CURRICULUM VITAE. STEPHEN A. COOPER, D.M.D., Ph.D.
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1 REVISED 11/13 CURRICULUM VITAE STEPHEN A. COOPER, D.M.D., Ph.D. PERSONAL INFORMATION DATE OF BIRTH: April 11, 1946 CITIZENSHIP: MARITAL STATUS: MAILING ADDRESS: United States of America Married - 2 children 117 Dalena Palm Beach Gardens, FL BUSINESS TELEPHONE: WEB ADDRESS: (973) (mobile) sacooper3@aol.com EDUCATION JUNE 1967 MAY 1971 MARCH 1975 B.S. Adelphi University Long Island, New York D.M.D. University of Pennsylvania School of Dental Medicine Philadelphia, Pennsylvania Ph.D. Georgetown University Department of Pharmacology Washington, D.C
2 INDUSTRY APPOINTMENTS 2005-Present Consultant to the Pharmaceutical Industry Wyeth Consumer Healthcare Madison, NJ Senior VP Global Clinical & Medical Affairs in charge of all products VP Clinical & Medical Affairs in charge of all products AVP Clinical & Medical Affairs in charge of Analgesic Development ACADEMIC APPOINTMENTS Clinical Professor NYU College of Dentistry Director Analgesic Research Full Professor of Oral & Maxillofacial Surgery Temple Univ, School of Dentistry, Phila, PA Director of the Clinical Research Center Course Director for Clinical Pharmacology Chair of Univ IACUC (Animal Care Comm) Associate Dean for Research, Advanced Education Temple Univ, School of Dentistry, Phila, PA Responsible for Specialty Grad Programs Supervised all Dental School research PI for Prostaglandin Res Challenge Award Adjunct Associate Professor University of Pennsylvania, Sch of Dental Medicine Philadelphia, Pennsylvania Lecturer in Pharmacology Course PI Analgesic Study Unit Adjunct Clinical Professor of Medicine The Medical College of Pennsylvania Philadelphia, Pennsylvania Director of the Analgesic Study Unit 2
3 Associate Professor of Oral & Maxillofacial Surg, Director of Pharmacology and Advanced Education University of Pennsylvania, Sch of Dental Medicine Philadelphia, Pennsylvania Responsible for Specialty Graduate Programs Director of Div Adv Dental Ed Core Curric Director of Oral Surgery Clin Research Unit Professor of Oral & Maxillofacial Surgery and Biodental Sciences, Assoc. Dean for Research & Postdoctoral Studies UMDNJ- New Jersey Dental School, Newark, NJ Supervised all Dental School research Responsible for Specialty Grad Programs Director of Graduate Dental Ed Core Curric Director of Oral Surgery Clin Res Unit PI Analgesic Research Unit Associate Professor, Assoc. Dean for Research Department of Oral Surgery UMDNJ- New Jersey Dental School, Newark, NJ Supervised all Dental School research Director of Graduate Dental Ed Core Curric Director of Oral Surgery Clin Research Unit PI Analgesic Research Unit Assistant Professor Department of Pharmacology Georgetown University, Washington, D.C. Director Dental Pharmacology Program Director of Oral Surg Analgesic Study Unit ACADEMIC ADMINISTRATIVE APPOINTMENTS Acting Director Clinical Research Center Temple University, School of Dentistry Associate Dean for Research, Advanced and Continuing Education Temple University, School of Dentistry Director DADE (Advanced Education) University of Pennsylvania, Sch of Dental Medicine Director of Pharmacology University of Pennsylvania, Sch of Dental Medicine 3
