Table 2.1. Case-control studies of sun exposure and basal cell carcinoma, published after 1992

Transcription

1 Reference, study location & period Gallagher et al (995a), Alberta, Canada, Cases Controls Exposure assessment 226 M with incident BCC from cancer registry, yrs, stratified by site; response rate 72%; 00% histol confirmed 406 male controls selected from populationbased health care register, stratified by age and sex; response rate 7% Intervieweradministered Exposure categories Sunburn pain 2d life Sunburn pain 2d last0y Mean recreation sun/yr, 0 9yrs -med Mean rec sun/yr 0 9 on-tanners -med Mean rec sun/yr, life -med Mean occupatn sun -med Mean cumul sun/yr -med Mean cumul sun/yr Tanners -med Relative risk (95%CI)* 0.9 (0.6.3) 2.3 ( ). ( ).4 ( ) 2.6 (. 6.5). ( ).7 ( ) 3. ( 0.4) 0.9 (0.6.7) 0.6 (0.3.3) 0.4 (0.2 ) (0.6.8).3 ( ).4 ( ).3 ( ).2 ( ).3 ( ).8 ( ).5 ( ) 2.2 ( ) Adjustment for potential Age, mother s ethnicity, skin colour, hair colour Comments

2 Kricker et al (995 a,b) Geraldton, Western Australia, cases with incident BCC from population survey, yrs, response rate 89%; 00% histol confirmed 700 controls selected from disease free at population survey or year before; response rate 89% Personal calendar and intervieweradministd Ambient solar radiatn at places residence (mwh cm 2 x0 5 ) Whole year -med Lifetime sun hours Tanners -med Poor or non-tanners -med Painful sunburns-site Intermittency of sun 5 9 yrs Tanners Least ium -medium Most Poor or non-tanners Least ium -medium Most.3 ( ).7 (0.7 4.) 2.2 ( ) 0.6 (0. 2.8) 2.2 ( ) 2.5 ( ) 4.6 (.6 3.5) 4.9 (.7 4.6) 5.9 (2.0 8.) 2.2 ( ). (0.7.8).8 ( 2.9).5 ( 2.3) ( ) ( ) 0.9 ( ). ( ).9 ( ) 2.5 (. 5.5) 5.9 ( ) Age, sex, ability to tan Age, sex 2 Age, sex, ability to tan, site

3 Rosso et al, (996), Rosso et al (998); 8 centres in Italy, France, Spain, Rosso et al (999), Valais, Switzerland, Vlajinac et al, (2000), Belgrade & Zrenjanin, ugoslavia, cases, diagnosed in 5 cancer registries+ 2 hospitals, yrs, 00% histol confirm 20 cases from cancer registry, 25 75y, 00% histol confirmn 200 (24M) consec cases at Skin Dept, >30yrs 795 controls From 5 pop registers+ non-cancer, nondermatology patients of 3 hospitals 44 controls from two volunteer registers, 8% resp rate 399 controls Dermatology patients same Dept, non-cancer Physicianadministd Sunburns life 2 3+ Holidays at beach in life, hrs ever Medium Life outdoor work, h Low Medium Painful sunburns 2 3+ Seaside hols wks/yr Outdoor work summr??.3 (..6).5 (. 2.2).7 (.2 2.2). (.3).5 (.2.8) (0.8.2) (0.8.2) (0.6.6).3 ( ) 2.4 (.7 3.4) ot stated.8 (.2 2.6) 4.0 (.6 0.0) Age, sex, centre Age, sex, centre, other risk factors Age, sex ot stated 3 Prevalent cases Prevalent cases; sparse sun exposure data Incomplete exposure data

4 Corona et al (200) Rome, Italy, cases (87M, 79F) with incident BCC from referral hospital, 8+ yrs, 00% histol confirmed 58 dermatology patients with minor skin conditions from same hospital 4 Sunburn <20yrs Sunburn >20yrs Beach summer hols wk/yr <20yrs >8 Beach summer hols wk/yr >20yrs >8 Outdoor work, yrs 0 8 >8 Solar lentigines arm Absent Present Actinic keratoses Present/past Hx 0.9 (0.4.6) 0.7 (0.4.4).8 ( ) 3.7 (.5 9.0) 4.5 (.9 0.5) 0.7 (0.3.6) 0.3 (0. 0.7) 0.9 ( ).7 (0.7 4.).7 (0.9 3.) 3.2 (. 9.4) Age, sex, hair-eye pigment traits, family history skin cancer Age, sex, hair-eye pigment traits, freckles on face, family history skin cancer

5 Kennedy et al (2003) Leiden, The etherlands, cases with incident and prevalent BCC diagnosed in referral hospital, yrs, 00% histol confirmed 386 ophthalmology patients from same hospital Residence Work Calendar+ Sunburn <20yrs Sunburn 20 39yrs Sunburn 40 59yrs Sunburn <20yrs Sunburn 20 39yrs Sunburn 40 59yrs Lifetime sun exp, hrs ium -medium est Lifetime sun exp, hrs ium -medium est odular BCC.6 (. 2.2).2 (0.9.7).5 ( ) Multifocal BCC 2.6 (.7 3.8) (0.7.5) 0.9 (0.4.8) odular BCC.2 ( ).5 ( ) 2.3 ( 5.7) Multifocal BCC. ( ).9 ( ).6 (.6 4.4) Age, sex, skin type 5 Prevalent cases diagnosed up to 2 years before included

