PulseNet Gestalt. John Besser Minnesota Department of Health
|
|
|
- Timothy Grant
- 5 years ago
- Views:
Transcription
1 PulseNet Gestalt John Besser Minnesota Department of Health
2 Questions I Was sked to ddress How are epidemiologic investigations affected by 2 nd enzyme data? re investigations delayed until results are available? Does delay affect the outcome of investigations? re resources wasted if 2 nd enzymes later reveal that multiple patterns were found and therefore a common source is less likely? How often are epi clusters found that do not correlate with PFGE 2 enzyme clusters? re further investigations conducted or additional lab testing done (3 rd enzyme, MLV for salmonella)? What happens if no epi links can be found for 2 enzyme clusters? What effect does the inclusion of unrelated cases have on epi analyses such as hypothesis generation, odds ratio, etc?
3 Implications of the Two Enzyme Policy Sensitivity, specificity, and significance issues Public health/regulatory action Practical implications
4 PulseNet Gestalt ge stalt or Ge stalt ( P ) Pronunciation Key (gshtält, -shtôlt, -stält, -stôlt) n. pl. ge stalts or ge stalt en (-shtältn, -shtôltn, -stältn, -stôltn) physical, biological, psychological, or symbolic configuration or pattern of elements so unified as a whole that its properties cannot be derived from a simple summation of its parts.
5 Specificity Sensitivity discrimination The use of 2 enzymes increases subtype specificity
6 Direct Contact with Primary Reservoir
7 Transmission via Vehicle
8 Ingredient in Product amplification
9 Person-To-Person Transmission
10 Secondary Transmission
11 Person-To-Pet Transmission
12 Multiple Transmission Routes
13 Multiple Transmission Routes Environment Patron illness Contaminated product Workers Other foods
14 Multiple Transmission Routes 12 Number of Cases J FMMJJ SONDJ FMMJ JSOND J FMMJ J SOND JFMMJ JSOND
15 PFGE Case Definition
16 Goal: Identification of transmission event Method: marker for short-term evolutionary relationships minutes
17 conjugation transduction transformation mutation Via transposons plasmids integrons phage transcription errors
18
19 Subtyping (for hypothesis generating and testing): Refines the case definition to increase signal:noise
20 Refining the Case Definition One enzyme PFGE match Outbreakassociated
21 Refining the Case Definition Tenover criteria Outbreakassociated
22 Refining the Case Definition One enzyme PFGE match Outbreakassociated
23 Refining the Case Definition Two enzyme PFGE match Outbreakassociated
24 Refining the Case Definition Ten enzyme match Outbreakassociated
25 inflection point Type II error Type II error significance specificity of case definition
26 Specificity Sensitivity discrimination (Example: Bacteria not identified at all) ll inclusive ll isolates identical
27 Specificity Sensitivity (Example: Every isolate completely sequenced) ll exclusive ll isolates different discrimination
28 Gram Rxn genus species Tenover group subtype subtype, 2 enz Specificity Sensitivity discrimination
29
30 inflection point Type II error Type II error significance specificity of case definition
31 Gram Rxn genus species Tenover group subtype subtype, 2 enz Specificity Sensitivity discrimination How much discrimination is the right amount of discrimination?
32 It Depends On. The question you re trying to answer Prevalence of exposure Prevalence / type of agent Number of cases Other factors which contribute to specificity of case definition
33 Question: What is the vehicle for illnesses in a recognized outbreak?
34 Question: re two recognized outbreaks connected?
35 Question: What is the extent of an outbreak?
36 Question: Is there a clonal relationship between strains in different locations? Case Definition: Y. pestis isolated (biovar orientalis) from different geographic areas Burma India Indonesia US Vietnam Courtesy Kristy Kubota, CDC; ICEID Poster k2006