4 Associate Dean for Research and Postgrad Studies UMDNJ- New Jersey Dental School Acting Chairperson Department of Biodental Sciences UMDNJ- New Jersey Dental School Director of Research UMDNJ-New Jersey Dental School PRIVATE PRACTICE (part-time) Washington, D.C. & Hyattsville, Maryland PROFESSIONAL MEMBERSHIPS 1. American Association of Dental Schools ( ) 2. American Association of Dental Research ( ) Chairperson Pharmacology & Toxicology Section International Association of Dental Research ( ) 4. Eastern Pain Society (Board of Directors ) 5. American Pain Society (1975-Present) 6. International Association for Pain ( ) 7. American Society for Clinical Pharmacology and Therapeutics ( ) Chairperson Analgesiology Section ( ) FDA Guidelines Committee for Evaluation of Analgesic Drugs ( ) Finance Committee ( ) Government Affairs Committee ( ) 8. American College of Clinical Pharmacology ( ) 9. ADA National Board of Examiners- Pharmacology Test Construction ( ) 10. Center for Creative Leadership (Attended 1999) 11. ACCTION Comm: Working Group post-operative acute pain /clinical trial methodology ( ) 4
5 EDITORIAL BOARDS (past membership) 1. Advances in Drug Therapy 2. American Journal of Pain 3. Analgesia 4. Pain and Analgesia 5. Reviewer for JADA 6. Guest Editor Pharmacotherapy, Volume 6, No. 5, 1986 ADVISORY BOARDS 1. New York University, College of Dentistry, Dean s Advisory Council ( ) 2. University of Pennsylvania, School of Dental Medicine, Board of Overseers ( ) SPECIAL AWARDS 1. A.E.D. Pre-medical Honorary Society, Scholastic Scholarship- University of Pennsylvania, School of Dental Medicine, NIH (NIDR) Postdoctoral Fellowship, Distinction, Ph.D. Thesis Defense, Omicron Kappa Upsilon- Dental Honorary Society, G.V. Black Memorial Lecturer- Ohio State Dental School, Lindback Award- Excellence in Lecturing, U of Pa, Basic Science Teaching Award- University of Pennsylvania, Arthritis & Prostaglandin Research Challenge Award, Distinguished Scientist Award, Amer Assoc Dental Research, Outstanding Contribution Award to Pain Research, Inflammopharmacolgy Meeting, Sheffield, England, 2000 PUBLICATIONS 1. Cooper SA and Dretchen KL: The effects of ethanol on the rat diaphragm preparation. Eur J Pharmacol 13: , Cooper SA and Beaver WT: A model to evaluate mild analgesics in oral surgery out-patients. Clin Pharmacol Ther 20: , (Studies 109 & 113) 3. Cooper SA, Needle SE and Kruger GO: An analgesic relative potency assay comparing aspirin, ibuprofen and placebo. J Oral Surg 35: , (Study 2) 5
6 4. Cooper SA: Peripheral versus central analgesics, Current concepts of analgesic action. 4th Symposium Therap Groups, IADR, Cooper SA, Anthony J et al: A technique for investigating the psychomotor impairment after intravenous diazepam. Oral Surg, Oral Med, Oral Path 45: , (Study 12) 6. Dionne R and Cooper SA: Evaluation of preoperative ibuprofen for postoperative pain after removal of third molars. Oral Surg, Oral Med, Oral Path 45: , Cooper SA, Breen JF and Giuliani RL: Replicate studies comparing the relative efficacies of aspirin and indoprofen in oral surgery outpatients. J Clin Pharmacol 19: , (Studies 8 & 9) 8. Cooper SA, Kruger GO et al: An analgesic relative potency assay comparing zomepirac sodium and aspirin. J Clin Pharmacol 20:98-106, (Study 6) 9. Cooper SA: Double-blind comparison of zomepirac sodium, propoxyphene-acetaminophen combination and placebo in the treatment of oral surgical pain. Curr Ther Res 28: , (Study 31) 10. Cooper SA, Precheur J et al: Evaluation of oxycodone and acetaminophen in the treatment of postoperative dental pain. Oral Surg, Oral Med, Oral Path 50: , (Study 20) 11. Cooper SA: Efficacy of zomepirac in oral surgical pain. J Clin Pharmacol 20: , (Study 15) 12. Cooper SA: Clinical update- Basic principles of drug action. J Clin Prevent Dent 2:31-32, Cooper SA: Clinical update- The clinical relevance of pharmacokinetics. J Clin Prevent Dent 2:26-28, Cooper SA: Clinical update- The nervous system in the dental chair. J Clin Prevent Dent 2:26-29, Cooper SA: Clinical update- Antianxiety, Sedatives and Hypnotics. J Clin Prevent Dent 3:25-26, Cooper SA: Clinical update- Oral analgesics used to treat dental pain. J Clin Prevent Dent 3:28-32, Cooper SA, Breen JF and Giuliani RL: The relative efficacy of indoprofen compared with opioid analgesic combinations. J Oral Surg 39:21-25, (Study 18) 18. Cooper SA: Comparative analgesic efficacies of aspirin and acetaminophen. Arch Int Med 141: ,
