Munich, Germany, June 16 18, 2010
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1 ISTC s Contributions to Bio Sciences Yesterday-Today-TomorrowTomorrow Vyacheslav Melnikov ISTC Munich, Germany, June 16 18, 2010
2 YESTERDAY: ISTC Project Funding Since Inception $900 million (2700 projects) Other Basic Sciences Space, Aircraft and 1% Non-Nuclear Energy Physics Surface Transportation 3% 13% Agriculture 4% Materials 3% 8% Biotechnology & 13% Manufacturing Technology 3% Medicine Instrumentation 10% 5% Information and Chemistry Communications 6% 3% Fusion Fission Reactors Environment 2% 10% 16%
3 TODAY: ISTC Life Sciences Activities ($219 Million, 594 projects) Genomics, Proteomics and Bioinformatics Molecular & Epidemiological Surveillance of Pathogens and Infections (human, animals, plants, health network) Food and Agriculture (Bio)technology Food and Agriculture (Bio)technology Drug & Vaccine Discovery Diagnostics and Detection g Bioremediation Biodiversity Biosafety and BioSecurity
4 TODAY: Genomics, Proteomics & Bioinformatics Genomic analysis of organisms: For Agriculture: Potato Aspergillus For Disease Control: Hantaviruses HIV Cancer Tuberculosis For Evolutionary Studies: -Prokaryotes Proteomic analyses: Cancer Hepatitis C Bioinformatic analyses of diseases: Cancer HIV Influenza (Avian)
5 TODAY: New Drug Discovery in silico modelling: Search Chemical tuning Screening New targets Delivery systems Ecotoxicity Prediction Quantitative Structure Activity Relationships (QSAR) Method ORCHEMED Consortium - Established in 2004 to advance drug development efforts of its members for licensing to pharmaceutical companies TB Consortium Established in 2007 to advance TB research in RF
6 TODAY: Drug Development Infrastructure for Preclinical Trials 13 institutes within RF improved vivariums to conduct animal work according it international ti standards. d Accreditation for international preclinical trials is being conducted according to standards set by AAALAC International (Association for Assessment and Accreditation of Laboratory Animal Care International) Accredited Institutions: Institute of Bioorganic Chemistry, Puschino: Laboratory of Biological Trials SPF rodents Breeding Facility Institutions Undergoing Accreditation: Institute tute of Physiologically og y Active Substances, Chernogolovka ov Centre for Preclinical trials Research Center of Toxicology and Hygienic Regulation of Biopreparations, Serpukhov
7 TODAY: Diagnostics & Detection ti BIOCHIPS: 9 projects for $3 million Application: MDR-TB, XDR-TB orthopox virus, herpes virus, HCV/B, HIV, STD, biosecurity, individual genetic identification, blood safety, seasonal & pandemic flu New company created to produce p y p microchips for RF MOH (OOO Biochip-IMB,
8 TODAY: Vaccine Development Animal/ Live-stock Vaccines: Avian Viral Influenza Newcastle Disease Human Vaccines: Tuberculosis Measles Influenza Characterization of Disease Strains for Future Vaccine Development: Hantaviruses Lyme Disease Hepatitis C Gastroenteritis ii HIV
9 TODAY: Molecular & Epidemiological Surveillance RF Pandemic Flu Preparedness Further Improvement of Influenza Surveillance in Russia. Contribution in Global Influenza Pandemic Preparedness with participation of WHO & CDC Research Institute of Influenza, St Petersburg Ivanovsky Institute of Virology, Moscow +50 regional RF laboratories Main tasks: improving reporting to RF MOH, WHO Comprehensive methods of flu diagnostics Training of lab staff Result front line of pandemic flu detection in RF May- August, 2009 Training Centre for other regional labs including Rospotrebnadzor
10 TODAY: Disease Surveillance Central Asia Biosafety & Biosecurity Avian Influenza, FMD, Brucellosis, Rabies, Anthrax, Arbovirus in Kyrgyzstan Regional laboratory and biosafety training in Almaty Arbovirus, Brucellosis, Malaria, Plague, Hepatitis, Anthrax in Tajikistan Creation of a Regional Biosafety Association Training Center, Almaty Field Plague lab, Tajikistan Cow with FMD, Kyrgyzstan Security system at anthrax cattle grave, Kyrgyzstan