37 Question: Is their a common source for a cluster of cases?
38 For hypothesis generating and testing: In general, more subtype specificity is better..to a point
39 Factors That ffect the Need for Specificity Prevalence of exposure Prevalence / type of agent Number of cases
40 Odds Ratio exp+ exp- case C control B D OR = D CB
41 Prevalence of Exposure exp+ exp- case C control B D OR = D C B Odds ratio: inversely proportional to odds ratio
42 Low Prevalence Exposure case control exp+ exp- C B D Example: my mother s fruit cocktail surprise OR = D CB Consequence: less cases needed to reach significance
43 High Prevalence Exposure case control exp+ B Example: tomato consumption exp- C D OR = D CB Consequence: more cases needed to reach significance
44 Specific Exposure Definition case control exp+ exp- C B D Example: tomato consumption, supplier X OR = D CB Consequence: less cases needed to reach significance
45 Specificity and ssociation Exposure: tomatoes Case: S. Montevideo Control: not ill Exposed Not Exposed controls cases
46 Specificity and ssociation Exposure: tomatoes Case: S. Montevideo Control: not ill Case Control Exposed 6 3 Not Exposed 5 4 controls odds ratio = 1.6 cases
47 Specificity and ssociation Exposure: source tomatoes Case: S. Montevideo Control: not ill Tomato source Tomato source B Store X Store Y controls cases
48 Specificity and ssociation Exposure: source tomatoes Case: S. Montevideo Control: not ill Case Control Exposed 5 1 Not Exposed 6 6 controls odds ratio = 5 cases
49 Refining the EXPOSURE information: Increases signal noise ratio
50 exp+ case control B exp- C D OR = D CB
51 Case Classification exp+ Outbreak case control B exp- C C D Non-outbreak exp+ exp- C
52 Exposure Ratio Outbreak case control exp+ B exp- C C D Non-outbreak Ratio = specificity of case definition exp+ exp- C ffected by.. Prevalence of agent Specificity of agent definition Other case definitions
53 exp+ Outbreak Exposure Ratio case control B exp- C C D Non-outbreak exp+ exp- C
54 Low Prevalence gent case control exp+ exp- C B D Example: Salmonella Poona OR = D CB Few misclassified cases
55 High Prevalence gent case control exp+ exp- C B D Example: S. Typhimurium common subtype OR = D CB Many misclassified cases
56 More Specific Case Definition: 2 Enzymes case control exp+ exp- C B D Example: S. Typhimurium Subtype X1, B7 OR = D CB Less misclassified cases
57 Specificity and ssociation Exposure: tomatoes Case: S. Montevideo Control: not ill Exposed Not Exposed controls cases
58 Specificity and ssociation Exposure: tomatoes Case: S. Montevideo subt. Control: not ill Exposed Not Exposed controls cases
59 Specificity and ssociation Exposure: tomatoes Case: S. Montevideo subt. Control: not ill Case Control Exposed 5 3 Not Exposed 1 4 controls odds ratio = 6.7 cases
60 Specificity and ssociation Exposure: source tomatoes Case: S. Montevideo subt. Control: not ill Case Control Exposed 5 3 Not Exposed 1 4 controls odds ratio = 6.7 cases
61 Specificity and ssociation Exposure: source tomatoes Case: S. Montevideo subt. Control: not ill Case Control Exposed 5 1 Not Exposed 1 6 controls odds ratio = 30 cases
62 Specificity and ssociation Case Definition Non-specific Case Definition Specific Exposure Non-specific OR=1.6 OR=6.7 Exposure Specific OR=5 OR=30
63 Timeliness of the interview exp+ exp- case C control B D OR = D CB affects the sensitivity ND specificity of exposure information
64 E. coli O157:H7 Subtype Surveillance; Minnesota, No. of cases Jan Feb Mar pr May Jun Jul ug Sep Oct Nov Dec Month
65 Statistical ssociation with Consumption of Hamburger from Producer ; November- December No. of cases No. of cases Nov Dec Nov Dec Without PFGE OR = 1.93; p = NOT significant- With PFGE OR = 17.1; p = SIGNIFICNT-
66 Implications of the Two Enzyme Policy Sensitivity, specificity, and significance issues Public health/regulatory action Practical implications
67 E. coli O157:H7 Outbreak ssociated with Pre-packaged Salad: Whole Different Timeline MDH issues Press Release 3:29 P.M. from Seattle law firm to MDH 3:56 p.m. Contact person for outbreak posted on law firm website 4:45 p.m. Minneapolis Law Firm Star Tribune d Solicitation First lawsuit filed in Minneapolis Second lawsuit filed in Minneapolis September October 2005
68
69
70 Microbial DN Fingerprinting : dependent on continuous genetic change
71 Question: Does the DN in a specimen match the DN in an individual? Human DN testing X Year
72 Crime investigation: 22 Odds of exposure given illness Outbreak investigation: No. of cases in With PFGE OR = 17.1; p = 0.005
73 Multi-State Salmonella Typhimurium Outbreak ssociated with Cold Stone Creamery Ice Cream gent: rare (never seen before subtype), multiple cases, multiple states Temporal relationship: 10 cases/1 week Exposure: rare ( cake batter ice cream )
74 Implications of the Two Enzyme Policy Sensitivity, specificity, and significance issues Public health/regulatory action Practical implications
75 Practical Considerations gent and exposure prevalence information is not generally available Routine real-time 2 nd enzyme assays speeds up investigation and interventions for those situations where it s needed
76 Practical Considerations Multiple case definitions may be needed (e.g. definitions based on 2 enzymes, 1 enzyme, and no PFGE) if the number of cases is small significance specificity of case definition
77 Practical Considerations I you can t use 2 nd enzyme analysis on all recommended pathogens: use for clusters of common subtypes, or when highprevalence exposures are suspected
78 When are 2 nd enzymes likely necessary? Exposure common rare gent common rare ++ + lso recommended High consequence pathogens Multi-state clusters
79 Practical Considerations The 2 enzyme policy is designed to make specific agent data readily available It is NOT a required criteria for epidemiological significance!