7 19. Cooper SA: Clinical pharmacological evaluation of efficacy in analgesia. Curr Ther Res 39:S95-S101, Cooper SA, Engel J et al: Analgesic efficacy of an ibuprofen-codeine combination. Pharmacotherapy 2: , (Study 19) 21. Cooper SA: New peripherally-acting analgesic agents. Annual Rev Pharmacol Toxicol 23: , Desjardins PJ, Cooper SA et al: The effects of fendosal, aspirin and placebo on post-operative dental pain- A dose-ranging and efficacy study. Pharmacotherapy 3:52-57, (Study 26) 23. Cooper SA, Wagenberg B et al: Double- blind evaluation of suprofen and aspirin in the treatment of periodontal pain. Pharmacology 27: Suppl. 1:23-30, (Study 37) 24. Dionne RA, Cooper SA et al: Suppression of post-operative pain by preoperative administration of ibuprofen in comparison to placebo, acetaminophen, and acetaminophen plus codeine. J Clin Pharmacol 23:37-43, Cooper SA: Emphasis-Ten year future of analgesics. J Amer Dent Assoc 107:724, Cooper SA: Models for clinical assessment of oral analgesics. Amer J Med Suppl: Antipyretic-Analgesic Symposium, 24-29, Vogel RI, Cooper SA et al: The effects of topical steroid and systemic nonsteroidal antiinflammatory drugs on experimental gingivitis in man. J Periodontol 55: , (Study 53) 28. Cooper SA, Gelb SB et al: An analgesic relative potency assay comparing ketoprofen and aspirin in postoperative dental pain. Advances in Therapy 1: , (Study 43) 29. Cooper SA: Five studies on ibuprofen for postsurgical dental pain. Amer J Med Suppl Ten year update on Motrin, 70-77, Desjardins PJ, Cooper SA et al: The relative analgesic efficacy of propiram fumarate, codeine, aspirin and placebo in post-impaction dental pain. J Clin Pharmacol 24:35-42, (Study 44) 31. Cooper SA, Gelb S et al: Comparative efficacy of fenoprofen calcium and zomepirac sodium in postsurgical dental pain. Oral Surg, Oral Med, Oral Path 57: , (Study 56) 32. Cooper SA, Desjardins PJ et al: Analgesic efficacy of suprofen in pain from dental impaction. Postgraduate Medicine: 27-36, (Study 34) 33. Cooper SA and Press K: Review of side effects- Ten years of experience with the dental pain model. Advances in Therapy 2:20-29,
8 34. Mardirossian G and Cooper SA: Comparison of the analgesic efficacy of flurbiprofen and aspirin for postsurgical pain. J Oral Surg. 43: , (Study 35) 35. Cooper SA et al: The analgesic efficacy of suprofen in periodontal and oral surgical pain models. Pharmacotherapy 6: , (Study 42) 36. Cooper SA: The relative efficacy of ibuprofen in dental pain. Compen Contin Educ Dent 7: , Cooper SA, Erlichman M.C. and Mardirossian G.: Double-blind comparison of an acetaminophen-codeine-caffeine combination in oral surgery pain. Anesth Prog, May/June , (Study 62) 38. Cooper SA, Firestein A and Cohn P: Double-blind comparison of meclofenamate sodium with acetaminophen, acetaminophen with codeine, and placebo for relief of postsurgical dental pain. J Clin Dent 1:31-34, (Study 80) 39. Cooper SA: Review of Ketoprofen. J Clin Dent 1:1-5, Cooper SA, Berrie R and Cohn P: Comparison of ketoprofen, ibuprofen and placebo. In a dental surgery pain model. Advances in Therapy 5:43-53, (Study 81) 41. Cooper SA, Mardirossian G and Milles M: Analgesic relative potency assay comparing flurbiprofen 50, 100, and 150 mg, aspirin 600 mg, and placebo in postsurgical dental pain. Clin J Pain 4: , (Study 47) 42. Cooper SA, Schachtel BP et al: Ibuprofen and acetaminophen in the relief of acute pain: A randomized, double-blind, placebo-controlled study. J Clin Pharmacol 29: , (Study 93) 43. Corner AM, Cooper SA et al: Clinical study