Adult Immuniza-on Update
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1 Adult Immuniza-on Update Maggie Zettle, PharmD Lieutenant, United States Public Health Service Management Analyst, National Vaccine Program OfBice U.S. Department of Health and Human Services
2 Overview Adult vaccination coverage Coverage by age group, race/ethnicity, vaccination indication NVPO initiatives to improve adult immunization rates across the nation NVAC Standards for Adult Immunization Practice Draft National Adult Immunization Plan Interactive InBluenza Map Vaccine Finder Tool
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6 Data Source Na0onal Health Interview Survey, 2013 Annual in- home survey of U.S. non- institutionalized civilian population Detailed health survey of one adult per family in each household sampled Provides national coverage estimates Final sample of adult component: Response rate: 61% N = 34,227
7 Na0onal Health Interview Survey, 2013 Vaccina0on Ques0ons InBluenza (not reported here) PPSV or PCV13, Td/Tdap, HepA, HepB, Zoster, HPV Proportion of pneumococcal vaccination by type not measured High- risk status Limited information collected for Hep A and Hep B Hep A (travel status & chronic liver disease) Hep B (travel status, chronic liver disease, & diabetes mellitus) PPSV or PCV13 Health Care Personnel (HCP)
8 Defini0on of High- Risk for Pneumococcal Disease Adults were considered at high risk for pneumococcal disease if they had been told by a doctor or other health care professional that they: Ever had: Diabetes Mellitus Emphysema Coronary Heart Disease, Angina, Heart Attack, or other Heart Condition Lymphoma, Leukemia, or Blood Cancer Had during the preceding 12 months: Cancer Diagnosis (excluding non- melanoma skin cancer) Asthma Episode or Attack Chronic Bronchitis Weak or Failing Kidneys Or were Current Smokers
9 Adult Vaccina0on Coverage, Selected Vaccines by Age and High- risk Status, United States Pneumococcal, HR 19-64yrs 21 Pneumococcal, 65 yrs 60 Herpes Zoster (Shingles), 60 yrs 24 (+4.1) % Vaccinated HP2020 Targets: 60% PPV HR years, 90% PPV 65 years, 30% Shingles Data Source: 2013 NHIS
10 Adult Tetanus- containing Vaccina0on Coverage by Age and High- risk Status, United States Td past 10 yrs, yrs Td past 10 yrs, yrs Td past 10 yrs, 65 yrs 56 Tdap past 8 yrs, 19 yrs Tdap past 8 yrs, Living with infant <1 yr, 19 yrs 17 (+2.9) 29 Tdap past 8 yrs, HCP 19 yrs 37 (+5.9) % Vaccinated Data Source: 2013 NHIS
11 Poten0al for Bias in Tdap Es0mates 34% of respondents were excluded Those: without a yes or no response for tetanus vaccination, past 10 years (5%) without a response to tetanus vaccination during (4%) who reported tetanus vaccination but not told (21%) or did not know the vaccine type (4%) Sensitivity analysis to assess magnitude of bias Tdap coverage could range from: 13% - 42% (adults years); 9%- 35% (adults >65 years) Data Source: 2013 NHIS
12 Propor0on of Adults >19 Years of Age who Received Tdap Vaccine Group Not Told (%) Not Recall (%) Tdap/Td+Tdap Adults, >19 years, Overall HCP, >19 years * Non- HCP, >19 years *p<0.05 by T test for comparisons between HCP and non- HCP >19 years. Data Source: 2013 NHIS
13 Hepa00s A Vaccina0on Coverage by Age and High- risk Status, United States HepA ( 2 doses), 19 yrs 9 HepA ( 2 doses), Travel Endemic Area 16 HepA ( 2 doses), No Endemic Area Travel 6 HepA ( 2 doses), Chronic Liver Disease 13 HepA ( 2 doses), yrs % Vaccinated Data Source: 2013 NHIS
14 Hepa00s B Vaccina0on Coverage by Age and High- risk Status, United States HepB ( 3 doses), 19 yrs HepB ( 3 doses), Travel Endemic Area HepB ( 3 doses), No Endemic Area HepB ( 3 doses), Chronic Liver Disease 25 (- 2.1) (- 2.3) 34 HepB ( 3 doses), HCP 19 yrs 62 HepB ( 3 doses), yrs HepB ( 3 doses), Diabetes yrs (- 2.6) HepB ( 3 doses), Diabetes 60 yrs % Vaccinated HP2020 Target: 90% HepB Healthcare Personnel (HCP) Data Source: 2013 NHIS
15 HPV Vaccina0on Coverage ( 1 dose ever), Adults years of age by Sex, United States Females yrs 37 Females yrs 45 Females yrs 32 Males yrs Males yrs Males yrs 6 (+3.6) 8 (+5.3) 5 (+2.7) % Vaccinated Data Source: 2013 NHIS
16 Age at First Dose of HPV Vaccina0on, Among Adults years, NHIS 2013 United States
17 Non- Influenza Adult Vaccina0on Coverage Rate Increases from 2012 to 2013 HPV ( 1 dose), Men yrs 3.6 6% Tdap, HCP 19 yrs % Herpes Zoster, 60 yrs % Tdap, 19 yrs % Data Source: NHIS
