Depression & Diabetes: Pathways and TeamCare Studies
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1 Depression & Diabetes: Pathways and TeamCare Studies Wayne Katon, MD 1 Mike VonKorff, ScD 2 Elizabeth Lin, MD, MPH 2 Paul Ciechanowski, MD, MPH 1 Evette Ludman, PhD 2 Joan Russo, PhD 1 Carolyn Rutter, PhD 2 Bessie Young, MD, MPH 1 1 University of Washington School of Medicine 2 Center for Health Studies, Group Health Cooperative NIMH Grants MH and MH (Dr. Katon)
2 Pathways Randomized Controlled Trial Participants randomly assigned to Pathways nurse collaborative care intervention (N = 165) vs. usual care (N = 164) Usual Care Primary care or referral to specialty MH care as available Pathways Care Collaborative/stepped care disease management program for depression in primary care Katon et al. Arch Gen Psych 2004
3 Treatment Protocol 1) Behavioral Activation/Pleasant Events Scheduling 2) Antidepressant Medication usually an SSRI or other newer antidepressant OR Problem Solving Treatment in Primary Care (PST- PC) 6-8 individual sessions followed by monthly group maintenance sessions 3) Maintenance and Relapse Prevention Plan for Patients in Remission Katon et al. Arch Gen Psych 2004
4 Collaborative Care Patient Chooses treatment in consultation with provider(s) Primary care provider (PCP) Refers; prescribes antidepressant medications + Depression Care Manager + Consulting Psychiatrist
5 Intervention vs Control Differences on Mean SCL Depression Scores (Range 0 4) Mean SCL-20 Depression Score I UC Baseline 3 mos 6 mos 12 mos Katon et al. Arch Gen Psych 2004
6 Intervention vs Control Differences on Mean SCL Depression Scores (Range 0 4) Mean SCL-20 Depression Score Baseline 3 mos 6 mos 12 mos 24 mos I UC Katon et al. Arch Gen Psych 2004
7 Satisfaction with Treatment for Depression % Very Satisfied p <.01 p <.01 Baseline 6 Months 12 Months Usual Care (N=165) Intervention (N=164) Katon et al. Arch Gen Psych 2004
8 Patient Global Improvement % Very Improved from Baseline month 12-month Usual Care (N=165) Intervention (N=164) Follow-Up Visit Katon et al. Arch Gen Psych 2004
9 Intervention vs Control Differences on Mean HbA 1c 8 Mean HbA 1C % UC I 6 Baseline 6 mos 12 mos Katon et al. Arch Gen Psych 2004
10 Depression: Diabetes Lower Total Health Care Costs Over 2 Years $25,000 $22,258 $21,148 $18,932 $20,000 $18,035 $15,000 $10,000 $5,000 Usual Care Intervention Savings $1,110 Usual Care Intervention Savings $897 $0 Pathways IMPACT
11 $14,000 $12,000 $10,000 $8,000 $6,000 $4,000 $2,000 Total Costs per Year Over 5 Years: CM vs. UC Cost Differences $0 YR 1 YR 2 YR 3 YR 4 YR 5 Usual Care Care Management
12 Conclusion: Depression in Patients with Diabetes Depression is associated with higher symptom burden, additive functional impairment, poor self care (diet, exercise, adherence to medication), increased medical costs, increased complications and mortality Enhanced treatment of depression is associated with improved depressive outcomes, improved physical functioning (in one of two trials), lower BMI (in one trial), no change in HbA 1c, and a high probability of medical cost savings
13 Treating depression and other mental Illness is a necessary first step, but not sufficient alone to improve health risk behaviors and chronic medical disease control
14 Health Services Models TeamCare Approaches have been shown to improve quality of care and outcomes of patients with depression, diabetes, asthma and CHF The most complex and medical costly patients often have multiple comorbidities including at least one mental health diagnosis
15 Medicare Patients Depression, diabetes and heart disease are among the most common illnesses in aging populations but fewer than 4% of Medicare beneficiaries with any of these three illnesses have no other chronic medical conditions 80% of those with CHF, 71% with depression and 56% with diabetes have 4 or more chronic conditions Partnership for Solutions 2001
16 Challenge: Development of Health Services Models for Natural Clusters of Illness Definition: Illnesses with high prevalence, high comorbidity and bidirectional adverse interactions Examples: Diabetes, CAD, depression Depression, chronic pain, substance abuse
17 New NIMH-Funded Study: TeamCare Inclusion Criteria Evidence via automated date (ICD-9) of having diabetes and/or coronary artery disease (CAD) Evidence of poor disease control (HbA 1c > 8.5, blood pressure >140/90, LDL >130) PHQ-9 > 10
18 TeamCare Intervention Goals Improve depression care: behavioral activation and antidepressants Improve medical disease control: HbA 1c, HTN, LDL Improve self-care (diet, exercise, cessation of smoking, glucose checks)
19 TeamCare Interventionists 3 diabetes nurse educators Caseload supervision Depression: 2 psychiatrists Diabetes and CAD: nephrologist, family doctor to diabetologist for complex cases
20 Nurse Training Motivational interviewing Problem solving Behavioral activation Antidepressants TREAT-to-TARGET: blood glucose, HTN, LDLS
21 TeamCare Summary Report Initial Clinic Enroll Date BL PHQ Now BL BP Now HbA 1c BL Now LDL BL Now NSH 5/19/ /69 127/ NSH 1/9/ /80 130/ EVM 11/12/ /98 150/ EVM 10/30/ / / LYN 8/23/ /71 111/
22
23 Improving Adherence Patient self-care materials: book and video on depression, patient manual (Tools for Managing Your Chronic Disease) Nurse support/education/motivational interviewing Medisets Simplifying medication regimen $4 generics to avoid $10 co-pays
24 Self-Care Enhancements Glucometers: Group Health provides Home blood pressure monitors Pedometers to increase exercise Medisets to improve adherence
25 Phases of Treatment Intervene on depression initially Behavioral activation Antidepressant medication
26 Medical Disease Control Is patient adhering to medication regimen? If adhering and in poor control, is patient on optimal dosage? If maximum dosage has been reached should a new medication be tried instead or augmentation of initial medication? Team recommendations of medication changes are reviewed with primary care physician for approval
27 TREAT-to-TARGET Guidelines Nurses ask for physician approval for gradually increasing insulin or blood pressure medications based on these guidelines
28 Behavioral Goals Behavioral activation/exercise Dietary changes Checking blood glucose/altering insulin Cessation of smoking
29 Conclusions Training diabetes nurses to integrate depression screening and treatment is feasible and potentially enhances their ability to effectively treat a larger population of patients. Study results: Fall 2009
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