80 Practical Considerations Lack of 2 enzyme data is NOT reason to delay a public health action, if a significant association is found with any other case definition
81 Subtype Interpretation subtype mismatch does not automatically exclude association subtype match does not guarantee association The significance of a subtype match is greater if the agent and/or exposure is rare More so than human DN fingerprinting, molecular subtype data cannot be evaluated outside epidemiological context
82 Practical Considerations Obtaining sensitive and specific exposure information is at least as important as agent specificity (Realtime interview, detailed, open-ended questions)
83 Important notes for epidemiology investigators: a Using strict case definitions based on two enzymes is useful for increasing the specificity of hypothesis generation and testing. However, since multiple PFGE strains are on occasion found among epidemiologically-linked cases, investigators should not rule out using both stringent case definitions based on two enzyme results and less stringent case definitions based on single enzyme results. b The significance of clusters is dependent on epidemiological measures. In any particular situation, second enzyme results may or may not ultimately prove to be a useful refinement of the case definition. While it is prudent for laboratories to begin second enzyme testing under these circumstances, this does NOT mean that investigators should wait for the second enzyme results before taking action. c In all cases, investigators should obtain as specific exposure information as possible, which strengthens measures of association between illness and exposure
84
Outbreak Investigations: The Minnesota Perspective A Dynamic Process
Outbreak Investigations: The Minnesota Perspective A Dynamic Process Carlota Medus, PhD, MPH Epidemiologist Principal Foodborne Diseases Unit Minnesota Department of Health Some Recent Notable Multi-state
E. coli O157:H7 - American Chef s Selection Angus Beef Patties, 2007
Introduction This series focuses on investigations of outbreaks caused by commercially distributed food items and detected through pathogen specific surveillance. The etiologic agents often are Salmonella,
Outbreak of Salmonella Newport Infections Linked to Cucumbers United States, 2014
Outbreak of Salmonella Newport Infections Linked to Cucumbers United States, 2014 Laura Gieraltowski, PhD, MPH Outbreak Response and Prevention Branch Division of Foodborne, Waterborne, and Environmental
Industry Uses of Microbiological Criteria and Testing for Raw Food Products. R. B. Tompkin Food Safety Consultant
Industry Uses of Microbiological Criteria and Testing for Raw Food Products R. B. Tompkin Food Safety Consultant October 31-November 1, 2005 Washington, DC This presentation is limited to food safety,
Investigation of foodborne disease outbreaks
Investigation of foodborne disease outbreaks Wan Chin Chen, M.D. Field Epidemiology Training Program Taiwan Centers for Disease Control Foodborne Infections Network in Taiwan CDC Laboratory diagnosis Surveillance
Findings presented are considered preliminary and subject to change
Cracking the Case: Multi-state Outbreak of SalmonellaEnteritidis associated with Eggs Thai-An Nguyen, MPH Centers for Disease Control and Prevention Outbreak Response and Prevention Branch Outbreak Response
The PulseNet Cost Benefit Study and Beyond: What We Have Learned & Where We Are Headed for Molecular Enteric Surveillance
The PulseNet Cost Benefit Study and Beyond: What We Have Learned & Where We Are Headed for Molecular Enteric Surveillance Craig Hedberg, PhD University of Minnesota Our mission is to identify and evaluate
Surveillance and outbreak response are major components
CHAPTER Performance Indicators for Foodborne Disease Programs Surveillance and outbreak response are major components of states foodborne investigation capacity and are essential for preventing and controlling
Foodborne Outbreaks in Alaska,
Department of Health and Social Services William H. Hogan, MSW, Commissioner 3601 C Street, Suite 540 Anchorage, Alaska 99503 http://www.epi.alaska.gov Division of Public Health Ward Hurlburt, MD, MPH,
How Whole-Genome Sequencing Impacts Outbreak Investigations A Public Health Perspective
How Whole-Genome Sequencing Impacts Outbreak Investigations A Public Health Perspective Anna Carlson, PhD Nebraska Department of Health and Human Services Foodborne Disease Epidemiology Surveillance Coordinator
E. coli O157:H7 - Multistate Outbreak Associated with Hazelnuts, 2010
Introduction This series focuses on investigations of outbreaks caused by commercially distributed food items and detected through pathogen specific surveillance. The etiologic agents often are Salmonella,
Multistate Foodborne Outbreaks: Investigation and Communication Process
National Center for Emerging and Zoonotic Infectious Diseases Multistate Foodborne Outbreaks: Investigation and Communication Process Matthew Wise, MPH, PhD Deputy Branch Chief for Outbreak Response Laura
Changing Trends in Foodborne and Enteric Zoonotic Outbreaks Colin Basler, DVM, MPH
Changing Trends in Foodborne and Enteric Zoonotic Outbreaks Colin Basler, DVM, MPH Veterinary Epidemiologist Outbreak Response and Prevention Branch Centers for Disease Control and Prevention Salmonella
SALMONELLOSIS. 35 Cases per 100,000 LAC US
SALMONELLOSIS CRUDE DATA Number of Cases 1,236 Annual Incidence a LA County California United States 13.6 14. 16.2 3 2 Figure 79 Incidence Rates by Year LAC and US, 1989-1998 3 Cases per, LAC US Age at
Outbreak Alert! Trends in Foodborne Illness Outbreaks in the United States ( )
5 th MEETING PAN AMERICAN COMMISSION ON FOOD SAFETY (COPAIA) Rio de Janeiro, Brazil, June 10, 2008 Provisional Agenda Item 5 COPAIA5/5 (Eng.) May, 28 th 2008 ORIGINAL: ENGLISH Outbreak Alert! Trends in
APril PUlseNet
Issues in Brief Pulsenet: A Critical Food Safety Surveillance System Association of Public Health Laboratories APril 2010 PUlseNet A Critical Food Safety Surveillance System Public health laboratorians
Flu Watch. MMWR Week 3: January 14 to January 20, and Deaths. Virologic Surveillance. Influenza-Like Illness Surveillance
Flu Watch MMWR Week 3: January 14 to January 2, 218 All data are provisional and subject to change as more reports are received. Geographic Spread South Carolina reported widespread activity this week.