18 Racial/Ethnic Vaccina0on Dispari0es Vaccination Group % Vaccinated Whites Disparity, Blacks Disparity, Hispanics Disparity, Asians Pneumo., HR yrs Pneumo., 65 yrs Tetanus, yrs Tetanus, yrs Tetanus, 65 yrs Tdap, 19 yrs Tdap, yrs Tdap, 65 yrs HepA, yrs HepB, yrs Herpes Zoster, 60 yrs HPV, Females yrs Tdap, HCP 19 yrs HepB, HCP 19 yrs
19 Racial/Ethnic Vaccina0on Dispari0es - - NHIS 2013 Compared with 2012, racial/ethnic differences persisted for all six and widened for Tdap and herpes zoster: Non- Hispanic blacks, Hispanics, and Non- Hispanic Asians had lower vaccination coverage than that of non- Hispanic whites for all of the vaccines routinely recommended for adults, except for: PPSV/PCV HR - - Blacks had coverage similar to whites Tdap Asians had coverage similar to whites Hep A Blacks had coverage similar to and Asians had coverage higher than whites Hep B Asians had coverage higher than whites Herpes zoster 60+ Asians had coverage similar to whites Health Care Personnel (HCP) Non- Hispanic black and Hispanic HCP had lower coverage than white HCP for Tdap, and Hispanic HCP had lower coverage than white HCP for Hep B.
20 Limita0ons of Findings NHIS excludes persons in the military and those residing in institutions results apply to the civilian, non- institutionalized population Response rate 61.2% - - low response rate can result in sampling bias if the nonresponse is unequal among participants regarding vaccination Reported vaccination status and high- risk conditions not validated by medical records Self- report of vaccination subject to recall bias Tdap estimates: potential bias due to exclusions
21 What We Learned Overall coverage remains below HP2020 targets 90% for 65+ years for pneumococcal vaccine 60% for high risk years for pneumococcal vaccine 30% for 60+ years for Zoster vaccine 90% for hepatitis B vaccine for healthcare personnel Some improvement from 2012 Modest increases for HPV (men, 19-26), Tdap ( 19 year olds), and herpes zoster ( 60 year olds) vaccines No improvements for other vaccines Racial and ethnic disparities remain Much remains to be done to increase vaccine utilization among adults and to eliminate disparities
22 Assess Recommend Administer or Refer Document
23 Adult Immuniza0on Standards
24 Adult Immuniza0on Standards
25 Na0onal Adult Immuniza0on Plan Protect public health through vaccination of all adults 5 year plan Diverse stakeholders (public and private) National scope Aligned with other HHS initiatives
26 Development of the Na0onal Adult Immuniza0on Plan Environmental scan of literature over past 10 years Key stakeholders convened to provide high- level feedback Survey to generate feedback on possible plan priorities 96 respondents 8 focus groups, 90 participants Designed to reblect diverse sectors One- on- one interviews with dozens of thought leaders Follow up meetings to discuss indicators and metrics Public comment period Approximately 5,000 comments received
27 Goals of the Na0onal Adult Immuniza0on Plan 1. Strengthen the Adult Immunization Infrastructure 2. Improve Access to Adult Vaccines 3. Increase Community Demand for Adult Immunizations 4. Foster Innovation in Adult Vaccine Development and Vaccination Related Technologies
28 Goal 1: Strengthen the Adult Immuniza0on Infrastructure Objective 1: Monitor and report trends in adult vaccine- preventable disease levels and vaccination coverage data for all ACIP recommended vaccines. Measure progress towards established targets in cases where there are HP2020 goals. Objective 2: Enhance current vaccine safety monitoring systems and develop new methods to accurately and more rapidly assess vaccine safety and efbicacy in adult populations. Objective 3: Continue to analyze claims Biled as part of the Vaccine Injury Compensation Program to identify causal links between vaccines and adverse events. Objective 4: Increase the use of Immunization Information Systems and Electronic Health Records to collect and track adult immunization data. Objective 5: Evaluate and advance targeted quality improvement initiatives. Objective 6: Generate and disseminate evidence about the economic impact of adult immunization, including potential disease burden averted and cost effectiveness with the use of current vaccines.
