pandemic in Brazil. 11:30 11:45 am Maria de Lourdes Oliveira, Oswaldo Cruz Institute, National Reference Laboratory for Influenza, Brazil: Influenza A(H1N1)pdm09 and other viral respiratory infections among fatal cases in pregnant and non-pregnant women preliminary findings. 11:45 12:00 pm Alberto Laguna Torres, NAMRU-6, Peru. The challenges of developing and maintaining a respiratory surveillance network.

2 12:00 12:15 pm Margot González, Instituto Mexicano del Seguro Social, México: Risk factors for hospitalization and death among influenza A (H1N1) patients, Mexico, :30 1:45 pm Lunch 1:45 2:50 pm Session III: Influenza in the Americas: Seasonality, time series models, and disease burden. 1:45 2:00 pm Walquiria Aparecida Ferreira de Almeida, Brazil Ministry of Health. Influenza surveillance in Brazil. 2:00 2:15 pm Aba Mahamat, MD, PhD, Cayenne General Hospital, Cayenne, French Guiana: Climatic drivers of influenza seasonality in French Guiana, :15 2:30 pm Diego Garcilazo, Instituto Nacional de Enfermedades Respiratorias, Argentina: Time series analysis of pneumonia and influenza mortality: Argentina, :30 2:45 pm Andreu Comas-Garcia, Instituto Nacional de Salud Publica, Mexico: Model for early detection of influenza outbreaks based on weekly reports of acute respiratory infections. 2:45 3:00 pm Po-Yung Cheng et al., CDC/PAHO: Influenza-associated Deaths in the Pan American Health Organization (PAHO) Region during Influenza Seasons and 2009 H1N1 Pandemic 3:00-3:15 pm Cécile Viboud, FIC, NIH: Burden of the 2009 pandemic in the United States compared to seasonal influenza 3:15-3:45 pm Coffee Break 3:45 4:15 pm Session IV: Influenza in swine and birds: Transmission and risks for humans 3:45 4:00 pm Martha Nelson, FIC, NIH, USA: Evolutionary dynamics of influenza viruses in North American swine. 4:00 4:15 pm Bruno Ghersi, NAMRU-6, Peru: Influenza and the human-animal interface in Peru. 4:15-5:30 pm Session V: Etiology of influenza and other respiratory diseases: Part I 4:15 4:30 pm Yeny Tinoco, NAMRU-6, Peru: Population-based active surveillance cohort studies for influenza in Peru. 4:30 4:45 pm Edwin Miranda, Instituto Nacional de Salud del Niño, Peru: Severity of pneumonia hospitalizations in children infected with the AH1N1/2009 influenza virus, Peru. 4:45 5:00 pm Bruno Alfredo, Insituto Nacional de Higiene, Ecuador: Surveillance of influenza virus and other causes of SARI in Ecuador. 5:00 5:15 pm Ana E. Arango, Universidad de Antioquia, Colombia: Monitoring influenza-like illness at a hospital in Medellin, Colombia.

3 5:15 5:30 pm Victoria Pando-Robles, Instituto Nacional de Salud, Mexico: Respiratory pathogens detection by RT-PCR and Mass-tag Multiplex PCR during the influenza A (H1N1 pdm) pandemic period, Mexico Day 2 - Tuesday, June 26: Scientific presentations 9:00 10:00 am Session VI: Etiology of influenza and other respiratory diseases: Part II 9:00-9:15 am Dan Weinberger, FIC, NIH, USA: Interactions between pneumococcus and viral respiratory infections. 9:15 9:30am Víctor Raúl Ocaña Gutierrez, NAMRU-6, Peru, Sentinel Surveillance, epidemiological, clinical and virological features of influenza-like illness: Piura, 2000 to :30 9:45 am Ivette Lorenzana, Universidad Nacional Autónoma de Honduras,Tegucigalpa, Honduras: Surveillance of viral respiratory pathogens in Tegucigalpa, Honduras, :45 10:00 am Sergio Jaramillo, Hospital Pablo Tobón Uribe, Colombia. Human metapneumovirus in hospitalized children, Medellín, Colombia. 10:00-10:30 am Coffee break 10:30 am -12:00 pm Session VII: Genetic evolution of influenza and other respiratory viruses, Part I. 10:40 11:05 am Eddie Holmes, Penn State University and FIC, NIH, USA: Evolutionary dynamics of influenza viruses. 11:05 11:30 am Andrew Rambaut. University of Edinburgh, Scotland and FIC, NIH, USA: Antigenic and spatial evolution of influenza viruses. 11:30 11:45 am Elsa Baumeister, National Influenza Centre, INEI-ANLIS Carlos G Malbran, Argentina. Sequencing and phylogenetic analysis of influenza virus A(H3N2) and (H1N1)pdm09 viruses in Argentina, :45 12:00 Luis Felipe Paulin Paz, Instituto de Biotecnología UNAM, Mexico: Development of a microarray to determine the phylogenetic origin of the influenza A segmented genome. 12:00 12:15 Yi Tany Tan, FIC, NIH, USA: Epidemiological dynamics and phylogeography of influenza in southern China. 12:15 1:15 pm Lunch 1:15 2:30 pm Session VIII: Genetic evolution of influenza and other respiratory viruses, Part II. 1:15 1:30 pm Paola Cristina Resende, FIOCRUZ, Brazil: Molecular analyses of influenza A H1N1pdm09 viruses at the hemagglutinin gene in mild, severe, and death cases in Brazil from 2009 to 2011.