Flu Watch. MMWR Week 4: January 21 to January 27, and Deaths. Virologic Surveillance. Influenza-Like Illness Surveillance
Flu Watch MMWR Week 4: January 21 to January 27, 218 All data are provisional and subject to change as more reports are received. Geographic Spread South Carolina reported widespread activity this week.
Outbreak Investigations and Whole Genome Sequencing
Outbreak Investigations and Whole Genome Sequencing Adiam Tesfai, PHD FDA CFSAN Coordinated Outbreak Response and Evaluation GenomeTrakr Meeting September 7,018 Outline Role of FDA in Foodborne Outbreak
An Overview of Syndromic Surveillance
1 An Overview of Syndromic Surveillance Community Health Care Association of New York State Don Weiss, MD, MPH Bureau of Communicable Disease New York City Department of Health & Mental Hygiene March 9,
SURVEILLANCE AND DETECTION OF FOODBORNE ILLNESSES
SURVEILLANCE AND DETECTION OF FOODBORNE ILLNESSES Ratih Dewanti-Hariyadi Department of Food Science and Technology SEAFAST Center Bogor Agricultural University INTRODUCTION Detecting outbreaks requires
Evaluation of Tennessee Foodborne Illness and Outbreak Response Using the Council to Improve Foodborne Outbreak and Response (CIFOR) Metrics
Evaluation of Tennessee Foodborne Illness and Outbreak Response Using the Council to Improve Foodborne Outbreak and Response (CIFOR) Metrics 12/31/2014 Tennessee Integrated Food Safety Center of Excellence
Salmonellosis Associated with Exposure to Live Animal Slaughter Markets
Salmonellosis Associated with Exposure to Live Animal Slaughter Markets Amy Saupe 1, Carlota Medus 1, Nicole Neeser 2, Ginette Short 1, Joni Scheftel 1, Kirk Smith 1 1 Minnesota Department of Health 2
HAEMOPHILUS INFLUENZAE INVASIVE DISEASE
23 Annual Morbidity Report HAEMOPHILUS INFLUENZAE INVASIVE DISEASE CRUDE DATA 35 Annual Incidence a LA County.37 California b. United States c.2 Age at Diagnosis Mean 4. years Median 36. years Range Birth
E. Coli O157:H7 and Spinach Jeff Farrar, DVM, PhD, MPH Branch Chief Food and Drug Branch California Department of Health Services
E. Coli O157:H7 and Spinach 2006 Jeff Farrar, DVM, PhD, MPH Branch Chief Food and Drug Branch California Department of Health Services Number of cases of E. coli O157:H7 reported in California - 2000-2005
CIFOR performance measure Measurement methods Target Range Minnesota 2013 Performance 1. Foodborne illness complaint reporting system:
CIFOR Target Ranges for Select Performance Measures Interested in calculating the CIFOR target range performance measures for your jurisdiction, but have questions or need assistance? Contact Joshua.rounds@state.mn.us
Performance Indicators for Foodborne Disease Programs
Chapter A long-standing goal of CDC and national public health professional organizations has been to build state and local capacity for detecting and preventing illness. In 1997, CDC convened an expert
When a Cluster Becomes an Outbreak The Multistate Perspective
National Center for Emerging and Zoonotic Infectious Diseases When a Cluster Becomes an Outbreak The Multistate Perspective Matthew Wise, MPH, PhD Outbreak Response and Prevention Branch Division of Foodborne,
SHIGA-TOXIN PRODUCING ESCHERICHIA COLI STEC Update. Roshan Reporter, MD, MPH Rita Bagby, PS-PHN Leticia Martinez, PS-PHN
SHIGA-TOXIN PRODUCING ESCHERICHIA COLI STEC Update Roshan Reporter, MD, MPH Rita Bagby, PS-PHN Leticia Martinez, PS-PHN Objectives At the conclusion of this presentation the participant should be able
Salmonella Typhimurium Associated with Unpasteurized Homemade Queso Fresco March-April, 2013
Salmonella Typhimurium Associated with Unpasteurized Homemade Queso Fresco March-April, 2013 C. Medus 1, B. Crosby 1, H. Fox 1, G. Dobbins 1, H. Kassenborg 2, D. Huff 3, K. Smith 1 1 Minnesota Department
In accordance with 902 KAR 2:020, cases of acute hepatitis A should be reported within 24 hours.