29 Goal 2: Improve Access to Adult Vaccines Objective 1: Reduce _inancial barriers for individuals who receive vaccines routinely recommended for adults. Objective 2: Assess and improve understanding of providers _inancial barriers to delivering vaccinations, including stocking and administering vaccines. Objective 3: Expand the adult immunization provider network. Objective 4: Ensure a reliable supply of vaccines and the ability to track vaccine inventories, including during public health emergencies.
30 Goal 3: Increase Community Demand for Adult Immuniza0ons Objective 1: Educate and encourage individuals to be aware of and receive adult immunizations. Objective 2: Educate and encourage healthcare professionals to recommend and/or deliver adult vaccinations. Objective 3: Educate and encourage other groups (e.g., community and faith based groups) to promote the importance of adult immunization.
31 Goal 4: Foster Innova0on in Adult Vaccine Development and Vaccina0on Related Technologies Objective 1: Develop new vaccines and improve the effectiveness of existing vaccines for adults. Objective 2: Encourage new technologies to improve the distribution storage, and delivery of adult vaccines.
32 Goal 1: Strengthen the Adult Immuniza0on Infrastructure Indicator Baseline Data Source Adult vaccination coverage levels for HP2020 measures Racial/ethnic disparities in adult vaccination coverage for HP2020 measures Percentage of surveyed primary care physicians who record information on adult immunizations in a state or regional IIS Percentage of surveyed pharmacies that submit adult vaccination data to an IIS Percentage of surveyed providers who routinely query information on adult immunization from a state IIS Percentage of surveyed health care providers who have identibied an adverse event following immunization and reported it to VAERS CDC/AHRQ Dashboard CDC/AHRQ Dashboard 8% of internists 36% of family practitioners CDC, CMS CDC CDC, NVPO 25% APhA In development ONC 17% NVPO 32
33 Goal 2: Improve Access to Adult Immuniza0ons Indicator Baseline Data Source Percentage of states and territories that allow pharmacists to administer all routinely recommended vaccines for adults 19+ Percentage of surveyed primary care providers who stock adult routinely recommended vaccines Percentage of state Medicaid programs that include all recommended vaccinations for adults as a preventive benebit for existing patients and prohibit cost sharing 85% APhA 20% of internists 31% of family practitioners NVPO 33% CMS 33
34 Goal 3: Increase Community Demand for Adult Immuniza0ons Indicator Baseline Data Source Percentage of surveyed adults who believe they are recommended to receive an inbluenza vaccine (within a specibied year) Percentage of adults who report receiving a provider recommendation for an inbluenza vaccine Percentage of pregnant women who report receiving the following immunizations during pregnancy (inbluenza, Tdap) Percentage of surveyed adults that are aware of the routinely recommended adult vaccines they are supposed to receive Percentage of surveyed adult healthcare providers who report assessing vaccination status at every visit 45% CDC 45% CDC In development In development 29% of internists 32% of family practitioners CDC NVPO CDC 34
35 Goal 4: Foster Innova0on in Adult Vaccine Development and Vaccina0on Related Technologies Indicator Baseline Data Source Number of vaccines in clinical development (Phase II or Phase III clinical trials) with an expected adult indication Number of vaccines on CDC contracted vaccine price lists that include a 2D barcode In development BIO 38 CDC 35
36 Interac0ve Influenza Vaccina0on Map
37 Iowa
38 Iowa
39 Iowa
40 Na0onal Trend Data
41 National In_luenza Vaccination Rate By Race/ Ethnicity Week National Hispanic Black Asian White % 0.22% 0.11% 0.38% 0.15% % 28.82% 30.58% 47.27% % % 31.69% 33.51% 50.11% 50.85% National Demographic Disparity Week Hispanic Black Asian White % % % % % % % % % - - 4/13/15 vaccination- time- trends.html
42 HealthMap Vaccine Finder
43 Collaborators Peng- Jun Lu, MD, PhD Alissa O Halloran, MSPH Carolyn B. Bridges, MD David K. Kim, MD Tamara Pilishvili, MPH Craig M. Hales, MD Lauri E. Markowitz, MD Walter W. Williams, MD Bruce Gellin, MD Rebecca Fish
44 For Addi0onal Informa0on: - ACIP Recommendations for SpeciBic Vaccines recs/ index.html - Non- inbluenza Adult Vaccination Coverage mmwrhtml/mm6404a6.htm? s_cid=mm6404a6_e - Interactive InBluenza Map vaccination- map/index.html - Vaccine Finder