of a C31G containing mouthrinse: Effect on salivary microorganisms. J Clin Dent 2:34-38, Cooper SA: Treating acute pain: Do s and Don'ts, Pros and Cons. J Endodontics 16:85-91, Cooper SA, Quinn PD et al: Reversing intravenous sedation with flumazenil. Oral Surg, Oral Med, Oral Path 72:2-9, (Study 103) 46. Cooper SA and Kupperman A: The analgesic efficacy of flurbiprofen. J Clin Dent 2:70-74, (Study 50) 47. Cooper SA, Hutton C et al: Dose-response analgesic activity of meclofenamate sodium in dental pain. Advances in Therapy 8: , (Study 109) 48. Cooper SA, Itkin A and Zweig B.: Comparison of oxaprozin, aspirin, and placebo in a dental impaction pain model. Advances in Therapy 9: , (Study 57) 8
9 49. Hersh EV and Cooper SA: Anesthetic activity of the lipospheres bupivacaine delivery system in the rat. Anesth Prog 39: , Cooper SA, Quinn PD et al: Ibuprofen controlled release formulation- A clinical trial in dental impaction pain. Oral Surg, Oral Med, Oral Path 75: , (Study 117) 51. Hersh EV, Cooper SA et al: Narcotic receptor blockade and its effect on the analgesic response to placebo and ibuprofen following oral surgery. Oral Surg, Oral Med, Oral Path 75: , (Study 120) 52. Hersh EV, Cooper SA, et al: Analgesic onset time as a measure of topical anesthetic efficacy in spontaneous toothache pain. J Clin Dent 4:52-54, (Study 124) 53. Hersh EV, Cooper SA et al: Single dose and multidose analgesic study of ibuprofen and meclofenamate sodium after third molar surgery. Oral Surg, Oral Med, Oral Path 76: , (Study 125) 54. Hersh EV, Cooper SA et al: Single dose and multidose analgesic study of two formulations of mefanamic acid after third molar surgery. Analgesia 1:65-71, (Study 138) 55. Cooper SA: Narcotic analgesics in dental practice. Compend Contin Educ 14: , Cooper SA, Hersh EV et al: Evaluation of two controlled release formulations of morphine. Advances in Drug Therapy 11: , (Study 105) 57. Goldstein DJ, Cooper SA et al: Picenadol in a large multicenter dental pain study. Pharmacotherapy 14:54-59, (Study 110) 58. Cooper SA: Treating Acute Dental Pain. Postgraduate Dentistry 2:7-14, Cooper SA, Hersh EV et al: Lornoxicam: Analgesic Efficacy and Safety of a New Oxicam Derivative. Advances in Therapy Volume 13, No. 1:67-77, (Study 130) 60. Hersh EV, Cooper SA et al: Analgesic efficacy and safety of an intraoral lidocaine patch. J Amer Dent Assoc 127: , (Study 170) 61. Cooper SA, Cowan A., et al: The analgesic interaction of misoprostol with NSAIDs. Amer J Therap 3: , (Study 149) 62. Levin L.M., Cooper SA et al: Ketoprofen dental pain study. J Clin Dent 8: , (Study 139) 63. Johnson G, Cooper SA et al: Bromfenac sodium, acetaminophen/oxycodone, ibuprofen, and placebo for relief of postoperative pain. Clin Therap 19: , (Study 153) 9
10 64. Hersh EV, Cooper SA et al: A dose-ranging study of bromfenac sodium in oral surgery pain. Oral Surg, Oral Med, Oral Path 86:36-41, (Study 147) 65. Cooper SA, Reynolds DC et al: Analgesic efficacy and safety of (R)- ketoprofen in postoperative dental pain. J Clin Pharmacol 38:1-8, (Study 160) 66. Boni J, Cooper SA et al: Pharmacokinetic and pharmacodynamic action of etodolac in patients after oral surgery. J Clin Pharmacol 39: , (Study 168) 67. Doyle G, Cooper SA et al: Gastrointestinal safety and tolerance of ibuprofen at maximum over-the-counter use. Aliment Pharmacol Ther 13: , (Study PV-96-04) 68. Hersh EV, Cooper SA et al: Conventional and extended release etodolac for postsurgical dental pain. Clin Ther 21: Vol 8, (Study 168) 69. Kellstein DE, Waksman JA, Cooper SA et al: The safety profile of nonprescription ibuprofen in multiple-dose use: A meta analysis. J Clin Pharmacol 39: , Ashraf E, Ford L, Geetha R and Cooper S: Safety profile of ibuprofen suspension in young