Kentucky Department for Public Health KY7-89 - Acute Hepatitis A Outbreak Weekly Report Morbidity and Mortality Weekly Report (MMWR) Week May, 8 May, 8 Brief Description of Outbreak: In November 7, the
Foodborne Disease in the Region of Peel
Foodborne Disease in the Region of Peel HIGHLIGHTS The incidence of selected foodborne diseases was generally higher in Peel than in Ontario between 1993 and 22. A higher incidence was observed in Peel
Module 4: Estimated Annual U.S. Foodborne Disease Burden, 2011 Foodborne Illnesses 48 million Hospitalizations 128,000 Deaths 3,000
Module 4: Epidemiology Investigation Epidemiology Division Analysis and Reporting Branch 2 Module Learning Objectives Develop a case definition Explain an epidemic curve Develop an initial hypothesis List
Retrospective Outbreak Investigations Initiated by Product or Environmental Sampling. LCDR Kari Irvin November 19, InFORM
Retrospective Outbreak Investigations Initiated by Product or Environmental Sampling LCDR Kari Irvin November 19, 2015 2015 InFORM 1 Traditional VS Retrospective Outbreak Investigations Investigation begins
Outbreak Case Study. Ralstonia Outbreak Investigation Background
Outbreak Case Study CAPT Arjun Srinivasan, MD Division of Healthcare Quality Promotion Centers for Disease Control and Prevention Ralstonia Outbreak Investigation Background CDC notified of 5 cases of
Surveillance Networks and the detection and Investigation of Foodborne Disease Outbreaks What You See is What you Get
Surveillance Networks and the detection and Investigation of Foodborne Disease Outbreaks What You See is What you Get 10 th CSL/JIFSAN Symposium Methods and Systems for Tracking, Tracing and Verifying
the Future Hold? May 30, 2018
Food Safety and High-Throughput Sequencing What does the Future Hold? Government Agencies Institute for Food Safety and Health May 30, 2018 Robert Tauxe, MD, MPH Director Division of Foodborne, Waterborne
Lessons Learned from an Outbreak: E. coli O157:H7 linked to Romaine Lettuce National Investigation and Communication Process
National Center for Emerging and Zoonotic Infectious Diseases Lessons Learned from an Outbreak: E. coli O157:H7 linked to Romaine Lettuce National Investigation and Communication Process Natasha Dowell,
The NCFOODSAFE Project Developing a Foodborne Events Data Integration and Analysis Tool for North Carolina (NCFEDA)
The NCFOODSAFE Project Developing a Foodborne Events Data Integration and Analysis Tool for North Carolina (NCFEDA) Noel Greis and Monica Nogueira Center for Logistics and Digital Strategy Kenan-Flagler
Syndromic Surveillance in Public Health Practice
Syndromic Surveillance in Public Health Practice Michael A. Stoto IOM Forum on Microbial Threats December 12, 2006, Washington DC Outline Syndromic surveillance For outbreak detection Promise Problems
Foodborne Outbreak of E. coli Infections and Hemolytic Uremic Syndrome in Germany, 2011
Foodborne Outbreak of E. coli Infections and Hemolytic Uremic Syndrome in Germany, 2011 Kirk Smith, DVM, MS, PhD Supervisor Foodborne, Vectorborne and Zoonotic Diseases Unit Minnesota Department of Health
Starting from the bench Prevention and control of foodborne and zoonotic diseases
Starting from the bench Prevention and control of foodborne and zoonotic diseases Martin Wiedmann Department of Food Science Cornell University, Ithaca, NY E-mail: mw16@cornell.edu Yrjo Overview Foodborne
What's for dinner? Current issues in foodborne illness
What's for dinner? Current issues in foodborne illness Alicia Cronquist, RN, MPH Foodborne/Enteric Disease Epidemiologist Colorado Dept. of Public Health and Environment Today s Goals What s new in foodborne
Core 3 Update: Epidemiology and Risk Analysis
Core 3 Update: Epidemiology and Risk Analysis Aron J. Hall, DVM, MSPH Centers for Disease Control and Prevention NoroCORE Full Collaborative & Stakeholder Meeting, Dallas, TX October 30, 2014 Core 3: Purpose
FDA/NSTA Web Seminar: Teach Science Concepts and Inquiry with Food
LIVE INTERACTIVE LEARNING @ YOUR DESKTOP FDA/NSTA Web Seminar: Teach Science Concepts and Inquiry with Food Tuesday, December 4, 2007 Outbreak Investigation Be the Detective Sherri A. McGarry Food & Drug
Introduction. Future U.S. initiatives regarding the food safety for fresh produce. FoodNet Partners. FoodNet Partners
Introduction Future U.S. initiatives regarding the food safety for fresh produce This presentation is based upon FDA s testimony about the E. coli outbreaks to the U.S. Congress delivered on November 15,
GSK Medicine: Study No.: Title: Rationale: Study Period Objectives: Indication: Study Investigators/Centers: Research Methods: Data Source:
The study listed may include approved and non-approved uses, formulations or treatment regimens. The results reported in any single study may not reflect the overall results obtained on studies of a product.