6 Walther et al (2004), Ulm & Dresden, southern Germany, Zanetti et al (2006), 4 centres in Italy, Spain, France, Portugal, Denmark, Germany, Argentina, Pelucchi et al (2007); aldi et al, 2000, orth &South Italy *23 cases (03M, 0F) with sporadic BCC in past 5 years, diagnosed in dermatology department, all ages, 00% histol confirmed 25 cases with incident BCC diagnosed in hospitals in study centres, yrs, 00% histol confirmed 528 consecutive cases with incident BCC diagnosed in 6 hospital-based study centres, median age 65 yrs, 00% histol confirmed **4 patients with allergic, vascular or genital conditions from same department and general surgical patients 349 non-dermatology patients of same hospitals 52 acute patients of same hospitals, age and sex matched to cases Sunburn ever Occupational UV exposure ever/rare S times/frequent Solar lentigo Actinic keratosis Sunburn ever Sometimes Often Holidays at beach, weighted hrs in life Low Outdoor work, weighted hrs in life ever Low ium -medium est Severe sunburn Age st severe s burn <8yrs 8yrs o. severe sunburns (.9 6.8) 2.4 (.3 4.7) 2.5 (.2 5.3) 2.7 (.3 5.9).4 ( 2.4).7 ( 2.8) 2. (. 4.0).4 ( ) 0.7 (0.4.4).4 ( ).2 (0.7 2.) odular 3.4 ( ) 6.9 ( ) 2.8 (.8 4.5) 3.2 ( ) 6.5 (3. 3.8) ot stated Age, significant independent risk factors 6 Age, country, significant host factors Age, sex, study centre, education, eye, hair, and skin colour Prevalent cases diagnosed up to 5 years before included; *46 cases, **264 controls in multivariate analyses

7 Pelucchi et al (2007); aldi et al, (2000) (contd) 7 Severe sunburn Age st severe s burn <8yrs 8yrs o. severe sunburns 2+ Life occupational sun ever ever Life recreational sun ever ever.7 ( 2.8) 3.3 (.2 8.7).3 ( ). (0.5 2.) 4.5 ( ) odular.5 (. 2.2).7 (. 2.6).4 (0.9 2.) 0.7 (0.4.2) 0.9 (0.5.6) 0.5 (0.3 ) odular.8 (.3 2.4) 2. (.4 3.).4 ( 2.2).4 ( ).3 ( ).3 ( )

8 Pelucchi et al (2007); aldi et al, 2000 (contd) 8 Life sun total o es Rec or Occ Sun Rec + Occ Sun o es Rec or Occ Sun Rec + Occ Sun Solar lentigines Actinic keratoses Solar lentigines Actinic keratoses odular 2.0 (.5 2.8) 2.0 (.4 2.7) 2.9 (.6 5.4) (0.7.5) (0.7.5).2 ( ) odular.5 ( 2.).7 (. 2.6) 0.9 (0.5.6) 3.4 (2. 5.5)

9 Pelucchi et al (2007); aldi et al, 2000 (contd) 9 Severe sunburn Age st severe s burn <8yrs 8yrs o. severe sunburns 2+ Severe sunburn Age st severe s burn <8yrs 8yrs o. severe sunburns 2+ Life occupational sun ever ever H& 3.4 (2.3 5.) 6.0 ( ) 2.9 (.9 4.6) 3.2 ( ) 6.7 (3. 3.7) Trunk 2.4 (.5 3.9) 4.2 (.5.2) 2. (.2 3.6).7 ( ) 6.0 ( ) H&.5 ( 2.).7 (. 2.7).2 (0.8.9) Trunk 0.7 (0.4.2) 0.9 (0.5.7) 0.5 (0.2.)

10 Reference, study location & period Pelucchi et al (2007); aldi et al, 2000 (contd) Cases Controls Exposure assessment 0 Exposure categories Life recreational sun ever ever Life sun total o es Rec or Occ Sun Rec + Occ Sun o es Rec or Occ Sun Rec + Occ Sun Solar lentigines Actinic keratoses Solar lentigines Actinic keratoses Relative risk (95%CI)* H&.9 (.4 2.6) 2. (.4 3.).7 (.2 2.5) Trunk.6 (. 2.5).8 (. 3.0).4 ( ) H& 2.0 (.4 2.7).9 (.4 2.6) 3.4 (.9 6.0) Trunk.2 (0.8.3).2 (0.8.8).5 ( ) H&.5 ( 2.).8 (.2 2.7) Trunk (0.6.6) 3.0 (.8 5.) Adjustment for potential. When data from a case-control study have been published in different papers, the most comprehensive and/or detailed version of the data have been tabulated Comments