children. Inflammopharmacol 7: , Kellstein DE, Lipton RB, Cooper SA et al: Evaluation of a novel solubilized formulation of ibuprofen in the treatment of migraine headache. Cephalalgia 20: , (Study AM-98-01) 72. Hersh EV, Levin L, Cooper SA, et al: Ibuprofen liquigel for oral surgery pain. Clin Ther 22: , (Study PV-96-01) 73. Packman B, Packman E, Cooper SA et al: Solubilized ibuprofen: Evaluation of onset, relief and safety of a novel formulation in the treatment of episodic tensiontype headache. Headache 40: , (Study PV-96-06) 74. Olson NZ, Otero AM, Cooper SA et al: Onset of analgesia for liquigel ibuprofen 400 mg, acetaminophen 1000 mg, ketoprofen 25 mg and placebo in the treatment of postoperative dental pain. J Clin Pharmacol 41: , (Study KP-98-01) 75. Ashraf E, Cooper S et al: Safety profile of nonprescription ibuprofen in the elderly osteoarthritis patient: A meta analysis. Inflammopharmacol 9: 35-41, Doyle G, Jayawardena S, Ashraf E, Cooper SA. Efficacy and Tolerability of Nonprescription Ibuprofen versus Celecoxib for Dental Pain. J Clin Pharmacol 42: , (Study PV-99-05) 77. Meltzer EO, Berman GD, Cooper SA et al: Addition of ibuprofen to pseudoephedrine, and chlorpheniramine in the treatment of seasonal allergic rhinitis. Ann Asthma, Allergy & Immunol 93: ,
11 78. Cryer B, Berlin RG, Cooper SA et al: Double-blind, randomized, parallel, placebocontrolled study of ibuprofen effects on thromboxane B2 concentrations in aspirin-treated healthy volunteers. 2: 104, Clin Ther 27: , Cooper SA, Voelker M: Evaluation of onset of pain relief of micronized aspirin in a dental pain model. Inflammopharmacology 20:233-42, Qi DS, Cooper SA, et al: A randomized, double-blind, placebo-controlled study of acetaminophen 1000 mg versus acetaminophen 650 mg for the treatment of postsurgical dental pain. Clin Ther 34: , BOOKS/CHAPTERS 1. Cooper SA: Physiology and Pharmacologic Advances in Pain Control, Chapter 5, Cooper SA and Desjardins PJ: Pharmacology and Therapeutics for Dentistry, Eds.: Neidle, Kroeger and Yagiela Peripherally acting (nonopioid) analgesics, Chapter 21, 1997 (2 nd edition 1985, 3 rd edition 1988, 4 th edition 1997) 3. Cooper SA: Principles and Techniques of Human Research and Therapeutics- Selected Topics Volume 2, Ed. McMahon, Chapter 3 4. Cooper SA (Participating author) Commentary: Single-dose Analgesic Studies Advances in Pain Research and Therapy 18: , Cooper SA Quick Look Pharmacology- Drugs Used in Dentistry (Chapter 70) Eds: Raffa, Fence Creek Publishing, 1st edition Dionne RA and Cooper SA Ibuprofen: A critical bibliographic review Chapter 8- Use of ibuprofen in dentistry Ed: Rainsford KD, Cooper SA and Desjardins PJ The Value Of The Dental Impaction Pain Model In Drug Development Analgesia, Methods in Molecular Biology Series- The Humana Press Ed: Szallasi A, March
12 ABSTRACTS ( ) 1. Cooper SA and Strow L: Comparing assay sensitivities of pain models. Clin Pharmacol Ther 47:189, Cooper SA, Quinn PQ et al: Efficacy of a new ibuprofen formulation. J Dent Res 70:516, Cooper SA, Itkin A and Zweig B: Comparison of oxaprozin, aspirin and placebo in a dental impaction pain model. American Pain Society, New Orleans, LA, Cooper SA, Finizio T and Nathan G: Analgesic dose-response of flurbiprofen. Clin Pharmacol Ther 51:122, Cooper SA, Hersh EV et al: Correlation of tissue drug levels to analgesia. Clin Pharmacol Ther 51:148, Cooper SA et al: Analgesic efficacy of an ibuprofen-oxycodone combination. Clin Pharmacol Ther 53:172, Hersh EV, Cooper SA et al: Single and multiple dose analgesic study of meclofenamate Na and ibuprofen. Clin Pharmacol Ther 53:173, Hersh EV, Cooper SA et al: Single and multidose analgesic study. J Dent Res 72:186, Betts N, Cooper SA et al: Multidose analgesic study of