Telehealth Data for Syndromic Surveillance
Telehealth Data for Syndromic Surveillance Karen Hay March 30, 2009 Ontario Ministry of Health and Long-Term Care Public Health Division, Infectious Diseases Branch Syndromic Surveillance Ontario (SSO)
U.S. Food & Drug Administration Center for Food Safety & Applied Nutrition Foodborne Pathogenic Microorganisms and Natural Toxins Handbook
U.S. Food & Drug Administration Center for Food Safety & Applied Nutrition Foodborne Pathogenic Microorganisms and Natural Toxins Handbook Salmonella spp. 1. Name of the Organism: Salmonella spp. Salmonella
TB Outbreak in a Homeless Shelter
TB Outbreak in a Homeless Shelter Objectives Epidemiology of Outbreak Population Health Interventions Population Health Goals 2007 One active case identified Less than compliant Prolonged recovery Contact
Salmonella Enteritidis: Surveillance Data and Policy Implications
Salmonella Enteritidis: Surveillance Data and Policy Implications Alejandro Pérez, MPH Enteric Diseases Epidemiology Branch Division of Foodborne, Bacterial and Mycotic Diseases National Center for Zoonotic,
The power of information to prevent foodborne illness
The power of information to prevent foodborne illness Craig Hedberg, PhD University of Minnesota, School of Public Health Decrease the burden of foodborne illness using improved techniques in detection,
Part 1: Epidemiological terminology. Part 2: Epidemiological concepts. Participant s Names:
Part 1: Epidemiological terminology Participant s Names: _ a. Define the following terms: (award 2 points for each word that is defined correctly) 1. Fomite: a physical object that serves to transmit an
Vibrio surveillance in the CIDT Era
National Center for Emerging and Zoonotic Infectious Diseases Vibrio surveillance in the CIDT Era Erin K. Stokes, MPH Surveillance Epidemiologist, National Surveillance Team PulseNet/OutbreakNet West Coast
Wild Poliovirus*, 03 Aug 2004 to 02 Aug 2005
Wild Poliovirus*, 03 Aug 2004 to 02 Aug 2005 Wild virus type 1 Wild virus type 3 Wild virus type 1 & 3 Endemic countries Re-established transmission countries Case or outbreak following importation *Excludes
Weekly Influenza News 2016/17 Season. Communicable Disease Surveillance Unit. Summary of Influenza Activity in Toronto for Week 43
+ Weekly / Influenza News Week 43 (October 23 to October 29, 2016) Summary of Influenza Activity in Toronto for Week 43 Indicator (Click on the indicator Activity Level * Description name for more details)
Hepatitis A Outbreaks From Green Onions
Hepatitis A Outbreaks From Green Onions Foodborne Threats to Health Institute of Medicine October, 2005 Beth P. Bell, MD, MPH Centers for Disease Control and Prevention Hepatitis A Virus (HAV) Infection
DO NOT TURN THE PAGE UNTIL THE EVENT LEADER TELLS YOU TO!
DISEASE DETECTIVES DIRECTIONS DO NOT WRITE ON THIS TEST!! All answers must be written on your response sheet. This test is long. You may wish to divide the test between you. If you take the pages out of
E. coli O157:H7 Outbreak Associated with Consumption of Unpasteurized Milk, Kentucky, 2014
E. coli O157:H7 Outbreak Associated with Consumption of Unpasteurized Milk, Kentucky, 2014 Association of Food and Drug Officials of the Southern States Fall Educational Conference September 15, 2015 Speakers
Foodborne Illness and Outbreak Surveillance in the USA. Alison Samuel, Naghmeh Parto, Emily Peterson
Foodborne Illness and Outbreak Surveillance in the USA Alison Samuel, Naghmeh Parto, Emily Peterson 1 Context Where is the information coming from: Attended the CDC/ Emory University; Environmental Microbiology:
FMD Control Initiatives in Bangladesh
FMD Control Initiatives in Bangladesh Dr. Md. Mohsin Ali Dr. Md. Ainul Haque Department of Livestock Services, Bangladesh Country Profile In Short Bangladesh is a Republic of South Asia It is bordered
Total population 20,675,000. Live births (LB) 349,715. Children <1 year 346,253. Children <5 years 1,778,050. Children <15 years 5,210,100
