Tissue Transplantation: Past, Present and Future Jelena Holovati, PhD
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1 Tissue Transplantation: Past, Present and Future Jelena Holovati, PhD Scientific Director, Comprehensive Tissue Centre Associate Professor, University of Alberta Adjunct Scientist, Canadian Blood Services
2 Tissue Transplant Medical procedure in which a tissue is transferred from one person (donor) to another (recipient) life and/or function restoring procedure
3 TISSUE TRANSPLANTATION PAST
4 Tissue Transplant: Past 3000 BC: first description of skin transplant (ancient India) Susruta (600 BC): rhinoplasty and skin transplant for a mutilated nose..in 7 easy steps Herman AR.The history of skin grafts.j Drugs Derm 2002;1:298.
5 Tissue Transplant: Past 346: Leggenda Aura (Golden Legend of Lives of the Saints) Miracle of the Black Leg DeBoer HH.The history of bone grafts.clin Orthop Real Res 1986:226:292002;1:298.
6 Tissue Transplant: Past 1597: Gaspare Tagliacozzi Surgery of the Mutilated by Grafting 1668: grafting of animal bone to a human 1800s: clinical skin grafting (auto and allografts) Herman AR.The history of skin grafts.j Drugs Derm 2002;1:298.
7 Tissue Transplant: Past 1905: the first corneal transplant by Eduard Zirm (Vienna, Austria) Moffatt SL eta al. Centennial review of corneal transplantation. Clin Experiment Ophthalmol 2005:33;642.
8 Tissue Transplant: Past 1912: Alexis Carrel receives Nobel Prize in Medicine Carrel A. The Preservation of tissues and its application in surgery. JAMA 1912;59:527
9 Tissue Transplant: Past 1944: the first eye bank (New York) 1949: U.S. Navy Tissue Bank (Bethesda, MA) 1950s: tissue banks in Europe 1961: Eye Bank Association of America 1976: American Association of Tissue Banks 1991: European Association of Tissue Banks Carrel A. The Preservation of tissues and its application in surgery. JAMA 1912;59:527
10 TISSUE TRANSPLANTATION PRESENT
11 Tissue Banking 2 3 Comprehensive Tissue Banks 5 Surgical Bone Banks Muskoskeletal Tissue Banks 4 8 Eye Banks Other Tissue Specific Banks ~40,000 tissue allografts transplanted annually (~80 % imported) CBS OTDT
12 DONOR PER MILLION POPULATION Tissue Banking vs. TISSUE DONORS OCCULAR DONORS ALLOGRAFT YIELD PER DONOR CBS OTDT
13
14 Comprehensive Tissue Centre Comprehensive tissue bank operated by Alberta Health Services in Edmonton Accreditations and Licenses Cadaveric and living donor programs
15 CTC: Mission The Comprehensive Tissue Centre takes great pride in providing safe, effective and high quality allograft tissue for transplantation through excellence in practice and leadership in research
16 CTC: Transplantable Tissues Heart valves Eyes Skin Bone Tendons Amniotic Membrane
17 Tissue Banking Process HOPE Program Palliative Care Family Medical Examiner s Office Direct Approach Hospital staff Clinics Hospital staff Patients
18 Tissue Banking Process Cont d
19 Tissue Banking Process Cont d Recipient Forms, CTOSS
20 Quality Management System Designed to prevent, detect, and correct deficiencies that may lead to increased risk of introduction, transmission, or spread of communicable diseases Environmental control and monitoring Donor suitability and screening Supplies, reagents, equipment and process controls Good documentation practices Internal/external audits and inspections Corrective and preventative actions Training and competencies
21 CTC Activity Referrals Donors Tissues Recovered Tissues Distributed Recipients
22 CTC Activity TISSUES RECOVERED TISSUES DISTRIBUTED
23 Recipients 1028 Referrals 2490 Gifts of Tissue Distributed patients benefited from the CTC team efforts in 2014 Gifts of Tissue Recovered 2558 Donors 485
24 TISSUE TRANSPLANTATION FUTURE
25 Tissue Transplant: Future 2005: the first successful 2008: transplant of a facial transplant bioengineered trachea Dubernard JM et al Outcomes 18 months after the first human partial face transplantation.n Engl J Med 2007:357:2451. Gonfiotti A. et al. The first tissue-engineered airway transplantation: 5-year follow-up results. Lancet 2014;383:238.
26 Tissue Transplant: Future
27 In Conclusion..
28 Tissue Donation: Gift of Life
29
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