mefanamic acid. J Dent Res 72:414, Cooper SA et al: Pharmacokinetic/pharmacodynamic study of ibuprofen formulations. Clin Pharmacol Ther 55:126, Cooper SA et al: An analgesic evaluation of lornoxicam. Clin Pharmacol Ther 55:126, Korn SH, Cooper SA et al: Onset of Analgesia with Dexibuprofen Lysine vs. Ibuprofen for Postoperative Dental Pain. Clin Pharmacol Ther, 59:133, Xue Y, Cooper SA et al: Absorption Kinetics of Diclofenac in Dental Patients After Molar Extraction. Clin Pharmacol Ther 59:204, Jamali F, Cooper SA and Kunz-Dober C: Altered Pharmacokinetics of Ibuprofen Enantiomers Caused by Dental Surgery. Clin Pharmacol Ther 59:217, Lemmems H, Cooper S et al: Pharmacokinetic-Pharmacodynamics of Ibuprofen in Dental Pain. J Clin Pharmacol 36:
13 16. Cooper SA, Reynolds DC et al: Efficacy of Ketoprofen 12.5 mg, Aspirin 650 mg and Placebo in the Relief of Postoperative Dental Pain. J Clin Pharmacol 36, Boni J, Cooper SA et al: Population PK/PD analysis of etodolac and etodolac extendedrelease in patients following oral surgery. Clin Pharmacol Ther 61:155, Doyle G, Cooper SA et al: Evaluation of the gastrointestinal safety profile of a 200 mg ibuprofen liquigel. J Clin Pharmacol 37:871, Packman E, Cooper SA et al: Onset of ibuprofen liquigel (400 mg) compared to acetaminophen caplets (1000 mg) in the treatment of tension headache. J Clin Pharm 38:876, Doyle G, Cooper SA et al: Evaluation of the gastrointestinal safety profile of over-thecounter (OTC) ibuprofen in the elderly. Amer J Gastro 93:1715, Hersh EV, Cooper SA et al: Analgesic evaluation of ibuprofen liquigel and acetaminophen. J Dent Res 79 (suppl): 3866, Kellstein DE, Cooper SA et al: Assessment of the overall efficacy of ibuprofen liquigels in migraine using a composite symptom score: a pooled analysis of two randomized, placebo-controlled trials. Headache 40: , Kellstein DE, Cooper SA et al: Efficacy of ibuprofen (I) liquigels in menstrual migraine: a pooled analysis of two randomized, placebo-controlled trials. Clin Pharmacol Ther 67:116, Fricke J, Cooper S et al: Ibuprofen and celecoxib-a comparison of analgesic effects of a non-specific and a specific COX-2 inhibitor: a randomized, placebo-controlled clinical trial. Arth Rheum 43 (suppl.):s223, Fricke J, Cooper S et al: Ibuprofen and celecoxib- comparison of analgesic effects. J Dent Res 80 (suppl): 141, Levin LM, Cooper SA et al: Evaluation of ibuprofen liquigel and an aspirin/acetaminophen/caffeine combination. J Dent Res 80 (suppl): 141, Ashraf EA, Cooper S, Marinucci L, Doyle G, Berlin R. GI safety of a non-selective NSAID vs a Cox-2 inhibitor: Equivalency of ibuprofen and celecoxib in an OTC setting. American Journal of Gastroenterology, September Supplement, (Abstracts) ps45, Meltzer EO, Berman GD, Cooper SA et al: Low-dose ibuprofen augments the effects of pseudoephedrine, and chlorpheniramine in the treatment of seasonal allergic rhinitis. Ann Asthma, Allergy & Immunol 92: 104, Turner S, Cooper S, Christensen S, Brain P, Podolsky G and Brown J. A double-blind, repeat dose, parallel study comparing the efficacy and safety of a controlled-release ibuprofen to placebo in postoperative oral surgery pain. J Pain:11, Suppl 1,
14 30. Qi D, May L, Zimmerman B, Cooper SA et al. Comparison of acetaminophen 1000 mg and acetaminophen 650 mg in an acute pain model: Results from a randomized, doubleblind, placebo-controlled efficacy and safety study. OARSI Osteoarthritis and Cartilage, Volume 20 Supplement 1, ISSN , S175, April Qi D, May L, Zimmerman B, Cooper SA et al. A randomized, double-blind, placebocontrolled efficacy and safety study of acetaminophen 1000 mg and acetaminophen 650 mg in postoperative dental pain. J Pain,13:74: Suppl 1,
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