Sri Lanka 4 Immunization system highlights There is a comprehensive multi-year plan (cmyp) for immunization system strengthening covering -6. A national policy on immunization has been developed. A standing
EPIDEMIOLOGY SURVEILLANCE REPORT NORTHEAST REGION FALL Namitha Reddy Regional Coordinator North/Central West Region NJDOH/EEOH/CDS
EPIDEMIOLOGY SURVEILLANCE REPORT NORTHEAST REGION FALL 2014 Namitha Reddy Regional Coordinator North/Central West Region NJDOH/EEOH/CDS Overview Purpose/Objectives State and Regional Highlights Select
Whole genome sequencing
Downloaded from orbit.dtu.dk on: Dec 20, 2017 Whole genome sequencing Torpdahl, Mia; Löfström, Charlotta; Møller Nielsen, Eva Published in: Publication date: 2014 Document Version Publisher's PDF, also
The Triple Axel: Influenza, TB and MERS-CoV. Carolyn Pim, MD December 10, 2015
The Triple Axel: Influenza, TB and MERS-CoV Carolyn Pim, MD December 10, 2015 1. Influenza 2 Influenza 10-20% of the population is infected each year (up to 30% of children) Infection rates are highest
Disease Detectives Investigate Outbreaks of Salmonella enteritidis
2018 DISEASE DETECTIVES SAMPLE FOODBORNE ILLNESS Disease Detectives Investigate Outbreaks of Salmonella enteritidis As population growth continues demand for food production will also increase. Avenues
New Brunswick Influenza Activity Summary Report: season (Data from August 30,2015 to June 4,2016)
New Brunswick Influenza ctivity Summary Report: - season (Data from ugust 30, to June 4,) Highlights of the - Influenza season: This season, we experienced later influenza activity than expected. This
National Environmental Assessment Reporting System (NEARS)
National Environmental Assessment Reporting System (NEARS) Identifying Environmental Factors Contributing to Foodborne Illness Outbreaks National Center for Environmental Health CDC s National Center for
California Food Emergency Response Team (CalFERT)
California Food Emergency Response Team (CalFERT) Outbreak Investigations and Response to Listeria monocytogenes Outbreak Associated with Caramel Apples Investigative Team California Food Emergency Response
Global and National Trends in Vaccine Preventable Diseases. Dr Brenda Corcoran National Immunisation Office.
Global and National Trends in Vaccine Preventable Diseases Dr Brenda Corcoran National Immunisation Office Global mortality 2008 Children under 5 years of age 1.5 million deaths due to vaccine preventable
Core 3: Epidemiology and Risk Analysis
Core 3: Epidemiology and Risk Analysis Aron J. Hall, DVM, MSPH, DACVPM CDC Viral Gastroenteritis Team NoroCORE Full Collaborative Meeting, Atlanta, GA November 7, 2012 Core 3: Purpose and Personnel * Purpose:
Expanded Programme on Immunization (EPI)
Timor-Leste 217 Expanded Programme on Immunization (EPI) FACT SHEET Acronyms AD Auto disable MCV1 First dose measles containing vaccine AEFI Adverse events following immunization MCV2 Second dose measles
Assessing Change with IIS. Steve Robison Oregon Immunization Program
Assessing Change with IIS Steve Robison Oregon Immunization Program Assessing Change with IIS Steve Robison Oregon Immunization Program Overview IIS Use in Public Health Static vs Dynamic Assessment Working
Before development of pathogen-specific surveillance,
Chapter Investigation of Clusters and Outbreaks Before development of pathogen-specific surveillance, foodborne disease outbreaks were typically recognized because of the occurrence of large numbers of
Total population 1,212,110. Live births (LB) 43,924. Children <1 year 40,351. Children <5 years 192,340. Children <15 years 510,594
Draft version for the SEAR-ITAG 5-9 June 5 All data provisional as of May 5 Timor Leste 4 Immunization system highlights There is a comprehensive multi-year plan (cmyp) for immunization covering 3-5. 8%
Influenza A (H1N1)pdm09 in Minnesota Epidemiology
Influenza A (H1N1)pdm09 in Minnesota Epidemiology Infectious Disease Epidemiology, Prevention and Control Division PO Box 64975 St. Paul, MN 55164-0975 Number of Influenza Hospitalizations by Influenza
LABORATORY TRENDS. National Collaboration. Laboratory News PUBLIC HEALTH MICROBIOLOGY & REFERENCE LABORATORY. Vancouver, BC.