11 TOMORROW Co-Funding Targeted Initiatives Global multinational projects Partners Private sector and government agencies
12 TOMORROW- Co-funding Centre for New Drugs Development in Chernogolovka co-funding from ISTC Governmental Partner (BII) and RF Academy of Science (#3283) Bacteriological Safety in Fergana Valley, Kyrgyzstan (#KR-1516) International Partner has agreed to co-fund at GBM50 Obsolete Pesticide Destruction and Soil Remediation in Central Asia ISTC coordinating separate projects with World Bank, FAO, UNEP CBRN Anti-Terror Issues in Central Asia IAEA, OPCW, UK MOD Epitiozoological Disease Surveillence within RF (Ministry of Agriculture is working with ISTC and international Partners to develop a prototype project and plans to contribute significant funds to the effort)
13 TOMORROW - Targeted Initiatives Science and Technology in the Prevention of Biological Threats Drug Design & Development Probiotics & Health
14 TOMORROW Science and Technology in the Prevention of Biological Threats Focus on projects developing new techniques & technologies for rapid detection ti of microorganisms i of concerns; Development of reliable field diagnostic kits & supporting activities to enhance high throughput clinical diagnostics; Focus on developing projects to protect the food supply chain via new & better diagnostics to detect dangerous bio-agents & measures to protect against intentional and unintentional contamination; New focus areas as determined by a Steering Committee formed by funding Parties
15 TOMORROW Drug Design & Development Promotion for excellent chemical teams in CIS to foster Drug Discovery Focused at the new compounds to treat bacterial (Tuberculosis) and viral infections Approved at ISTC in 2008, supported by RF, Armenia & Belarus TB Drug Discovery Action Fiche and Position paper to attract co funding from governmental and private companies and programs developed and spread among Parties and Partners
16 TOMORROW Probiotics and Health Project proposals under preparation: 100 years of vast experience Astro yoghurt (Institute of Biomedical Problems, Moscow, Russia) Bacteriocines (Institute of Highly Pure Biopreparations, St. Petersburg, Russia), Probiotics and Bacteriophage Depositary (Institute of Immunological Engineering, Lyubuchany, Russia) Yughurt with Seaweed Compounds (Institute of Epidemiology and Microbiology, Vladivostok, Russia) Probiotic i Metabolites (Institute of Microbiology, Minsk, Belarus) Lactic Acid Bacteria Biodiversity (Institute of Biotechnology, Yerevan, Armenia) Probiotics and Aging (Eliava Institute of Microbiology and Bacteriophages, Tbilisi, Georgia) Fermented Beet Root Juice (Institute of Microbiology and Virology, Almaty, Kazakhstan), etc. Ilya Mechnikov There is enormous untapped potential amongst the Russian scientific community for studies on the human and animal microbiomes that have the potential to not only lead to scientific advances, but new food and pharma products that will improve the health and well-being of people around the world. Gregor Reid, President of International Scientific Association for Probiotics and Prebiotics
17 TOMORROW Global Multinational Projects Engaging private sector, government agencies, multiple countries in implementing large projects of global value Playing a supporting role in implementation i of such projects Working together with Foundations, other international organizations such as WHOt to implement tjit joint or complementary activities Support international cooperation on global outbreaks of infectious diseases Engage in discussions on worldwide biosafety issues and concerns
18 TOMORROW Partners Partners Private sector and government agencies Engage Private companies using the incentives provided to new partners from Canada and EU for funded partner projects
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