45 Thank you!
46 Extra Slides
47 Highlights: Non- Influenza Adult Vaccina-on Coverage NHIS 2013 Compared with 2012 NHIS, modest increases only for : q Tdap vaccination (17.2%) 19 years (+2.9 percentage points) q Herpes zoster vaccination (24.2%) >60 years (+4.1 percentage points) q HPV vaccination (> 1 dose) (5.9%) men, years (+3.6 percentage points) q No overall improvement in coverage for other vaccines
48 Tetanus Vaccina-on Including Pertussis Vaccine, Past 8 Years, 19 years, NHIS United States Group and Race/ethnicity 2012 (%) 2013 (%) Difference* 19 years, Overall White, non- Hispanic Black, non- Hispanic Hispanic Asian, non- Hispanic Others Living with an infant aged<1 year Not living with an infant aged<1 year *p<0.05 by T test for comparisons between 2013 and 2012 within each level of each characteristic. p<0.05 by T test for comparisons with non- Hispanic white as the reference.
49 Herpes Zoster (shingles) Vaccina-on, 60 years and older, NHIS 2013 United States Group and Race/ethnicity 2012 (%) 2013 (%) Difference* 60 years and over, Overall White, non- Hispanic Black, non- Hispanic Hispanic Asian, non- Hispanic Others *p<0.05 by T test for comparisons between 2013 and 2012 within each level of each characteristic. p<0.05 by T test for comparison with non- Hispanic white as the reference.
50 Human Papillomavirus Vaccina-on Among Males (at least 1 dose), NHIS 2013 United States Age group 2012 (%) 2013 (%) Difference* years, total years, total years, total *p<0.05 by T test for comparisons between 2013 and 2012 within each level of each characteristic.
51 Adult Vaccina-on Coverage, Selected Vaccines, by Age & High- risk Status, NHIS United States Group 2012 (%) 2013 (%) Difference* Pneumococcal years, HR, overall >65 years, overall Tetanus, Past 10 Years years, overall years, overall >65 years, overall Tetanus with Pertussis, Past 8 Years 19 years, overall Living w/ infant aged <1 year *p<0.05 by T- test for comparisons between 2013 and 2012.
52 Adult Vaccina-on Coverage, Selected Vaccines, by Age & High- risk Status, NHIS United States Group 2012 (%) 2013 (%) Difference* Hepatitis A (at least 2 doses) 19 yrs, overall yrs, Chronic Liver Disease Traveled to endemic area No travel to endemic area Hepatitis B (at least 3 doses) 19 yrs, overall yrs, Chronic Liver Disease Traveled to endemic area No travel to endemic area yrs, with diabetes, overall >60 years, w/ diabetes, overall *p<0.05 by T- test for comparisons between 2013 and p<0.05 by T- test for comparisons with had not traveled to endemic area as the reference.
53 Adult Vaccina-on Coverage, Selected Vaccines, by Age & High- risk Status, NHIS United States Group 2012 (%) 2013 (%) Difference* Herpes Zoster (Shingles) >60 years, overall Human Papillomavirus, Females years, overall years, overall years, overall Human Papillomavirus, Males years, overall years, overall years, overall *p<0.05 by T- test for comparisons between 2013 and 2012.
54 Health Care Personnel (HCP) Tetanus Vaccina-on Including Pertussis Vaccine, past 8 years, and Hepa--s B Vaccina-on, by Age, NHIS 2013 United States Group 2012 (%) 2013 (%) Difference* HCP, Tetanus with pertussis 19 years, overall HCP, Hepatitis B >19 years, overall *p<0.05 by T test for comparisons between 2013 and Adults were classi_ied as HCP if they reported they currently work in a hospital, medical clinic, doctor s of_ice, dentist s of_ice, nursing home or some other healthcare facility, including part- time and unpaid work as well as professional nursing care provided in the home.
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