LABORATORY November 7, 11 In this Issue: National Collaboration Canadian Public Health Laboratory Network The Canadian Public Health Laboratory Network (CPHLN) provides national leadership in the public
Pandemic Influenza Preparedness
Pandemic Influenza Preparedness Of the many health threats that we are preparing for, this is the one that we know will happen. Bruce G. Gellin, MD, MPH Director, National Vaccine Program Office Department
Salmonella Enteritidis:
Salmonella Enteritidis: Outbreak, Findings, and Update David K. Elder Director, Office of Regional Operations Office of Regulatory Affairs FDA AFDO Annual Meeting 2011 Topics Outbreak Information (thank
Annual Epidemiological Report
December 2018 Annual Epidemiological Report Key Facts Cryptosporidium 1 infection in Ireland, 2017 In 2017, 589 cases of cryptosporidiosis were notified in Ireland 36 were hospitalised, with no reported
AVIAN INFLUENZA (A/H5N1) SITUATION IN VIETNAM, National Institute of Hygiene and Epidemiology
AVIAN INFLUENZA (A/H5N1) SITUATION IN VIETNAM, 2003-2005 National Institute of Hygiene and Epidemiology General Information Area: 332,600 km2 Provinces: 64 Districts: 668 Communes/wards: 10,732 Population:
Overview of the Radiation Exposure Doses of the Workers at Fukushima Daiichi Nuclear Power Station
Click here for the corrections made < Reference > December 3, 212 Tokyo Electric Power Company Overview of the Radiation Exposure Doses of the Workers at Fukushima Daiichi Nuclear Power Station * As of
Middle East respiratory syndrome coronavirus (MERS-CoV) and Avian Influenza A (H7N9) update
30 August 2013 Middle East respiratory syndrome coronavirus (MERS-CoV) and Avian Influenza A (H7N9) update Alert and Response Operations International Health Regulations, Alert and Response and Epidemic
Disease Detectives 2016 B/C
Disease Detectives 2016 B/C What you can bring Two (2) non-programmable nongraphing calculators One (1) 8.5 x 11 inch sheet of notes, double sided Difference between B and C division Same types of questions
Update on infections with and clinical lab guidelines for Shiga toxin-producing E. coli (STEC) in the United States
Update on infections with and clinical lab guidelines for Shiga toxin-producing E. coli (STEC) in the United States Patricia M. Griffin, MD Enteric Diseases Epidemiology Branch Centers for Disease Control
Retrospective Investigations
Retrospective Investigations Jessie Marus, MPH CDC Outbreak Response and Prevention Branch What are they? Why investigate? How do we do it? What is a Retrospective Outbreak? Food or Environmental Isolate
OIE Situation Report for Highly Pathogenic Avian Influenza
OIE Situation Report for Highly Pathogenic Avian Influenza Latest update: 28/02/2018 The epidemiology of avian influenza is complex. The virus constantly evolves and the behavior of each new subtype (and
An Overview of Outbreak Investigations
An Overview of Outbreak Investigations CDR Arjun Srinivasan, MD Division of Healthcare Quality Promotion Centers for Disease Control and Prevention Is This the Anatomy of an Outbreak? 1 Is This the Anatomy
Adam Aragon Lisa Onischuk Paul Torres NM DOH, Scientific Laboratory Division
Adam Aragon Lisa Onischuk Paul Torres NM DOH, Scientific Laboratory Division New Mexico Scientific Laboratories 1101 Camino de Salud, NE Albuquerque, NM 87102 Scientific Laboratory Division SLD Office
Outbreak Investigation Step by Step
Outbreak Investigation Step by Step Darin Areechokchai MD., DTM&H., MCTM. Surveillance and Investigation Section Bureau of Epidemiology, Department of Disease Control Ministry of Public Health, Thailand
MA PHIT- Food Certificate Program
1 Explain MDPH role in foodborne illness prevention and control Describe the function of the Working Group Summarize the role of local board of health (LBOH) 2 The Centers for Disease Control & Prevention
Multistate Outbreak of Listeriosis Associated with Imported Ricotta Salata and Evidence of Cross- Contamination of Cut and Repackaged Cheeses
Multistate Outbreak of Listeriosis Associated with Imported Ricotta Salata and Evidence of Cross- Contamination of Cut and Repackaged Cheeses Katherine Heiman, MPH Epidemiologist Outbreak Prevention and
USAID s approach to the control of avian and pandemic influenza
USAID s approach to the control of avian and pandemic influenza Murray Trostle, Dr. PH Deputy Director Avian and Pandemic Influenza Unit USAID December 19, 2006 USAID goals Prevent an influenza pandemic
Turtlepocalypse 2012
Photo courtesy of www.sodahead.com Turtlepocalypse 2012 Latoya Simmons Technical Research Assistant Outbreak Response and Prevention Branch Division of Foodborne, Waterborne, and Environmental Diseases
Foodborne Illness. How can it affect your business?
Foodborne Illness How can it affect your business? November 3, 2013 Why this topic? Foodborne illnesses affect millions of Americans each year The Centers for Disease Control and Prevention estimate that
USDA s New Shiga Toxin- Producing Escherichia coli Policy. James Hodges Executive Vice President American Meat Institute
USDA s New Shiga Toxin- Producing Escherichia coli Policy James Hodges Executive Vice President American Meat Institute June 20, 2012 Final Determination and Request for Comments (FDRC) September 20, 2011
Durham Region Influenza Bulletin: 2017/18 Influenza Season
Durham Region Influenza Bulletin: 2017/18 Influenza Season Surveillance Week 21 (May 20, 2018 to May 26, 2018) Table 1: Assessment of influenza activity in Durham Region Measure Laboratory confirmed cases
New York State Health Department's experience with implementing Whole Genome Cluster Analysis for Salmonella outbreak investigations
New York State Health Department's experience with implementing Whole Genome Cluster Analysis for Salmonella outbreak investigations William Wolfgang Wadsworth Center NYSDOH InForm 2013 11/20/13 Current
Total population 24,759,000. Live births (LB) 342,458. Children <1 year 337,950. Children <5 years 1,698,664. Children <15 years 5,233,093
DPR Korea 4 Immunization system highlights There is a comprehensive multiyear plan (cmyp) for immunization covering -5. A standing national technical advisory group on immunization (NTAGI) with formal