4 1:30 1:45 pm Maria de Lourdes Oliveira, Oswaldo Cruz Institute, National Reference Laboratory for Influenza, Brazil: Epidemiological and molecular patterns of influenza A(H1N1)pdm09 infections in Brazil: findings from the pandemic and post-pandemic periods. 1:45 2:00 pm José Correa-Basurto, ESM-IPN, Mexico: Outside-binding site mutations modify the active site shapes from neuraminidase of influenza A H1N1. 2:00 2:15 pm Marina Escalera Zamudio, IBT-UNAM, Mexico: Evolutionary dynamics of H3N2 influenza viruses in Mexico. 2:15 2:30 pm Karen Gallegos, College of Medicine, University of Cincinnati, USA. Neuraminidase assays for detection and differentiation of influenza viruses. 2:30 3:15 pm Session IX: Influenza vaccination issues. 2:30 2:45 pm Mark Miller, FIC, NIH, USA: Assessing the value of vaccination strategies for epidemic and pandemic influenza. 2:45 3:00 pm Isaias Raw, Butantan, Brazil: New developments in influenza vaccine production. 3:00 3:15 pm Juan Cristina, Facultad de Ciencias, Uruguay: Phylogenetic analysis of pandemic 2009 influenza A virus circulating in the South American region: genetic relations and vaccine strain match. 3:15 3:45 pm Coffee break 3:45-5:00 pm Session X: Roundtable discussions on influenza vaccine and surveillance issue in Latin America 5:00-5:30 pm Closing remarks and opportunities for future collaboration

5 Day 3 - Wednesday, June 27: Technical Workshops 9:00-10:30 am Wladimir Alonso and Dan Weinberger, FIC, USA: Practical in time-series and spatial analysis methodologies and tools, visualization of data. 10:30-11:00 am Coffee break 11:00 am - 12:00 pm Gerardo Chowell and Cecile Viboud, FIC, USA: Reproduction number estimation and disease modeling. 12:00-1:30 pm Lunch 1:30-2:30 pm Eddie Holmes, FIC, USA: Phylogenetics :30-3:00 pm Coffee break 3:00-4:00 pm Andrew Rambaut, FIC, USA: Introduction to the BEAST software package for Bayesian methods in phylogenetics. 4:00 pm - 5:30 pm Dataset presentations by participants (3 minutes each) Day 4 - Thursday, June 28: Technical Workshops 9:00 10:00 am Hands-on tutorials, small group collaboration, one-on-one instruction 10:00-10:30 am Coffee break 12:30-1:30 pm Lunch 1:30-3:00 pm Hands-on tutorials, small group collaboration, one-on-one instruction 3:00-3:30 pm Coffee break 3:30-5:00 pm Hands-on tutorials, small group collaboration, one-on-one instruction

MISMS: International influenza research activities at the Fogarty International Center, NIH

MISMS: International influenza research activities at the Fogarty International Center, NIH Stacey Knobler and Gerardo Chowell For the Multinational Influenza Seasonal Mortality Study Group (MISMS) Division